HUP0000641A2 - orto-Szulfonamido-aril-hidroxámsav-származékok, mátrix metalloprotenáz, valamint TACE-gátlóként való alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
orto-Szulfonamido-aril-hidroxámsav-származékok, mátrix metalloprotenáz, valamint TACE-gátlóként való alkalmazásuk és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0000641A2 HUP0000641A2 HU0000641A HUP0000641A HUP0000641A2 HU P0000641 A2 HUP0000641 A2 HU P0000641A2 HU 0000641 A HU0000641 A HU 0000641A HU P0000641 A HUP0000641 A HU P0000641A HU P0000641 A2 HUP0000641 A2 HU P0000641A2
- Authority
- HU
- Hungary
- Prior art keywords
- sulfonamido
- optionally substituted
- group
- ortho
- tace
- Prior art date
Links
- 108010000684 Matrix Metalloproteinases Proteins 0.000 title abstract 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- -1 aryl hydroxamic Chemical compound 0.000 title 1
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002447 tumor necrosis factor alpha converting enzyme inhibitor Substances 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 abstract 1
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 abstract 1
- 108060005980 Collagenase Proteins 0.000 abstract 1
- 102000029816 Collagenase Human genes 0.000 abstract 1
- 108010026132 Gelatinases Proteins 0.000 abstract 1
- 102000013382 Gelatinases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102100040247 Tumor necrosis factor Human genes 0.000 abstract 1
- 206010054094 Tumour necrosis Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- BFPSDSIWYFKGBC-UHFFFAOYSA-N chlorotrianisene Chemical compound C1=CC(OC)=CC=C1C(Cl)=C(C=1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 BFPSDSIWYFKGBC-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 108091007196 stromelysin Proteins 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
- 230000036269 ulceration Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
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- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
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Abstract
A találmány mátrix metalloproteázokat (például zselatinázokat,stromelizineket és kollagenázokat) és TNF-a átalakító enzimet (TACE-t,tumor nekrozis faktor-a konvertáló enzimet) gátló nem-peptid típusúvegyületekre vonatkozik, amelyek olyan betegségek kezelésérealkalmasak, amely betegségekben ezek az enzimek szerepet játszanakilyen betegségek például ízületi gyulladás, a tumornövekedés ésáttétel, angiogenézis, szövetfekélyesedés. A találmány szerinti TACEés MMP gátló orto-szulfonamido-aril-hidroxámsavak, azok gyógyászatilagelfogadható sói, optikai izomerjei és diasztereomerjei (I) általánosképletű vegyületek, ahol a hidroxámsav-molekularész és a szulfonamido-molekularész az A csoport szomszédos szénatomjaihoz kapcsolódik, aholA jelentése adott esetben helyettesített fenil- vagy naftilcsoport; Zjelentése adott esetben helyettesített fenil- vagy naftilcsoport vagy5-6-tagú heterociklusos gyűrű, amely a nitrogén-, oxigén- és kénatomközül egymástól függetlenül választott 1-3 heteroatomot tartalmaz, ésadott esetben fenilcsoporttal kondenzált; R7 jelentése hidrogénatomvagy adott esetben helyettesített alkil-, alkenil- vagyalkinilcsoport. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73263196A | 1996-10-16 | 1996-10-16 | |
PCT/US1997/018280 WO1998016503A2 (en) | 1996-10-16 | 1997-10-08 | The preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0000641A2 true HUP0000641A2 (hu) | 2000-10-28 |
HUP0000641A3 HUP0000641A3 (en) | 2001-02-28 |
Family
ID=24944349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0000641A HUP0000641A3 (en) | 1996-10-16 | 1997-10-08 | Ortho-sulfonamido aryl hydroxamic acid derivatives, their use, as matrix metalloproteinase and tace inhibitors and pharmaceutical compositions containing them |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0938471B1 (hu) |
