HUP0001300A2 - Eljárás 2,4'-dipiridil-származékok előállítására és elkülönítésére, valamint benzoxazepinszármazékok és sóik előállítására - Google Patents
Eljárás 2,4'-dipiridil-származékok előállítására és elkülönítésére, valamint benzoxazepinszármazékok és sóik előállításáraInfo
- Publication number
- HUP0001300A2 HUP0001300A2 HU0001300A HUP0001300A HUP0001300A2 HU P0001300 A2 HUP0001300 A2 HU P0001300A2 HU 0001300 A HU0001300 A HU 0001300A HU P0001300 A HUP0001300 A HU P0001300A HU P0001300 A2 HUP0001300 A2 HU P0001300A2
- Authority
- HU
- Hungary
- Prior art keywords
- dipyridyl
- derivatives
- derivative
- production
- benzoxazepine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- ZCXLTWVZYXBHJS-UHFFFAOYSA-N 1,2-benzoxazepine Chemical class O1N=CC=CC2=CC=CC=C12 ZCXLTWVZYXBHJS-UHFFFAOYSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- RMHQDKYZXJVCME-UHFFFAOYSA-N 2-pyridin-4-ylpyridine Chemical group N1=CC=CC=C1C1=CC=NC=C1 RMHQDKYZXJVCME-UHFFFAOYSA-N 0.000 abstract 3
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 abstract 3
- MWVTWFVJZLCBMC-UHFFFAOYSA-N 4,4'-bipyridine Chemical group C1=NC=CC(C=2C=CN=CC=2)=C1 MWVTWFVJZLCBMC-UHFFFAOYSA-N 0.000 abstract 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000000889 atomisation Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011435 rock Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/22—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing two or more pyridine rings directly linked together, e.g. bipyridyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány 2,4'-dipiridil-származékők előállítására vőnatkőzik egy 2-halőgénpiridin-származék és egy 4-halőgénpiridin cserebőmlásireakcióban való kapcsőlása útján egy kőmplex nikkelkatalizátőrjelenlétében. A találmány tárgya tővábbá eljárás egy 2,4'-piridil-származék elkülönítésére dipiridil-izőmerek egy 2,2'-dipiridil-származékőt, 2,4'-dipiridilszármazékőt és 4,4'-dipiridil-származékőtkeverékéből híg vizes rézszűlfát-őldatőt használva inszőlűbilizáláscéljából, majd a 2,2'-dipiridil-származékőt és a 4,4'-dipiridil-származékőt eltávőlítva. A találmány tővábbá benzőxazepin-származékőknak a találmány szerinti 2,4'-dipiridil-származékőkbólkiindűló előállítására vőnatkőzik. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13263197 | 1997-05-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001300A2 true HUP0001300A2 (hu) | 2000-08-28 |
| HUP0001300A3 HUP0001300A3 (en) | 2002-01-28 |
Family
ID=15085850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001300A HUP0001300A3 (en) | 1997-05-22 | 1998-05-22 | Method of production and method of separation of 2,4'-dipyridil derivatives and methods of production of benzoxazepine derivatives and salts thereof |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6096884A (hu) |
| EP (1) | EP0966440B1 (hu) |
| KR (1) | KR100362958B1 (hu) |
| CN (1) | CN1107054C (hu) |
| AT (1) | ATE309218T1 (hu) |
| AU (1) | AU727647B2 (hu) |
| CA (1) | CA2260989C (hu) |
| DE (1) | DE69832263T2 (hu) |
| ES (1) | ES2247693T3 (hu) |
| HU (1) | HUP0001300A3 (hu) |
