HU202120B - Process for film coating of medical compositions with polymer dispersions - Google Patents
Process for film coating of medical compositions with polymer dispersions Download PDFInfo
- Publication number
- HU202120B HU202120B HU883346A HU334688A HU202120B HU 202120 B HU202120 B HU 202120B HU 883346 A HU883346 A HU 883346A HU 334688 A HU334688 A HU 334688A HU 202120 B HU202120 B HU 202120B
- Authority
- HU
- Hungary
- Prior art keywords
- coating
- film
- aqueous
- ethyl acrylate
- xanthan gum
- Prior art date
Links
- 239000006185 dispersion Substances 0.000 title claims abstract description 42
- 229920000642 polymer Polymers 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims abstract description 13
- 230000008569 process Effects 0.000 title claims abstract description 13
- 239000000203 mixture Substances 0.000 title claims description 14
- 239000007888 film coating Substances 0.000 title abstract description 25
- 238000009501 film coating Methods 0.000 title abstract description 25
- 238000000576 coating method Methods 0.000 claims abstract description 74
- 239000011248 coating agent Substances 0.000 claims abstract description 73
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 30
- 239000004816 latex Substances 0.000 claims abstract description 26
- 229920000126 latex Polymers 0.000 claims abstract description 26
- 239000000049 pigment Substances 0.000 claims abstract description 23
- 239000000230 xanthan gum Substances 0.000 claims abstract description 16
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 16
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 16
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229920001577 copolymer Polymers 0.000 claims abstract description 15
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims abstract description 15
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims abstract description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000454 talc Substances 0.000 claims abstract description 10
- 229910052623 talc Inorganic materials 0.000 claims abstract description 10
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 5
- 239000004815 dispersion polymer Substances 0.000 claims abstract description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 3
- 239000007788 liquid Substances 0.000 claims description 35
- 239000000178 monomer Substances 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000000725 suspension Substances 0.000 abstract description 27
- 239000000463 material Substances 0.000 abstract description 19
- 239000012530 fluid Substances 0.000 abstract description 8
- 230000035699 permeability Effects 0.000 abstract description 2
- 239000000975 dye Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 10
- 239000007787 solid Substances 0.000 description 9
- 239000008367 deionised water Substances 0.000 description 8
- 229910021641 deionized water Inorganic materials 0.000 description 8
- 229920001971 elastomer Polymers 0.000 description 8
- 239000002245 particle Substances 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 238000010073 coating (rubber) Methods 0.000 description 6
- 210000004211 gastric acid Anatomy 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 229920003134 Eudragit® polymer Polymers 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 5
- 238000005345 coagulation Methods 0.000 description 5
- 230000015271 coagulation Effects 0.000 description 5
- 230000008021 deposition Effects 0.000 description 5
- 239000003826 tablet Substances 0.000 description 5
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 3
- 229920003161 Eudragit® RS 30 D Polymers 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- -1 polyoxymethylene Polymers 0.000 description 3
- 239000011343 solid material Substances 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000006255 coating slurry Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000007720 emulsion polymerization reaction Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 239000004922 lacquer Substances 0.000 description 2
- QPNHNCISNUAHNE-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;trimethylazanium;chloride Chemical compound [Cl-].C[NH+](C)C.COC(=O)C(C)=C QPNHNCISNUAHNE-UHFFFAOYSA-N 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- MUZDXNQOSGWMJJ-UHFFFAOYSA-N 2-methylprop-2-enoic acid;prop-2-enoic acid Chemical compound OC(=O)C=C.CC(=C)C(O)=O MUZDXNQOSGWMJJ-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229920003163 Eudragit® NE 30 D Polymers 0.000 description 1
- 229920003151 Eudragit® RL polymer Polymers 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 241000589636 Xanthomonas campestris Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- 238000007922 dissolution test Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229960004667 ethyl cellulose Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 238000005243 fluidization Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 229930182480 glucuronide Natural products 0.000 description 1
- 150000008134 glucuronides Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000000383 hazardous chemical Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- DNKKLDKIFMDAPT-UHFFFAOYSA-N n,n-dimethylmethanamine;2-methylprop-2-enoic acid Chemical compound CN(C)C.CC(=C)C(O)=O.CC(=C)C(O)=O DNKKLDKIFMDAPT-UHFFFAOYSA-N 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 239000007971 pharmaceutical suspension Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/04—Homopolymers or copolymers of esters
- C09D133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09D133/08—Homopolymers or copolymers of acrylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU883346A HU202120B (en) | 1988-06-29 | 1988-06-29 | Process for film coating of medical compositions with polymer dispersions |
| CH2388/89A CH678917A5 (enrdf_load_stackoverflow) | 1988-06-29 | 1989-06-27 | |
| GB8914906A GB2220142B (en) | 1988-06-29 | 1989-06-29 | Process for the film-coating of pharmaceutical compositions with polymer dispersions |
| IT8921024A IT1230167B (it) | 1988-06-29 | 1989-06-29 | Procedimento per il rivestimento con pellicola di composizioni farmaceutiche con dispersioni di polimeri. |
| DE3921403A DE3921403A1 (de) | 1988-06-29 | 1989-06-29 | Verfahren zur herstellung von mittels waessriger polymerdispersionen mit einem film ueberzogenen pharmazeutischen praeparaten und filmueberzugsfluessigkeiten |
| JP1165510A JPH0248521A (ja) | 1988-06-29 | 1989-06-29 | 薬剤のフィルムコーティング方法 |
| FR898908680A FR2633517B1 (fr) | 1988-06-29 | 1989-06-29 | Procede pour l'enduction pelliculaire de compositions pharmaceutiques avec des dispersions de polymeres |
| NL8901655A NL8901655A (nl) | 1988-06-29 | 1989-06-29 | Werkwijze voor het filmcoaten van farmaceutische preparaten met polymeerdispersies. |
| AT0159989A AT400297B (de) | 1988-06-29 | 1989-06-29 | Verfahren zum filmüberziehen von pharmazeutischen präparaten mit wässrigen dispersionen von copolymeren des äthylacrylates |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU883346A HU202120B (en) | 1988-06-29 | 1988-06-29 | Process for film coating of medical compositions with polymer dispersions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT52965A HUT52965A (en) | 1990-09-28 |
| HU202120B true HU202120B (en) | 1991-02-28 |
Family
ID=10963667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU883346A HU202120B (en) | 1988-06-29 | 1988-06-29 | Process for film coating of medical compositions with polymer dispersions |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPH0248521A (enrdf_load_stackoverflow) |
| AT (1) | AT400297B (enrdf_load_stackoverflow) |
| CH (1) | CH678917A5 (enrdf_load_stackoverflow) |
| DE (1) | DE3921403A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2633517B1 (enrdf_load_stackoverflow) |
| GB (1) | GB2220142B (enrdf_load_stackoverflow) |
| HU (1) | HU202120B (enrdf_load_stackoverflow) |
| IT (1) | IT1230167B (enrdf_load_stackoverflow) |
| NL (1) | NL8901655A (enrdf_load_stackoverflow) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10260921A1 (de) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zum Überziehen von Substraten für pharmazeutische Anwendungen mit einem Gemisch aus zwei filmbildenden Überzugsmitteln |
| DE10260919A1 (de) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von überzogenen Arzneiformen und Nahrungsergänzungsmitteln mit Konzentrationsgradienten im Überzug |
| DE10260920A1 (de) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von Arnzeiformen oder Nahrungsergänzungsmitteln mit pigmentierten Polymerüberzügen |
| CN112739761B (zh) * | 2018-09-28 | 2023-07-14 | 日本瑞翁株式会社 | 聚合物胶乳及层叠体 |
| KR102724153B1 (ko) | 2019-06-07 | 2024-10-30 | 닛뽕소다 가부시키가이샤 | 미립자용 습식 코팅제 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3981984A (en) * | 1968-04-01 | 1976-09-21 | Colorcon Incorporated | Color film coating of tablets and the like |
| US3663284A (en) * | 1970-01-09 | 1972-05-16 | Marine Colloids Inc | Titanium dioxide suspensions |
| US4652313A (en) * | 1984-10-24 | 1987-03-24 | Crompton And Knowles Corporation | Aqueous lake pigment suspension |
| ZA86252B (en) * | 1985-01-30 | 1986-09-24 | Warner Lambert Co | Coated dosage forms |
| CH666405A5 (de) * | 1985-06-24 | 1988-07-29 | Ciba Geigy Ag | Feste, haltbare darreichungsformen mit elastischem filmueberzug. |
| JPS62125847A (ja) * | 1985-11-27 | 1987-06-08 | クロンプトン・アンド・ノウルス・コ−ポレ−シヨン | 薄塗り技術に有用な水性二酸化チタン懸濁物 |
| DE3600576A1 (de) * | 1986-01-10 | 1987-07-16 | Stotmeister Gmbh | Pulveriges beschichtungsmaterial zum beschichten von baustoffen |
| FR2595249B1 (fr) * | 1986-03-10 | 1989-12-01 | Univ Victor Segalen Bordeaux 2 | Composition pharmaceutique consistant en une suspension de carbonate de calcium |
| US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
-
1988
- 1988-06-29 HU HU883346A patent/HU202120B/hu not_active IP Right Cessation
-
1989
- 1989-06-27 CH CH2388/89A patent/CH678917A5/de not_active IP Right Cessation
- 1989-06-29 DE DE3921403A patent/DE3921403A1/de not_active Withdrawn
- 1989-06-29 IT IT8921024A patent/IT1230167B/it active
- 1989-06-29 JP JP1165510A patent/JPH0248521A/ja active Pending
- 1989-06-29 FR FR898908680A patent/FR2633517B1/fr not_active Expired - Lifetime
- 1989-06-29 AT AT0159989A patent/AT400297B/de not_active IP Right Cessation
- 1989-06-29 GB GB8914906A patent/GB2220142B/en not_active Expired - Lifetime
- 1989-06-29 NL NL8901655A patent/NL8901655A/nl not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IT1230167B (it) | 1991-10-14 |
| FR2633517B1 (fr) | 1990-12-07 |
| GB2220142A (en) | 1990-01-04 |
| AT400297B (de) | 1995-11-27 |
| NL8901655A (nl) | 1990-01-16 |
| ATA159989A (de) | 1995-04-15 |
| GB2220142B (en) | 1991-09-04 |
| IT8921024A0 (it) | 1989-06-29 |
| GB8914906D0 (en) | 1989-08-23 |
| JPH0248521A (ja) | 1990-02-19 |
| CH678917A5 (enrdf_load_stackoverflow) | 1991-11-29 |
| HUT52965A (en) | 1990-09-28 |
| FR2633517A1 (fr) | 1990-01-05 |
| DE3921403A1 (de) | 1990-02-08 |
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