HUE029855T2 - p97-antitest konjugátumok - Google Patents
p97-antitest konjugátumok Download PDFInfo
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- HUE029855T2 HUE029855T2 HUE12735414A HUE12735414A HUE029855T2 HU E029855 T2 HUE029855 T2 HU E029855T2 HU E12735414 A HUE12735414 A HU E12735414A HU E12735414 A HUE12735414 A HU E12735414A HU E029855 T2 HUE029855 T2 HU E029855T2
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6815—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6865—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from skin, nerves or brain cancer cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
- C12Y306/04—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; involved in cellular and subcellular movement (3.6.4)
- C12Y306/04006—Vesicle-fusing ATPase (3.6.4.6)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6863—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from stomach or intestines cancer cell
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
- C12Y306/04—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; involved in cellular and subcellular movement (3.6.4)
Claims (5)
- p97»a0iiest kenj optuumk l, E©n|\íiÉOT, tauely egy p9?poilpepiidet äM1»2 kovalensen vggy működőképesen kapcsolva egy antitesthez vagy annak anhgén-kőio íragmenséhez, amely speeifílmsao kötődik a humáö lieiÄe« Mtétjehez, ahol a p9? poírpégtid képes m antitestnek vagy Mgmensének m. agylvér hatirun t9önénő átszállítására. 2> ÉM L igénypont satóni koojugátum, altöl a p97 polípepíid egy olyan szekvenciát tartalmaz, amely legalább 90 %-os azonosságot mutat az: !. sz. szekvencia 20-711 csoportjaival
- 3. Az I. igénypont szerinti konjugatom, ahol a p9? polipeptid egy humán p97 fehérje íragmenst mrtalmaz, amely az 1. m szekvencia legalább 100 egymást követő aminosav-csoportjai tartalmazza, 4 Az 1. igénypont szetisti kopipgâtum, ahol a p97 polipeptid egy oldható humán, pf ? polipeptid, előnyösben, ahol m oldhat® humán p97 polipeptid tartalmazza az 1. sz. szekumeia 20-711 csoportjait. I. Az t »4 s Igén ypontok ahol a p97 polipeptid és az ami» lest vagy annak antigén-kötő Ixugmcnse kövaiensen, íuzios poiipepdiMnt kapcsolódnak. ö. Az 't»5, igénypontok bármelyike /Szerirtii konjugatnm, ahol a p97 polipeptid az antitesthez vagy annak antigén-kötő ftagmenséhez kovalensen, égy linkeren keresztül kapcsolódik,
- 7. Az I -5, igénypontok báBpelyike szerinti konjugàtum, ahol a p97 polipeptid (a) kova» lensen kötődik az antitesthez vagy annak antigéo-kötö iragotéhséhez egy polimer eross^ linkeren keresztül, (b) kovalensén kötődik az antitesthez vagy annak antigémkitö Hagmensehez egy mmorészeeskén keresztük vagy to) működőképesen kötődik az antitesthez vagy annak antigén-kötő íragmenséhez egy liposzórnán keresztül. í. Az 1-5, igénypontok harmelyike szerinti knpngltum, ahol a p9? polipeptid kovalensen kötődik az antitesthez vagy annak antígén-kötő ftagménsehez egy úoeter-kötést tartalmazó polimer cross- -litikeren keresztaiL fl Az 1-5. igénypontok bármelyike szerinti konjugátum, ahol a p$7 polipeptid kovalensen kötődik az antitesthez vagy annak antigén-kötő fragmenséhez: egy polietilén-glikoií tartalmazó polimer cross-linkeren keresztül. |0. Az 1-9. igénypontok bármelyike szerinti konjagáhim, áltól az antitest trastűzuináh vagy annak antigén-kötő Ifagmensé.
- 11, Kompozíció lïerSmeud espresazáló rák kezdésnél történő alkalmazásra,, amely: kompozíció egy m 140. Igénypontok bármelyike szerinti konjugátomot tartalmaz, előnyösen, ahoi aller' neu-í e\ptes$/a:o tak & központi Idegrerufezer (CHS), adott esetben az agy elsőd-leges rákbetegsége.
