HU190219B - Process for preparing in 3",7'-position cyclized dimer-cinca-alkaloid-derivatives - Google Patents
Process for preparing in 3",7'-position cyclized dimer-cinca-alkaloid-derivatives Download PDFInfo
- Publication number
- HU190219B HU190219B HU8449A HU4984A HU190219B HU 190219 B HU190219 B HU 190219B HU 8449 A HU8449 A HU 8449A HU 4984 A HU4984 A HU 4984A HU 190219 B HU190219 B HU 190219B
- Authority
- HU
- Hungary
- Prior art keywords
- acid
- acid addition
- addition salt
- formula
- compound
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 239000002253 acid Substances 0.000 claims abstract description 25
- 150000003839 salts Chemical class 0.000 claims abstract description 20
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 claims abstract description 16
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims abstract description 9
- 229960003048 vinblastine Drugs 0.000 claims abstract description 9
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000007800 oxidant agent Substances 0.000 claims abstract description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 7
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims abstract description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 7
- KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 claims abstract 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical group CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 24
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 229910052783 alkali metal Inorganic materials 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 150000001340 alkali metals Chemical class 0.000 claims description 3
- 150000003797 alkaloid derivatives Chemical class 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- QEYLDKWOZQLWNL-UHFFFAOYSA-N CCC(C)(C)O[Cr](=O)(=O)OC(C)(C)CC Chemical compound CCC(C)(C)O[Cr](=O)(=O)OC(C)(C)CC QEYLDKWOZQLWNL-UHFFFAOYSA-N 0.000 claims description 2
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 claims description 2
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 claims description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 claims 2
- 239000007810 chemical reaction solvent Substances 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 4
- -1 chromic acid alcohol ester Chemical class 0.000 abstract description 3
- SOCTUWSJJQCPFX-UHFFFAOYSA-N dichromate(2-) Chemical compound [O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O SOCTUWSJJQCPFX-UHFFFAOYSA-N 0.000 abstract description 2
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 42
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 25
- 239000000243 solution Substances 0.000 description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 238000007254 oxidation reaction Methods 0.000 description 9
- 229960004528 vincristine Drugs 0.000 description 9
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 9
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 9
- 230000003647 oxidation Effects 0.000 description 8
- 239000011541 reaction mixture Substances 0.000 description 7
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 6
- 235000011114 ammonium hydroxide Nutrition 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000000010 aprotic solvent Substances 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 238000004440 column chromatography Methods 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 4
- 229960000583 acetic acid Drugs 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
- 239000011651 chromium Substances 0.000 description 3
- 239000012043 crude product Substances 0.000 description 3
- 239000003480 eluent Substances 0.000 description 3
- ROAYSRAUMPWBQX-UHFFFAOYSA-N ethanol;sulfuric acid Chemical compound CCO.OS(O)(=O)=O ROAYSRAUMPWBQX-UHFFFAOYSA-N 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 239000012362 glacial acetic acid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 3
- 238000004809 thin layer chromatography Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 150000001845 chromium compounds Chemical class 0.000 description 2
- 229930193689 cyclovinblastine Natural products 0.000 description 2
- 230000001085 cytostatic effect Effects 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- 239000011877 solvent mixture Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 1
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 1
