HUE046089T2 - Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához - Google Patents
Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításáhozInfo
- Publication number
- HUE046089T2 HUE046089T2 HUE12795954A HUE12795954A HUE046089T2 HU E046089 T2 HUE046089 T2 HU E046089T2 HU E12795954 A HUE12795954 A HU E12795954A HU E12795954 A HUE12795954 A HU E12795954A HU E046089 T2 HUE046089 T2 HU E046089T2
- Authority
- HU
- Hungary
- Prior art keywords
- biocatalysts
- hydroxy
- preparation
- substituted carbamates
- carbamates
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 239000011942 biocatalyst Substances 0.000 title 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161561665P | 2011-11-18 | 2011-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE046089T2 true HUE046089T2 (hu) | 2020-01-28 |
Family
ID=47295185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12795954A HUE046089T2 (hu) | 2011-11-18 | 2012-11-14 | Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához |
Country Status (8)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| JP6088535B2 (ja) | 2011-10-27 | 2017-03-08 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ベータ３アゴニストおよび中間体を製造するプロセス |
| JP6063948B2 (ja) | 2011-10-27 | 2017-01-18 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ベータ３アゴニストおよび中間体を製造するプロセス |
| EP2780448B1 (en) | 2011-11-18 | 2019-09-11 | Codexis, Inc. | Biocatalysts for the preparation of hydroxy substituted carbamates |
| EP2970927A4 (en) * | 2013-03-15 | 2016-10-12 | Merck Sharp & Dohme | IMMOBILIZED KETOREDUCASTASES AND METHOD FOR THE PRODUCTION AND USE OF IMMOBILIZED KETOREDUCASTASES |
| JP6383403B2 (ja) * | 2013-03-15 | 2018-08-29 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | β−３作動薬および中間体の製造方法 |
| EP3256577B1 (en) | 2015-02-10 | 2020-08-26 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
| CN106011095B (zh) * | 2016-07-27 | 2021-02-26 | 苏州汉酶生物技术有限公司 | 工程化酮还原酶多肽及使用其制备依替米贝中间体的方法 |
| CN117695287A (zh) | 2017-06-06 | 2024-03-15 | 住友制药(苏州)有限公司 | 使用维贝隆以治疗膀胱过度活动症 |
| JP2022510084A (ja) | 2018-12-05 | 2022-01-26 | ウロバント サイエンシズ ゲーエムベーハー | 良性前立腺肥大症の男性の過活動膀胱症状を治療するためのビベグロンの使用 |
| CN109943543B (zh) * | 2019-03-28 | 2020-12-11 | 上海健康医学院 | 醇脱氢酶突变体及其制备方法和应用 |
| CN114410599B (zh) * | 2022-01-29 | 2023-08-18 | 浙江工业大学 | 羰基还原酶突变体及其制备瑞舒伐他汀手性中间体的应用 |
| CN116814569B (zh) * | 2023-05-30 | 2025-07-25 | 华东理工大学 | 一种催化活性提高的醇脱氢酶突变体、基因工程菌及其应用 |
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| US5538867A (en) | 1988-09-13 | 1996-07-23 | Elf Aquitaine | Process for the electrochemical regeneration of pyridine cofactors |
| JP3155107B2 (ja) | 1993-01-12 | 2001-04-09 | ダイセル化学工業株式会社 | 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法 |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| KR100477070B1 (ko) | 1994-03-25 | 2006-04-21 | 이소테크니카 인코포레이티드 | 중수소화작용에의한의약품의효능강화법 |
| JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
| FI104465B (fi) | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
| US5891685A (en) | 1996-06-03 | 1999-04-06 | Mitsubishi Chemical Corporation | Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid |
| US6342507B1 (en) | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
| ATE423130T1 (de) | 1997-10-08 | 2009-03-15 | Isotechnika Inc | Deuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agenzien |
| KR20010032861A (ko) | 1997-12-08 | 2001-04-25 | 캘리포니아 인스티튜트 오브 테크놀로지 | 폴리뉴클레오티드 및 폴리펩티드 서열을 형성하는 방법 |
| US6495023B1 (en) | 1998-07-09 | 2002-12-17 | Michigan State University | Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration |
| DE19857302C2 (de) | 1998-12-14 | 2000-10-26 | Forschungszentrum Juelich Gmbh | Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester |
| JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
| US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| EP1621613B1 (en) | 1999-03-11 | 2009-04-22 | Eastman Chemical Company | Enzymatic reductions with dihydrogen via metal catalyzed cofactor regeneration |
| WO2001040450A1 (fr) | 1999-12-03 | 2001-06-07 | Kaneka Corporation | Nouvelle carbonyl reductase, son gene et son procede d'utilisation |
| AU4964101A (en) | 2000-03-30 | 2001-10-15 | Maxygen Inc | In silico cross-over site selection |
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| US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
