HUE056551T2 - Az akamprozát alkalmazása az ERK 1-2 aktiváció modulálására az FXS és az ASD állati modelljeiben, valamint az FXS és ASD diagnózissal rendelkezõ egyéneken - Google Patents
Az akamprozát alkalmazása az ERK 1-2 aktiváció modulálására az FXS és az ASD állati modelljeiben, valamint az FXS és ASD diagnózissal rendelkezõ egyénekenInfo
- Publication number
- HUE056551T2 HUE056551T2 HUE14854852A HUE14854852A HUE056551T2 HU E056551 T2 HUE056551 T2 HU E056551T2 HU E14854852 A HUE14854852 A HU E14854852A HU E14854852 A HUE14854852 A HU E14854852A HU E056551 T2 HUE056551 T2 HU E056551T2
- Authority
- HU
- Hungary
- Prior art keywords
- fxs
- asd
- acamprosate
- activation
- animal models
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/48—Nerve growth factor [NGF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361890756P | 2013-10-14 | 2013-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE056551T2 true HUE056551T2 (hu) | 2022-02-28 |
Family
ID=52828619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE14854852A HUE056551T2 (hu) | 2013-10-14 | 2014-10-14 | Az akamprozát alkalmazása az ERK 1-2 aktiváció modulálására az FXS és az ASD állati modelljeiben, valamint az FXS és ASD diagnózissal rendelkezõ egyéneken |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10634677B2 (hu) |
| EP (1) | EP3058371B1 (hu) |
| JP (1) | JP6637414B2 (hu) |
| AU (1) | AU2014337504B2 (hu) |
| CA (1) | CA2926645C (hu) |
| DK (1) | DK3058371T3 (hu) |
| HU (1) | HUE056551T2 (hu) |
| PL (1) | PL3058371T3 (hu) |
| PT (1) | PT3058371T (hu) |
| RU (1) | RU2696481C2 (hu) |
| WO (1) | WO2015057736A1 (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015057736A1 (en) | 2013-10-14 | 2015-04-23 | Indiana University Research And Technology Corporation | Use of acamprosate to modulate erk 1-2 activation in animal models for fxs and asd and individuals diagnosed with fxs and asd |
| WO2017147044A1 (en) * | 2016-02-22 | 2017-08-31 | Indiana University Research And Technology Corporation | Peptides and methods for treatment of neurodegenerative diseases |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316635B1 (en) * | 1995-06-07 | 2001-11-13 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| CN1213970A (zh) | 1996-03-11 | 1999-04-14 | 伊莱利利公司 | 治疗孤独癖的方法 |
| PL198599B1 (pl) | 1998-07-06 | 2008-07-31 | Nsgene As | Izolowany kwas nukleinowy neublastyny, wektor ekspresji, izolowana komórka, polipeptyd, sposób wytwarzania polipeptydu, oczyszczony polipeptyd, kompozycja, zastosowanie polipeptydu, sekwencja kwasu nukleinowego primera, sposób wytwarzania peptydów, sposób wytwarzania peptydu neublastyny, syntetyczny gen, peptyd neublastyny, przeciwciało, zastosowanie czynnika neurotroficznego neublastyny i zastosowanie kwasu nukleinowego |
| US6593133B1 (en) | 1998-07-06 | 2003-07-15 | Nsgene A/S | Neurotrophic factors |
| CN1382047A (zh) | 1999-08-16 | 2002-11-27 | 雷瓦尔克斯药品有限公司 | 神经病治疗组合物和方法 |
| SE0300586L (sv) | 2003-03-04 | 2004-09-05 | Forskarpatent I Syd Ab | Diagnos av autism |
| EP1753738B1 (en) | 2004-05-14 | 2014-07-09 | Vertex Pharmaceuticals Inc. | Pyrrole compounds as inhibitors of ERK protein kinases and pharmaceutical compositions containing these compounds |
| US7595167B2 (en) | 2005-10-11 | 2009-09-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio |
| WO2008060375A2 (en) | 2006-10-06 | 2008-05-22 | The Regents Of The University Of Californina | Upregulating bdnf levels to mitigate mental retardation |
| WO2008066750A1 (en) * | 2006-11-22 | 2008-06-05 | Seaside Therapeutics, Llc | Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism |
| KR20090094854A (ko) | 2006-12-22 | 2009-09-08 | 제넨테크, 인크. | Ａｐｐ에 대한 ｄｒ６의 결합을 억제하는 ｄｒ６ 항체, 및 신경학적 질환의 치료에 있어서의 그의 용도 |
