HUP0700269A2 - Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use - Google Patents

Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use

Info

Publication number
HUP0700269A2
HUP0700269A2 HU0700269A HUE07000269A HUP0700269A2 HU P0700269 A2 HUP0700269 A2 HU P0700269A2 HU 0700269 A HU0700269 A HU 0700269A HU E07000269 A HUE07000269 A HU E07000269A HU P0700269 A2 HUP0700269 A2 HU P0700269A2
Authority
HU
Hungary
Prior art keywords
pyrimidinyl
pharmaceutical compositions
compositions containing
receptor ligands
piperazines useful
Prior art date
Application number
HU0700269A
Other languages
English (en)
Inventor
Szalai Gizella Bartane
Csongor Eva Againe
Gyoergy Dr Domany
Istvan Gyertyan
Bela Kiss
Judit Dr Laszy
Katalin Dr Saghy
Eva Schmidt
Sandor Dr Farkas
Zsolt Komlodi
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to HU0700269A priority Critical patent/HUP0700269A2/hu
Publication of HU0700269D0 publication Critical patent/HU0700269D0/hu
Priority to PCT/HU2008/000032 priority patent/WO2008125891A2/en
Priority to PL08737283T priority patent/PL2132185T3/pl
Priority to ES08737283T priority patent/ES2370748T3/es
Priority to RS20110478A priority patent/RS51979B/en
Priority to CA2682817A priority patent/CA2682817C/en
Priority to UAA200911488A priority patent/UA103748C2/uk
Priority to SI200830405T priority patent/SI2132185T1/sl
Priority to NZ579754A priority patent/NZ579754A/en
Priority to CN2008800116439A priority patent/CN101652351B/zh
Priority to BRPI0809641-4A2A priority patent/BRPI0809641A2/pt
Priority to AT08737283T priority patent/ATE518843T1/de
Priority to EP08737283A priority patent/EP2132185B1/en
Priority to MX2009010896A priority patent/MX2009010896A/es
Priority to EA200901391A priority patent/EA016174B1/ru
Priority to KR1020097020486A priority patent/KR101540821B1/ko
Priority to JP2010502585A priority patent/JP4580464B2/ja
Priority to AU2008237696A priority patent/AU2008237696B2/en
Priority to DK08737283.5T priority patent/DK2132185T3/da
Priority to MYPI20094131A priority patent/MY148384A/en
Priority to GEAP200811554A priority patent/GEP20115272B/en
Priority to AP2009004970A priority patent/AP2460A/xx
Priority to PT08737283T priority patent/PT2132185E/pt
Priority to TW097125706A priority patent/TWI445534B/zh
Publication of HUP0700269A2 publication Critical patent/HUP0700269A2/hu
Priority to IL200801A priority patent/IL200801A0/en
Priority to TNP2009000386A priority patent/TN2009000386A1/fr
Priority to ZA200906543A priority patent/ZA200906543B/xx
Priority to CU2009000161A priority patent/CU23853B1/es
Priority to NI200900179A priority patent/NI200900179A/es
Priority to CR11071A priority patent/CR11071A/es
Priority to EC2009009702A priority patent/ECSP099702A/es
Priority to MA32320A priority patent/MA31359B1/fr
Priority to CO09126013A priority patent/CO6241116A2/es
Priority to HK10101486.7A priority patent/HK1134491A1/xx
Priority to CY20111101000T priority patent/CY1111962T1/el
Priority to HR20110785T priority patent/HRP20110785T8/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU0700269A 2007-04-11 2007-04-11 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use HUP0700269A2 (en)

Priority Applications (36)