| EP1660648B1 (en) | 2003-08-11 | 2013-10-09 | Codexis, Inc. | Improved glucose dehydrogenase polypeptides and related polynucleotides |
| KR20060064617A (ko) | 2003-08-11 | 2006-06-13 | 코덱시스, 인코포레이티드 | 개량된 할로히드린 디할로게나제 및 관련 폴리뉴클레오티드 |
| JP2007502111A (ja) | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | ４−置換３−ヒドロキシ酪酸誘導体およびビシナルなシアノ，ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス |
| WO2005017135A1 (en) | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
| US20080050787A1 (en) | 2003-12-02 | 2008-02-28 | Hazuki Nagai | Method for Manufacturing Optically Active Tetrahydrothiophene Derivative and Method for Crystallization of Optically Active Tetrahydrothiophene-3-Ol |
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| JP2010517574A (ja) | 2007-02-08 | 2010-05-27 | コデクシス， インコーポレイテッド | ケトレダクターゼおよびその使用 |
| US20090118130A1 (en) | 2007-02-12 | 2009-05-07 | Codexis, Inc. | Structure-activity relationships |
| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| JP5973131B2 (ja) | 2007-09-13 | 2016-08-23 | コデクシス， インコーポレイテッド | アセトフェノンの還元のためのケトレダクターゼポリペプチド |
| KR20100061571A (ko) | 2007-09-28 | 2010-06-07 | 코덱시스, 인코포레이티드 | 케토리덕타제 폴리펩티드 및 이의 용도 |
| HUE027683T2 (en) * | 2007-10-01 | 2016-10-28 | Codexis Inc | Ketoreductase polypeptides for the production of azetidinone |
| PE20091825A1 (es) | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
| US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010027710A2 (en) | 2008-08-27 | 2010-03-11 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| HUE026181T2 (en) * | 2008-08-27 | 2016-05-30 | Codexis Inc | Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine |
| SI2329014T1 (sl) | 2008-08-29 | 2015-01-30 | Codexis, Inc. | Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona |
| SG10201405022PA (en) | 2009-08-19 | 2014-10-30 | Codexis Inc | Ketoreductase polypeptides for the preparation of phenylephrine |
| EP2566497B1 (en) | 2010-05-04 | 2015-07-29 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
| EP2780448B1 (en) | 2011-11-18 | 2019-09-11 | Codexis, Inc. | Biocatalysts for the preparation of hydroxy substituted carbamates |
-
2012
- 2012-11-14 EP EP12795954.2A patent/EP2780448B1/en active Active
- 2012-11-14 US US14/357,964 patent/US9139819B2/en active Active
- 2012-11-14 CN CN201610911937.3A patent/CN106479990B/zh active Active
- 2012-11-14 HU HUE12795954A patent/HUE046089T2/hu unknown
- 2012-11-14 CN CN201280067329.9A patent/CN104053771B/zh active Active
- 2012-11-14 IN IN4470CHN2014 patent/IN2014CN04470A/en unknown
- 2012-11-14 WO PCT/US2012/065046 patent/WO2013074650A1/en active Application Filing
- 2012-11-14 SG SG11201402401TA patent/SG11201402401TA/en unknown
-
2014
- 2014-05-14 IL IL23262114A patent/IL232621B/en active IP Right Grant
-
2015
- 2015-08-13 US US14/825,688 patent/US9422531B2/en active Active
-
2016
- 2016-07-15 US US15/211,990 patent/US9803178B2/en active Active
-
2017
- 2017-09-21 US US15/711,119 patent/US10100287B2/en active Active
-
2018
- 2018-09-10 US US16/126,044 patent/US10253303B2/en active Active
-
2019
- 2019-02-25 US US16/284,235 patent/US10851351B2/en active Active
-
2020
- 2020-10-29 US US17/084,405 patent/US11713451B2/en active Active
-
2023
- 2023-06-12 US US18/333,393 patent/US12241093B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10100287B2 (en) | 2018-10-16 |
| US11713451B2 (en) | 2023-08-01 |
| WO2013074650A1 (en) | 2013-05-23 |
| CN104053771A (zh) | 2014-09-17 |
| US20240018489A1 (en) | 2024-01-18 |
| US20140322769A1 (en) | 2014-10-30 |
| US9139819B2 (en) | 2015-09-22 |
| US9803178B2 (en) | 2017-10-31 |
| US20190177702A1 (en) | 2019-06-13 |
| US10851351B2 (en) | 2020-12-01 |
| CN104053771B (zh) | 2016-11-09 |
| CN106479990B (zh) | 2020-09-18 |
| US10253303B2 (en) | 2019-04-09 |
| US20210071151A1 (en) | 2021-03-11 |
| US20180010100A1 (en) | 2018-01-11 |
| EP2780448A1 (en) | 2014-09-24 |
| CN106479990A (zh) | 2017-03-08 |
| US20160319247A1 (en) | 2016-11-03 |
| US12241093B2 (en) | 2025-03-04 |
| US9422531B2 (en) | 2016-08-23 |
| IN2014CN04470A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-09-04 |
| EP2780448B1 (en) | 2019-09-11 |
| US20150344850A1 (en) | 2015-12-03 |
| SG11201402401TA (en) | 2014-06-27 |
| IL232621B (en) | 2019-10-31 |
| US20180371427A1 (en) | 2018-12-27 |
| IL232621A0 (en) | 2014-06-30 |
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