| WO2008112772A2 (en) | 2007-03-14 | 2008-09-18 | Baylor Research Institute | Gene expression in peripheral blood mononuclear cells from children with diabetes |
| WO2009033079A1 (en) * | 2007-09-07 | 2009-03-12 | Xenoport, Inc. | Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
| US20090239888A1 (en) * | 2008-02-12 | 2009-09-24 | Wisconsin Alumni Research Foundation | Methods for Inhibiting Amyloid Precursor Protein and Beta-Amyloid Production and Accumulation |
| WO2010008995A2 (en) * | 2008-07-14 | 2010-01-21 | Otonomy, Inc. | Controlled-release apoptosis modulating compositions and methods for the treatment of otic disorders |
| PT2395990E (pt) | 2009-02-12 | 2015-02-09 | Univ Indiana Res & Tech Corp | Material e métodos de tratamento de transtornos do desenvolvimento incluindo autismo comórbido e idiopático |
| US8008539B1 (en) | 2009-03-19 | 2011-08-30 | University Of South Florida | Generation of transgenic human soluble amyloid precursor protein alpha expressing mice |
| MA34263B1 (fr) | 2010-04-30 | 2013-05-02 | Novartis Ag | Marqueurs de prédiction utiles dans traitement du syndrome de l'x fragile (fxs) |
| US20110294879A1 (en) * | 2010-05-28 | 2011-12-01 | Xenoport, Inc. | Method of treatment of fragile x syndrome, down's syndrome, autism and related disorders |
| WO2012024630A1 (en) | 2010-08-19 | 2012-02-23 | Blanchette Rockefeller Neurosciences Institute | Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators |
| RU2465273C2 (ru) | 2010-08-31 | 2012-10-27 | Общество С Ограниченной Ответственностью "Биофарм-Меморейн" | ГЕТЕРОЦИКЛИЧЕСКИЕ НИЗКОМОЛЕКУЛЯРНЫЕ sAPP-МИМЕТИКИ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБЫ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| WO2014018468A1 (en) | 2012-07-22 | 2014-01-30 | Indiana University Research And Technology Corporation | Modulation sapp, sapp alpha and bdnf levels in individuals diagnosed with fxs and asd |
| WO2015057736A1 (en) | 2013-10-14 | 2015-04-23 | Indiana University Research And Technology Corporation | Use of acamprosate to modulate erk 1-2 activation in animal models for fxs and asd and individuals diagnosed with fxs and asd |
-
2014
- 2014-10-14 WO PCT/US2014/060527 patent/WO2015057736A1/en active Application Filing
- 2014-10-14 HU HUE14854852A patent/HUE056551T2/hu unknown
- 2014-10-14 PL PL14854852T patent/PL3058371T3/pl unknown
- 2014-10-14 CA CA2926645A patent/CA2926645C/en active Active
- 2014-10-14 AU AU2014337504A patent/AU2014337504B2/en active Active
- 2014-10-14 RU RU2016118551A patent/RU2696481C2/ru active
- 2014-10-14 DK DK14854852.2T patent/DK3058371T3/da active
- 2014-10-14 JP JP2016522755A patent/JP6637414B2/ja active Active
- 2014-10-14 PT PT148548522T patent/PT3058371T/pt unknown
- 2014-10-14 EP EP14854852.2A patent/EP3058371B1/en active Active
- 2014-10-14 US US15/029,596 patent/US10634677B2/en active Active
-
2020
- 2020-03-13 US US16/818,854 patent/US11733243B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20160266120A1 (en) | 2016-09-15 |
| DK3058371T3 (da) | 2021-08-02 |
| EP3058371A4 (en) | 2017-04-19 |
| CA2926645C (en) | 2022-10-25 |
| WO2015057736A1 (en) | 2015-04-23 |
| US10634677B2 (en) | 2020-04-28 |
| RU2696481C2 (ru) | 2019-08-02 |
| PL3058371T3 (pl) | 2021-11-08 |
| US11733243B2 (en) | 2023-08-22 |
| AU2014337504B2 (en) | 2020-01-30 |
| EP3058371A1 (en) | 2016-08-24 |
| RU2016118551A (ru) | 2017-11-21 |
| CA2926645A1 (en) | 2015-04-23 |
| JP6637414B2 (ja) | 2020-01-29 |
| RU2016118551A3 (hu) | 2018-07-24 |
| US20200225233A1 (en) | 2020-07-16 |
| EP3058371B1 (en) | 2021-06-16 |
| PT3058371T (pt) | 2021-07-26 |
| JP2016536293A (ja) | 2016-11-24 |
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