HUP0001505A1 - Aktivált, K-vitamintól függő vérfaktor és eljárás előállítására - Google Patents

Aktivált, K-vitamintól függő vérfaktor és eljárás előállítására

Info

Publication number
HUP0001505A1
HUP0001505A1 HU0001505A HUP0001505A HUP0001505A1 HU P0001505 A1 HUP0001505 A1 HU P0001505A1 HU 0001505 A HU0001505 A HU 0001505A HU P0001505 A HUP0001505 A HU P0001505A HU P0001505 A1 HUP0001505 A1 HU P0001505A1
Authority
HU
Hungary
Prior art keywords
blood factor
plant
production
dependent
activated vitamin
Prior art date
Application number
HU0001505A
Other languages
English (en)
Inventor
Johann Eibl
Anton Philapitsch
Günter Richter
Hans-Peter Schwarz
Peter Turecek
Original Assignee
Baxter Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Aktiengesellschaft filed Critical Baxter Aktiengesellschaft
Publication of HUP0001505A1 publication Critical patent/HUP0001505A1/hu
Publication of HUP0001505A3 publication Critical patent/HUP0001505A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgya eljárás K-vitaminfüggő vérfaktőrők aktiválásáraprőteázzal történő kezeléssel, melynek sőrán növényből, gőmbából vagyprőkariőtából származó prőteázt alkalmaznak, amely a növényből vagysejttenyészetből nyert nyers extraktűmhőz viszőnyítva legalábbkétszeresen megnövelt specifikűs vérfaktőr-aktiváló hatássalrendelkezik. A találmány kiterjed a fenti kőmpőnenseket tartalmazógyógyszerkészítményekre és gyógyászati készletre, valamint az aktiváltK-vitamintól függő vérfaktőrra. ŕ
HU0001505A 1997-03-12 1998-03-10 Activated vitamin k-dependent blood factor and method for the production thereof HUP0001505A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19710190A DE19710190A1 (de) 1997-03-12 1997-03-12 Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung
PCT/EP1998/001364 WO1998040474A2 (de) 1997-03-12 1998-03-10 Aktivierter vitamin k-abhängiger blutfaktor und verfahren zu dessen herstellung

Publications (2)

Publication Number Publication Date
HUP0001505A1 true HUP0001505A1 (hu) 2000-09-28
HUP0001505A3 HUP0001505A3 (en) 2002-01-28

Family

ID=7823110

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001505A HUP0001505A3 (en) 1997-03-12 1998-03-10 Activated vitamin k-dependent blood factor and method for the production thereof

Country Status (9)

Country Link
EP (1) EP0968280A1 (hu)
JP (1) JP2001514516A (hu)
AU (1) AU740727B2 (hu)
CA (1) CA2284122A1 (hu)
DE (1) DE19710190A1 (hu)
HU (1) HUP0001505A3 (hu)
NO (1) NO994394L (hu)
SK (1) SK124699A3 (hu)
WO (1) WO1998040474A2 (hu)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE13810T1 (de) * 1981-06-25 1985-07-15 Serapharm Gmbh & Co Kg Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundabdeckung.
DK0485504T3 (da) * 1989-08-11 1994-04-18 Zymogenetics Inc Fremgangsmåde til fremstilling af aktiveret protein C ved celledyrkning
DE69130990T2 (de) * 1990-02-20 1999-12-02 Baxter Int Gereinigtes, virusfreies menschliches Thrombin
WO1993006855A1 (en) * 1991-10-11 1993-04-15 Novo Nordisk A/S Hemostatic composition for local hemostasis
WO1993009807A1 (en) * 1991-11-18 1993-05-27 The Scripps Research Institute Methods of inhibiting thrombosis via elevation of circulating endogenous activated protein c levels
US5476777A (en) * 1991-12-31 1995-12-19 Zymogenetics, Inc. Methods for producing thrombin
AT397390B (de) * 1992-04-06 1994-03-25 Immuno Ag Verfahren zur spaltung von proteinen
US5514373A (en) * 1992-05-22 1996-05-07 Harris, Jr.; Roosevelt D. Topical preparation
WO1994021284A1 (en) * 1993-03-15 1994-09-29 Pharma Pacific Pty. Ltd. Therapeutic formulation and method
DE4325872C1 (de) * 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
DE4430205A1 (de) * 1994-08-26 1996-02-29 Behringwerke Ag Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung
US5589571A (en) * 1994-10-28 1996-12-31 Cor Therapeutics, Inc. Process for production of inhibited forms of activated blood factors
DE19503338C2 (de) * 1995-02-02 1998-07-30 Lohmann Therapie Syst Lts Arzneiform zur Abgabe von Kollagenase an Wunden und Verfahren zu ihrer Herstellung und ihre Verwendung

Also Published As

Publication number Publication date
AU6829598A (en) 1998-09-29
AU740727B2 (en) 2001-11-15
NO994394L (no) 1999-11-11
SK124699A3 (en) 2000-06-12
DE19710190A1 (de) 1998-09-17
CA2284122A1 (en) 1998-09-17
WO1998040474A2 (de) 1998-09-17
WO1998040474A3 (de) 1999-02-11
HUP0001505A3 (en) 2002-01-28
NO994394D0 (no) 1999-09-10
EP0968280A1 (de) 2000-01-05
JP2001514516A (ja) 2001-09-11

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