JP (1) | JP2001504809A (hu) |
KR (1) | KR20000049196A (hu) |
AR (1) | AR009382A1 (hu) |
AT (1) | ATE210637T1 (hu) |
AU (1) | AU731737B2 (hu) |
BR (1) | BR9712525A (hu) |
CA (1) | CA2268894A1 (hu) |
DE (1) | DE69709160T2 (hu) |
DK (1) | DK0938471T3 (hu) |
ES (1) | ES2166102T3 (hu) |
HK (1) | HK1021178A1 (hu) |
HU (1) | HUP0000641A3 (hu) |
IL (1) | IL129147A0 (hu) |
NZ (1) | NZ335028A (hu) |
PT (1) | PT938471E (hu) |
TW (1) | TW410220B (hu) |
WO (1) | WO1998016503A2 (hu) |
ZA (1) | ZA979233B (hu) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4229499A (en) | 1998-07-30 | 2000-02-21 | Warner-Lambert Company | Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases |
ID27192A (id) * | 1998-07-30 | 2001-03-08 | Warner Lambert Co | Sulfonamida trisiklik dan turunannya sebagai inhibitor metaloproteinase matriks |
WO2000015213A1 (fr) * | 1998-09-11 | 2000-03-23 | Shionogi & Co., Ltd. | Agent de prevention ou de traitement de l'insuffisance cardiaque congestive |
US6277885B1 (en) | 1999-01-27 | 2001-08-21 | American Cyanamid Company | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
AR035478A1 (es) * | 1999-01-27 | 2004-06-02 | Wyeth Corp | Acido amida-hidroxamico, acido acetilenico, beta-sulfonamido y fosfinico como inhibidores de la tace, uso de los mismos para la manufactura de un medicamento y composicion farmaceutica que los contiene |
US6225311B1 (en) | 1999-01-27 | 2001-05-01 | American Cyanamid Company | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors |
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US5863949A (en) * | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
-
1997
- 1997-10-08 AU AU51458/98A patent/AU731737B2/en not_active Ceased
- 1997-10-08 AT AT97946246T patent/ATE210637T1/de not_active IP Right Cessation
- 1997-10-08 NZ NZ335028A patent/NZ335028A/xx unknown
- 1997-10-08 KR KR1019990703294A patent/KR20000049196A/ko not_active Application Discontinuation
- 1997-10-08 DE DE69709160T patent/DE69709160T2/de not_active Expired - Fee Related
- 1997-10-08 HU HU0000641A patent/HUP0000641A3/hu unknown
- 1997-10-08 JP JP51844898A patent/JP2001504809A/ja not_active Ceased
- 1997-10-08 CA CA002268894A patent/CA2268894A1/en not_active Abandoned
- 1997-10-08 PT PT97946246T patent/PT938471E/pt unknown
- 1997-10-08 WO PCT/US1997/018280 patent/WO1998016503A2/en not_active Application Discontinuation
- 1997-10-08 EP EP97946246A patent/EP0938471B1/en not_active Expired - Lifetime
- 1997-10-08 DK DK97946246T patent/DK0938471T3/da active
- 1997-10-08 BR BR9712525-3A patent/BR9712525A/pt not_active Application Discontinuation
- 1997-10-08 IL IL12914797A patent/IL129147A0/xx unknown
- 1997-10-08 ES ES97946246T patent/ES2166102T3/es not_active Expired - Lifetime
- 1997-10-15 AR ARP970104751A patent/AR009382A1/es not_active Application Discontinuation
- 1997-10-15 TW TW086114187A patent/TW410220B/zh not_active IP Right Cessation
- 1997-10-15 ZA ZA979233A patent/ZA979233B/xx unknown
-
2000
- 2000-01-06 HK HK00100090A patent/HK1021178A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1998016503A3 (en) | 1998-05-28 |
DE69709160D1 (de) | 2002-01-24 |
CA2268894A1 (en) | 1998-04-23 |
AR009382A1 (es) | 2000-04-12 |
NZ335028A (en) | 2000-09-29 |
ES2166102T3 (es) | 2002-04-01 |
AU731737B2 (en) | 2001-04-05 |
KR20000049196A (ko) | 2000-07-25 |
ZA979233B (en) | 1999-04-15 |
EP0938471A1 (en) | 1999-09-01 |
DE69709160T2 (de) | 2002-08-14 |
EP0938471B1 (en) | 2001-12-12 |
IL129147A0 (en) | 2000-02-17 |
PT938471E (pt) | 2002-05-31 |
TW410220B (en) | 2000-11-01 |
HK1021178A1 (en) | 2000-06-02 |
AU5145898A (en) | 1998-05-11 |
BR9712525A (pt) | 1999-10-19 |
DK0938471T3 (da) | 2002-01-28 |
HUP0000641A3 (en) | 2001-02-28 |
WO1998016503A2 (en) | 1998-04-23 |
JP2001504809A (ja) | 2001-04-10 |
ATE210637T1 (de) | 2001-12-15 |
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