HUE030322T2 - Vérlemezkében gazdag plazma kompozíciók - Google Patents

Vérlemezkében gazdag plazma kompozíciók Download PDF

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Publication number
HUE030322T2
HUE030322T2 HUE12155924A HUE12155924A HUE030322T2 HU E030322 T2 HUE030322 T2 HU E030322T2 HU E12155924 A HUE12155924 A HU E12155924A HU E12155924 A HUE12155924 A HU E12155924A HU E030322 T2 HUE030322 T2 HU E030322T2
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Hungary
Prior art keywords
platelet
prp
growth factor
pharmaceutical composition
agents
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HUE12155924A
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English (en)
Inventor
Sanchez Julian Agut
Navarro Carlos Fernandez
Trullas Joan Cos
Safont Laura Ocana
Corominas Elsa Genove
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Opko Lab Europe Sl
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Publication of HUE030322T2 publication Critical patent/HUE030322T2/hu

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Claims (6)

Vérlemezkében gazdag pi az ma ko rnpoz: k: iők
1. Beteroièg forrásból szerit veriemezMbeü pzclag plazmái íFE.P) tartalmazó gyógyászati kompozíció, íxüfetí' és ^betegségekkel, rendellenességekkel vagy sérülésekké! összefüggő fájdalom, kezdésénél vagy megelőzésénél történő alkalmazásra, ahol »kompozíciót orálisan adjak he.
2. Az. I. igénypont szerinti kompozíció, ahol az ízületi- vagy ínbetegség, rendellenesség vagy sérülés az osteoarthritis.
3. Az 1 - Fagy 2. igénypont szerinti gyógyászati kompozíció, ahöi a viriomezkében gazdag plaz-nta sertésbe! származik.
4. Az előző igénypontok bármelyike szerinti gyógyászait koiüpözfoíő, akol áz ©mlííett kompoző eió továbbá növekedési faktorokat tartalmaz, és a növekedési faktorokat az alábbi csoportból választ? juk; transzformáló növek, dési faktor íTGF}, fibroblaszt növekedési faktor (FGF>, vérmemezkéboí száríüaző növekedési faktor (PDöF), eplderínális növekedési faktor (EOF), vaszkuiáns endoteiiális növekedési faktor (VEGF), inzuíirs-jeliegii növekedési faktor (IGF), vérlemezkébó) származó endoteiiális növekedési faktor. .fFDBGF). véríomczkéből származó angiogenezis növekedési faktor (PDAF), vérieniezke faktor 4 {10--4), hepatoeita növekedési faktor (HG.F) és ezek keverékei,
5; Az 14. igénypontok bármelyike szerinti gyógyászati az alábbiakat tartalmazza; a) I és 25 tömeg % közötti véríemezkében gazdag plazma ÍFRP) b) .1 és 25 tömeg % közötti duzzasztó szer, és c) 50 és 98 tömeg % közötti mennyiségben legalább egy excipiens vagy bördözóányag, an:?e~ lyet az alábbi csoportból válaszúink: kötőanyagok, töltőanyagok, hígítöszerek, fílmképző anyagok, kenőanyagok, csúsztató anyapk, dezintégrálö szerek, tartósító szerek, stabilizáló szerek, antiozidáns-ok, bevonó anyagok, tapadást gátló szerek, ízauyagok, édesítőszerek, színezőanyagok és ezek keveréke í.
6. Az 1-5, igénypontok bármelyike szerinti gyógyászati kompozíció, ahol az említett kompozíció szemcse, tabletta, folyékony hordozóval képzett szuszpsnziőv kapszula vagy por formájú.
HUE12155924A 2012-02-17 2012-02-17 Vérlemezkében gazdag plazma kompozíciók HUE030322T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12155924.9A EP2628484B9 (en) 2012-02-17 2012-02-17 Platelet-rich plasma compositions

Publications (1)

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HUE030322T2 true HUE030322T2 (hu) 2017-05-29

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US (1) US9233126B2 (hu)
EP (1) EP2628484B9 (hu)
BR (1) BR102013003570A8 (hu)
CL (1) CL2013000426A1 (hu)
CO (1) CO7030201A1 (hu)
DK (1) DK2628484T3 (hu)
ES (1) ES2579857T3 (hu)
HR (1) HRP20160719T1 (hu)
HU (1) HUE030322T2 (hu)
MX (1) MX341202B (hu)
PL (1) PL2628484T3 (hu)
RS (1) RS54845B1 (hu)
SI (1) SI2628484T1 (hu)

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WO2017082441A1 (ko) * 2015-11-13 2017-05-18 중부대학교 산학협력단 활성화된 혈소판 풍부 혈장을 유효성분으로 포함하는 동물의 창상 치료용 수의학적 조성물
RU2618649C1 (ru) * 2015-12-02 2017-05-05 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО КубГМУ Минздрава России) Способ хирургического лечения осложненной язвы двенадцатиперстной кишки
BR112019001052A2 (pt) 2016-07-21 2019-04-30 F Khorakiwala Habil composição farmacêutica tópica para promover crescimento capilar e/ou reduzir perda de cabelo
RU2644934C1 (ru) * 2016-12-29 2018-02-14 Руслан Расулжанович Шеров Способ эндоскопического лечения гастродуоденальных язв
US10624615B2 (en) 2017-10-06 2020-04-21 Stephen S Ho Apparatus and method for collecting and isolating cells
CN107929711B (zh) * 2017-12-01 2021-08-31 福建蓝昊肽生物科技发展有限公司 一种血源酶解肽在制备抑制动物肠道炎症药物中的应用
JP7175055B1 (ja) * 2021-05-14 2022-11-18 セルソース株式会社 血液由来成長因子含有組成物及びその調製方法
CN114272359A (zh) * 2021-12-21 2022-04-05 青岛恩普生物技术有限公司 一种重组人血小板衍生生长因子pdgf治疗急性伤害性疼痛的新应用

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Publication number Publication date
US9233126B2 (en) 2016-01-12
RS54845B1 (sr) 2016-10-31
US20130216626A1 (en) 2013-08-22
EP2628484B1 (en) 2016-04-20
BR102013003570A8 (pt) 2017-03-21
DK2628484T3 (en) 2016-08-01
MX341202B (es) 2016-08-09
EP2628484B9 (en) 2016-08-17
BR102013003570A2 (pt) 2013-12-17
MX2013001842A (es) 2013-08-27
ES2579857T3 (es) 2016-08-17
SI2628484T1 (sl) 2016-07-29
CO7030201A1 (es) 2014-08-21
CL2013000426A1 (es) 2014-02-14
EP2628484A1 (en) 2013-08-21
HRP20160719T1 (hr) 2016-09-23
PL2628484T3 (pl) 2016-10-31

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