HUE031818T2 - Gyomornak ellenálló gyógyászati vagy táplálék készítmény, amely ellenáll az etanol hatásának - Google Patents

Gyomornak ellenálló gyógyászati vagy táplálék készítmény, amely ellenáll az etanol hatásának Download PDF

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Publication number
HUE031818T2
HUE031818T2 HUE12775668A HUE12775668A HUE031818T2 HU E031818 T2 HUE031818 T2 HU E031818T2 HU E12775668 A HUE12775668 A HU E12775668A HU E12775668 A HUE12775668 A HU E12775668A HU E031818 T2 HUE031818 T2 HU E031818T2
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coating
pellets
suspension
weight
pharmaceutical
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HUE12775668A
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English (en)
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Priyanka Bansilal Haksar
Shraddha Sanjeev Joshi
Harsh Shah
Preeti Patil
Smitha Shetty
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Evonik Roehm Gmbh
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Publication of HUE031818T2 publication Critical patent/HUE031818T2/hu

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (3)

  1. Ciyonmripsk Äßi» gy%yá«ts vágy SrssbasMim tgösiypontok i. öyógyáiwsat» v&amp;gy táplálék készítmény, amdy a?: alábbiakat tarmlm&amp;zza: a) mag, amely gyógy teats vagy táplálék hatóanyagot tártaiméi·'#: b) öehó hevotsó rde». amely legalább.)!) tômegVban sigzsnv egy vagy több sóját tartalmasat «H •ç) küKo beytmè réteg· amely: legalább· $Q. tómegbu-han »mottes altiak söpörtök at tartalmazó pohnurtl vagy tegdllmert tartalmaz, ahol a külső bevonó tétvgben lévő amonov polimer vagy kopmifnPr <> :||öe«)^IIÜi:kö|3©iteeyak töfexi^s^tlHKsöl-eeHalöx »ottót $«skon,it közöl választott. %, Az I, igénypont mariait gyögyássrssn' vagy isplálök készítmény,. ahol a belső bevonó röisg mennyisbe •egssíábh egyenlő v&amp;gy nagyobb, mint a kölsö hevonö féseg mennyisége. I Ul v.svy ' ire^wnwe.sdi gMVgy.Vvxte v.*ev tapizok g^rimern, dse> a be '<' bee« \s r< eg ás 5 M'\ó bevess» öSmg kivételével i««eríft*lfebí::ÍÉMIyeí6ő »Heg-,jelem amely szabályénál· » gyógyászát) vagy í%í||«k kaÂny^Wszabadalâsàà. a, , ' ^'mpaak'l· Kernekjkv« vctmu g>ogy,K.'.gs v,^y töpklek kommen"·, ahol az algasavIÄbteöntf rétegbe!· isikahmszots legalább egy-1 v-rgy ; Óbb sójának a viszkozitása ÎÔ - <20 snPa.s teP) \ 5örneg%Os vtsea oldatban,
  2. 5. Λζ M igénypontok· $ÍfB^!^:iszerinii gyomornak. ellenálló gyógyászati vagy sápialók.készítmény, «bol a "belső cs vagy kohó 'fe<Âî*iibg massinssm Ó0 tömegé gyógyászátiíag vagy élelmiszertpartlap elfogadható fxa^pícnvuaítaísnaz., ö kz 5 b sges'>sV"*ok M-mchske ,-\ s'í gyem.,··,:',!'! vags -Apőe,k é /ii',»ii\ obéi a gy sg\,y,.;(,ji capv táplálék hatóanyag felszabadulása nem több mini iti % in-vjtro körülmények között pH 1,2·« 2 (ka elteltével a* t'SP 4,/etaíb púderek közegben a,> " , \) ,tósx>t Ρο.'/ο,χΐ ívod vagy marikul 7„ A« l-ó igénypontok bármelyike szerinti gy0-y.y«\s/;ai vagy táplálék készítmény, ahol » gyógyászati vsj&amp;y tópMHk h.isK'-HiYkt'. felszúbadolása nem több mim ίο ?t> in-vor» körülmények közöd pH 1,2.·« '2 óra »Ítéltével az. 'MSP »/érinti puthrdt közegben i,25 «iM kalcium ion hozzáadásával vagy anélkül.
  3. 8, Λζ 1-2. igénypontok bármelyike szarinh gyógyászati vagy táplálók készítmény, abet a gyógyászati vagy táplálék hatóanyag felszabtRitiläsa legaíábi; 7S % m-vsiro köröliriónyok: között pH 6<8»» pere eböttévpl az I ;SP vzertaii pofívrdí közeglxm. íkAa i-8. ígéayponiok bártndyake szerinti gyógyászati vagy táplálók köszilínónv. aboi a gyógyászati vagy láplólék bátöanyag fbis«shatl«ltolpj^lS^'ÓO:;|| in vu o kb ö nvn>»\ köz«'*' oh s s *« \x nUvUÍ % Í-ÍSP γζίρ-ίρΐί prstTereit közegbet); lüU*· :ί;·8. Igénypontok bfemetyg« gyógyászait vagy %âât&amp; késdtmóoy. akti ^ *&amp;«*** *&amp; a «|#m#gl«át. Mwà&amp;b ItiP*##»# vagy fœ&amp;p-ap» »W '«* keverékét ko/.ül választoltak1. •IL Az MO.. igénypontok hártnelytk« szerűm gyOgyásznirvögy mfiMk kés*.|p<Éi, r«iW rétegben tévő apionas oMaltsoportokat tmatfmrz.ó agy vagy több poiúnar vagy kopobmer «Ä8V vagy mernem ~ m c*Ä^ * n i iartatsnaző smetíítkrílát monomert tamlmsa. szemógyögyibtzalivagy iápláiéfeikészitmém, aboi a gyomornak ebeaálió gyógyászati vagy ;%!« |t«#f fevosnttos íabtetig bövbÄs pnituhletl«. bevotmtos pótlék bevonatos graaoiátnsn.. tavak, h«veasb>s pallattel vagy porra! -vagy gtaa«l#»smsbää ntegtbitou kapszula. ’-agy bevonatos kapszula... id I '<!«\ λ< »-j ' 'i.vi jfvi'iak Kot\MU· üt; g'.Pí.vrsrah vagy táplálék késdSïnépy előállítására a lanoany&amp;goi tarisim&amp;zO snag közvetlen préselése}, száraz. nedves vagy sztnkavzeíi granulátum prése tesvvd és pzt Köveid takarekkesOvol. nedve» vagy »vára* granulálásával, Kor.vcUoa petletozésével vagy pótoknak Imtóenyagoftcntes gyöngyökre vagy semleges magokra vagy halóauvag-tottalmt'} részecskékre yaié kötésével történő kialakításával, és a belső bevonó réteg és a külső bevonó réteg vlaes diszpetzKt vagy 'szerves oktat pémtPtogéáí átjárásokkal vagy tolyadekágyas {>emtei<vi^wl|||^tô^^;:^ïg!ïfp'^lr :|4 Äa l»í:3, igbnypoosotcMnteK »U «rerUm gyógyászait vagy táplálék készítmény a|kalmagása gyposorngk. dfeP«Ósgy%sfemt:-:fagy üpl dek k* vr meny ken^ atply: elkïiül etandl batásáiuk es ellenáll. :s pálcásra Ionéi •batMnak;
HUE12775668A 2012-08-27 2012-10-18 Gyomornak ellenálló gyógyászati vagy táplálék készítmény, amely ellenáll az etanol hatásának HUE031818T2 (hu)

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US (1) US10639283B2 (hu)
EP (1) EP2887925B1 (hu)
JP (1) JP6150896B2 (hu)
KR (1) KR20150047493A (hu)
CN (1) CN104507460A (hu)
AU (1) AU2012388440B2 (hu)
BR (1) BR112015001371A8 (hu)
CA (1) CA2877502C (hu)
ES (1) ES2625017T3 (hu)
HK (1) HK1203841A1 (hu)
HU (1) HUE031818T2 (hu)
IL (1) IL236313B (hu)
MX (1) MX355662B (hu)
PL (1) PL2887925T3 (hu)
RU (1) RU2015110825A (hu)
SI (1) SI2887925T1 (hu)
WO (1) WO2014032741A1 (hu)

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CA2877502C (en) 2019-07-30
US20150209298A1 (en) 2015-07-30
IL236313B (en) 2020-03-31
MX355662B (es) 2018-04-25
AU2012388440A1 (en) 2015-01-22
AU2012388440B2 (en) 2017-08-31
SI2887925T1 (sl) 2017-06-30
JP6150896B2 (ja) 2017-06-21
JP2015528450A (ja) 2015-09-28
EP2887925B1 (en) 2017-02-22
WO2014032741A1 (en) 2014-03-06
IL236313A0 (en) 2015-02-26
EP2887925A1 (en) 2015-07-01
ES2625017T3 (es) 2017-07-18
HK1203841A1 (en) 2015-11-06
BR112015001371A2 (pt) 2017-07-04
RU2015110825A (ru) 2016-10-20
US10639283B2 (en) 2020-05-05
CN104507460A (zh) 2015-04-08
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BR112015001371A8 (pt) 2022-07-05
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