HU190729B - Process for preparing 1-phenethyl-alpha-phenyl-piperidine-3-propiontrile derivatives and pharmaceutical compositions containing such compounds - Google Patents

Process for preparing 1-phenethyl-alpha-phenyl-piperidine-3-propiontrile derivatives and pharmaceutical compositions containing such compounds Download PDF

Info

Publication number
HU190729B
HU190729B HU832825A HU282583A HU190729B HU 190729 B HU190729 B HU 190729B HU 832825 A HU832825 A HU 832825A HU 282583 A HU282583 A HU 282583A HU 190729 B HU190729 B HU 190729B
Authority
HU
Hungary
Prior art keywords
compound
formula
och
hydrogen
group
Prior art date
Application number
HU832825A
Other languages
English (en)
Hungarian (hu)
Inventor
Philippe Manoury
Jean Binet
Gerard Defosse
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of HU190729B publication Critical patent/HU190729B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
HU832825A 1982-08-16 1983-08-11 Process for preparing 1-phenethyl-alpha-phenyl-piperidine-3-propiontrile derivatives and pharmaceutical compositions containing such compounds HU190729B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8214154A FR2531702A1 (fr) 1982-08-16 1982-08-16 Derives de phenethyl-1a-phenylperidine-3-propanenitrile, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
HU190729B true HU190729B (en) 1986-10-28

Family

ID=9276888

Family Applications (1)

Application Number Title Priority Date Filing Date
HU832825A HU190729B (en) 1982-08-16 1983-08-11 Process for preparing 1-phenethyl-alpha-phenyl-piperidine-3-propiontrile derivatives and pharmaceutical compositions containing such compounds

Country Status (19)

Country Link
US (1) US4481207A (en, 2012)
EP (1) EP0103500B1 (en, 2012)
JP (1) JPS5953467A (en, 2012)
AT (1) ATE31924T1 (en, 2012)
AU (1) AU559173B2 (en, 2012)
CA (1) CA1239406A (en, 2012)
DE (1) DE3375299D1 (en, 2012)
DK (1) DK367983D0 (en, 2012)
ES (1) ES8404329A1 (en, 2012)
FI (1) FI832922L (en, 2012)
FR (1) FR2531702A1 (en, 2012)
GR (1) GR78689B (en, 2012)
HU (1) HU190729B (en, 2012)
IL (1) IL69490A (en, 2012)
MX (1) MX155971A (en, 2012)
NO (1) NO832897L (en, 2012)
NZ (1) NZ205250A (en, 2012)
PT (1) PT77194B (en, 2012)
ZA (1) ZA835970B (en, 2012)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932594A (en) * 1988-11-01 1999-08-03 Pfizer, Inc. Muscarinic receptor antagonists
GB8825505D0 (en) * 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB930459A (en) * 1963-09-26 1963-07-03 Aspro Nicholas Ltd Diphenyl methane derivatives and methods for the preparation thereof
GB1057145A (en) * 1963-08-16 1967-02-01 Bellon Labor Sa Roger Phenylcyclohexylacetonitrile derivatives
FR2302739A1 (fr) * 1975-03-03 1976-10-01 Synthelabo Nouveaux derives du phenyl-2(piperidinyl-4)-2 acetonitrile, leurs sels, leur preparation et les medicaments qui en contiennent
US4399286A (en) * 1981-07-16 1983-08-16 Mead Johnson & Company Antiarrhythmic phenethylpiperidine compounds

Also Published As

Publication number Publication date
PT77194A (fr) 1983-09-01
JPS6125708B2 (en, 2012) 1986-06-17
EP0103500A2 (fr) 1984-03-21
JPS5953467A (ja) 1984-03-28
ES524907A0 (es) 1984-05-01
EP0103500B1 (fr) 1988-01-13
FR2531702B1 (en, 2012) 1984-12-07
US4481207A (en) 1984-11-06
PT77194B (fr) 1986-03-21
ATE31924T1 (de) 1988-01-15
DK367983D0 (da) 1983-08-12
FR2531702A1 (fr) 1984-02-17
FI832922A7 (fi) 1984-02-17
ZA835970B (en) 1984-04-25
NZ205250A (en) 1985-07-31
GR78689B (en, 2012) 1984-09-27
FI832922A0 (fi) 1983-08-12
NO832897L (no) 1984-02-17
DE3375299D1 (en) 1988-02-18
MX155971A (es) 1988-06-03
AU1793483A (en) 1984-02-23
AU559173B2 (en) 1987-02-26
ES8404329A1 (es) 1984-05-01
FI832922L (fi) 1984-02-17
CA1239406A (en) 1988-07-19
EP0103500A3 (en) 1984-11-28
IL69490A (en) 1986-11-30

Similar Documents

Publication Publication Date Title
US4721723A (en) Anti-depressant crystalline paroxetine hydrochloride hemihydrate
US4374841A (en) Pyridoxine derivatives, and use in therapeutics
CS246080B2 (en) Method of piperazine derivatives production
FI92822C (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 4-fenyyli-piperidiiniyhdisteiden valmistamiseksi
US5328917A (en) Piperidine compounds for treating anoxia, cerebral ischemia migraine or epilepsy
JPH0794417B2 (ja) Ｎ−アミノブチル−ｎ−フェニルアリールアミド誘導体
JP4950170B2 (ja) 新規フェニルアセテート誘導体またはその薬学的に許容可能な塩、その製造方法及びそれを有効成分として含むｔ−型カルシウムイオンチャンネルの活性によって誘発される疾患の予防または治療用組成物
US4243666A (en) 4-Amino-2-piperidino-quinazolines
IE852285L (en) Piperazinylindanes
DK172787B1 (da) 4-Phenyl-4-(N-phenylamido)-piperidinderivater, optisk aktive isomere og farmaceutisk acceptable syreadditionssalte deraf sa
JPS59141558A (ja) ２−イミノ−ピロリジン類，その製造法および治療用組成物
HU190729B (en) Process for preparing 1-phenethyl-alpha-phenyl-piperidine-3-propiontrile derivatives and pharmaceutical compositions containing such compounds
US5227379A (en) Piperidine compounds and their preparation and use
SK158692A3 (en) 2-amino-5-cyano-1,4-dihydropyridines, method of their preparation and their use in medicines
JPH05271208A (ja) １，４‐ベンゾチアゼピン誘導体
US5158961A (en) Piperidine compounds and their preparation and use
US4948812A (en) 1-phenoxy-3-amino-2-propanols use thereof
JPS6124579A (ja) 置換されたフエノキシアルキルアミノプロパノール
GB2171997A (en) 4-Amino-6,7-dimethoxy-2-Piperazin-1-ylquinazoline derivatives
HU201320B (en) Process for producing 5-braces open 2-brackets open n-(2-amino-2-oxoethyl)-n-methylamino brackets closed-ethyl braces closed-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-5h-1,5-benzothiazepin-4-on derivatives and pharmaceutical compositions comprising same
US4626542A (en) 4-(5H-dibenzo[a,d]cyclohepten-5-yl)piperidine compounds, pharmaceutical compositions and methods
HU192501B (en) Process for producing /2-methyl-propoxy/-methyl-n-phenyl-n-/phenyl-methyl/-1-pyrrolidin-ethanamine
HU194213B (en) Process for production of 3-alkoxi-2-n-pirrolidin-n-piridil-n-furil /or n-tienil/-methil-prophil amins
US4237138A (en) Antihypertensive 4-amino-2-[4-(substituted-alkoxy)piperidino)]quinazolines
EP0124777B1 (en) 1,4-dihydropyridine derivatives