HRP20230698T1 - Ppripravci i metode za pospješivanje rasta i širenja te onkolitičke i imunoterapijske djelotvornosti onkolitičkih rnk virusa - Google Patents
Ppripravci i metode za pospješivanje rasta i širenja te onkolitičke i imunoterapijske djelotvornosti onkolitičkih rnk virusa Download PDFInfo
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- HRP20230698T1 HRP20230698T1 HRP20230698TT HRP20230698T HRP20230698T1 HR P20230698 T1 HRP20230698 T1 HR P20230698T1 HR P20230698T T HRP20230698T T HR P20230698TT HR P20230698 T HRP20230698 T HR P20230698T HR P20230698 T1 HRP20230698 T1 HR P20230698T1
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- Prior art keywords
- cancer
- vanadium
- cell
- containing compound
- tumor
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
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- A—HUMAN NECESSITIES
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
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- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20232—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20241—Use of virus, viral particle or viral elements as a vector
- C12N2760/20243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
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- Molecular Biology (AREA)
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Claims (15)
1. Spoj ili pripravak koji sadrži vanadij za upotrebu u terapijskoj metodi za pospješivanje infekcije, rasta, širenja ili titra onkolitičkog RNK virusa u stanici raka ili tumora, pri čemu navedena metoda uključuje primjenu navedenog spoja ili pripravka koji sadrži vanadij na stanicu raka ili tumora prije, nakon ili istovremeno s infekcijom stanica raka ili tumora onkolitičkim RNK virusom.
2. Spoj ili pripravak koji sadrži vanadij za upotrebu prema zahtjevu 1, pri čemu se primjenom spoja ili pripravka koji sadrži vanadij pospješuje onkolitička aktivnost, aktivnost stanične smrti izazvane citokinima i/ili citotoksična aktivnost onkolitičkog RNK virusa.
3. Spoj ili pripravak koji sadrži vanadij za upotrebu prema zahtjevu 1, pri čemu se primjenom spoja ili pripravka koji sadrži vanadij potencira imunosni odgovor na, pojačava citokinski odgovor na, i/ili pospješuje imunoterapijska aktivnost onkolitičkog RNK virusa.
4. Spoj ili pripravak koji sadrži vanadij za upotrebu prema zahtjevu 1, pri čemu primjena spoja ili pripravka koji sadrži vanadij na stanici raka ili tumora služi za liječenje tumora ili raka u ispitanika kojem je to potrebno.
5. Spoj ili pripravak koji sadrži vanadij za upotrebu prema bilo kojem od zahtjeva 1 – 4, pri čemu spoj ili pripravak koji sadrži vanadij sadrži ortovanadat, metavanadat, vanadij (V) oksitrietoksid (VOx), vanadij (IV) oksid sulfat (VS) i bismaltolato oksovanadij (IV) (BMOV), vanadij tetra-fluorid i vanadij tri-bromid ili farmaceutski prihvatljivu sol, solvat, hidrat, reducirani ili njezin oksidirani oblik.
6. Spoj ili pripravak koji sadrži vanadij za upotrebu prema bilo kojem od zahtjeva 1 – 5, pri čemu onkolitički RNK virus sadrži reovirus, virus Newcastleske bolesti, poliovirus, virus zaušnjaka, virus ospica, virus influence, virus Maraba (kao što je MG-1), virus bjesnoće, rotavirus, virus hepatitisa A, virus rubeole, virus denge, virus Chikungunya, respiratorni sincicijski virus, LCMV, lentivirus, replicirajući retrovirus ili rabdovirus ili njegovu varijantu ili derivat.
7. Spoj ili pripravak koji sadrži vanadij za upotrebu prema zahtjevu 6, pri čemu RNK virus sadrži rabdovirus koji je virus vezikularnog stomatitisa ili njegov derivat ili varijantu.
8. Spoj ili pripravak koji sadrži vanadij za upotrebu prema bilo kojem od zahtjeva 1 – 7, pri čemu RNK virus sadrži virus odabran pod specifičnim uvjetima rasta, podvrgnut jednom ili više selekcijskih pritisaka, genetski modificiran primjenom rekombinantne tehnike ili bilo koje kombinacije toga.
9. Spoj ili pripravak koji sadrži vanadij za upotrebu prema bilo kojem od zahtjeva 1 – 8, pri čemu je stanica od sisavca ili je ispitanik sisavac.
10. Spoj ili pripravak koji sadrži vanadij za upotrebu prema zahtjevu 9, pri čemu je stanica od čovjeka ili je ispitanik čovjek.
