HUP0000850A2 - Balszalazidszármazékokat tartalmazó új gyógyszerforma - Google Patents

Balszalazidszármazékokat tartalmazó új gyógyszerforma

Info

Publication number
HUP0000850A2
HUP0000850A2 HU0000850A HUP0000850A HUP0000850A2 HU P0000850 A2 HUP0000850 A2 HU P0000850A2 HU 0000850 A HU0000850 A HU 0000850A HU P0000850 A HUP0000850 A HU P0000850A HU P0000850 A2 HUP0000850 A2 HU P0000850A2
Authority
HU
Hungary
Prior art keywords
powder
pipe
pharmaceutical form
phenyl
general formula
Prior art date
Application number
HU0000850A
Other languages
English (en)
Inventor
Stefan Friess
Harald Heckenmüller
Oliver Szambien
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20406161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0000850(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of HUP0000850A2 publication Critical patent/HUP0000850A2/hu
Publication of HUP0000850A3 publication Critical patent/HUP0000850A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya egység-gyógyszerfőrma, amely egy általánős képletűvegyület -, ahől X szűlfőnil- vagy karbőnilcsőpőrt; R1 fenil-,(karbőxi-metil)-fenil-csőpőrt vagy -R2Y általánős képletű csőpőrt; R2adőtt esetben szűbsztitűált -(CH2)n,- vagy benzil-(CH2)n- általánősképletű csőpőrt; Y karbőxi-, szűlfő-, hidrőxi-, aminőcsőpőrt, -NHR3vagy -N(R3)2 általánős képletű csőpőrt; R3 adőtt esetben szűbsztitűáltalkilcsőpőrt; n 1 és 6 közötti egész szám - vagy észterét, hatásősmetabőlitját vagy nem-tőxikűs sóját tartalmazza gyógyszerészetilegelfőgadható hőrdőzó- és/vagy kötőanyaggal együtt, és amelygyógyszerfőrma sűrűsége legalább 0,9 mg/mm3. Az (I) általánős képletűvegyület előnyösen a balszalazid-nátriűmsó-dihidrát. A gyógyszerfőrmátúgy állítják elő, hőgy a hatóanyagőt granűlálják, a granűlátűmőt adőttesetben segédanyagőkkal összepréselik, és a tablettát adőtt esetbenbevőnattal látják el. A gyógyszerfőrmát gastrőintestinalis betegségekterápiájában alkalmazzák. ŕ
HU00008500000850A 1997-03-14 1998-03-13 New formulation contg. derivatives of balsalazide new formulation contg. derivatives of balsalazide HUP0000850A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9700934A SE9700934D0 (sv) 1997-03-14 1997-03-14 New formulation
PCT/SE1998/000455 WO1998041212A1 (en) 1997-03-14 1998-03-13 New formulation

Publications (2)

Publication Number Publication Date
HUP0000850A2 true HUP0000850A2 (hu) 2000-09-28
HUP0000850A3 HUP0000850A3 (en) 2000-10-30

Family

ID=20406161

Family Applications (1)

Application Number Title Priority Date Filing Date
HU00008500000850A HUP0000850A3 (en) 1997-03-14 1998-03-13 New formulation contg. derivatives of balsalazide new formulation contg. derivatives of balsalazide

Country Status (15)

