HU0700269D0 - Pyrimidinyl-piperazines useful as d3/d2 receptor ligands - Google Patents

Pyrimidinyl-piperazines useful as d3/d2 receptor ligands

Info

Publication number
HU0700269D0
HU0700269D0 HU0700269A HUE07000269A HU0700269D0 HU 0700269 D0 HU0700269 D0 HU 0700269D0 HU 0700269 A HU0700269 A HU 0700269A HU E07000269 A HUE07000269 A HU E07000269A HU 0700269 D0 HU0700269 D0 HU 0700269D0
Authority
HU
Hungary
Prior art keywords
pyrimidinyl
receptor ligands
piperazines useful
piperazines
useful
Prior art date
Application number
HU0700269A
Other languages
English (en)
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to HU0700269A priority Critical patent/HUP0700269A2/hu
Publication of HU0700269D0 publication Critical patent/HU0700269D0/hu
Priority to MX2009010896A priority patent/MX2009010896A/es
Priority to AU2008237696A priority patent/AU2008237696B2/en
Priority to EA200901391A priority patent/EA016174B1/ru
Priority to RS20110478A priority patent/RS51979B/en
Priority to PT08737283T priority patent/PT2132185E/pt
Priority to MYPI20094131A priority patent/MY148384A/en
Priority to EP08737283A priority patent/EP2132185B1/en
Priority to GEAP200811554A priority patent/GEP20115272B/en
Priority to JP2010502585A priority patent/JP4580464B2/ja
Priority to AT08737283T priority patent/ATE518843T1/de
Priority to DK08737283.5T priority patent/DK2132185T3/da
Priority to CA2682817A priority patent/CA2682817C/en
Priority to KR1020097020486A priority patent/KR101540821B1/ko
Priority to NZ579754A priority patent/NZ579754A/en
Priority to AP2009004970A priority patent/AP2460A/xx
Priority to PCT/HU2008/000032 priority patent/WO2008125891A2/en
Priority to UAA200911488A priority patent/UA103748C2/uk
Priority to ES08737283T priority patent/ES2370748T3/es
Priority to SI200830405T priority patent/SI2132185T1/sl
Priority to PL08737283T priority patent/PL2132185T3/pl
Priority to BRPI0809641-4A2A priority patent/BRPI0809641A2/pt
Priority to CN2008800116439A priority patent/CN101652351B/zh
Priority to TW097125706A priority patent/TWI445534B/zh
Publication of HUP0700269A2 publication Critical patent/HUP0700269A2/hu
Priority to IL200801A priority patent/IL200801A0/en
Priority to TNP2009000386A priority patent/TN2009000386A1/fr
Priority to ZA200906543A priority patent/ZA200906543B/xx
Priority to CU2009000161A priority patent/CU23853B1/es
Priority to NI200900179A priority patent/NI200900179A/es
Priority to CR11071A priority patent/CR11071A/es
Priority to EC2009009702A priority patent/ECSP099702A/es
Priority to MA32320A priority patent/MA31359B1/fr
Priority to CO09126013A priority patent/CO6241116A2/es
Priority to HK10101486.7A priority patent/HK1134491A1/xx
Priority to CY20111101000T priority patent/CY1111962T1/el
Priority to HR20110785T priority patent/HRP20110785T8/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00Asymmetric syntheses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09Geometrical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU0700269A 2007-04-11 2007-04-11 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use HUP0700269A2 (en)

Priority Applications (36)