| WO (1) | WO1998052922A1 (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0001300A3 (en) * | 1997-05-22 | 2002-01-28 | Daiichi Asubio Pharma Co Ltd | Method of production and method of separation of 2,4'-dipyridil derivatives and methods of production of benzoxazepine derivatives and salts thereof |
| JP4603646B2 (ja) | 1999-11-15 | 2010-12-22 | 富士フイルムファインケミカルズ株式会社 | 新規なジピリジル誘導体 |
| JP4603648B2 (ja) | 1999-11-30 | 2010-12-22 | 富士フイルムファインケミカルズ株式会社 | ピリジン誘導体の製造方法 |
| CN103030594A (zh) * | 2012-12-11 | 2013-04-10 | 安徽国星生物化学有限公司 | 一种2,2'-联吡啶的合成方法 |
| CN103030595A (zh) * | 2012-12-11 | 2013-04-10 | 安徽国星生物化学有限公司 | 一种2,2'-联吡啶的双碱解合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996024594A1 (fr) * | 1995-02-10 | 1996-08-15 | Suntory Limited | Derives de benzodiazepines, sels issus de ces derives, et medicaments a base de ces derives et sels |
| HUP0001300A3 (en) * | 1997-05-22 | 2002-01-28 | Daiichi Asubio Pharma Co Ltd | Method of production and method of separation of 2,4'-dipyridil derivatives and methods of production of benzoxazepine derivatives and salts thereof |
-
1998
- 1998-05-22 HU HU0001300A patent/HUP0001300A3/hu unknown
- 1998-05-22 CN CN98800941A patent/CN1107054C/zh not_active Expired - Fee Related
- 1998-05-22 AU AU74505/98A patent/AU727647B2/en not_active Ceased
- 1998-05-22 US US09/230,168 patent/US6096884A/en not_active Expired - Lifetime
- 1998-05-22 AT AT98921776T patent/ATE309218T1/de not_active IP Right Cessation
- 1998-05-22 EP EP98921776A patent/EP0966440B1/en not_active Expired - Lifetime
- 1998-05-22 DE DE69832263T patent/DE69832263T2/de not_active Expired - Lifetime
- 1998-05-22 WO PCT/JP1998/002264 patent/WO1998052922A1/en active IP Right Grant
- 1998-05-22 CA CA002260989A patent/CA2260989C/en not_active Expired - Fee Related
- 1998-05-22 KR KR1019997000461A patent/KR100362958B1/ko not_active IP Right Cessation
- 1998-05-22 ES ES98921776T patent/ES2247693T3/es not_active Expired - Lifetime
-
2000
- 2000-06-09 US US09/590,678 patent/US6624308B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69832263T2 (de) | 2006-06-08 |
| ATE309218T1 (de) | 2005-11-15 |
| EP0966440A1 (en) | 1999-12-29 |
| KR20000029467A (ko) | 2000-05-25 |
| CA2260989C (en) | 2005-04-19 |
| EP0966440B1 (en) | 2005-11-09 |
| ES2247693T3 (es) | 2006-03-01 |
| US20030125547A1 (en) | 2003-07-03 |
| CN1107054C (zh) | 2003-04-30 |
| US6096884A (en) | 2000-08-01 |
| CA2260989A1 (en) | 1998-11-26 |
| HUP0001300A3 (en) | 2002-01-28 |
| AU7450598A (en) | 1998-12-11 |
| DE69832263D1 (de) | 2005-12-15 |
| CN1230950A (zh) | 1999-10-06 |
| AU727647B2 (en) | 2000-12-21 |
| KR100362958B1 (ko) | 2002-11-30 |
| WO1998052922A1 (en) | 1998-11-26 |
| US6624308B2 (en) | 2003-09-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC9A | Change of name, address |
Owner name: ASUBIO PHARMA CO., LTD., JP Free format text: FORMER OWNER(S): DAIICHI ASUBIO PHARMA CO., LTD., JP; DAIICHI SUNTORY PHARMA CO., LTD., JP; SUNTORY LIMITED, JP |
|
| GB9A | Succession in title |
Owner name: DAIICHI SANKYO COMPANY, LIMITED, JP Free format text: FORMER OWNER(S): ASUBIO PHARMA CO., LTD., JP; DAIICHI ASUBIO PHARMA CO., LTD., JP; DAIICHI SUNTORY PHARMA CO., LTD., JP; SUNTORY LIMITED, JP |
|
| FD9A | Lapse of provisional protection due to non-payment of fees |