HU186975B - Process for preparing new triazolo-quinazolone derivatives - Google Patents

Process for preparing new triazolo-quinazolone derivatives Download PDF

Info

Publication number
HU186975B
HU186975B HU823090A HU309082A HU186975B HU 186975 B HU186975 B HU 186975B HU 823090 A HU823090 A HU 823090A HU 309082 A HU309082 A HU 309082A HU 186975 B HU186975 B HU 186975B
Authority
HU
Hungary
Prior art keywords
formula
compound
carbones
acid addition
triazolo
Prior art date
Application number
HU823090A
Other languages
English (en)
Hungarian (hu)
Inventor
Wilfred R Tully
Robert Westwood
David A Rowlands
Stephen Clements-Jewery
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of HU186975B publication Critical patent/HU186975B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
HU823090A 1981-09-24 1982-09-24 Process for preparing new triazolo-quinazolone derivatives HU186975B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8128875 1981-09-24

Publications (1)

Publication Number Publication Date
HU186975B true HU186975B (en) 1985-10-28

Family

ID=10524710

Family Applications (1)

Application Number Title Priority Date Filing Date
HU823090A HU186975B (en) 1981-09-24 1982-09-24 Process for preparing new triazolo-quinazolone derivatives

Country Status (18)

Country Link
US (1) US4472400A (en, 2012)
EP (1) EP0076199B1 (en, 2012)
JP (1) JPS5865292A (en, 2012)
AT (1) ATE24509T1 (en, 2012)
AU (1) AU554959B2 (en, 2012)
CA (1) CA1193597A (en, 2012)
DE (1) DE3274860D1 (en, 2012)
DK (1) DK160308C (en, 2012)
ES (1) ES515904A0 (en, 2012)
FI (1) FI73435C (en, 2012)
GB (1) GB2108495B (en, 2012)
GR (1) GR78044B (en, 2012)
HU (1) HU186975B (en, 2012)
IE (1) IE53858B1 (en, 2012)
IL (1) IL66835A (en, 2012)
MA (1) MA19604A1 (en, 2012)
PT (1) PT75602B (en, 2012)
ZA (1) ZA826891B (en, 2012)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5442062A (en) * 1991-10-24 1995-08-15 The Upjohn Company Imidazole derivatives and pharmaceutical compositions containing the same
JP2828506B2 (ja) * 1994-05-24 1998-11-25 エフ・ホフマン−ラ ロシュ アーゲー 三環式ジカルボニル誘導体
US5756502A (en) * 1994-08-08 1998-05-26 Warner-Lambert Company Quinazolinone derivatives as cholyecystokinin (CCK) ligands
US6897213B1 (en) 1995-11-21 2005-05-24 Warner-Lambert Company Heterocycles as cholecystokinin (CCK) ligands
US6492364B1 (en) * 1998-12-04 2002-12-10 Toray Industries, Inc. Triazolo and derivatives as chemokine inhibitors
FR2792938B1 (fr) 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
PA8539501A1 (es) 2001-02-14 2002-09-30 Warner Lambert Co Compuestos triazolo como inhibidores de mmp
EP1285922A1 (en) * 2001-08-13 2003-02-26 Warner-Lambert Company 1-Alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors
FR2832711B1 (fr) 2001-11-26 2004-01-30 Warner Lambert Co Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
CN1891704A (zh) * 2005-07-08 2007-01-10 中国科学院上海药物研究所 一类二肽酶四抑制剂及其制备方法和用途
US20230372348A1 (en) * 2020-10-06 2023-11-23 Gabather Ab Lipid formulations of triazoloquinazolinone compounds
CN115197225B (zh) * 2021-09-03 2023-04-11 贵州大学 一种五元杂环并喹唑啉酮类化合物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50116498A (en, 2012) * 1974-02-27 1975-09-11
US4145419A (en) * 1976-05-21 1979-03-20 Roussel Uclaf Novel imidazobenzoxazines
GB1596652A (en) * 1977-01-20 1981-08-26 Roussel Lab Ltd Imidazo (1,2-a) quinoline-2-carboxylic acid and derivatives
GB1576077A (en) * 1977-04-13 1980-10-01 Roussel Lab Ltd 4,5-dihydro-4-oxophyrrolo(1,2-)-quinoxaline-2-carboxylic acids and derivatives
SE444319B (sv) * 1977-11-18 1986-04-07 Roussel Uclaf Nya imidazobensoxazinderivat, forfarande for framstellning derav och farmaceutiska kompositioner innehallande dessa foreningar
SE439308B (sv) * 1978-08-02 1985-06-10 Roussel Uclaf Imidazo(1,2-a)kinoxaliner och farmaceutiska kompositioner derav
DD139715A1 (de) * 1978-09-29 1980-01-16 Karl Kottke Verfahren zur herstellung von 1-substituierten 4-aryl-s-triazolo(4,3-a)chinazolonen-(5)
FR2448541A1 (fr) * 1979-02-09 1980-09-05 Roussel Uclaf Nouveaux derives de l'oxoimidazoquinoxaline et leurs sels, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
IL59104A (en) * 1979-02-09 1984-02-29 Roussel Uclaf Heterotricyclic derivatives,process for their preparation and pharmaceutical compositions incorporating them
ZA81708B (en) * 1980-02-14 1982-06-30 Roussel Uclaf Triazoloquinazolinone derivatives

Also Published As

Publication number Publication date
IE822310L (en) 1983-03-24
GR78044B (en, 2012) 1984-09-26
ES8400440A1 (es) 1983-10-16
FI823278L (fi) 1983-03-25
FI73435B (fi) 1987-06-30
EP0076199A2 (fr) 1983-04-06
EP0076199A3 (en) 1984-03-21
ATE24509T1 (de) 1987-01-15
DK420682A (da) 1983-03-25
ZA826891B (en) 1983-10-26
MA19604A1 (fr) 1983-04-01
GB2108495B (en) 1985-07-24
EP0076199B1 (fr) 1986-12-30
IL66835A0 (en) 1982-12-31
PT75602B (fr) 1985-12-09
FI823278A0 (fi) 1982-09-23
DK160308B (da) 1991-02-25
ES515904A0 (es) 1983-10-16
US4472400A (en) 1984-09-18
JPS5865292A (ja) 1983-04-18
AU554959B2 (en) 1986-09-11
JPH0322389B2 (en, 2012) 1991-03-26
DE3274860D1 (en) 1987-02-05
PT75602A (fr) 1982-10-01
CA1193597A (fr) 1985-09-17
IE53858B1 (en) 1989-03-29
AU8862382A (en) 1983-03-31
GB2108495A (en) 1983-05-18
DK160308C (da) 1991-07-29
FI73435C (fi) 1987-10-09
IL66835A (en) 1988-05-31

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee