HUE055431T2 - Eljárás fermentatív alfa-jonon elõállítására - Google Patents

Eljárás fermentatív alfa-jonon elõállítására

Info

Publication number
HUE055431T2
HUE055431T2 HUE15757235A HUE15757235A HUE055431T2 HU E055431 T2 HUE055431 T2 HU E055431T2 HU E15757235 A HUE15757235 A HU E15757235A HU E15757235 A HUE15757235 A HU E15757235A HU E055431 T2 HUE055431 T2 HU E055431T2
Authority
HU
Hungary
Prior art keywords
fermentative
alpha
ionone production
ionone
production
Prior art date
Application number
HUE15757235A
Other languages
English (en)
Inventor
Guido Jach
Sanae Azdouffal
Katrin Schullehner
Peter Welters
Angela Goergen
Original Assignee
Phytowelt Greentechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytowelt Greentechnologies Gmbh filed Critical Phytowelt Greentechnologies Gmbh
Publication of HUE055431T2 publication Critical patent/HUE055431T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/99—Oxidoreductases acting on the CH-CH group of donors (1.3) with other acceptors (1.3.99)
    • C12Y103/9903—Phytoene desaturase (3,4-didehydrolycopene-forming) (1.3.99.30)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/99—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with other acceptors (1.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01007—1-Deoxy-D-xylulose-5-phosphate synthase (2.2.1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01029—Geranylgeranyl diphosphate synthase (2.5.1.29)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01032—15-Cis-phytoene synthase (2.5.1.32)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
    • C12Y503/03002—Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y505/00—Intramolecular lyases (5.5)
    • C12Y505/01—Intramolecular lyases (5.5.1)
    • C12Y505/01018—Lycopene epsilon-cyclase (5.5.1.18)
HUE15757235A 2015-08-28 2015-08-28 Eljárás fermentatív alfa-jonon elõállítására HUE055431T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15757235.5A EP3341490B1 (de) 2015-08-28 2015-08-28 Verfahren zur fermentativen alpha-ionon produktion
PCT/EP2015/069751 WO2017036495A1 (de) 2015-08-28 2015-08-28 Verfahren zur fermentativen alpha-ionen produktion

Publications (1)

Publication Number Publication Date
HUE055431T2 true HUE055431T2 (hu) 2021-11-29

Family

ID=58188456

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE15757235A HUE055431T2 (hu) 2015-08-28 2015-08-28 Eljárás fermentatív alfa-jonon elõállítására

Country Status (7)

Country Link
US (1) US11326173B2 (hu)
EP (1) EP3341490B1 (hu)
JP (1) JP6940503B2 (hu)
CA (1) CA2996711C (hu)
ES (1) ES2882077T3 (hu)
HU (1) HUE055431T2 (hu)
WO (1) WO2017036495A1 (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10364434B2 (en) 2015-03-23 2019-07-30 Arch Innotek, Llc Compositions and methods of biosynthesizing carotenoids and their derivatives
SG11201907812TA (en) * 2017-02-24 2019-09-27 Agency Science Tech & Res Production of carotenoids and apocarotenoids
EP3404107A1 (de) * 2017-05-19 2018-11-21 Jowat SE Verfahren zur fermentativen de novo synthese von harzsäuren
CN108285902A (zh) * 2017-11-03 2018-07-17 杭州爱蔻思生物科技有限公司 生产高价值天然产物的工程菌的构造方法
US11124809B2 (en) 2017-12-21 2021-09-21 Centrome, Inc. Production of alpha-(R)-(E)-(+)-ionone in recombinant Saccharomyces cerevisiae
EP4022032A4 (en) * 2019-10-04 2022-12-14 Conagen Inc. BIOSYNTHESIS OF ALPHA-IONONE AND BETA-IONONE

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020086380A1 (en) * 1996-03-29 2002-07-04 Francis X. Cunningham Jr Genes encoding epsilon lycopene cyclase and method for producing bicyclic carotene
US20040171822A1 (en) * 2001-01-12 2004-09-02 Cunningham Jr. Francis X. Methods for determining ring number in carotenoids by lycopene epsilon-cyclasses and uses thereof
EP1392824B1 (en) * 2001-06-06 2008-08-20 DSM IP Assets B.V. Improved isoprenoid production
US20050287625A1 (en) * 2004-03-05 2005-12-29 Miller Edward S Jr Process for expression of foreign genes in methylotrophic bacteria through chromosomal integration
WO2007032375A1 (ja) * 2005-09-13 2007-03-22 Takasago International Corporation 光学活性α－ヨノンの製造方法
KR101440922B1 (ko) * 2011-07-29 2014-09-18 경상대학교산학협력단 ＹｂｂＯ 유전자가 결실 또는 증폭된 에세리키아 속 미생물 및 그를 이용한 레티노이드의 생산 방법
US10059974B2 (en) * 2012-02-06 2018-08-28 The Research Foundation Of The City University Of New York Cells and methods for producing lutein
KR20140147982A (ko) * 2013-06-20 2014-12-31 경상대학교산학협력단 레티노이드 생산에 관여하는 효소를 코딩하는 유전자를 포함하는 미생물 및 이를 이용한 레티노이드의 생산 방법
WO2016036915A1 (en) * 2014-09-03 2016-03-10 Coffa Gianguido Genetically modified microbes for the biological conversion of carbonaceous materials to protocatechuic acid
US10364434B2 (en) * 2015-03-23 2019-07-30 Arch Innotek, Llc Compositions and methods of biosynthesizing carotenoids and their derivatives

Also Published As

Publication number Publication date
CA2996711C (en) 2021-09-28
EP3341490A1 (de) 2018-07-04
ES2882077T3 (es) 2021-12-01
CA2996711A1 (en) 2017-03-09
JP2018526027A (ja) 2018-09-13
WO2017036495A1 (de) 2017-03-09
EP3341490B1 (de) 2021-05-12
US11326173B2 (en) 2022-05-10
JP6940503B2 (ja) 2021-09-29
US20180251796A1 (en) 2018-09-06

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