HUE055367T2 - Eljárás új intermedierek 11-metilén-szteroidok elõállítására - Google Patents

Eljárás új intermedierek 11-metilén-szteroidok elõállítására

Info

Publication number
HUE055367T2
HUE055367T2 HUE17707356A HUE17707356A HUE055367T2 HU E055367 T2 HUE055367 T2 HU E055367T2 HU E17707356 A HUE17707356 A HU E17707356A HU E17707356 A HUE17707356 A HU E17707356A HU E055367 T2 HUE055367 T2 HU E055367T2
Authority
HU
Hungary
Prior art keywords
preparation
new intermediates
methylene steroids
steroids
methylene
Prior art date
Application number
HUE17707356A
Other languages
English (en)
Inventor
Rodriguez Celso Miguel Sandoval
Sierra Ignacio Herraiz
Ivano Messina
Retuerto Jesus Miguel Iglesias
Original Assignee
Crystal Pharma Sau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crystal Pharma Sau filed Critical Crystal Pharma Sau
Publication of HUE055367T2 publication Critical patent/HUE055367T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0077—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HUE17707356A 2016-03-03 2017-03-02 Eljárás új intermedierek 11-metilén-szteroidok elõállítására HUE055367T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16382092 2016-03-03

Publications (1)

Publication Number Publication Date
HUE055367T2 true HUE055367T2 (hu) 2021-11-29

Family

ID=55628968

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17707356A HUE055367T2 (hu) 2016-03-03 2017-03-02 Eljárás új intermedierek 11-metilén-szteroidok elõállítására

Country Status (7)

Country Link
US (2) US11034716B2 (hu)
EP (2) EP3865501A1 (hu)
JP (2) JP7264569B2 (hu)
ES (1) ES2881336T3 (hu)
HU (1) HUE055367T2 (hu)
MX (1) MX2018010559A (hu)
WO (1) WO2017149091A1 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108840895B (zh) * 2018-04-24 2020-09-04 上海共拓医药化工有限公司 依托孕烯以及去氧孕烯中间体的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI54128C (fi) * 1972-12-09 1978-10-10 Akzo Nv Foerfarande foer framstaellning av nya 11,11-alkylidensteroider ur oestran- och 19-norpregnanserien med foerbaettrad hormonell verkan
ZA94715B (en) * 1993-02-08 1994-10-24 Akzo Nv Steroids for treating menopausal complaints
WO1994021667A1 (en) * 1993-03-25 1994-09-29 Iskra Industry Co., Ltd. Compound for inhibiting bone resorption and accelerating osteogenesis
KR20020092907A (ko) * 1999-09-06 2002-12-12 악조 노벨 엔.브이. 11번 위치에 탄화수소 치환기를 보유한 비방향족에스트로겐 스테로이드
ITMI20021755A1 (it) 2002-08-02 2002-11-01 Poli Ind Chimica Spa Processo e nuovi intermedi per la preparazione di steroidi ad attivita' progestinica.
CN1865276A (zh) 2005-05-20 2006-11-22 上海迪赛诺化学制药有限公司 合成甾体孕激素的方法
CN101440112B (zh) 2008-12-19 2011-04-20 北京紫竹药业有限公司 甾体化合物及其用途
CN102964418B (zh) * 2010-06-25 2015-04-15 华润紫竹药业有限公司 去氧孕烯的制备工艺及其中间体化合物
US20130123523A1 (en) 2011-11-10 2013-05-16 Klaus Nickisch Methods for the preparation of etonogestrel and desogestrel
WO2013135744A1 (en) 2012-03-15 2013-09-19 Msd Oss B.V. Combined synthesis route for etonogestrel and desogestrel
ITMI20121472A1 (it) * 2012-09-04 2014-03-05 Ind Chimica Srl Processo per la preparazione di 11-metilen-18-metilestr-4-en-3,17-dione, utile come intermedio per la sintesi di molecole ad attivita' farmacologica
CN105906680A (zh) * 2016-04-27 2016-08-31 华润紫竹药业有限公司 去氧孕烯的制备方法和中间体化合物

Also Published As

Publication number Publication date
JP2021183627A (ja) 2021-12-02
EP3865501A1 (en) 2021-08-18
WO2017149091A1 (en) 2017-09-08
ES2881336T3 (es) 2021-11-29
US11034716B2 (en) 2021-06-15
JP7264569B2 (ja) 2023-04-25
EP3423464A1 (en) 2019-01-09
EP3423464B1 (en) 2021-05-26
US20190092807A1 (en) 2019-03-28
MX2018010559A (es) 2019-03-28
JP2019512481A (ja) 2019-05-16
US20210269474A1 (en) 2021-09-02
JP7419302B2 (ja) 2024-01-22

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