HUE033352T2 - Bicyclic compounds as alpha4-beta2 nicotinic acetylcholine receptor ligands - Google Patents
Bicyclic compounds as alpha4-beta2 nicotinic acetylcholine receptor ligands Download PDFInfo
- Publication number
- HUE033352T2 HUE033352T2 HUE09818648A HUE09818648A HUE033352T2 HU E033352 T2 HUE033352 T2 HU E033352T2 HU E09818648 A HUE09818648 A HU E09818648A HU E09818648 A HUE09818648 A HU E09818648A HU E033352 T2 HUE033352 T2 HU E033352T2
- Authority
- HU
- Hungary
- Prior art keywords
- azabicyclo
- esia
- compound
- yloxymethyl
- hexane
- Prior art date
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- 108010052671 nicotinic receptor alpha4beta2 Proteins 0.000 title description 8
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2838CH2009 | 2009-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE033352T2 true HUE033352T2 (en) | 2017-11-28 |
Family
ID=42228992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE09818648A HUE033352T2 (en) | 2009-11-18 | 2009-12-31 | Bicyclic compounds as alpha4-beta2 nicotinic acetylcholine receptor ligands |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8735423B2 (pl) |
| EP (1) | EP2513085B1 (pl) |
| JP (1) | JP5536227B2 (pl) |
| KR (1) | KR101376145B1 (pl) |
| CN (1) | CN102741239B (pl) |
| CA (1) | CA2773409C (pl) |
| CY (1) | CY1118361T1 (pl) |
| DK (1) | DK2513085T3 (pl) |
| EA (1) | EA020506B1 (pl) |
| ES (1) | ES2601905T3 (pl) |
| HR (1) | HRP20161461T1 (pl) |
| HU (1) | HUE033352T2 (pl) |
| IL (1) | IL219637A (pl) |
| LT (1) | LT2513085T (pl) |
| MX (1) | MX2012005637A (pl) |
| NZ (1) | NZ600536A (pl) |
| PL (1) | PL2513085T3 (pl) |
| PT (1) | PT2513085T (pl) |
| RS (1) | RS55469B1 (pl) |
| SI (1) | SI2513085T1 (pl) |
| SM (1) | SMT201600444B (pl) |
| WO (1) | WO2011061751A1 (pl) |
| ZA (1) | ZA201203522B (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012271024B2 (en) * | 2011-06-17 | 2015-07-09 | Eli Lilly And Company | Bicyclo (3.1.0) hexane- 2, 6 -dicarboxylic acid derivatives as mGlu2 receptor agonist |
| JP6103240B2 (ja) | 2013-11-18 | 2017-03-29 | トヨタ紡織株式会社 | ピッチ材料の調整方法及び調整装置 |
| EP3634408B1 (en) | 2017-06-09 | 2022-12-28 | Merck Sharp & Dohme LLC | Azabicyclo[4.1.0]heptane allosteric modulators of the m4 muscarinic acetylcholine receptor |
| KR20240132502A (ko) | 2022-01-11 | 2024-09-03 | 수벤 라이프 사이언시스 리미티드 | 헤테로지환형 유도체 및 이의 cns 장애의 치료에서의 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4337341A (en) * | 1976-11-02 | 1982-06-29 | Eli Lilly And Company | 4a-Aryl-octahydro-1H-2-pyrindines |
| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| AU7871498A (en) * | 1996-12-20 | 1998-07-17 | Novo Nordisk A/S | A method of treating hypercholesterolemia and related disorders |
| EP1189612A4 (en) * | 1999-06-30 | 2005-02-16 | Daiichi Seiyaku Co | VLA-4 INHIBITABLE COMPOUNDS |
| JP2004534026A (ja) | 2001-05-05 | 2004-11-11 | スミスクライン ビーチャム パブリック リミテッド カンパニー | オレキシン受容体アンタゴニストとしてのｎ−アロイルサイクリックアミン誘導体 |
| FR2889187B1 (fr) * | 2005-07-28 | 2007-09-07 | Servier Lab | Nouveaux composes 1,1-pyridinyloxycyclopropanamines polysusbstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| TWI454262B (zh) | 2006-11-02 | 2014-10-01 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
-
2009
- 2009-12-31 PL PL09818648T patent/PL2513085T3/pl unknown
- 2009-12-31 EP EP09818648.9A patent/EP2513085B1/en active Active
- 2009-12-31 MX MX2012005637A patent/MX2012005637A/es active IP Right Grant
- 2009-12-31 PT PT98186489T patent/PT2513085T/pt unknown
- 2009-12-31 JP JP2012539471A patent/JP5536227B2/ja active Active
- 2009-12-31 HR HRP20161461TT patent/HRP20161461T1/hr unknown
- 2009-12-31 RS RS20160961A patent/RS55469B1/sr unknown
- 2009-12-31 LT LTEP09818648.9T patent/LT2513085T/lt unknown
- 2009-12-31 NZ NZ600536A patent/NZ600536A/xx unknown
- 2009-12-31 HU HUE09818648A patent/HUE033352T2/en unknown
- 2009-12-31 KR KR1020127008755A patent/KR101376145B1/ko active Active
- 2009-12-31 US US13/499,998 patent/US8735423B2/en active Active
- 2009-12-31 EA EA201290344A patent/EA020506B1/ru unknown
- 2009-12-31 ES ES09818648.9T patent/ES2601905T3/es active Active
- 2009-12-31 DK DK09818648.9T patent/DK2513085T3/en active
- 2009-12-31 SI SI200931545A patent/SI2513085T1/sl unknown
- 2009-12-31 WO PCT/IN2009/000758 patent/WO2011061751A1/en not_active Ceased
- 2009-12-31 CA CA2773409A patent/CA2773409C/en active Active
- 2009-12-31 CN CN200980162485.1A patent/CN102741239B/zh active Active
-
2012
- 2012-05-07 IL IL219637A patent/IL219637A/en active IP Right Grant
- 2012-05-15 ZA ZA2012/03522A patent/ZA201203522B/en unknown
-
2016
- 2016-11-07 CY CY20161101138T patent/CY1118361T1/el unknown
- 2016-12-06 SM SM201600444T patent/SMT201600444B/it unknown
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