Application Number Priority Date Filing Date Title
HU0700269A HUP0700269A2 (en) 2007-04-11 2007-04-11 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use
PT08737283T PT2132185E (pt) 2007-04-11 2008-04-10 Pirimidinil-piperazinas úteis como ligandos do receptor d3/d2
JP2010502585A JP4580464B2 (ja) 2007-04-11 2008-04-10 Ｄ３／ｄ２受容体リガンドとして有用なピリミジニル−ピペラジン
MYPI20094131A MY148384A (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine d3/d2 receptor ligands
AU2008237696A AU2008237696B2 (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine D3 /D2 receptor ligands
PL08737283T PL2132185T3 (pl) 2007-04-11 2008-04-10 Pirymidynylopiperazyny użyteczne jako ligandy receptora dopaminowego D₃/D₂
CA2682817A CA2682817C (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands
UAA200911488A UA103748C2 (uk) 2007-04-11 2008-04-10 Піримідинілпіперазини, застосовні як ліганди рецепторів d3/d2 допаміну
SI200830405T SI2132185T1 (sl) 2007-04-11 2008-04-10 Pirimidinil-piperazini uporabni kot ligandi receptorja dopamina d3/d2
NZ579754A NZ579754A (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine d3 /d2 receptor ligands
CN2008800116439A CN101652351B (zh) 2007-04-11 2008-04-10 可用作d3/d2受体配体的嘧啶基-哌嗪类化合物
BRPI0809641-4A2A BRPI0809641A2 (pt) 2007-04-11 2008-04-10 Pirimidinil-piperazinas úteis como ligantes do receptor d3/d2hu
AT08737283T ATE518843T1 (de) 2007-04-11 2008-04-10 Pyrimidinyl-piperazine als dopamin d3/d2- rezeptorliganden
EP08737283A EP2132185B1 (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine d3/d2 receptor ligands
MX2009010896A MX2009010896A (es) 2007-04-11 2008-04-10 Pirimidinil-piperazinas utiles como ligandos del receptor d3 y d2.
EA200901391A EA016174B1 (ru) 2007-04-11 2008-04-10 Пиримидинилпиперазины, применимые в качестве лигандов рецепторов d/d
KR1020097020486A KR101540821B1 (ko) 2007-04-11 2008-04-10 도파민 ｄ3／ｄ2 수용체 리간드로서 유용한 피리미디닐-피페라진
PCT/HU2008/000032 WO2008125891A2 (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine d3 /d2 receptor ligands
ES08737283T ES2370748T3 (es) 2007-04-11 2008-04-10 PIRIMIDIL-PIPERAZINAS ÚTILES COMO LIGANDOS DEL RECEPTOR D3/D2 DE LA DOPAMINA.
RS20110478A RS51979B (en) 2007-04-11 2008-04-10 PYRIMIDINYL-PIPERAZINE USED AS D3 / D2 LIGAND RECEPTOR
DK08737283.5T DK2132185T3 (da) 2007-04-11 2008-04-10 Pyrimidinyl-piperaziner nyttige som dopamin-D3/D2-receptorligander
GEAP200811554A GEP20115272B (en) 2007-04-11 2008-04-10 Pyrimidinyl piperazines useful as dopamine d3 /d2 receptor ligands
AP2009004970A AP2460A (en) 2007-04-11 2008-04-10 Pyrimidinyl-piperazines useful as dopamine D3/D2 receptor ligands
TW097125706A TWI445534B (zh) 2007-04-11 2008-07-08 可作為ｄ3／ｄ2受體配體之嘧啶基哌嗪類化合物
IL200801A IL200801A0 (en) 2007-04-11 2009-09-08 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands
TNP2009000386A TN2009000386A1 (en) 2007-04-11 2009-09-18 Pyrimidinyl-piperazines useful as dopamine d3 / d2 receptor ligands
ZA200906543A ZA200906543B (en) 2007-04-11 2009-09-18 Pyrimidinyl-piperazines useful as dopamine D3/D2 receptor ligands
CU2009000161A CU23853B1 (es) 2007-04-11 2009-09-25 Pirimidinil-piperazinas útiles como ligandos del receptor d3/d2
NI200900179A NI200900179A (es) 2007-04-11 2009-10-07 Pirimidinil - piperazinas útiles como ligandos receptores de dopamina d3/d2.
CR11071A CR11071A (es) 2007-04-11 2009-10-21 Pirimidinil-piperazinas utiles como ligandos del receptor d3/d2
EC2009009702A ECSP099702A (es) 2007-04-11 2009-10-23 Pirimidinil-piperazinas útiles como ligandos del receptor d3/d2
MA32320A MA31359B1 (fr) 2007-04-11 2009-11-02 Pyrimidinyl-pipérazines utiles en tant que ligands des récepteurs d3/d2
CO09126013A CO6241116A2 (es) 2007-04-11 2009-11-06 Pirimidil piperazinas utiles como ligandos del receptor d3/d2
HK10101486.7A HK1134491A1 (en) 2007-04-11 2010-02-10 Pyrimidinyl-piperazines useful as dopamine d3/d2 receptor ligands
CY20111101000T CY1111962T1 (el) 2007-04-11 2011-10-21 Πυριμιδινυλ-πιπεραζινες χρησιμες ως συνδετηρες υποδοχεα d3/d2 ντοπαμινης
HR20110785T HRP20110785T8 (en) 2007-04-11 2011-10-26 Pyrimidinyl-piperazines useful as dopamine d3/d2 receptor ligands

