HU9403252D0 - A process for the preparation of ribonucleotide reductase inhibitors - Google Patents

A process for the preparation of ribonucleotide reductase inhibitors

Info

Publication number
HU9403252D0
HU9403252D0 HU9403252A HU9403252A HU9403252D0 HU 9403252 D0 HU9403252 D0 HU 9403252D0 HU 9403252 A HU9403252 A HU 9403252A HU 9403252 A HU9403252 A HU 9403252A HU 9403252 D0 HU9403252 D0 HU 9403252D0
Authority
HU
Hungary
Prior art keywords
reductase inhibitors
ribonucleotide reductase
preparation
oxy
methylene
Prior art date
Application number
HU9403252A
Other languages
English (en)
Other versions
HUT68903A (en
HU217963B (hu
Inventor
Donald Paul Matthews
Jeffrey Stephen Sabol
James R Mccarthy
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of HU9403252D0 publication Critical patent/HU9403252D0/hu
Publication of HUT68903A publication Critical patent/HUT68903A/hu
Publication of HU217963B publication Critical patent/HU217963B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
HU9403252A 1992-05-12 1993-04-01 Eljárás ribonukleotid-reduktáz inhibitorok előállítására HU217963B (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88197892A 1992-05-12 1992-05-12
US3101293A 1993-03-26 1993-03-26

Publications (3)

Publication Number Publication Date
HU9403252D0 true HU9403252D0 (en) 1995-02-28
HUT68903A HUT68903A (en) 1995-08-28
HU217963B HU217963B (hu) 2000-05-28

Family

ID=26706717

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9403252A HU217963B (hu) 1992-05-12 1993-04-01 Eljárás ribonukleotid-reduktáz inhibitorok előállítására

Country Status (15)

Country Link
EP (1) EP0640092B1 (hu)
JP (1) JP3265548B2 (hu)
KR (1) KR100255258B1 (hu)
AT (1) ATE146183T1 (hu)
AU (1) AU662630B2 (hu)
CA (1) CA2133961C (hu)
DE (1) DE69306570T2 (hu)
DK (1) DK0640092T3 (hu)
ES (1) ES2098032T3 (hu)
FI (1) FI106127B (hu)
GR (1) GR3022400T3 (hu)
HU (1) HU217963B (hu)
NO (1) NO302524B1 (hu)
NZ (1) NZ251886A (hu)
WO (1) WO1993023414A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69421721T2 (de) * 1994-01-07 2000-04-27 Merrell Pharma Inc (e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydrat
AU2768295A (en) * 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
US20040002476A1 (en) * 2002-02-14 2004-01-01 Stuyver Lieven J. Modified fluorinated nucleoside analogues
CN102435068B (zh) * 2011-09-01 2013-12-25 安徽海螺建材设计研究院 一种水泥熟料烧成系统
DK2794627T3 (en) 2011-12-22 2019-01-14 Alios Biopharma Inc SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGUES THEREOF
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU204843B (en) * 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
CA2002648C (en) * 1988-11-15 2000-02-29 James R. Mccarthy 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives

Also Published As

Publication number Publication date
EP0640092B1 (en) 1996-12-11
AU662630B2 (en) 1995-09-07
KR950701641A (ko) 1995-04-28
ATE146183T1 (de) 1996-12-15
NO302524B1 (no) 1998-03-16
DE69306570D1 (de) 1997-01-23
JP3265548B2 (ja) 2002-03-11
FI945290A (fi) 1994-11-10
JPH07507774A (ja) 1995-08-31
ES2098032T3 (es) 1997-04-16
DE69306570T2 (de) 1997-04-10
AU4024793A (en) 1993-12-13
HUT68903A (en) 1995-08-28
WO1993023414A1 (en) 1993-11-25
KR100255258B1 (ko) 2000-05-01
HU217963B (hu) 2000-05-28
GR3022400T3 (en) 1997-04-30
CA2133961A1 (en) 1993-11-25
CA2133961C (en) 1998-03-31
NO944309D0 (no) 1994-11-11
EP0640092A1 (en) 1995-03-01
FI106127B (fi) 2000-11-30
NZ251886A (en) 1996-02-27
NO944309L (no) 1994-11-11
FI945290A0 (fi) 1994-11-10
DK0640092T3 (da) 1996-12-30

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees