HUE052067T2 - Mutáns IDH1 és mutáns IDH2 inhibitor 7-feniletilamino-4H-pirimido[4,5-d][1,3]oxazin-2-on vegyületek - Google Patents
Mutáns IDH1 és mutáns IDH2 inhibitor 7-feniletilamino-4H-pirimido[4,5-d][1,3]oxazin-2-on vegyületekInfo
- Publication number
- HUE052067T2 HUE052067T2 HUE17822882A HUE17822882A HUE052067T2 HU E052067 T2 HUE052067 T2 HU E052067T2 HU E17822882 A HUE17822882 A HU E17822882A HU E17822882 A HUE17822882 A HU E17822882A HU E052067 T2 HUE052067 T2 HU E052067T2
- Authority
- HU
- Hungary
- Prior art keywords
- mutant
- phenylethylamino
- pyrimido
- oxazin
- idh1
- Prior art date
Links
- USFRTQXJZLVVJL-UHFFFAOYSA-N 7-(2-phenylethylamino)-1,4-dihydropyrimido[4,5-d][1,3]oxazin-2-one Chemical compound C1(=CC=CC=C1)CCNC=1N=CC2=C(NC(OC2)=O)N=1 USFRTQXJZLVVJL-UHFFFAOYSA-N 0.000 title 1
- 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 title 1
- 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 title 1
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 title 1
- 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 title 1
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662435283P | 2016-12-16 | 2016-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE052067T2 true HUE052067T2 (hu) | 2021-04-28 |
Family
ID=60888651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17822882A HUE052067T2 (hu) | 2016-12-16 | 2017-12-08 | Mutáns IDH1 és mutáns IDH2 inhibitor 7-feniletilamino-4H-pirimido[4,5-d][1,3]oxazin-2-on vegyületek |
Country Status (37)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102209667B1 (ko) | 2014-09-19 | 2021-01-29 | 포르마 세라퓨틱스 인크. | 돌연변이-아이소시트레이트 탈수소효소 저해제로서의 피리딘-2(1h)-온 퀴놀린 유도체 |
| MX372964B (es) | 2014-09-19 | 2020-03-27 | Forma Therapeutics Inc | Derivados de fenil quinolinona como inhibidores de isocitrato deshidrogenasa mutante (mt-idh) |
| AU2015317321B2 (en) | 2014-09-19 | 2020-03-12 | Forma Therapeutics, Inc. | Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors |
| EP3201185B1 (en) | 2014-09-19 | 2018-11-21 | Forma Therapeutics, Inc. | Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
| WO2016171755A1 (en) | 2015-04-21 | 2016-10-27 | Forma Therapeutics, Inc. | Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
| US9624216B2 (en) | 2015-04-21 | 2017-04-18 | Forma Therapeutics, Inc. | Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors |
| JOP20190090B1 (ar) | 2016-10-24 | 2023-03-28 | Astrazeneca Ab | مشتقات 9،8،7،6-رابع هيدرو-3h-بيرازولو [4،3-f]أيزوكينولين مفيدة في علاج السرطان |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| PH12019501328B1 (en) * | 2016-12-16 | 2023-05-12 | Lilly Co Eli | 7-phenylethlamino-4h-pyrimido][4,5-d][1,3] oxazin-2-one compounds as mutant 1dh1 and 1dh2 inhibitors |
| JP7291077B2 (ja) | 2016-12-16 | 2023-06-14 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｊａｋファミリーのキナーゼの低分子阻害物質 |
| EP3689873B1 (en) | 2017-01-30 | 2022-09-14 | Astrazeneca AB | Estrogen receptor modulators |
| US20210196701A1 (en) | 2018-05-16 | 2021-07-01 | Forma Therapeutics, Inc. | Inhibiting mutant idh-1 |
| US11497743B2 (en) | 2018-05-16 | 2022-11-15 | Forma Therapeutics, Inc. | Treating patients harboring an isocitrate dehydrogenase 1 (IDH-1) mutation |
| US11013733B2 (en) | 2018-05-16 | 2021-05-25 | Forma Therapeutics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1) |
| WO2019222551A1 (en) | 2018-05-16 | 2019-11-21 | Forma Therapeutics, Inc. | Solid forms of ((s)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile |
| US11013734B2 (en) | 2018-05-16 | 2021-05-25 | Forma Therapeutics, Inc. | Treating patients harboring an isocitrate dehydrogenase-1 (IDH-1) mutation |
| US11738018B2 (en) | 2018-05-16 | 2023-08-29 | FORMA Therapeuetics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1) |
| US11311527B2 (en) | 2018-05-16 | 2022-04-26 | Forma Therapeutics, Inc. | Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1) |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| ES3033669T3 (en) | 2019-11-08 | 2025-08-06 | Nerviano Medical Sciences Srl | Gem-disubstituted heterocyclic compounds and their use as idh inhibitors |
| AU2021241470B2 (en) * | 2020-03-23 | 2023-12-14 | Board Of Regents, The University Of Texas System | Combination therapy with a mutant IDH inhibitor and a Bcl-2 inhibitor |
| ES2981250T3 (es) * | 2020-03-23 | 2024-10-08 | Lilly Co Eli | Terapia combinada con un inhibidor de IDH mutante |
| IL296094A (en) * | 2020-03-23 | 2022-11-01 | Lilly Co Eli | Method for treating idh1 inhibitor-resistant subjects |
| JP7712955B2 (ja) | 2020-04-24 | 2025-07-24 | アストラゼネカ・アクチエボラーグ | 癌の治療のための投薬レジメン |
| MX2022013258A (es) | 2020-04-24 | 2022-11-14 | Astrazeneca Ab | Formulaciones farmaceuticas. |
| CN115768775B (zh) * | 2020-06-28 | 2024-10-25 | 微境生物医药科技(上海)有限公司 | Idh突变体抑制剂及其用途 |
| JP2023534991A (ja) * | 2020-07-20 | 2023-08-15 | イーライ リリー アンド カンパニー | 変異型ｉｄｈ１阻害剤、デオキシアデノシン類似体、及び白金剤を用いた併用療法 |
| AU2022233254A1 (en) | 2021-03-11 | 2023-10-26 | Janssen Pharmaceutica Nv | Lorpucitinib for use in the treatment of jak mediated disorders |
| CN113588768B (zh) * | 2021-05-18 | 2022-07-05 | 国家卫生健康委科学技术研究所 | 一种以分子图像方式定量组织内内源性代谢物的质谱方法 |
| CN117460514A (zh) * | 2021-06-09 | 2024-01-26 | 伊莱利利公司 | 用于治疗idh抑制剂耐药的对象的方法 |
| US20240208978A1 (en) * | 2021-06-15 | 2024-06-27 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Idh mutant inhibitor and use thereof |
| CA3224704A1 (en) | 2021-08-13 | 2023-02-16 | David Andrew Coates | Solid forms of 7-[[(1s)-1-[4-[(1s)-2-cyclopropyl-1-(4-prop-2-enoylpiper azin-1-yl)ethyl]phenyl]ethyl]amino]-1-ethyl-4h- pyrimido[4,5-d] [1,3]oxazin-2-one |
| WO2023141087A1 (en) | 2022-01-19 | 2023-07-27 | Eli Lilly And Company | Combination therapy with a mutant idh inhibitor |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012313888B2 (en) * | 2011-09-27 | 2016-03-31 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH |
| BR112015022483A2 (pt) * | 2013-03-14 | 2017-07-18 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inibidores de idh mutante |