Country Link
US (1) US6197341B1 (hu)
EP (1) EP1003524A1 (hu)
JP (1) JP2001519782A (hu)
AU (1) AU6430198A (hu)
BE (1) BE1011837A5 (hu)
BR (1) BR9808140A (hu)
CA (1) CA2283297A1 (hu)
FR (1) FR2760638A1 (hu)
GR (1) GR980100096A (hu)
HU (1) HUP0000850A3 (hu)
NL (1) NL1008575C2 (hu)
NO (1) NO994431L (hu)
PL (1) PL335700A1 (hu)
SE (1) SE9700934D0 (hu)
WO (1) WO1998041212A1 (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9700934D0 (sv) * 1997-03-14 1997-03-14 Astra Ab New formulation
DE60141520D1 (de) * 2000-08-29 2010-04-22 Biocon Ltd 5-asa-derivate mit entzündungshemmender und antibiotischer wirkung und verfahren zur behandlung von krankheiten mit diesen derivaten
ATE448194T1 (de) 2000-08-29 2009-11-15 Biocon Ltd Verwendung einer pharmazeutischen zusammensetzung mit einem para-aminophenylessigsäurederivat für die behandlung von entzündlichen erkrankungen des magen-darmtrakts
US8048924B2 (en) * 2001-08-29 2011-11-01 Biocon Limited Methods and compositions employing 4-aminophenylacetic acid compounds
MY140707A (en) * 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
ATE554752T1 (de) 2004-02-06 2012-05-15 Pharmatel R & D Pty Ltd As Trustee For The Pharmatel R & D Trust Verwendung von aminosalicylaten beim reizdarmsyndrom mit durchfall als vorherrschendem symptom
KR20110121730A (ko) * 2004-05-28 2011-11-08 샐릭스 파마슈티컬스 인코포레이티드 방사선 유발성 장염의 예방, 치료 및 개선 방법
US20080306029A1 (en) * 2004-05-28 2008-12-11 Salix Pharmaceuticals, Inc. Prevention, Treatment, and Amelioration of Radiation Induced Enteritis
WO2006014549A2 (en) * 2004-07-07 2006-02-09 Nobex Corporation Synthesis of azo bonded immunoregulatory compounds
US20060270635A1 (en) * 2005-05-27 2006-11-30 Wallace John L Derivatives of 4- or 5-aminosalicylic acid
WO2006125293A1 (en) 2005-05-27 2006-11-30 Antibe Therapeutics Inc. Derivatives of 4- or 5-aminosalicylic acid
US7498355B2 (en) 2005-05-27 2009-03-03 Antibe Therapeutics Inc. Derivatives of 4- or 5-aminosalicylic acid
US7741359B2 (en) * 2005-05-27 2010-06-22 Antibe Therapeutics Inc. Hydrogen sulfide derivatives of non-steroidal anti-inflammatory drugs
US7452872B2 (en) * 2005-08-24 2008-11-18 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
CN103948609A (zh) 2005-08-24 2014-07-30 萨利克斯药品公司 巴柳氮制剂及其生产和应用
US8921344B2 (en) * 2006-11-03 2014-12-30 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
AU2007257174B2 (en) * 2006-06-06 2012-07-12 Gicare Pharma Inc. Salts of trimebutine and N-desmethyl trimebutine
JP2013525440A (ja) 2010-04-26 2013-06-20 サリックス ファーマシューティカルズ リミテッド 男性の治療のための２−ヒドロキシ−５−フェニルアゾ安息香酸誘導体の製剤および使用
US12053447B2 (en) 2019-06-25 2024-08-06 NuBioPharma, LLC Oral solution and powder to liquid compositions of balsalazide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045429A (en) 1970-03-06 1977-08-30 Pharmacia Aktiebolag 4-(4-Hydroxy- or acetoxy-3-carbomethoxyphenylazo)-benzenesulphonyl chloride
BE791889A (fr) 1971-11-26 1973-05-24 Pharmacia Ab Nouveaux derives de la pyridine
WO1981002671A1 (en) * 1980-03-20 1981-10-01 Ferring Farma Lab Pharmaceutical composition and method for the treatment of colitis ulcerosa and crohn's disease by oral administration
US4412992A (en) 1980-07-21 1983-11-01 Biorex Laboratories Limited 2-Hydroxy-5-phenylazobenzoic acid derivatives and method of treating ulcerative colitis therewith
GB2080796B (en) * 1980-07-21 1983-10-12 Biorex Laboratories Ltd 2-hydroxy-5-phenylazobenzoic acid derivatives
SE9003296L (sv) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab Foerfarande foer att formulera laekemedel
US5316772A (en) * 1990-12-19 1994-05-31 Solvay & Cie, S.A. (Societe Anonyme) Bilayered oral pharmaceutical composition with pH dependent release
US5498608A (en) * 1994-01-07 1996-03-12 Salix Pharmaceuticals Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents
SE9700934D0 (sv) * 1997-03-14 1997-03-14 Astra Ab New formulation

Also Published As

Publication number Publication date
NO994431D0 (no) 1999-09-13
WO1998041212A1 (en) 1998-09-24
US6197341B1 (en) 2001-03-06
HUP0000850A3 (en) 2000-10-30
CA2283297A1 (en) 1998-09-24
AU6430198A (en) 1998-10-12
NO994431L (no) 1999-09-13
FR2760638A1 (fr) 1998-09-18
PL335700A1 (en) 2000-05-08
SE9700934D0 (sv) 1997-03-14
BR9808140A (pt) 2000-03-28
NL1008575C2 (nl) 1999-09-10
EP1003524A1 (en) 2000-05-31
JP2001519782A (ja) 2001-10-23
GR980100096A (el) 1998-11-30
BE1011837A5 (fr) 2000-02-01
NL1008575A1 (nl) 1998-09-15

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