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0700269A HUP0700269A2 (en) 2007-04-11 2007-04-11 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use

Publications (2)

Publication Number Publication Date
HU0700269D0 HU0700269D0 (en) 2007-05-29
HUP0700269A2 true HUP0700269A2 (en) 2009-04-28

Family

ID=38336883

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0700269A HUP0700269A2 (en) 2007-04-11 2007-04-11 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use

Country Status (36)

Country Link
EP (1) EP2132185B1 (hu)
JP (1) JP4580464B2 (hu)
KR (1) KR101540821B1 (hu)
CN (1) CN101652351B (hu)
AP (1) AP2460A (hu)
AT (1) ATE518843T1 (hu)
AU (1) AU2008237696B2 (hu)
BR (1) BRPI0809641A2 (hu)
CA (1) CA2682817C (hu)
CO (1) CO6241116A2 (hu)
CR (1) CR11071A (hu)
CU (1) CU23853B1 (hu)
CY (1) CY1111962T1 (hu)
DK (1) DK2132185T3 (hu)
EA (1) EA016174B1 (hu)
EC (1) ECSP099702A (hu)
ES (1) ES2370748T3 (hu)
GE (1) GEP20115272B (hu)
HK (1) HK1134491A1 (hu)
HR (1) HRP20110785T8 (hu)
HU (1) HUP0700269A2 (hu)
IL (1) IL200801A0 (hu)
MA (1) MA31359B1 (hu)
MX (1) MX2009010896A (hu)
MY (1) MY148384A (hu)
NI (1) NI200900179A (hu)
NZ (1) NZ579754A (hu)
PL (1) PL2132185T3 (hu)
PT (1) PT2132185E (hu)
RS (1) RS51979B (hu)
SI (1) SI2132185T1 (hu)
TN (1) TN2009000386A1 (hu)
TW (1) TWI445534B (hu)
UA (1) UA103748C2 (hu)
WO (1) WO2008125891A2 (hu)
ZA (1) ZA200906543B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9091489B2 (en) 2010-05-14 2015-07-28 Paragon Space Development Corporation Radiator systems
RS55645B1 (sr) * 2010-06-18 2017-06-30 Altos Therapeutics Llc Antagonisti d2, postupci za sintezu i postupci upotrebe
US9376396B2 (en) * 2012-10-22 2016-06-28 AbbVie Deutschland GmbH & Co. KG Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor
HU229987B1 (en) * 2012-11-21 2015-04-28 Richter Gedeon Nyrt Process for the preparation of pyrimidinyl-piperazines
JP7015092B2 (ja) 2016-07-28 2022-02-02 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物
WO2019146739A1 (ja) 2018-01-26 2019-08-01 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する縮環化合物
US11447484B2 (en) 2018-01-26 2022-09-20 Shionogi & Co., Ltd. Cyclic compound having dopamine D3 receptor antagonistic effect
WO2024072930A1 (en) * 2022-09-30 2024-04-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2311776A1 (fr) 1975-05-23 1976-12-17 Sogeras Diamino-2,4 bromo-5 chloro-6 pyrimidines et procede pour leur preparation
US5047406A (en) * 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
US4957921A (en) 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
SE9802208D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
EP1870405A1 (en) * 2006-06-22 2007-12-26 Bioprojet Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands

Also Published As

Publication number Publication date
CA2682817C (en) 2015-11-24
NZ579754A (en) 2011-11-25
AU2008237696A1 (en) 2008-10-23
RS51979B (en) 2012-02-29
HRP20110785T1 (hr) 2011-11-30
CO6241116A2 (es) 2011-01-20
ECSP099702A (es) 2009-11-30
KR20100082713A (ko) 2010-07-19
JP2010523642A (ja) 2010-07-15
CY1111962T1 (el) 2015-11-04
PL2132185T3 (pl) 2011-12-30
CU23853B1 (es) 2012-10-15
CA2682817A1 (en) 2008-10-23
MA31359B1 (fr) 2010-05-03
SI2132185T1 (sl) 2011-11-30
TWI445534B (zh) 2014-07-21
IL200801A0 (en) 2010-05-17
EP2132185B1 (en) 2011-08-03
AU2008237696B2 (en) 2013-03-14
AP2009004970A0 (en) 2009-10-31
DK2132185T3 (da) 2011-10-03
GEP20115272B (en) 2011-08-25
ES2370748T3 (es) 2011-12-22
NI200900179A (es) 2010-06-30
CU20090161A7 (es) 2011-09-21
ATE518843T1 (de) 2011-08-15
AP2460A (en) 2012-09-13
HU0700269D0 (en) 2007-05-29
PT2132185E (pt) 2011-11-21
JP4580464B2 (ja) 2010-11-10
TN2009000386A1 (en) 2010-12-31
CN101652351B (zh) 2012-07-04
KR101540821B1 (ko) 2015-07-30
BRPI0809641A2 (pt) 2014-11-11
MY148384A (en) 2013-04-15
WO2008125891A2 (en) 2008-10-23
UA103748C2 (uk) 2013-11-25
MX2009010896A (es) 2009-12-14
WO2008125891A3 (en) 2009-01-08
HRP20110785T8 (en) 2012-04-30
CR11071A (es) 2009-11-20
EA200901391A1 (ru) 2010-02-26
CN101652351A (zh) 2010-02-17
EP2132185A2 (en) 2009-12-16
EA016174B1 (ru) 2012-02-28
ZA200906543B (en) 2010-06-30
TW201002328A (en) 2010-01-16
HK1134491A1 (en) 2010-04-30

Similar Documents

Publication Publication Date Title
HUS1800007I1 (hu) Gyógyászati készítmény
EP2133095A4 (en) PHARMACEUTICAL COMPOSITION
EP2133094A4 (en) PHARMACEUTICAL COMPOSITION
EP2191826A4 (en) PHARMACEUTICAL COMPOSITION
HK1136968A1 (en) Novel pharmaceutical composition
IL200206A0 (en) Quinoxaline darivatives, their preparation and pharmaceutical compositions containing them
IL200125A0 (en) Pharmaceutical composition
EP2116242A4 (en) NEW PHARMACEUTICAL COMPOSITION
EP2224805A4 (en) PHARMACEUTICAL COMPOSITION
EP2224915A4 (en) PHARMACEUTICAL COMPOSITIONS
EP2241569A4 (en) THIENOPYRIDAZINE COMPOUNDS, PREPARATIONS THEREOF, PHARMACEUTICAL COMPOSITIONS AND USES
IL213452A0 (en) Phenylpyrimidone compounds, pharmaceutical compositions, preparation methods and uses thereof
RS58950B1 (sr) Farmaceutske kompozicije koje sadrže korteksolon-17-alfa-propionat
HUP0700269A2 (en) Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use
HK1138774A1 (en) Pharmaceutical composition
EP2224808A4 (en) PHARMACEUTICAL COMPOSITION
EP2156832A4 (en) PHARMACEUTICAL COMPOSITION
IL212171A (en) 1-Phenylpyrol compounds, pharmaceuticals containing them and their use
EP2224806A4 (en) PHARMACEUTICAL COMPOSITION
GB0716907D0 (en) Pharmaceutical powder compositions
IL205975A0 (en) Pharmaceutical composition
IL205931A0 (en) Pharmaceutical composition
HU0700755D0 (en) Pharmaceutical compositions containing capsaicionid
EP2114156A4 (en) Chemical compounds, pharmaceutical compositions and corresponding methods
GB0712558D0 (en) Pharmaceutical composition

Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished