HU203107B - Process for producing 23-deoxy-delta-22 derivatives of ll-f28249 compounds and pharmaceutical compositions containing them as active components - Google Patents
Process for producing 23-deoxy-delta-22 derivatives of ll-f28249 compounds and pharmaceutical compositions containing them as active components Download PDFInfo
- Publication number
- HU203107B HU203107B HU874055A HU405587A HU203107B HU 203107 B HU203107 B HU 203107B HU 874055 A HU874055 A HU 874055A HU 405587 A HU405587 A HU 405587A HU 203107 B HU203107 B HU 203107B
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- Hungary
- Prior art keywords
- compounds
- methyl
- compound
- present
- derivatives
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- 238000000034 method Methods 0.000 title claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 4
- 241001465754 Metazoa Species 0.000 claims abstract description 30
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
- -1 thiocarbonyl halide Chemical class 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 5
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 2
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- 239000007858 starting material Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 230000000507 anthelmentic effect Effects 0.000 abstract description 4
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- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Polymers & Plastics (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Animal Husbandry (AREA)
- Insects & Arthropods (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/907,284 US4886828A (en) | 1986-09-12 | 1986-09-12 | Δ22 -derivatives of LL-F28249 compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT45537A HUT45537A (en) | 1988-07-28 |
| HU203107B true HU203107B (en) | 1991-05-28 |
Family
ID=25423830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU874055A HU203107B (en) | 1986-09-12 | 1987-09-11 | Process for producing 23-deoxy-delta-22 derivatives of ll-f28249 compounds and pharmaceutical compositions containing them as active components |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4886828A (forum.php) |
| EP (1) | EP0259688B1 (forum.php) |
| JP (1) | JPS63107986A (forum.php) |
| KR (1) | KR950008972B1 (forum.php) |
| AR (1) | AR246268A1 (forum.php) |
| AT (1) | ATE88708T1 (forum.php) |
| AU (1) | AU594816B2 (forum.php) |
| BR (1) | BR8704739A (forum.php) |
| CA (1) | CA1303034C (forum.php) |
| DE (1) | DE3785628T2 (forum.php) |
| DK (1) | DK167219B1 (forum.php) |
| ES (1) | ES2053487T3 (forum.php) |
| GR (1) | GR3007911T3 (forum.php) |
| HU (1) | HU203107B (forum.php) |
| IE (1) | IE59834B1 (forum.php) |
| IL (1) | IL83794A (forum.php) |
| NZ (1) | NZ221694A (forum.php) |
| PT (1) | PT85675B (forum.php) |
| ZA (1) | ZA876837B (forum.php) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106994A (en) * | 1984-06-05 | 1992-04-21 | American Cyanamid Company | Agents and method of production thereof |
| US4806527A (en) * | 1987-03-16 | 1989-02-21 | Merck & Co., Inc. | Avermectin derivatives |
| BR8902167A (pt) * | 1988-05-10 | 1990-01-02 | American Cyanamid Co | Processo para a preparacao de compostos macrolidos,composicoes pesticidas e processo para o controle de pragas |
| HU219020B (hu) * | 1993-10-05 | 2001-01-29 | Pfizer Inc. | Eljárás doramektin előállítására, és antiparazita hatású köztitermékek és eljárás ezek előállítására |
| EG23124A (en) | 2001-02-27 | 2004-04-28 | Syngenta Participations Ag | Avermectins substituted in the 4-position having pesticidal properties |
| CR6574A (es) | 2001-02-27 | 2004-10-28 | Syngenta Participations Ag | Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas |
| AR036486A1 (es) | 2001-08-28 | 2004-09-15 | Syngenta Participations Ag | Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion |
| AR040073A1 (es) | 2002-05-07 | 2005-03-16 | Syngenta Participations Ag | Derivados de 4''-desoxi-4''-(s)-amido avermectina y su uso como plaguicidas |
| GB0302308D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties |
| GB0302309D0 (en) * | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin monosaccharide derivatives substituted in the 4 -position having pesticidal properties |
| GB0302310D0 (en) | 2003-01-31 | 2003-03-05 | Syngenta Participations Ag | Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties |
| BR112012008185A2 (pt) | 2009-10-07 | 2016-08-16 | Wyeth Llc | composições que compreendem adjuvante, macrolídeo e antígeno proteináceo, e métodos para uso dessas composições |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US32034A (en) * | 1861-04-09 | Langdon sawyer | ||
| PH16612A (en) * | 1977-12-19 | 1983-11-28 | Merck & Co Inc | 13-halo and 13-deoxy derivatives of c-076 compounds |
| USRE32034E (en) | 1977-12-19 | 1985-11-19 | Merck & Co., Inc. | 13-Halo and 13-deoxy derivatives of C-076 compounds |
| US4328335A (en) * | 1979-08-13 | 1982-05-04 | Merck & Co., Inc. | Process for the interconversion of C-076 compounds |
| US4378353A (en) * | 1981-02-17 | 1983-03-29 | Merck & Co., Inc. | Novel C-076 compounds |
| NZ201681A (en) * | 1981-09-03 | 1985-11-08 | Merck & Co Inc | Avermectin derivatives and parasiticidal compositions |
| DE3519834C2 (de) * | 1984-06-05 | 1993-12-16 | American Cyanamid Co | Neue antibiotische Wirkstoffe, Verfahren zu ihrer Gewinnung und ihre Anwendung zur Bekämpfung von Infektionen bei Tieren und Pflanzen |
| GB2166436B (en) * | 1984-09-14 | 1989-05-24 | Glaxo Group Ltd | Antibiotic compounds and their preparation |
| ES8800986A1 (es) * | 1985-07-27 | 1987-12-01 | Pfizer | Un procedimiento para la produccion de un nuevo derivado de avermectina |
| AU598204B2 (en) * | 1985-09-13 | 1990-06-21 | American Cyanamid Company | Chemical derivatives of antibiotics S541 |
| NZ219577A (en) * | 1986-03-12 | 1989-01-06 | Glaxo Group Ltd | Milbemycin derivatives and compositions |
| CA1296329C (en) * | 1986-06-06 | 1992-02-25 | Derek R. Sutherland | Macrolide compounds |
-
1986
- 1986-09-12 US US06/907,284 patent/US4886828A/en not_active Expired - Lifetime
-
1987
- 1987-08-25 EP EP87112282A patent/EP0259688B1/en not_active Expired - Lifetime
- 1987-08-25 ES ES87112282T patent/ES2053487T3/es not_active Expired - Lifetime
- 1987-08-25 AT AT87112282T patent/ATE88708T1/de not_active IP Right Cessation
- 1987-08-25 DE DE8787112282T patent/DE3785628T2/de not_active Expired - Lifetime
- 1987-09-06 IL IL83794A patent/IL83794A/xx not_active IP Right Cessation
- 1987-09-07 NZ NZ221694A patent/NZ221694A/xx unknown
- 1987-09-10 PT PT85675A patent/PT85675B/pt unknown
- 1987-09-10 CA CA000546557A patent/CA1303034C/en not_active Expired - Fee Related
- 1987-09-11 BR BR8704739A patent/BR8704739A/pt not_active Application Discontinuation
- 1987-09-11 DK DK475187A patent/DK167219B1/da not_active IP Right Cessation
- 1987-09-11 IE IE243687A patent/IE59834B1/en not_active IP Right Cessation
- 1987-09-11 KR KR1019870010117A patent/KR950008972B1/ko not_active Expired - Fee Related
- 1987-09-11 ZA ZA876837A patent/ZA876837B/xx unknown
- 1987-09-11 AR AR87308704A patent/AR246268A1/es active
- 1987-09-11 HU HU874055A patent/HU203107B/hu unknown
- 1987-09-11 AU AU78276/87A patent/AU594816B2/en not_active Expired
- 1987-09-12 JP JP62229436A patent/JPS63107986A/ja active Pending
-
1993
- 1993-05-20 GR GR920402699T patent/GR3007911T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0259688A1 (en) | 1988-03-16 |
| KR950008972B1 (ko) | 1995-08-10 |
| AU7827687A (en) | 1988-03-17 |
| ATE88708T1 (de) | 1993-05-15 |
| DK167219B1 (da) | 1993-09-20 |
| IL83794A (en) | 1993-01-14 |
| PT85675B (pt) | 1990-05-31 |
| DK475187A (da) | 1988-03-13 |
| EP0259688B1 (en) | 1993-04-28 |
| IL83794A0 (en) | 1988-02-29 |
| ZA876837B (en) | 1988-03-15 |
| US4886828A (en) | 1989-12-12 |
| JPS63107986A (ja) | 1988-05-12 |
| DE3785628T2 (de) | 1993-09-23 |
| KR880003946A (ko) | 1988-06-01 |
| IE872436L (en) | 1988-03-12 |
| NZ221694A (en) | 1989-11-28 |
| PT85675A (en) | 1987-10-01 |
| GR3007911T3 (forum.php) | 1993-08-31 |
| BR8704739A (pt) | 1988-05-03 |
| AR246268A1 (es) | 1994-07-29 |
| ES2053487T3 (es) | 1994-08-01 |
| HUT45537A (en) | 1988-07-28 |
| AU594816B2 (en) | 1990-03-15 |
| CA1303034C (en) | 1992-06-09 |
| DE3785628D1 (de) | 1993-06-03 |
| IE59834B1 (en) | 1994-04-06 |
| DK475187D0 (da) | 1987-09-11 |
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