HUE028550T2 - Polymorphs of 6- (Piperidin-4-yloxy) -2H-isoquinolin-1-one hydrochloride - Google Patents
Polymorphs of 6- (Piperidin-4-yloxy) -2H-isoquinolin-1-one hydrochloride Download PDFInfo
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- HUE028550T2 HUE028550T2 HUE12730525A HUE12730525A HUE028550T2 HU E028550 T2 HUE028550 T2 HU E028550T2 HU E12730525 A HUE12730525 A HU E12730525A HU E12730525 A HUE12730525 A HU E12730525A HU E028550 T2 HUE028550 T2 HU E028550T2
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- polymorph
- legalább legalább
- dihydrate
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- yloxy
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- 230000001404 mediated effect Effects 0.000 description 1
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- 229930182817 methionine Natural products 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- 229960003415 propylparaben Drugs 0.000 description 1
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- 239000013074 reference sample Substances 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 235000011649 selenium Nutrition 0.000 description 1
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- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000000373 single-crystal X-ray diffraction data Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
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- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
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- 238000000844 transformation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
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- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pregnancy & Childbirth (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305891 | 2011-07-08 | ||
| EP11306034 | 2011-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE028550T2 true HUE028550T2 (en) | 2016-12-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12730525A HUE028550T2 (en) | 2011-07-08 | 2012-06-27 | Polymorphs of 6- (Piperidin-4-yloxy) -2H-isoquinolin-1-one hydrochloride |
Country Status (17)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109810173B (zh) * | 2017-11-21 | 2020-11-27 | 首都医科大学 | 二氢异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用 |
| CN119630643A (zh) * | 2022-08-01 | 2025-03-14 | 瓦洛健康公司 | 用于制备6-取代的-1-(2h)-异喹啉酮的方法和中间化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0107456A (pt) * | 2000-01-07 | 2002-10-08 | Transform Pharmaceuticals Inc | Formação de amostras, métodos de preparar uma formação de múltiplas formas sólidas de um composto de interesse, de triar uma pluralidade de formas sólidas de um composto de interesse e condições e/ou componentes para compatibilidade com uma ou mais formas sólidas selecionadas de um composto de interesse, de identificar formas sólidas ótimas de um composto de interesse e de determinar conjuntos de condições e/ou componentes para produzir formas sólidas de um composto de interesse, um conjunto de parâmetros de processamento e/ou componentes e as condições e/ou componentes que produzem um composto de interesse ou um seu derivado diastereomérico e sistema para identificar formas sólidas ótimas de um composto de interesse |
| CA2615577C (en) | 2005-07-26 | 2014-09-09 | Sanofi-Aventis | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
| TW200738682A (en) | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| CN101616909B (zh) * | 2006-12-27 | 2013-09-11 | 塞诺菲-安万特股份有限公司 | 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物 |
| EP2240441B1 (en) | 2007-12-26 | 2015-06-03 | Sanofi | Process for the preparation of 6-substituted-1-(2h)-isoquinolinones |
-
2012
- 2012-06-27 ES ES12730525.8T patent/ES2567317T3/es active Active
- 2012-06-27 RU RU2014104357/04A patent/RU2014104357A/ru not_active Application Discontinuation
- 2012-06-27 HU HUE12730525A patent/HUE028550T2/en unknown
- 2012-06-27 US US13/534,910 patent/US8598201B2/en active Active
- 2012-06-27 IN IN834CHN2014 patent/IN2014CN00834A/en unknown
- 2012-06-27 HR HRP20160358TT patent/HRP20160358T1/hr unknown
- 2012-06-27 CN CN201280043622.1A patent/CN103781777A/zh active Pending
- 2012-06-27 AU AU2012283277A patent/AU2012283277B2/en active Active
- 2012-06-27 WO PCT/EP2012/062444 patent/WO2013007519A1/en active Application Filing
- 2012-06-27 CA CA2843777A patent/CA2843777C/en active Active
- 2012-06-27 PL PL12730525T patent/PL2729461T3/pl unknown
- 2012-06-27 DK DK12730525.8T patent/DK2729461T3/en active
- 2012-06-27 EP EP12730525.8A patent/EP2729461B1/en active Active
- 2012-06-27 SI SI201230513A patent/SI2729461T1/sl unknown
- 2012-06-27 KR KR1020147003355A patent/KR102013567B1/ko active Active
- 2012-06-27 JP JP2014517676A patent/JP2014518236A/ja active Pending
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2016
- 2016-04-19 CY CY20161100324T patent/CY1117545T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1192234A1 (zh) | 2014-08-15 |
| HRP20160358T1 (hr) | 2016-05-06 |
| ES2567317T3 (es) | 2016-04-21 |
| CA2843777C (en) | 2018-11-06 |
| RU2014104357A (ru) | 2015-08-20 |
| AU2012283277A1 (en) | 2014-02-27 |
| EP2729461A1 (en) | 2014-05-14 |
| CN103781777A (zh) | 2014-05-07 |
| KR20140046460A (ko) | 2014-04-18 |
| US8598201B2 (en) | 2013-12-03 |
| AU2012283277B2 (en) | 2016-07-21 |
| PL2729461T3 (pl) | 2016-06-30 |
| WO2013007519A1 (en) | 2013-01-17 |
| EP2729461B1 (en) | 2016-01-20 |
| DK2729461T3 (en) | 2016-04-11 |
| CY1117545T1 (el) | 2017-04-26 |
| JP2014518236A (ja) | 2014-07-28 |
| IN2014CN00834A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-04-03 |
| KR102013567B1 (ko) | 2019-08-23 |
| CA2843777A1 (en) | 2013-01-17 |
| US20130012479A1 (en) | 2013-01-10 |
| SI2729461T1 (sl) | 2016-06-30 |
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