- 229940122803 Vinca alkaloid Drugs 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- ZCVVTMNXXQGLLF-UHFFFAOYSA-N chromium(5+) oxygen(2-) Chemical group [O-2].[O-2].[O-2].[O-2].[O-2].[Cr+5].[Cr+5] ZCVVTMNXXQGLLF-UHFFFAOYSA-N 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000824 cytostatic agent Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU8449A HU190219B (en) | 1984-01-06 | 1984-01-06 | Process for preparing in 3",7'-position cyclized dimer-cinca-alkaloid-derivatives |
| ZA849909A ZA849909B (en) | 1984-01-06 | 1984-12-19 | Process for the preparation of dimeric alkaloids |
| IL73884A IL73884A (en) | 1984-01-06 | 1984-12-20 | Aspidosperimidine-3-carboxylic acid derivatives and their use in preparing vincristine |
| CA000471111A CA1242192A (en) | 1984-01-06 | 1984-12-28 | Process for the preparation of dimeric alkaloids |
| SE8500040A SE462685B (sv) | 1984-01-06 | 1985-01-04 | Foerfarande foer framstaellning av vinkristin |
| FR858500076A FR2557877B1 (fr) | 1984-01-06 | 1985-01-04 | Procede de preparation d'alcaloides dimeres |
| US06/688,932 US4659816A (en) | 1984-01-06 | 1985-01-04 | Process for the preparation of dimeric alkaloids |
| JP60000019A JPS60174791A (ja) | 1984-01-06 | 1985-01-04 | 新規二量体アルカロイドおよびその製法 |
| BE0/214292A BE901446A (fr) | 1984-01-06 | 1985-01-04 | Procede de preparation d'alcaloides dimeres. |
| GB08500321A GB2152506B (en) | 1984-01-06 | 1985-01-07 | Vinca alkaloids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU8449A HU190219B (en) | 1984-01-06 | 1984-01-06 | Process for preparing in 3",7'-position cyclized dimer-cinca-alkaloid-derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT36131A HUT36131A (en) | 1985-08-28 |
| HU190219B true HU190219B (en) | 1986-08-28 |
Family
ID=10947652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU8449A HU190219B (en) | 1984-01-06 | 1984-01-06 | Process for preparing in 3",7'-position cyclized dimer-cinca-alkaloid-derivatives |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4659816A (enExample) |
| JP (1) | JPS60174791A (enExample) |
| BE (1) | BE901446A (enExample) |
| CA (1) | CA1242192A (enExample) |
| FR (1) | FR2557877B1 (enExample) |
| GB (1) | GB2152506B (enExample) |
| HU (1) | HU190219B (enExample) |
| IL (1) | IL73884A (enExample) |
| SE (1) | SE462685B (enExample) |
| ZA (1) | ZA849909B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2582651B1 (fr) * | 1985-06-03 | 1987-08-28 | Pf Medicament | Procede de preparation de vincristine |
| JPH09314479A (ja) * | 1996-05-28 | 1997-12-09 | Fuji Tekunika:Kk | 位置決めピン用引き抜き装置 |
| JP5046356B2 (ja) * | 2006-01-12 | 2012-10-10 | 株式会社Ｌｉｘｉｌ | 開口部装置 |
| CN119569755B (zh) * | 2025-02-07 | 2025-04-22 | 山东省中医药研究院 | 一种吲哚生物碱化合物及其提取方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH434281A (de) * | 1964-03-04 | 1967-04-30 | Geigy Ag J R | Verfahren zur Herstellung von polycyclischen Indolderivaten |
| US3899493A (en) * | 1972-12-29 | 1975-08-12 | Richter Gedeon Vegyeszet | Chromic acid oxidation of vinblastine sulfate to form vincristine |
| US4303584A (en) * | 1980-04-02 | 1981-12-01 | Eli Lilly And Company | Method of preparing vincristine |
| US4375432A (en) * | 1981-05-12 | 1983-03-01 | Eli Lilly And Company | Method of preparing vincristine |
-
1984
- 1984-01-06 HU HU8449A patent/HU190219B/hu not_active IP Right Cessation
- 1984-12-19 ZA ZA849909A patent/ZA849909B/xx unknown
- 1984-12-20 IL IL73884A patent/IL73884A/xx unknown
- 1984-12-28 CA CA000471111A patent/CA1242192A/en not_active Expired
-
1985
- 1985-01-04 US US06/688,932 patent/US4659816A/en not_active Expired - Fee Related
- 1985-01-04 FR FR858500076A patent/FR2557877B1/fr not_active Expired
- 1985-01-04 BE BE0/214292A patent/BE901446A/fr not_active IP Right Cessation
- 1985-01-04 SE SE8500040A patent/SE462685B/sv not_active IP Right Cessation
- 1985-01-04 JP JP60000019A patent/JPS60174791A/ja active Granted
- 1985-01-07 GB GB08500321A patent/GB2152506B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2557877A1 (fr) | 1985-07-12 |
| SE8500040D0 (sv) | 1985-01-04 |
| SE8500040L (sv) | 1985-07-07 |
| GB2152506B (en) | 1987-12-23 |
| SE462685B (sv) | 1990-08-13 |
| JPH0544472B2 (enExample) | 1993-07-06 |
| HUT36131A (en) | 1985-08-28 |
| US4659816A (en) | 1987-04-21 |
| ZA849909B (en) | 1985-10-30 |
| IL73884A (en) | 1988-09-30 |
| JPS60174791A (ja) | 1985-09-09 |
| BE901446A (fr) | 1985-07-04 |
| FR2557877B1 (fr) | 1989-06-16 |
| IL73884A0 (en) | 1985-03-31 |
| GB8500321D0 (en) | 1985-02-13 |
| GB2152506A (en) | 1985-08-07 |
| CA1242192A (en) | 1988-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |