HU9603443D0 - Benzoylecgonine, ecgonine and ecgonidine derivatives - Google Patents

Benzoylecgonine, ecgonine and ecgonidine derivatives

Info

Publication number
HU9603443D0
HU9603443D0 HU9603443A HU9603443A HU9603443D0 HU 9603443 D0 HU9603443 D0 HU 9603443D0 HU 9603443 A HU9603443 A HU 9603443A HU 9603443 A HU9603443 A HU 9603443A HU 9603443 D0 HU9603443 D0 HU 9603443D0
Authority
HU
Hungary
Prior art keywords
disorders
ecgonine
benzoylecgonine
ecgonidine derivatives
relates
Prior art date
Application number
HU9603443A
Other languages
English (en)
Other versions
HU224634B1 (hu
HUT75869A (en
Inventor
Lowell M Somers
James E Wynn
Original Assignee
Entropin Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entropin Inc filed Critical Entropin Inc
Publication of HU9603443D0 publication Critical patent/HU9603443D0/hu
Publication of HUT75869A publication Critical patent/HUT75869A/hu
Publication of HU224634B1 publication Critical patent/HU224634B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Non-Portable Lighting Devices Or Systems Thereof (AREA)
  • Materials For Medical Uses (AREA)
HU9603443A 1994-06-16 1995-06-07 Benzoil-ekgonin-származékok és ezeket tartalmazó gyógyszerkészítmények HU224634B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/260,054 US5525613A (en) 1994-06-16 1994-06-16 Covalently coupled benzoylecgonine ecgonine and ecgonidine

Publications (3)

Publication Number Publication Date
HU9603443D0 true HU9603443D0 (en) 1997-02-28
HUT75869A HUT75869A (en) 1997-05-28
HU224634B1 HU224634B1 (hu) 2005-12-28

Family

ID=22987610

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9603443A HU224634B1 (hu) 1994-06-16 1995-06-07 Benzoil-ekgonin-származékok és ezeket tartalmazó gyógyszerkészítmények

Country Status (21)

Country Link
US (1) US5525613A (hu)
EP (2) EP0765326B1 (hu)
JP (1) JP2951409B2 (hu)
KR (1) KR100407458B1 (hu)
CN (1) CN1046511C (hu)
AT (1) ATE255108T1 (hu)
AU (1) AU693571B2 (hu)
CA (1) CA2190611A1 (hu)
DE (1) DE69532203T2 (hu)
DK (1) DK0765326T3 (hu)
ES (1) ES2210296T3 (hu)
HK (1) HK1012626A1 (hu)
HU (1) HU224634B1 (hu)
IL (1) IL114177A (hu)
MX (1) MX9606374A (hu)
NO (1) NO965276D0 (hu)
NZ (1) NZ288844A (hu)
PL (1) PL186000B1 (hu)
PT (1) PT765326E (hu)
WO (1) WO1995034561A1 (hu)
ZA (1) ZA955002B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6270766B1 (en) * 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
US6482831B1 (en) 1994-06-16 2002-11-19 Entropin, Inc. Covalently coupled benzoylecgonine, egconine and ecgonidine derivatives
US5763456A (en) * 1995-06-07 1998-06-09 Entropin, Inc. Benzoylecgonine, ecgonine and ecgonidine derivatives
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
JP2005509035A (ja) 2001-11-13 2005-04-07 エントロピン， インコーポレイテッド 新規ベンゾイルエクゴニン組成物およびその生成方法
US20040171635A1 (en) * 2002-12-05 2004-09-02 Archer Nicholas J. Novel tropane esters and methods for producing and using them
TW200808739A (en) * 2006-04-06 2008-02-16 Novartis Vaccines & Diagnostic Quinazolines for PDK1 inhibition
PT2018380E (pt) 2006-05-19 2012-01-17 Abbott Lab Derivados de alcanos azabicíclicos substituídos com biciclo-heterociclo fundidos activos no cns

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893996A (en) * 1957-10-14 1959-07-07 Grace W R & Co N-amino derivatives of tropine alkaloids
US2948730A (en) * 1959-02-04 1960-08-09 Grace W R & Co 8-aminotropanium compounds
US4469700A (en) * 1981-06-19 1984-09-04 Lowell M. Somers Benzoylecgonine or benzoylnorecgonine as active agents for the treatment of rheumatoid arthritis
US4512996A (en) * 1982-12-13 1985-04-23 Lowell Somers Benzoylecgonine or benzoylnorecgonine as active agents for the treatment of rheumatoid arthritis
US4556663A (en) * 1982-12-13 1985-12-03 Somers Lowell M Benzoylecgonine, benzoylnorecgonine and ecgonine as active agents for the treatment of rheumatoid arthritis and osteoarthritis
FR2569563B1 (fr) * 1984-09-03 1987-07-03 Somers Lowell Formulation a base de benzoylecgonine ou de benzoylnorecgonine pour le traitement du rhumatisme articulaire
US5376667A (en) * 1992-12-31 1994-12-27 Entropin, Inc. Derivatives of benzoylecgonine, ecgonine and their multiple pharmacological properties

Also Published As

Publication number Publication date
CN1046511C (zh) 1999-11-17
AU693571B2 (en) 1998-07-02
EP0765326A1 (en) 1997-04-02
WO1995034561A1 (en) 1995-12-21
HU224634B1 (hu) 2005-12-28
NO965276L (no) 1996-12-10
NZ288844A (en) 1998-05-27
ZA955002B (en) 1996-02-08
HK1012626A1 (en) 1999-08-06
PT765326E (pt) 2004-03-31
PL186000B1 (pl) 2003-09-30
DE69532203T2 (de) 2004-09-09
NO965276D0 (no) 1996-12-10
EP1466913A1 (en) 2004-10-13
US5525613A (en) 1996-06-11
AU2820095A (en) 1996-01-05
ES2210296T3 (es) 2004-07-01
JPH09510991A (ja) 1997-11-04
PL317754A1 (en) 1997-04-28
JP2951409B2 (ja) 1999-09-20
IL114177A (en) 2000-02-17
MX9606374A (es) 1997-03-29
IL114177A0 (en) 1995-10-31
CN1150802A (zh) 1997-05-28
DK0765326T3 (da) 2004-04-05
HUT75869A (en) 1997-05-28
EP0765326B1 (en) 2003-11-26
DE69532203D1 (de) 2004-01-08
CA2190611A1 (en) 1995-12-21
ATE255108T1 (de) 2003-12-15
KR100407458B1 (ko) 2004-03-26

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20051019

MM4A Lapse of definitive patent protection due to non-payment of fees