HUE034247T2 - Veszettség glikoprotein vírusszerû részecskék (VLP-K) - Google Patents
Veszettség glikoprotein vírusszerû részecskék (VLP-K) Download PDFInfo
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- HUE034247T2 HUE034247T2 HUE11838942A HUE11838942A HUE034247T2 HU E034247 T2 HUE034247 T2 HU E034247T2 HU E11838942 A HUE11838942 A HU E11838942A HU E11838942 A HUE11838942 A HU E11838942A HU E034247 T2 HUE034247 T2 HU E034247T2
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- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
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Claims (6)
- VESZËTTSÊÔOOKOFBOTEIM VÍRiiSSZEMÜ MiilICilClE |¥LM) Szabd igimi fginyponfoà L Eljárás mfceliftk elöaUhására, amelyek íamlmajínálí veszettaég-vfms fRVy glikoproiooteket (ö-proteinekéin ahol a CNproteioek egy trimert képeznek, »hol az eljárás magában fo||:íaifa a következeket: ïïs) egy Sf9 mvar-gazdasej: átalakítása egy bakalovims-vektoiïak antely tmämm egy nuklemsavat, amely kódol egy RV-G-protemt; (bj :a nevezett gazdnsejt tenyésztése, hogy a nukleinsav e^pfesszíoia iöninjón; és fej m RV-G-protein tiaztitása núccUák foanájában.
- 2, Eljárás az I, igénypont szerint, ahol a nukleinsav kodon-pp^Mahzafe a nevezeti gazdasejtekben történő expresszió céljából •1* ,Eljárásnak :L igénypont vagy a 2. igénypont szerint, ahol az RV-G-proiei&%É^tuaá&a i SEQ ID NO: 2 azonosító számú szekvenciát, 4 Eljárás az l.-töi 3.~ig igénypontok bármelyike szerint* ::akd .az 'RV-G-profofü égy li¥'· törzsből van származtatva, amely a következők közül van választva: esBbér, kutya, denevér, mosomcdvo. bűzös borz (szkunk) és róka. i* Eljárás egy vakcina- vagy antigén-készítmény előállítására, ahol az magában foglalja a veszettség virus ghkoproíeinekeí tartalmazó mieelláknnk az előállítását az 1 .-tői 4.-tg igénypontok bármelyike szenna eljárás révén, és továbbá magában foglal egy lépést, amely abból áll hogy a ntkellák egy vakcina- vagy antigén-készítményként· vannak fbnnulázva azáltal hogy a mieeiíák egy hatásos áóztsa van hozzáadva a készítményhez, ő. Eljárás az 5. igénypont szerint, ahol a nevezett készítmény tartalmaz egy gyógyászablag elfogadható hordozót, hígítói vagy segédanyagot texespienst),
- 7, Eljárás az 5. Igénypont vagy a 6 igénypont szerda, ahol a készítmény tartalmaz egy adjuvánst.
- 8, Eljárás a 7, Igénypont szerint, ahol az adjuváns egy aluminium-adjuváns. % Eljárás az 1. igénypont szerint, ahol a micella alkalmas az aniNGvprótéfo (Grpolem ellen irányuló) antitestek termelésének a növeléséreegy gazdában.
- 10, Eljárás a 9- igénypont szerint, ahol a nevezett ami-G-prolein (G-proteni ellen irányuló) antitestek nenírali/ilo ísemlegeyto) amstCMCS 1L Eljárás a 9. Igénypont szerint, ahol a nevezett élen iránynloj sniiestek protőktivek {védelmet nyújtanák).
- 12. Eljárás a 9. igénypont, szennt, ahol a micollák alkalmasak az anti-G-protcin (G-protein el« Irányuló) antitestek termelésének, az índukálására a gazdában egyetlen dózis beadása után. Ll Eljárás a 9. igénypont szerint, ahol a micellák alkalmasak arra, hogy egy szeroprotekeiét biztosító (szeroproiektiv) liter tangóiul: „seroproteetive *&<#*) álljon rendelkezésre 7 napon belül
Applications Claiming Priority (1)
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| US41076710P | 2010-11-05 | 2010-11-05 |
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| DK2480560T3 (en) | 2009-09-22 | 2018-04-16 | Medicago Inc | PROCEDURE FOR THE PREPARATION OF PLANT DERIVATIVE PROTEINS |
| KR101847908B1 (ko) * | 2010-11-05 | 2018-04-11 | 노바백스, 인코포레이티드 | 광견병 당단백질 바이러스-유사 입자(VLPs) |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| KR101963792B1 (ko) * | 2011-06-13 | 2019-07-31 | 메디카고 인코포레이티드 | 식물에서 광견병 바이러스 유사 입자 생성 |
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| CN103777021B (zh) * | 2012-10-18 | 2016-03-02 | 辽宁成大生物股份有限公司 | 狂犬疫苗糖蛋白含量的检测方法 |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
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| CN106905434B (zh) * | 2017-02-28 | 2021-01-26 | 国药中生生物技术研究院有限公司 | 一种包含蹄蝠肝炎病毒核心蛋白的重组融合蛋白及其制备方法和应用 |
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| CN110662556A (zh) | 2017-03-09 | 2020-01-07 | 哈佛大学的校长及成员们 | 癌症疫苗 |
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| KR101847908B1 (ko) * | 2010-11-05 | 2018-04-11 | 노바백스, 인코포레이티드 | 광견병 당단백질 바이러스-유사 입자(VLPs) |
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- 2011-11-07 CN CN201810963479.7A patent/CN109157658A/zh active Pending
- 2011-11-07 ES ES11838942.8T patent/ES2636965T3/es active Active
- 2011-11-07 HU HUE11838942A patent/HUE034247T2/hu unknown
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- 2011-11-07 WO PCT/US2011/059602 patent/WO2012061815A2/en not_active Ceased
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