HUE042173T2 - 'Signal transducer and activator of transcription 3' (stat3) expresszió modulálása - Google Patents

'Signal transducer and activator of transcription 3' (stat3) expresszió modulálása

Info

Publication number
HUE042173T2
HUE042173T2 HUE12763390A HUE12763390A HUE042173T2 HU E042173 T2 HUE042173 T2 HU E042173T2 HU E12763390 A HUE12763390 A HU E12763390A HU E12763390 A HUE12763390 A HU E12763390A HU E042173 T2 HUE042173 T2 HU E042173T2
Authority
HU
Hungary
Prior art keywords
stat3
activator
transcription
modulation
expression
Prior art date
Application number
HUE12763390A
Other languages
English (en)
Hungarian (hu)
Inventor
Eric E Swayze
Susan M Freier
Robert A Macleod
Youngsoo Kim
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of HUE042173T2 publication Critical patent/HUE042173T2/hu

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3525—MOE, methoxyethoxy
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
HUE12763390A 2011-04-01 2012-03-30 'Signal transducer and activator of transcription 3' (stat3) expresszió modulálása HUE042173T2 (hu)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161471035P 2011-04-01 2011-04-01
US201161471045P 2011-04-01 2011-04-01
US201161471015P 2011-04-01 2011-04-01
US201161471001P 2011-04-01 2011-04-01
US201161558308P 2011-11-10 2011-11-10
US201161558316P 2011-11-10 2011-11-10

Publications (1)

Publication Number Publication Date
HUE042173T2 true HUE042173T2 (hu) 2019-06-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12763390A HUE042173T2 (hu) 2011-04-01 2012-03-30 'Signal transducer and activator of transcription 3' (stat3) expresszió modulálása

Country Status (35)

Country Link
US (4) US8816056B2 (OSRAM)
EP (2) EP2697243B1 (OSRAM)
JP (1) JP5943993B2 (OSRAM)
KR (2) KR20190092590A (OSRAM)
CN (2) CN103562215B (OSRAM)
AU (1) AU2012236206C1 (OSRAM)
BR (1) BR112013024768B1 (OSRAM)
CA (1) CA2831915C (OSRAM)
CL (1) CL2013002773A1 (OSRAM)
CO (1) CO6821885A2 (OSRAM)
CY (1) CY1121460T1 (OSRAM)
DK (1) DK2697243T3 (OSRAM)
DO (1) DOP2013000216A (OSRAM)
EA (2) EA201792185A3 (OSRAM)
EC (1) ECSP13012909A (OSRAM)
ES (1) ES2709495T3 (OSRAM)
GT (1) GT201300232A (OSRAM)
HR (1) HRP20182169T1 (OSRAM)
HU (1) HUE042173T2 (OSRAM)
IL (2) IL228569A (OSRAM)
LT (1) LT2697243T (OSRAM)
ME (1) ME03317B (OSRAM)
MX (1) MX340086B (OSRAM)
MY (1) MY163004A (OSRAM)
NI (1) NI201300101A (OSRAM)
PE (2) PE20142463A1 (OSRAM)
PH (1) PH12013502049A1 (OSRAM)
PL (1) PL2697243T3 (OSRAM)
PT (1) PT2697243T (OSRAM)
RS (1) RS58489B1 (OSRAM)
SG (1) SG193504A1 (OSRAM)
SI (1) SI2697243T1 (OSRAM)
SM (1) SMT201900060T1 (OSRAM)
WO (1) WO2012135736A2 (OSRAM)
ZA (1) ZA201308153B (OSRAM)

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