- 12. All. Igénypont szerinti alkalmazásra szolgáló kompozíció, ahol a CHS elsődleges rákbetegségét az alábbiak közül választjuk: glioma (plldlpl aszteoeiíóma, oligodendroglioma,, egy choroid plesáts papillőmá), meningioma, hipofízis ádénotoa, föltomác sehxvaormtoa, elsődleges CHS limloma, és primitiv neoroektodemmiis tumor (medulloblasztómak vagy ahol á CHS elsődleges rákbetegsége változó: formájú gliobiasztóma, adott esetben 'Mássejtes glioblasztóma vagy giószsfkóma. 13. A 11 igénypont n/comi alkahna/ásm s/oigaló kompozíció, ahol a Her2/neu-t espreaszalo rak a központi ibependszer (CNS), adott esetben .az·agy áttételes rákbetegsége. 14, A 13 . igénypont szerinti alkalmazásra szolgáld konipozieié, abol az áttételes rákbetegség az agyra mellrákból, tüdőrákból, bágy- és ivarszeryi rÄdl, a .gpztroiPleszÄäKs.tfö^kl^s rákjából (példán! végbéMkbó! vagy lutsnyáknírigyrákbél}, oszteoszarkómábóh melanómákbóí, fej- és ny aktákból, pmaztatarákból (péídáti posztata adratokarcrnómábol) vagy vérképzőszervi rákból: tevődik át. Ä A 11:,. igénypont szerinti alkalmazásra szolgáló kmopozloio, abol a MerSőtem-t expresszáld: rák: a m ellÄ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201161504646P | 2011-07-05 | 2011-07-05 | |
US201261658217P | 2012-06-11 | 2012-06-11 |
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HUE029855T2 true HUE029855T2 (hu) | 2017-04-28 |
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HUE12735414A HUE029855T2 (hu) | 2011-07-05 | 2012-07-05 | p97-antitest konjugátumok |
Country Status (13)
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US (2) | US9150846B2 (hu) |
EP (2) | EP3088005B1 (hu) |
JP (2) | JP6208658B2 (hu) |
CN (1) | CN103747807B (hu) |
AU (1) | AU2012278944B2 (hu) |
BR (1) | BR112014002219A2 (hu) |
CA (1) | CA2840221A1 (hu) |
ES (1) | ES2582869T3 (hu) |
HK (1) | HK1196257A1 (hu) |
HU (1) | HUE029855T2 (hu) |
PL (1) | PL2717917T3 (hu) |
PT (1) | PT2717917T (hu) |
WO (1) | WO2013006706A1 (hu) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006506317A (ja) | 2002-01-11 | 2006-02-23 | バイオマリン ファーマシューティカル インコーポレイテッド | 治療用リソソーム酵素の送達のための酵素送達系としてのp97の使用 |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
CA2840221A1 (en) | 2011-07-05 | 2013-01-10 | Bioasis Technologies Inc. | P97-antibody conjugates and methods of use |
AU2012294673B2 (en) | 2011-08-05 | 2015-11-26 | Bioasis Technologies Inc. | p97 fragments with transfer activity |
WO2014022515A1 (en) | 2012-07-31 | 2014-02-06 | Bioasis Technologies, Inc. | Dephosphorylated lysosomal storage disease proteins and methods of use thereof |
WO2014160438A1 (en) | 2013-03-13 | 2014-10-02 | Bioasis Technologies Inc. | Fragments of p97 and uses thereof |
PT3611180T (pt) | 2013-03-15 | 2022-03-15 | Biomolecular Holdings Llc | Imunoglobulina híbrida que contém uma ligação não peptídica |
WO2014209804A1 (en) * | 2013-06-24 | 2014-12-31 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
CN112472699A (zh) | 2013-07-26 | 2021-03-12 | 种族肿瘤学公司 | 改善比生群及衍生物的治疗益处的组合方法 |
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US10392605B2 (en) | 2014-02-19 | 2019-08-27 | Bioasis Technologies Inc. | P97-IDS fusion proteins |
EP3137610B1 (en) | 2014-05-01 | 2019-03-06 | Bioasis Technologies, Inc. | P97-polynucleotide conjugates |
-
2012
- 2012-07-05 CA CA2840221A patent/CA2840221A1/en active Pending
- 2012-07-05 PT PT127354140T patent/PT2717917T/pt unknown
- 2012-07-05 US US13/542,435 patent/US9150846B2/en active Active
- 2012-07-05 JP JP2014519294A patent/JP6208658B2/ja active Active
- 2012-07-05 EP EP16166020.4A patent/EP3088005B1/en active Active
- 2012-07-05 ES ES12735414.0T patent/ES2582869T3/es active Active
- 2012-07-05 BR BR112014002219A patent/BR112014002219A2/pt not_active Application Discontinuation
- 2012-07-05 EP EP12735414.0A patent/EP2717917B1/en active Active
- 2012-07-05 WO PCT/US2012/045568 patent/WO2013006706A1/en active Application Filing
- 2012-07-05 CN CN201280040630.0A patent/CN103747807B/zh active Active
- 2012-07-05 AU AU2012278944A patent/AU2012278944B2/en not_active Ceased
- 2012-07-05 HU HUE12735414A patent/HUE029855T2/hu unknown
- 2012-07-05 PL PL12735414.0T patent/PL2717917T3/pl unknown
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2014
- 2014-09-24 HK HK14109588.3A patent/HK1196257A1/zh not_active IP Right Cessation
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2015
- 2015-08-27 US US14/837,662 patent/US9850472B2/en active Active
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2017
- 2017-09-07 JP JP2017172020A patent/JP6392427B2/ja active Active
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US9850472B2 (en) | 2017-12-26 |
CN103747807B (zh) | 2016-12-07 |
JP6208658B2 (ja) | 2017-10-04 |
JP2018016631A (ja) | 2018-02-01 |
JP6392427B2 (ja) | 2018-09-19 |
ES2582869T3 (es) | 2016-09-15 |
AU2012278944A1 (en) | 2013-05-02 |
CA2840221A1 (en) | 2013-01-10 |
WO2013006706A1 (en) | 2013-01-10 |
EP3088005A1 (en) | 2016-11-02 |
PL2717917T3 (pl) | 2016-12-30 |
PT2717917T (pt) | 2016-07-27 |
AU2012278944B2 (en) | 2015-09-17 |
US20160053237A1 (en) | 2016-02-25 |
BR112014002219A2 (pt) | 2018-08-07 |
US20130183368A1 (en) | 2013-07-18 |
EP2717917B1 (en) | 2016-04-20 |
JP2014520816A (ja) | 2014-08-25 |
HK1196257A1 (zh) | 2014-12-12 |
US9150846B2 (en) | 2015-10-06 |
EP2717917A1 (en) | 2014-04-16 |
CN103747807A (zh) | 2014-04-23 |
EP3088005B1 (en) | 2019-01-02 |
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