HU187425B - Process for producing morphinane derivatives - Google Patents

Process for producing morphinane derivatives Download PDF

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Publication number
HU187425B
HU187425B HU823578A HU357882A HU187425B HU 187425 B HU187425 B HU 187425B HU 823578 A HU823578 A HU 823578A HU 357882 A HU357882 A HU 357882A HU 187425 B HU187425 B HU 187425B
Authority
HU
Hungary
Prior art keywords
alkyl
formula
preparation
starting materials
compound
Prior art date
Application number
HU823578A
Other languages
English (en)
Hungarian (hu)
Inventor
Ernest Mohacsi
Original Assignee
F.Hoffmann-La Roche Et Co Ag,Ch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Et Co Ag,Ch filed Critical F.Hoffmann-La Roche Et Co Ag,Ch
Publication of HU187425B publication Critical patent/HU187425B/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
HU823578A 1981-11-09 1982-11-08 Process for producing morphinane derivatives HU187425B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/319,482 US4374139A (en) 1981-11-09 1981-11-09 Levorotatory N-substituted acylmorphinans useful as analgesic agents

Publications (1)

Publication Number Publication Date
HU187425B true HU187425B (en) 1986-01-28

Family

ID=23242421

Family Applications (1)

Application Number Title Priority Date Filing Date
HU823578A HU187425B (en) 1981-11-09 1982-11-08 Process for producing morphinane derivatives

Country Status (18)

Country Link
US (1) US4374139A (OSRAM)
EP (1) EP0079556A3 (OSRAM)
JP (1) JPS5888364A (OSRAM)
KR (1) KR840002357A (OSRAM)
AU (1) AU9027682A (OSRAM)
CA (1) CA1195324A (OSRAM)
DK (1) DK491582A (OSRAM)
ES (2) ES517222A0 (OSRAM)
FI (1) FI823824L (OSRAM)
GR (1) GR78317B (OSRAM)
HU (1) HU187425B (OSRAM)
IL (1) IL67180A0 (OSRAM)
MC (1) MC1490A1 (OSRAM)
NO (1) NO823707L (OSRAM)
NZ (1) NZ202404A (OSRAM)
PH (1) PH18458A (OSRAM)
PT (1) PT75815B (OSRAM)
ZA (1) ZA827905B (OSRAM)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423221A (en) * 1982-06-10 1983-12-27 Sisa Pharmaceutical Laboratories, Inc. 7-Carboethoxy-morphinan-6-one compounds
US4454141A (en) * 1982-09-23 1984-06-12 Sisa Pharmaceutical Laboratories, Inc. Trans-B/C-7-(1-hydroxypentyl)-3-methoxy-17 methyl-6,7-didehydromorphinans, and methods of relieving pain with them
EP0184041A1 (en) * 1984-11-13 1986-06-11 Miles Inc. 6-Methylene morphinan purification technique
US4929622A (en) * 1987-09-24 1990-05-29 Hoechst-Roussel Pharmaceuticals, Inc. 2,6-Methanopyrrolo-3-benzazocines
DE4304450A1 (de) * 1993-02-13 1994-08-18 Boehringer Mannheim Gmbh System zur Zubereitung von Flüssigkeiten
WO2002036573A2 (en) * 2000-10-31 2002-05-10 Rensselaer Polytechnic Institute 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US20040204862A1 (en) * 2003-04-11 2004-10-14 Wainer Irving W. Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
PT3395372T (pt) 2009-02-20 2022-05-05 Enhanx Biopharm Inc Sistema de entrega de medicamentos à base de glutationa
KR101741629B1 (ko) 2009-05-06 2017-05-31 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
PT2506712T (pt) 2009-12-04 2019-05-31 Alkermes Pharma Ireland Ltd Derivados de morfinano para o tratamento da overdose por fármaco
ES2582306T3 (es) 2010-03-22 2016-09-12 Rensselaer Polytechnic Institute Derivados de morfinano que contienen un grupo carboxamida como ligandos de receptores opioides
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
HUE034326T2 (en) 2011-06-29 2018-02-28 Alkermes Inc Peripherally acting opioid compounds
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
JP2016519161A (ja) 2013-05-24 2016-06-30 アルカームス ファーマ アイルランド リミテッド モルファン及びモルフィナン類似物及び使用の方法
US9656961B2 (en) 2013-05-24 2017-05-23 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
WO2018125716A1 (en) * 2017-01-02 2018-07-05 Purdue Pharma L.P. Morphinan derivatives and use thereof
WO2022101444A1 (en) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723437A (en) * 1970-09-15 1973-03-27 American Home Prod 4,10-(methaniminomethano phenanthrene derivatives
ZA73988B (en) * 1972-03-10 1973-10-31 Hoffmann La Roche Morphinan derivatives
US3914233A (en) * 1972-10-20 1975-10-21 Hoffmann La Roche 4-Hydroxy-N-substituted morphinan derivatives

Also Published As

Publication number Publication date
KR840002357A (ko) 1984-06-25
ES8506635A1 (es) 1985-08-01
AU9027682A (en) 1983-05-19
IL67180A0 (en) 1983-03-31
ES8500948A1 (es) 1984-12-01
FI823824A0 (fi) 1982-11-08
EP0079556A2 (de) 1983-05-25
FI823824A7 (fi) 1983-05-10
MC1490A1 (fr) 1983-09-12
NZ202404A (en) 1985-11-08
PT75815A (en) 1982-12-01
GR78317B (OSRAM) 1984-09-26
PH18458A (en) 1985-07-18
US4374139A (en) 1983-02-15
ZA827905B (en) 1983-08-31
EP0079556A3 (de) 1983-08-24
DK491582A (da) 1983-05-10
NO823707L (no) 1983-05-10
PT75815B (en) 1986-01-21
JPS5888364A (ja) 1983-05-26
CA1195324A (en) 1985-10-15
ES529349A0 (es) 1985-08-01
ES517222A0 (es) 1984-12-01
FI823824L (fi) 1983-05-10

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