HUE032885T2 - Avermektineket és egy nsaid-et tartalmazó szinergetikus kombináció tumorok gátlására - Google Patents
Avermektineket és egy nsaid-et tartalmazó szinergetikus kombináció tumorok gátlására Download PDFInfo
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- HUE032885T2 HUE032885T2 HUE12816147A HUE12816147A HUE032885T2 HU E032885 T2 HUE032885 T2 HU E032885T2 HU E12816147 A HUE12816147 A HU E12816147A HU E12816147 A HUE12816147 A HU E12816147A HU E032885 T2 HUE032885 T2 HU E032885T2
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- cancer
- ivermectin
- tumor growth
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- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Claims (2)
- LIMÁIM! IGÉNYPONTOK I* gatiáálnffílé fitÉáliláénfel történő #· isiit âiâeris im s^;iiitpozlSf é égy a vermeké n vég yüléi f%%f gyé § y Sasai \ tag eifog.Hlhaté soi a hmasos mennyrsepet halmozza egy nem uztmoY gyulladás-gátié szer IN SAID) vagy gyégyászahiag elíogaöhaté sója hatásos mérv-i sysségével iûntômàCïôOàm I. Ai 1.. igénypont szermik tuérof növekedés gátlásánál ii fái kezelésénél lártéii aitóts^:?ásra szolgáié kompeziold aid m ayststéiíin Yigyütatei az alá-PPi csoportiéi választjuk: ivemiekhn. mvermektm avsrmaitsn, abamektm öo-remektin, epánornektle, és szoiemeken. t> A
- 2. Igénypont szerinti, tumor néveködéé gátfééánál ás fii kázeilsinift történő atkatmézáera szolgáié kompztoié, ábéí az avarrnektin Yàgyu p isar-mai tin.. 4. az 1.3. fénypontok bármelyiké szárlnti. tömör nPéiáiéagátiésánái p; rak kezelésénél történő afkaintazilm szolgáié kompozíció. ahoi at nermsziar'OKi gyulladésgátlö szart (NSAID) azilppl çsépoééôi választjuk: szakellátók, proplém savak, ecelsavak, enoisavak, fepirnlnsav, szelektív COX-2 mhiblotii ás szultcmamkdek. 5. A <1. sgánypomszenntL tumor növekedés gátlásánál és rák kizefééloÉi történő alkalmazásra szolgáié tompozicióí altot a propiunsav vágyóiétól az alilll; ésôfxmpô! válásaitok. sbuprofen, rmptomn, fenoprotsn. kafopmíen, flurbiprofen, oaaprozsn és loxoorofen ló Az 5. igénypont szeneik tumor növekedés gátlásánál és rák kezelésénél toééné álkálmázásra szolpVIé kernpozlaö, ahol a propionsav vegyülő! az ém-profán. Ά A 4. igénypont szorínk. tumor növekedés gátlásánál és rák kezelésénél lörléni afkaintazlsra izpigilo kompozíció. a Μ 1 - igénypont szedni·, tumor növekedés iáfásánál és fik kezelésénél történő aíkakinazésra szolgaié kompozíció, amely i vermekén hotiios nmnoyk séf Inik ii egy HSÁíö hatásos snennyiságének kombinációiét tartalmasa f i A 8. igénypont szerinti, tumor növekedés gátlásénál és rák kezelésénél rtortááő áfkilnitéásré szolgáló kompozíció, amely ivemrektin hatásos nrnrntyb ségénea és Inupíofen hatásos menm/ts-ágének kombinációját tartalmazza. 11, A 8, Igénypont szénné, tumor nóvákedés; gátlásánál és fik Éiüisénél: tőrtipg alkalmazásra szolgáló kompozíció. amely iverroektln hatásos ségin|| :és díkfofehák batisóS íiibnyisegének kombinációját tattélmazza, ill. Az 1-10. Igénypontok bármelyike szerinti, tumor növekedés gátlásénál ás rák kezeléseméi történő alkalmazásra szolgáló tempoáítáó, ahol á fikot m áilbbb ah kosul választjuk: uroteliails rák. végbélrák, prosztatarák ás méilfák. 12, A 11 igénypont szemet:, túrt tor növekedés gátlásánál és rák kezelőiénél történő efehsisvèîus szolgáló kompozíció, aboi a rak arotekáks rák, 18 A 11 gtányoont szerint, tumor növekedve gátlásánál os rak kezelésénél történő alkalmazásra szolgáié kompozíció, ahol a rák végbélrák. lié. A 11. igénypont szerinti, tumor növekedés gátlásánál es rák kezelésénél' tlttinőialkalmazésra szolgáló kompozíció, ahol e fék prosztatái ÓK, 1b. A 11 igénypont szenna, tumor növekedés gátlásánál és rák kezelésénél történő alkalmazóéra szolgáló kompozíció, ahol a rák mellrák.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| SE1151223 | 2011-12-20 |
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| HUE032885T2 true HUE032885T2 (hu) | 2017-12-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12816147A HUE032885T2 (hu) | 2011-12-20 | 2012-12-20 | Avermektineket és egy nsaid-et tartalmazó szinergetikus kombináció tumorok gátlására |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9782424B2 (hu) |
| EP (1) | EP2793874B1 (hu) |
| AU (1) | AU2012354236B2 (hu) |
| CA (1) | CA2895289C (hu) |
| DK (1) | DK2793874T3 (hu) |
| ES (1) | ES2611086T3 (hu) |
| HR (1) | HRP20161799T1 (hu) |
| HU (1) | HUE032885T2 (hu) |
| PL (1) | PL2793874T3 (hu) |
| SM (2) | SMT201700033T1 (hu) |
| WO (1) | WO2013095286A2 (hu) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9351988B2 (en) * | 2011-05-02 | 2016-05-31 | Universite De Geneve | Macrocyclic lactones and use thereof |
| WO2016201354A1 (en) * | 2015-06-11 | 2016-12-15 | Globavir Biosciences, Inc. | Methods and compositions for treating cancer |
| US11058700B2 (en) * | 2015-10-28 | 2021-07-13 | City Of Hope | Macrocyclic lactones and uses thereof as modulators of purinergic receptors |
| AU2017305853B2 (en) * | 2016-08-04 | 2023-04-13 | Galderma Holding SA | Compositions and the use thereof for treating or preventing rosacea |
| CN108849912B (zh) * | 2018-07-26 | 2020-06-30 | 河南省农业科学院植物保护研究所 | 1,5-二芳基-3-三氟甲基吡唑类化合物在防治农业真菌病害中的应用 |
| CN114948947B (zh) * | 2021-12-31 | 2023-12-29 | 广州医科大学附属第五医院 | 硝酸芬替康唑在制备抗肿瘤药物中的应用 |
| CN117017910A (zh) * | 2023-07-25 | 2023-11-10 | 河北利华药业有限公司 | 一种含有伊维菌素的洛索洛芬钠口服溶液的制备方法 |
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| US6114376A (en) * | 1997-04-30 | 2000-09-05 | Mcgill University | Methods for using macrocyclic lactone compounds as multidrug resistance reversing agents in tumor and other cells |
| GB9916052D0 (en) * | 1999-07-08 | 1999-09-08 | Pfizer Ltd | Anthelmintic compositions |
| US6693125B2 (en) * | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
| GB2386836B (en) * | 2002-03-22 | 2006-07-26 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| EP1428528A1 (en) * | 2002-09-27 | 2004-06-16 | Tiense Suikerraffinaderij N.V. | Synergistic combinations of dietary fiber and NSAIDs for the treatment of cancer |
| JP2005247807A (ja) * | 2004-03-08 | 2005-09-15 | Japan Science & Technology Agency | Ｎｓａｉｄを利用した癌治療用組成物 |
| BRPI0820260A2 (pt) * | 2007-11-09 | 2015-05-26 | Intervet Internac B V | Composição anti-helmíntica e uso da composição |
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- 2012-12-20 CA CA2895289A patent/CA2895289C/en active Active
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- 2012-12-20 EP EP12816147.8A patent/EP2793874B1/en active Active
- 2012-12-20 US US14/366,604 patent/US9782424B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2793874A2 (en) | 2014-10-29 |
| US20140371164A1 (en) | 2014-12-18 |
| PL2793874T3 (pl) | 2017-06-30 |
| AU2012354236B2 (en) | 2017-10-05 |
| CA2895289A1 (en) | 2013-06-27 |
| AU2012354236A1 (en) | 2014-07-10 |
| ES2611086T3 (es) | 2017-05-04 |
| US9782424B2 (en) | 2017-10-10 |
| SMT201700033B (it) | 2017-03-08 |
| SMT201700033T1 (it) | 2017-03-08 |
| WO2013095286A3 (en) | 2013-11-07 |
| WO2013095286A2 (en) | 2013-06-27 |
| HRP20161799T1 (hr) | 2017-03-10 |
| CA2895289C (en) | 2020-06-30 |
| EP2793874B1 (en) | 2016-10-19 |
| DK2793874T3 (en) | 2017-02-06 |
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