HUE065793T2 - Biciklikus ketonvegyületek és azok felhasználási eljárásai - Google Patents

Biciklikus ketonvegyületek és azok felhasználási eljárásai

Info

Publication number
HUE065793T2
HUE065793T2 HUE18740815A HUE18740815A HUE065793T2 HU E065793 T2 HUE065793 T2 HU E065793T2 HU E18740815 A HUE18740815 A HU E18740815A HU E18740815 A HUE18740815 A HU E18740815A HU E065793 T2 HUE065793 T2 HU E065793T2
Authority
HU
Hungary
Prior art keywords
methods
ketone compounds
bicyclic ketone
bicyclic
compounds
Prior art date
Application number
HUE18740815A
Other languages
English (en)
Hungarian (hu)
Inventor
Snahel Patel
Gregory Hamilton
Guiling Zhao
Huifen Chen
Blake Daniels
Craig Stivala
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HUE065793T2 publication Critical patent/HUE065793T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
HUE18740815A 2017-07-14 2018-07-12 Biciklikus ketonvegyületek és azok felhasználási eljárásai HUE065793T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762532767P 2017-07-14 2017-07-14

Publications (1)

Publication Number Publication Date
HUE065793T2 true HUE065793T2 (hu) 2024-06-28

Family

ID=62916677

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE18740815A HUE065793T2 (hu) 2017-07-14 2018-07-12 Biciklikus ketonvegyületek és azok felhasználási eljárásai

Country Status (30)

Country Link
US (3) US11098058B2 (enExample)
EP (2) EP3652178B1 (enExample)
JP (2) JP7258843B2 (enExample)
KR (2) KR20240065201A (enExample)
CN (2) CN110914271B (enExample)
AR (1) AR112274A1 (enExample)
AU (3) AU2018300043B2 (enExample)
BR (1) BR112020000771A2 (enExample)
CA (2) CA3185865A1 (enExample)
CL (1) CL2020000101A1 (enExample)
CO (1) CO2020000134A2 (enExample)
CR (1) CR20200002A (enExample)
DK (1) DK3652178T3 (enExample)
ES (1) ES2973661T3 (enExample)
FI (1) FI3652178T3 (enExample)
HR (1) HRP20240354T1 (enExample)
HU (1) HUE065793T2 (enExample)
IL (2) IL294961A (enExample)
LT (1) LT3652178T (enExample)
MA (1) MA49560B1 (enExample)
PE (1) PE20200793A1 (enExample)
PH (1) PH12020500105A1 (enExample)
PL (1) PL3652178T3 (enExample)
PT (1) PT3652178T (enExample)
RS (1) RS65308B1 (enExample)
SG (1) SG11202000333UA (enExample)
SI (1) SI3652178T1 (enExample)
TW (1) TWI805595B (enExample)
UA (1) UA125448C2 (enExample)
WO (1) WO2019012063A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3548484B1 (en) 2016-12-02 2025-04-30 F. Hoffmann-La Roche AG Bicyclic amide compounds and methods of use thereof
SI3652178T1 (sl) 2017-07-14 2024-05-31 F. Hoffmann-La Roche Ag Biciklične ketonske spojine in načini njihove uporabe
CR20200168A (es) 2017-10-31 2020-07-12 Hoffmann La Roche Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos
EP3908586B1 (en) * 2019-01-11 2022-12-21 F. Hoffmann-La Roche AG Bicyclic pyrrolotriazolr ketone compounds and methods of use thereof
WO2021198981A1 (en) 2020-04-01 2021-10-07 Janssen Biopharma, Inc. Antiviral compounds and uses thereof
KR20220162155A (ko) * 2020-04-27 2022-12-07 주식회사 오토텍바이오 Ubr 박스 도메인 리간드로의 화합물
BR112023020229A2 (pt) 2021-04-02 2023-11-14 Hoffmann La Roche Processos para a preparação de um composto bicíclico de cetona quiral, composto de n-amino lactama quiral, composto de sal imidato e composto hidroxicetoéster, composto, ou um sal farmaceuticamente aceitável do mesmo e invenção
WO2023039795A1 (zh) * 2021-09-16 2023-03-23 维泰瑞隆（北京）生物科技有限公司 Rip1激酶抑制剂及其用途
TWI878888B (zh) * 2022-05-19 2025-04-01 美商默沙東有限責任公司 Ripk1抑制劑及使用方法
WO2024260932A2 (en) * 2023-06-19 2024-12-26 F. Hoffmann-La Roche Ag Process for the preparation of a chiral pyrrolo triazole alcohol

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1620508A1 (de) 1965-07-23 1969-09-18 Thomae Gmbh Dr K Verfahren zur Herstellung neuer 4,5,6,7-Tetrahydrothiazolo-[5,4-c]-pyridine
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3948903A (en) 1972-12-15 1976-04-06 Parke, Davis & Company Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -cephaloglycins
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
EP0102324A3 (de) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
GB8610530D0 (en) 1986-04-30 1986-06-04 Fbc Ltd Herbicides
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
US5112596A (en) 1990-04-23 1992-05-12 Alkermes, Inc. Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
JPH07509250A (ja) 1992-07-27 1995-10-12 アメリカ合衆国 血液脳バリヤーへのリポソームの標的化
US6080772A (en) 1995-06-07 2000-06-27 Sugen, Inc. Thiazole compounds and methods of modulating signal transduction
EP1007042A4 (en) 1997-06-13 2001-07-04 Sugen Inc NEW HETEROCYCLIC COMPOUNDS FOR MODULATING THE PROTEIN-TYROSIN-ENZYME-RELATED CELLULAR SIGNAL TRANSDUCTION
CA2399791A1 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
US6514221B2 (en) 2000-07-27 2003-02-04 Brigham And Women's Hospital, Inc. Blood-brain barrier opening
AU2001286930A1 (en) 2000-08-30 2002-03-13 The Board Of Trustees Of The Leland Stanford Junior University Glucocorticoid blocking agents for increasing blood-brain barrier permeability
US7034036B2 (en) 2000-10-30 2006-04-25 Pain Therapeutics, Inc. Inhibitors of ABC drug transporters at the blood-brain barrier
DE10121982B4 (de) 2001-05-05 2008-01-24 Lts Lohmann Therapie-Systeme Ag Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US20030162695A1 (en) 2002-02-27 2003-08-28 Schatzberg Alan F. Glucocorticoid blocking agents for increasing blood-brain barrier permeability
AU2003265585B2 (en) 2002-08-26 2008-07-03 Takeda Pharmaceutical Company Limited Calcium receptor modulating compound and use thereof
CN100386068C (zh) 2002-12-03 2008-05-07 布朗歇特洛克菲勒神经科学研究所 传输物质穿过血脑屏障的人工低密度脂蛋白载体
US7417152B2 (en) 2003-05-02 2008-08-26 Elan Pharmaceuticals, Inc. 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases
EP1663239A4 (en) 2003-09-10 2008-07-23 Cedars Sinai Medical Center KALIUM CHANNEL-MEDIATED FEEDING OF MEDICINES BY THE BLOOD BRAIN BARRIER
WO2006114706A1 (en) 2005-04-26 2006-11-02 Pfizer Limited Triazole derivatives as vasopressin antagonists
EP2083009A1 (de) 2008-01-22 2009-07-29 Grünenthal GmbH Substituierte Tethrahydroimidazopyridin-Verbindungen und deren Verwendung in Arzneimitteln
US8299077B2 (en) 2009-03-02 2012-10-30 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
CN101824036A (zh) 2009-03-05 2010-09-08 上海恒瑞医药有限公司 四氢咪唑并[1，5-a]吡嗪衍生物的盐,其制备方法及其在医药上的应用
AR077463A1 (es) 2009-07-09 2011-08-31 Irm Llc Derivados de imidazo[1, 2 - a]pirazina y su uso en medicamentos para el tratamiento de enfermedades parasitarias
US8722676B2 (en) 2011-11-03 2014-05-13 Genentech, Inc. Bicyclic piperazine compounds
EP2852584B1 (en) 2012-05-22 2018-02-28 F. Hoffmann-La Roche AG Substituted dipyridylamines and uses thereof
TWI498325B (zh) 2013-01-18 2015-09-01 Hoffmann La Roche ３－取代吡唑及其用途
TWI638815B (zh) * 2013-02-15 2018-10-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類（一）
KR20160002850A (ko) 2013-05-01 2016-01-08 에프. 호프만-라 로슈 아게 C-연결된 헤테로사이클로알킬 치환된 피리미딘 및 이의 용도
MA42164B1 (fr) 2013-05-01 2019-12-31 Hoffmann La Roche Composes biheteroaryle et leurs utilisations
JP6605462B2 (ja) 2013-07-10 2019-11-13 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとしての縮合ピペリジンアミド
MX2016008110A (es) 2013-12-20 2016-08-19 Hoffmann La Roche Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos.
CN106029667B (zh) 2014-03-26 2019-08-23 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物
WO2016027253A1 (en) 2014-08-21 2016-02-25 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as rip1 kinase inhibitors as medicaments
WO2016128908A1 (en) * 2015-02-12 2016-08-18 Advinus Therapeutics Limited Bicyclic compounds, compositions and medicinal applications thereof
JP6701225B2 (ja) 2015-03-09 2020-05-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 三環式ｄｌｋ阻害剤及びその使用
EP3760625B1 (en) * 2015-07-02 2024-03-27 F. Hoffmann-La Roche AG Bicyclic lactams as receptor-interacting protein-1 (rip1) kinase inhibitors for treating e.g. inflammatory diseases
WO2017096301A1 (en) 2015-12-04 2017-06-08 Denali Therapeutics Inc. Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (ripk 1)
WO2017109724A1 (en) 2015-12-21 2017-06-29 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as kinase inhibitors
SG11201806302RA (en) 2016-02-05 2018-08-30 Denali Therapeutics Inc Inhibitors of receptor-interacting protein kinase 1
EP3548484B1 (en) 2016-12-02 2025-04-30 F. Hoffmann-La Roche AG Bicyclic amide compounds and methods of use thereof
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
EP3566471B1 (en) 2017-01-05 2022-09-28 Microsoft Technology Licensing, LLC Audio simulation in video games comprising indirect propagation paths
SI3652178T1 (sl) 2017-07-14 2024-05-31 F. Hoffmann-La Roche Ag Biciklične ketonske spojine in načini njihove uporabe
CR20200151A (es) 2017-10-11 2020-05-23 Hoffmann La Roche Compuestos bicíclicos y métodos de utilización de los mismos
CR20200168A (es) 2017-10-31 2020-07-12 Hoffmann La Roche Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos

Also Published As

Publication number Publication date
IL271981B (en) 2022-09-01
JP2020526549A (ja) 2020-08-31
JP7258843B2 (ja) 2023-04-17
JP7734163B2 (ja) 2025-09-04
KR20200030558A (ko) 2020-03-20
AU2023203292B2 (en) 2025-01-30
KR102664604B1 (ko) 2024-05-14
TWI805595B (zh) 2023-06-21
MA49560B1 (fr) 2024-05-31
CL2020000101A1 (es) 2020-07-17
IL294961A (en) 2022-09-01
BR112020000771A2 (pt) 2020-07-14
PT3652178T (pt) 2024-03-18
FI3652178T3 (fi) 2024-03-19
PH12020500105A1 (en) 2020-11-09
EP3652178A1 (en) 2020-05-20
US11098058B2 (en) 2021-08-24
CA3067944A1 (en) 2019-01-17
US20190100530A1 (en) 2019-04-04
US20210139504A1 (en) 2021-05-13
SG11202000333UA (en) 2020-02-27
CA3185865A1 (en) 2019-01-17
US11834461B2 (en) 2023-12-05
CO2020000134A2 (es) 2020-01-17
CN110914271A (zh) 2020-03-24
HRP20240354T1 (hr) 2024-06-07
AR112274A1 (es) 2019-10-09
CN110914271B (zh) 2024-12-10
NZ760749A (en) 2024-08-30
KR20240065201A (ko) 2024-05-14
EP3652178B1 (en) 2024-01-24
RS65308B1 (sr) 2024-04-30
PL3652178T3 (pl) 2024-05-06
EP4397309A3 (en) 2024-09-04
US20240300974A1 (en) 2024-09-12
ES2973661T3 (es) 2024-06-21
CN119613408A (zh) 2025-03-14
LT3652178T (lt) 2024-04-10
EP4397309A2 (en) 2024-07-10
JP2023085449A (ja) 2023-06-20
AU2023203292A1 (en) 2023-06-22
CR20200002A (es) 2020-02-10
DK3652178T3 (da) 2024-03-25
PE20200793A1 (es) 2020-08-10
AU2018300043A1 (en) 2020-01-16
CA3067944C (en) 2023-03-14
TW201920149A (zh) 2019-06-01
RU2020106375A (ru) 2021-08-16
AU2021204369A1 (en) 2021-07-29
WO2019012063A1 (en) 2019-01-17
IL271981A (en) 2020-02-27
AU2018300043B2 (en) 2021-04-01
MA49560A (fr) 2020-05-20
SI3652178T1 (sl) 2024-05-31
RU2020106375A3 (enExample) 2022-03-25
UA125448C2 (uk) 2022-03-09

Similar Documents

Publication Publication Date Title
IL274391A (en) For bicycle clippings and methods of using them
IL271981A (en) Bicyclic ketone compounds and methods of using them
ZA201905677B (en) Glycan-interacting compounds and methods of use
IL261625B (en) Inhibitors of menin-mll in bridged cycles and methods of use
HUE068842T2 (hu) Vegyületek és alkalmazási eljárásaik
IL265800A (en) Anti-lag-3 antibodies and methods of using them
IL258768A (en) Compounds interacting with glycans and methods of use
IL265957A (en) Anti-c1s antibodies and methods of using them
EP3377070A4 (en) COMPOUNDS AND METHOD FOR THEIR USE
HUE061672T2 (hu) Glikán-interakcióban lévõ vegyületek és felhasználási módszerek
SI3089971T1 (sl) Spojine in postopki za uporabo
GB201609786D0 (en) Compounds and method of use
IL267671A (en) Pyrazolopyrimidine compounds and methods of their use
GB201514760D0 (en) Compounds and method of use
IL283387A (en) Diarylhydantoin compounds and methods of use thereof
IL277963A (en) Bicyclic carboxamides and methods of using them
IL265955A (en) Therapeutic compounds and methods of using them
ZA201606450B (en) Compounds and their methods of use
GB2565019B (en) Method of manufacture of ladder polybenzodifurans and use thereof
HK40092374A (zh) 聚糖相互作用化合物及使用方法
GB201403697D0 (en) Compounds and methods of use
HK40016047A (en) Fused hetero-hetero bicyclic compounds and methods of use thereof
HK40017698A (en) Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
HK40007173A (en) Glycan-interacting compounds and methods of use
HK40009339A (en) Amino-pyrrolopyrimidinone compounds and methods of use thereof