| WO2014147586A1 (en) * | 2013-03-22 | 2014-09-25 | Novartis Ag | 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh |
| WO2016171755A1 (en) * | 2015-04-21 | 2016-10-27 | Forma Therapeutics, Inc. | Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors |
| WO2016171715A1 (en) * | 2015-04-24 | 2016-10-27 | Halliburton Energy Services, Inc. | Methods of fabricating ceramic or intermetallic parts |
| JP6473270B2 (ja) * | 2015-07-27 | 2019-02-20 | イーライ リリー アンド カンパニー | ７−フェニルエチルアミノ−４ｈ−ピリミド［４，５−ｄ］［１，３］オキサジン−２−オン化合物及び変異体ｉｄｈ１阻害剤としてのそれらの使用 |
| ES2814290T3 (es) * | 2016-06-06 | 2021-03-26 | Lilly Co Eli | Inhibidores de IDH1 mutante |
| PH12019501328B1 (en) * | 2016-12-16 | 2023-05-12 | Lilly Co Eli | 7-phenylethlamino-4h-pyrimido][4,5-d][1,3] oxazin-2-one compounds as mutant 1dh1 and 1dh2 inhibitors |
-
2017
- 2017-12-08 PH PH1/2019/501328A patent/PH12019501328B1/en unknown
- 2017-12-08 SI SI201730488T patent/SI3555105T1/sl unknown
- 2017-12-08 KR KR1020197016855A patent/KR102276022B1/ko active Active
- 2017-12-08 CA CA3045303A patent/CA3045303C/en active Active
- 2017-12-08 NZ NZ754115A patent/NZ754115A/en unknown
- 2017-12-08 WO PCT/US2017/065246 patent/WO2018111707A1/en not_active Ceased
- 2017-12-08 PT PT178228821T patent/PT3555105T/pt unknown
- 2017-12-08 MA MA47399A patent/MA47399B1/fr unknown
- 2017-12-08 JP JP2019532088A patent/JP6793836B2/ja active Active
- 2017-12-08 US US16/349,873 patent/US11001596B2/en active Active
- 2017-12-08 JO JOP/2019/0142A patent/JOP20190142B1/ar active
- 2017-12-08 PE PE2019001077A patent/PE20190977A1/es unknown
- 2017-12-08 EP EP20189241.1A patent/EP3763717B1/en active Active
- 2017-12-08 ES ES17822882T patent/ES2835281T3/es active Active
- 2017-12-08 MY MYPI2019003350A patent/MY197313A/en unknown
- 2017-12-08 EA EA201991161A patent/EA036112B1/ru not_active IP Right Cessation
- 2017-12-08 EP EP17822882.1A patent/EP3555105B1/en active Active
- 2017-12-08 TN TNP/2019/000158A patent/TN2019000158A1/en unknown
- 2017-12-08 HU HUE17822882A patent/HUE052067T2/hu unknown
- 2017-12-08 AU AU2017378060A patent/AU2017378060B2/en active Active
- 2017-12-08 HR HRP20201882TT patent/HRP20201882T1/hr unknown
- 2017-12-08 LT LTEP17822882.1T patent/LT3555105T/lt unknown
- 2017-12-08 MA MA053881A patent/MA53881A/fr unknown
- 2017-12-08 CN CN202210758386.7A patent/CN115109075B/zh active Active
- 2017-12-08 CR CR20190252A patent/CR20190252A/es unknown
- 2017-12-08 PL PL17822882T patent/PL3555105T3/pl unknown
- 2017-12-08 MD MDE20191188T patent/MD3555105T2/ro unknown
- 2017-12-08 MX MX2019006830A patent/MX385562B/es unknown
- 2017-12-08 CN CN201780078017.0A patent/CN110072867B/zh active Active
- 2017-12-08 UA UAA201905584A patent/UA123640C2/uk unknown
- 2017-12-08 DK DK17822882.1T patent/DK3555105T3/da active
- 2017-12-08 ES ES20189241T patent/ES2941631T3/es active Active
- 2017-12-08 RS RS20201429A patent/RS61108B1/sr unknown
-
2019
- 2019-05-17 ZA ZA2019/03125A patent/ZA201903125B/en unknown
- 2019-05-23 CO CONC2019/0005287A patent/CO2019005287A2/es unknown
- 2019-05-30 SA SA519401897A patent/SA519401897B1/ar unknown
- 2019-06-06 CL CL2019001551A patent/CL2019001551A1/es unknown
- 2019-06-11 IL IL267236A patent/IL267236B/en active IP Right Grant
- 2019-06-11 DO DO2019000163A patent/DOP2019000163A/es unknown
- 2019-06-14 EC ECSENADI201942682A patent/ECSP19042682A/es unknown
-
2020
- 2020-10-29 AU AU2020260493A patent/AU2020260493B2/en active Active
- 2020-11-25 CY CY20201101122T patent/CY1123577T1/el unknown
-
2021
- 2021-03-16 US US17/202,867 patent/US11629156B2/en active Active
- 2021-03-16 US US17/202,515 patent/US11649247B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL267236B (en) | Derivatives of 7-phenylethylamino-4h-pyrimido[4,5-d][1,3]oxazin-2-one as 1idh and 2idh mutant inhibitors | |
| IL265449A (en) | Tcrs specific for minor histocompatibility (h) antigen ha-1 and uses thereof | |
| HUE057632T2 (hu) | KRAS G12C inhibitorok és eljárások alkalmazásukra | |
| PL3317284T3 (pl) | Związki oksazolidynonu benzoksazepiny i sposoby stosowania | |
| HUE055233T2 (hu) | Az EGFR gátló és annak elkészítése és alkalmazása | |
| HUE053737T2 (hu) | Piridopirrolokinoxalin vegyületek, készítményeik és alkalmazásaik | |
| EP3452029A4 (en) | INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS AND METHODS OF USE | |
| EP3452030A4 (en) | INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE AND METHOD FOR THEIR USE | |
| EP3519862A4 (en) | DETECTING GPS JAMMER AND SPOOFER | |
| EP3452451A4 (en) | INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS AND METHODS OF USE | |
| HUE053968T2 (hu) | Triazinon vázzal és imidazo-pirazinon vázzal rendelkezõ PDE9 inhibitorok perifériás betegségek kezelésére | |
| HUE050320T2 (hu) | PDE1 inhibitor 1,5-dihidro-4H-pirazolo[3-4-d]pirimidin-4-onok és 1,5-dihidro-4H-pirazolo[3-4-d]piridin-4-onok | |
| HUE054923T2 (hu) | Orvosi tükrözési tartozék, a tartozékot tartalmazó orvosi tükrözõ és annak használata | |
| EP3415518A4 (en) | MACROCYCLUS AND COMPOSITION THEREOF | |
| BR112017007158A2 (pt) | composições para higiene oral compreendendo zinco, arginina e serina. | |
| EP3782993A4 (en) | SELECTIVE JAK2 INHIBITOR AND ITS APPLICATION | |
| EP3476932C0 (en) | NEW MICROORGANISM BELONGING TO THE FAMILY OF SPORICHTHYACEAE AND ITS USE | |
| HUE063621T2 (hu) | ß-interferon elleni ellenanyagok és alkalmazásuk | |
| HUE060654T2 (hu) | Heterokondelzált piridonvegyületek és azok IDH-gátlóként történõ alkalmazása | |
| EP3452452A4 (en) | INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE AND METHOD FOR THEIR USE | |
| EP3617204A4 (en) | INDOLAMINE-2,3-DIOXYGENASE INHIBITOR AND APPLICATION | |
| ITUA20163193A1 (it) | Copolimeri biodegradabili ad uso cosmetico. | |
| EP3744836A4 (en) | Ketoreductase mutant and application thereof | |
| EP3482729A4 (en) | Pull-up type absorbent article | |
| EP3562837A4 (en) | MODIFIED LYSINE DECARBOXYLASE ENZYMES |