Application Number Priority Date Filing Date Title
HU0700269A HUP0700269A2 (en) 2007-04-11 2007-04-11 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use
CN2008800116439A CN101652351B (zh) 2007-04-11 2008-04-10 可用作d3/d2受体配体的嘧啶基-哌嗪类化合物
PCT/HU2008/000032 WO2008125891A2 (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine d3 /d2 receptor ligands
SI200830405T SI2132185T1 (sl) 2007-04-11 2008-04-10 Pirimidinil-piperazini uporabni kot ligandi receptorja dopamina d3/d2
UAA200911488A UA103748C2 (uk) 2007-04-11 2008-04-10 Піримідинілпіперазини, застосовні як ліганди рецепторів d3/d2 допаміну
AU2008237696A AU2008237696B2 (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine D3 /D2 receptor ligands
PT08737283T PT2132185E (pt) 2007-04-11 2008-04-10 Pirimidinil-piperazinas úteis como ligandos do receptor d3/d2
MYPI20094131A MY148384A (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine d3/d2 receptor ligands
EP08737283A EP2132185B1 (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine d3/d2 receptor ligands
GEAP200811554A GEP20115272B (en) 2007-04-11 2008-04-10 Pyrimidinyl piperazines useful as dopamine d3 /d2 receptor ligands
JP2010502585A JP4580464B2 (ja) 2007-04-11 2008-04-10 D3/d2受容体リガンドとして有用なピリミジニル−ピペラジン
AT08737283T ATE518843T1 (de) 2007-04-11 2008-04-10 Pyrimidinyl-piperazine als dopamin d3/d2- rezeptorliganden
DK08737283.5T DK2132185T3 (da) 2007-04-11 2008-04-10 Pyrimidinyl-piperaziner nyttige som dopamin-D3/D2-receptorligander
CA2682817A CA2682817C (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands
KR1020097020486A KR101540821B1 (ko) 2007-04-11 2008-04-10 도파민 d3/d2 수용체 리간드로서 유용한 피리미디닐-피페라진
NZ579754A NZ579754A (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine d3 /d2 receptor ligands
AP2009004970A AP2460A (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine D3/D2 receptor ligands
MX2009010896A MX2009010896A (es) 2007-04-11 2008-04-10 Pirimidinil-piperazinas utiles como ligandos del receptor d3 y d2.
EA200901391A EA016174B1 (ru) 2007-04-11 2008-04-10 Пиримидинилпиперазины, применимые в качестве лигандов рецепторов d/d
RS20110478A RS51979B (en) 2007-04-11 2008-04-10 PYRIMIDINYL-PIPERAZINE USED AS D3 / D2 LIGAND RECEPTOR
ES08737283T ES2370748T3 (es) 2007-04-11 2008-04-10 PIRIMIDIL-PIPERAZINAS ÚTILES COMO LIGANDOS DEL RECEPTOR D3/D2 DE LA DOPAMINA.
PL08737283T PL2132185T3 (pl) 2007-04-11 2008-04-10 Pirymidynylopiperazyny użyteczne jako ligandy receptora dopaminowego D₃/D₂
BRPI0809641-4A2A BRPI0809641A2 (pt) 2007-04-11 2008-04-10 Pirimidinil-piperazinas úteis como ligantes do receptor d3/d2hu
TW097125706A TWI445534B (zh) 2007-04-11 2008-07-08 可作為d3/d2受體配體之嘧啶基哌嗪類化合物
IL200801A IL200801A0 (en) 2007-04-11 2009-09-08 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands
TNP2009000386A TN2009000386A1 (en) 2007-04-11 2009-09-18 Pyrimidinyl-piperazines useful as dopamine d3 / d2 receptor ligands
ZA200906543A ZA200906543B (en) 2007-04-11 2009-09-18 Pyrimidinyl-piperazines useful as dopamine D3/D2 receptor ligands
CU2009000161A CU23853B1 (es) 2007-04-11 2009-09-25 Pirimidinil-piperazinas útiles como ligandos del receptor d3/d2
NI200900179A NI200900179A (es) 2007-04-11 2009-10-07 Pirimidinil - piperazinas útiles como ligandos receptores de dopamina d3/d2.
CR11071A CR11071A (es) 2007-04-11 2009-10-21 Pirimidinil-piperazinas utiles como ligandos del receptor d3/d2
EC2009009702A ECSP099702A (es) 2007-04-11 2009-10-23 Pirimidinil-piperazinas útiles como ligandos del receptor d3/d2
MA32320A MA31359B1 (fr) 2007-04-11 2009-11-02 Pyrimidinyl-pipérazines utiles en tant que ligands des récepteurs d3/d2
CO09126013A CO6241116A2 (es) 2007-04-11 2009-11-06 Pirimidil piperazinas utiles como ligandos del receptor d3/d2
HK10101486.7A HK1134491A1 (en) 2007-04-11 2010-02-10 Pyrimidinyl-piperazines useful as dopamine d3/d2 receptor ligands
CY20111101000T CY1111962T1 (el) 2007-04-11 2011-10-21 Πυριμιδινυλ-πιπεραζινες χρησιμες ως συνδετηρες υποδοχεα d3/d2 ντοπαμινης
HR20110785T HRP20110785T8 (en) 2007-04-11 2011-10-26 Pyrimidinyl-piperazines useful as dopamine d3/d2 receptor ligands

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0700269A HUP0700269A2 (en) 2007-04-11 2007-04-11 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use

Publications (2)

Publication Number Publication Date
HU0700269D0 true HU0700269D0 (en) 2007-05-29
HUP0700269A2 HUP0700269A2 (en) 2009-04-28

Family

ID=38336883

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0700269A HUP0700269A2 (en) 2007-04-11 2007-04-11 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use

Country Status (36)

Country Link
EP (1) EP2132185B1 (hu)
JP (1) JP4580464B2 (hu)
KR (1) KR101540821B1 (hu)
CN (1) CN101652351B (hu)
AP (1) AP2460A (hu)
AT (1) ATE518843T1 (hu)
AU (1) AU2008237696B2 (hu)
BR (1) BRPI0809641A2 (hu)
CA (1) CA2682817C (hu)
CO (1) CO6241116A2 (hu)
CR (1) CR11071A (hu)
CU (1) CU23853B1 (hu)
CY (1) CY1111962T1 (hu)
DK (1) DK2132185T3 (hu)
EA (1) EA016174B1 (hu)
EC (1) ECSP099702A (hu)
ES (1) ES2370748T3 (hu)
GE (1) GEP20115272B (hu)
HK (1) HK1134491A1 (hu)
HR (1) HRP20110785T8 (hu)
HU (1) HUP0700269A2 (hu)
IL (1) IL200801A0 (hu)
MA (1) MA31359B1 (hu)
MX (1) MX2009010896A (hu)
MY (1) MY148384A (hu)
NI (1) NI200900179A (hu)
NZ (1) NZ579754A (hu)
PL (1) PL2132185T3 (hu)
PT (1) PT2132185E (hu)
RS (1) RS51979B (hu)
SI (1) SI2132185T1 (hu)
TN (1) TN2009000386A1 (hu)
TW (1) TWI445534B (hu)
UA (1) UA103748C2 (hu)
WO (1) WO2008125891A2 (hu)
ZA (1) ZA200906543B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9091489B2 (en) 2010-05-14 2015-07-28 Paragon Space Development Corporation Radiator systems
KR101601383B1 (ko) * 2010-06-18 2016-03-08 알토스 세라퓨틱스, 엘엘씨 D2 길항제, 합성 방법 및 사용 방법
US9376396B2 (en) 2012-10-22 2016-06-28 AbbVie Deutschland GmbH & Co. KG Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor
HU229987B1 (en) * 2012-11-21 2015-04-28 Richter Gedeon Nyrt Process for the preparation of pyrimidinyl-piperazines
WO2018021447A1 (ja) 2016-07-28 2018-02-01 塩野義製薬株式会社 ドーパミンd3受容体拮抗作用を有する含窒素縮環化合物
JP7250405B2 (ja) * 2018-01-26 2023-04-03 塩野義製薬株式会社 ドーパミンd3受容体拮抗作用を有する環式化合物
WO2019146739A1 (ja) 2018-01-26 2019-08-01 塩野義製薬株式会社 ドーパミンd3受容体拮抗作用を有する縮環化合物
WO2024072930A1 (en) * 2022-09-30 2024-04-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2311776A1 (fr) * 1975-05-23 1976-12-17 Sogeras Diamino-2,4 bromo-5 chloro-6 pyrimidines et procede pour leur preparation
US4957921A (en) 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
US5047406A (en) * 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
SE9802208D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
EP1870405A1 (en) * 2006-06-22 2007-12-26 Bioprojet Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands

Also Published As

Publication number Publication date
NI200900179A (es) 2010-06-30
HUP0700269A2 (en) 2009-04-28
ES2370748T3 (es) 2011-12-22
EP2132185B1 (en) 2011-08-03
PT2132185E (pt) 2011-11-21
JP4580464B2 (ja) 2010-11-10
AP2460A (en) 2012-09-13
ECSP099702A (es) 2009-11-30
SI2132185T1 (sl) 2011-11-30
CA2682817A1 (en) 2008-10-23
CN101652351A (zh) 2010-02-17
TW201002328A (en) 2010-01-16
NZ579754A (en) 2011-11-25
HRP20110785T8 (en) 2012-04-30
TN2009000386A1 (en) 2010-12-31
RS51979B (en) 2012-02-29
WO2008125891A2 (en) 2008-10-23
MY148384A (en) 2013-04-15
UA103748C2 (uk) 2013-11-25
CO6241116A2 (es) 2011-01-20
CU20090161A7 (es) 2011-09-21
KR101540821B1 (ko) 2015-07-30
HRP20110785T1 (hr) 2011-11-30
EA016174B1 (ru) 2012-02-28
HK1134491A1 (en) 2010-04-30
CA2682817C (en) 2015-11-24
MA31359B1 (fr) 2010-05-03
AP2009004970A0 (en) 2009-10-31
IL200801A0 (en) 2010-05-17
AU2008237696A1 (en) 2008-10-23
DK2132185T3 (da) 2011-10-03
GEP20115272B (en) 2011-08-25
MX2009010896A (es) 2009-12-14
CR11071A (es) 2009-11-20
EA200901391A1 (ru) 2010-02-26
ZA200906543B (en) 2010-06-30
BRPI0809641A2 (pt) 2014-11-11
EP2132185A2 (en) 2009-12-16
AU2008237696B2 (en) 2013-03-14
CN101652351B (zh) 2012-07-04
PL2132185T3 (pl) 2011-12-30
WO2008125891A3 (en) 2009-01-08
CY1111962T1 (el) 2015-11-04
KR20100082713A (ko) 2010-07-19
TWI445534B (zh) 2014-07-21
ATE518843T1 (de) 2011-08-15
JP2010523642A (ja) 2010-07-15
CU23853B1 (es) 2012-10-15

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