HU191094B - Process for producing insoquinoline derivatives and pharmaceutical compositions containing them - Google Patents
Process for producing insoquinoline derivatives and pharmaceutical compositions containing them Download PDFInfo
- Publication number
- HU191094B HU191094B HU833134A HU313483A HU191094B HU 191094 B HU191094 B HU 191094B HU 833134 A HU833134 A HU 833134A HU 313483 A HU313483 A HU 313483A HU 191094 B HU191094 B HU 191094B
- Authority
- HU
- Hungary
- Prior art keywords
- hydrogen
- carboxylic acid
- isoquinoline
- alkyl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823233424 DE3233424A1 (de) | 1982-09-09 | 1982-09-09 | Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU191094B true HU191094B (en) | 1987-01-28 |
Family
ID=6172780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU833134A HU191094B (en) | 1982-09-09 | 1983-09-08 | Process for producing insoquinoline derivatives and pharmaceutical compositions containing them |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4673682A (OSRAM) |
| EP (1) | EP0105210B1 (OSRAM) |
| JP (1) | JPS5967270A (OSRAM) |
| KR (1) | KR840006206A (OSRAM) |
| AT (1) | ATE25679T1 (OSRAM) |
| AU (1) | AU1891683A (OSRAM) |
| CA (1) | CA1211445A (OSRAM) |
| DE (2) | DE3233424A1 (OSRAM) |
| DK (1) | DK408083A (OSRAM) |
| ES (1) | ES8404852A1 (OSRAM) |
| FI (1) | FI833200A7 (OSRAM) |
| GR (1) | GR79382B (OSRAM) |
| HU (1) | HU191094B (OSRAM) |
| IL (1) | IL69683A0 (OSRAM) |
| NO (1) | NO833217L (OSRAM) |
| NZ (1) | NZ205513A (OSRAM) |
| PH (1) | PH18186A (OSRAM) |
| PT (1) | PT77309B (OSRAM) |
| ZA (1) | ZA836663B (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4956371A (en) * | 1989-09-19 | 1990-09-11 | Euroceltique, S.A. | Substituted isoquinolines and methods of using same |
| DE69329787T2 (de) * | 1992-09-28 | 2001-06-13 | Hoechst Ag | Antiarrhythmische und cardioprotektive substituierte 1(2H)-Isochinoline, Verfahren zu deren Herstellung, diese enthaltende Arzneimittel und ihre Anwendung für die Herstellung eines Arzneimittels zur Behandlung von Herzinsuffizienzen |
| US5552412A (en) * | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| CN102718708A (zh) | 2003-06-06 | 2012-10-10 | 菲布罗根有限公司 | 含氮杂芳基化合物及其在增加内源性促红细胞生成素中的用途 |
| RU2457204C2 (ru) | 2006-01-27 | 2012-07-27 | Файброджен, Инк. | Цианоизохинолиновые соединения (варианты), фармацевтическая композиция на их основе, способ ингибирования активности гидроксилазы гипоксия-индуцибельного фактора (hif) и способ лечения и/или профилактики состояния, связанного с hif, и/или состояния, связанного с эритропоэтином, и/или анемии |
| AU2007234408B2 (en) * | 2006-04-04 | 2011-05-19 | Fibrogen, Inc. | Pyrrolo- and thiazolo-pyridine compounds as HIF modulators |
| CN105037323A (zh) | 2008-11-14 | 2015-11-11 | 菲布罗根有限公司 | 作为hif羟化酶抑制剂的苯并噻喃衍生物 |
| JP6129217B2 (ja) | 2012-03-09 | 2017-05-17 | フィブロジェン インコーポレイテッド | Ｈｉｆヒドロキシラーゼインヒビターとしての４−ヒドロキシ−イソキノリン化合物 |
| ES2631655T3 (es) | 2012-07-16 | 2017-09-01 | Fibrogen, Inc. | Procedimiento para fabricar compuestos de isoquinolina |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| KR20220164068A (ko) | 2012-07-16 | 2022-12-12 | 피브로겐, 인크. | 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형 |
| DK2951159T3 (en) | 2013-01-24 | 2018-11-19 | Fibrogen Inc | CRYSTALLIC FORMS OF {[1-CYANO-5- (4-CHLORPHENOXY) -4-HYDROXY-ISOQUINOLIN-3-CARBONYL] -AMINO} ACETIC ACID |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2054482B1 (OSRAM) * | 1969-07-11 | 1973-06-08 | Anvar | |
| FR2424270A1 (fr) * | 1978-04-24 | 1979-11-23 | Rhone Poulenc Ind | Nouveaux derives de l'isoquinoleine, leur preparation et les compositions qui les contiennent |
| DE2818423A1 (de) * | 1978-04-27 | 1979-11-08 | Hoechst Ag | Neue isochinolinderivate und verfahren zu ihrer herstellung |
-
1982
- 1982-09-09 DE DE19823233424 patent/DE3233424A1/de not_active Withdrawn
-
1983
- 1983-09-03 AT AT83108697T patent/ATE25679T1/de not_active IP Right Cessation
- 1983-09-03 EP EP83108697A patent/EP0105210B1/de not_active Expired
- 1983-09-03 DE DE8383108697T patent/DE3369983D1/de not_active Expired
- 1983-09-07 KR KR1019830004199A patent/KR840006206A/ko not_active Withdrawn
- 1983-09-07 ES ES525441A patent/ES8404852A1/es not_active Expired
- 1983-09-07 FI FI833200A patent/FI833200A7/fi not_active Application Discontinuation
- 1983-09-07 PH PH29505A patent/PH18186A/en unknown
- 1983-09-07 GR GR72399A patent/GR79382B/el unknown
- 1983-09-07 IL IL69683A patent/IL69683A0/xx unknown
- 1983-09-07 US US06/530,000 patent/US4673682A/en not_active Expired - Fee Related
- 1983-09-07 NZ NZ205513A patent/NZ205513A/en unknown
- 1983-09-08 JP JP58164274A patent/JPS5967270A/ja active Pending
- 1983-09-08 PT PT77309A patent/PT77309B/pt unknown
- 1983-09-08 CA CA000436316A patent/CA1211445A/en not_active Expired
- 1983-09-08 NO NO833217A patent/NO833217L/no unknown
- 1983-09-08 ZA ZA836663A patent/ZA836663B/xx unknown
- 1983-09-08 AU AU18916/83A patent/AU1891683A/en not_active Abandoned
- 1983-09-08 DK DK408083A patent/DK408083A/da not_active Application Discontinuation
- 1983-09-08 HU HU833134A patent/HU191094B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1211445A (en) | 1986-09-16 |
| US4673682A (en) | 1987-06-16 |
| DK408083D0 (da) | 1983-09-08 |
| DE3369983D1 (en) | 1987-04-09 |
| EP0105210A2 (de) | 1984-04-11 |
| DE3233424A1 (de) | 1984-03-15 |
| KR840006206A (ko) | 1984-11-22 |
| FI833200A7 (fi) | 1984-03-10 |
| IL69683A0 (en) | 1983-12-30 |
| PT77309B (de) | 1986-04-18 |
| NO833217L (no) | 1984-03-12 |
| DK408083A (da) | 1984-03-10 |
| GR79382B (OSRAM) | 1984-10-22 |
| ES525441A0 (es) | 1984-05-16 |
| AU1891683A (en) | 1984-03-15 |
| ES8404852A1 (es) | 1984-05-16 |
| FI833200A0 (fi) | 1983-09-07 |
| NZ205513A (en) | 1986-05-09 |
| EP0105210B1 (de) | 1987-03-04 |
| EP0105210A3 (en) | 1984-10-10 |
| PH18186A (en) | 1985-04-12 |
| JPS5967270A (ja) | 1984-04-16 |
| ZA836663B (en) | 1984-04-25 |
| ATE25679T1 (de) | 1987-03-15 |
| PT77309A (de) | 1983-10-01 |
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