11. Spoj ili pripravak koji sadrži vanadij za upotrebu prema bilo kojem od zahtjeva 1 – 10, pri čemu rak ili tumor uključuje limfoblastičnu leukemiju, mijeloičnu leukemiju, adrenokortikalni karcinom, rak povezan sa AIDS-om, limfom povezan sa AIDS-om, rak anusa, rak slijepog crijeva, astrocitoma, atipični teratoidni/rabdoidni tumor, karcinom bazalnih stanica, rak žučnih kanala, rak mokraćnog mjehura, rak kostiju, osteosarkom, maligni fibrozni histiocitom, gliom moždanog debla, tumor mozga, cerebelarni astrocitom, cerebralno astrocitom / maligni gliom, kraniofaringiom, ependimoblastom, meduloblastom, pinealni parenhimski tumori srednje diferencijacije, supratentorijalni primitivni neuroektodermalni tumori i pineoblastom, gliom vidnog puta i hipotalamusa, tumori leđne moždine, rak dojke, tumori bronha, Burkittov limfom, karcinoidni tumor, limfom središnjeg živčanog sustava, rak vrata maternice, kordom, kronična limfocitna leukemija, kronična mijeloična leukemija, kronični mijeloproliferativni poremećaji, rak debelog crijeva, kožni T-stanični limfom, embrionalni tumori, rak endometrija, ependimoblastom, ependimom, rak jednjaka, ekstrakranijalni tumor zametnih stanica, ekstragonadalni tumor zametnih stanica, rak ekstrahepatičnog žučnog kanala, rak oka, intraokularni melanom, retinoblastom, rak žučnog mjehura, gastrični rak (želuca), gastrointestinalni karcinoidni tumor, gastrointestinalni stromalni tumor (GIST), gastrointestinalni tumor stromalnih stanica, tumori zametnih stanica, ekstrakranijalni, ekstragonadalni, jajnički, gestacijski trofoblastični tumor, gliom, leukemija dlakavih stanica, rak glave i vrata, hepatocelularni (jetreni) rak, histiocitoza, rak Langerhansovih stanica, Hodgkinov limfom, hipofaringealni rak, tumori stanica otočića, Kaposijev sarkom, rak bubrega, rak larinksa, limfocitna leukemija, leukemija dlakavih stanica, rak usni i usne šupljine, rak jetre, rak nemalih stanica pluća, rak malih stanica pluća, Hodgkinov limfom, ne-Hodgkinov limfom, maligni fibrozni histiocitom kosti i osteosarkom, meduloblastom, meduloepiteliom, melanom, intraokularni melanom, karcinom Merkelovih stanica, mezoteliom, metastatski skvamozni karcinom vrata, rak usta, sindrom višestruke endokrine neoplazije, multipli mijelom / neoplazma plazma stanica, rak nosne šupljine i paranazalnog sinusa, rak nazofarinksa, neuroblastom, rak usne šupljine, rak orofaringeusa, rak jajnika, rak gušterače, rak paratiroidne žlijezde, rak penisa, rak ždrijela, feokromocitom, tumori parenhima epifize, pineoblastom i supratentorijalni primitivni neuroektodermalni tumori, tumor hipofize, neoplazma plazma stanica / multipli mijelom, pleuropulmonalni blastom, primarni limfom središnjeg živčanog sustava, rak prostate, rak rektuma, rak bubrežnih stanica (bubrega), rak bubrežne zdjelice i uretera, rak prijelaznih stanica, karcinom respiratornog trakta, retinoblastom, rabdomiosarkom, rak žlijezda slinovnica, sarkom maternice, rak kože, karcinom kože Merkelovih stanica, rak tankog crijeva, sarkom mekog tkiva, karcinom skvamoznih stanica, skvamozni karcinom vrata, rak želuca (gastrični), supratentorijalni primitivni neuroektodermalni tumori, T-stanični limfom, rak testisa, rak grla, karcinomi timome i timusa, rak štitnjače, trofoblastični tumor, rak uretre, rak maternice, rak endometrija, sarkom maternice, rak vagine, rak vulve ili Wilmsov tumor.
12. Pripravak koji sadrži vanadij koji sadrži onkolitički RNK virus i spoj koji sadrži vanadij.
13. Pripravak prema zahtjevu 12, pri čemu je RNK virus VSVΔ51.
14. Pripravak prema zahtjevu 12, pri čemu je spoj koji sadrži vanadij vanadat.
15. Pripravak prema zahtjevu 12, pri čemu je spoj koji sadrži vanadij farmaceutski prihvatljiva sol ortovanadata.
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| PCT/CA2017/051176 WO2018064762A1 (en) | 2016-10-03 | 2017-10-03 | Compositions and methods for enhancing growth, spread, and oncolytic and immunotherapeutic efficacy of oncolytic rna viruses |
| EP17857734.2A EP3518948B1 (en) | 2016-10-03 | 2017-10-03 | Compositions and methods for enhancing growth, spread, and oncolytic and immunotherapeutic efficacy of oncolytic rna viruses |
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| EP3876951A1 (en) * | 2018-11-06 | 2021-09-15 | Calidi Biotherapeutics, Inc. | Enhanced systems for cell-mediated oncolytic viral therapy |
| WO2020102295A1 (en) * | 2018-11-14 | 2020-05-22 | The Broad Institute, Inc. | Vanadium compositions and methods for treatment of cancer |
| CN113876957A (zh) * | 2020-07-01 | 2022-01-04 | 青岛海洋生物医药研究院股份有限公司 | Stat2磷酸化水平调节剂的用途 |
| US20240293352A1 (en) * | 2021-05-07 | 2024-09-05 | Ottawa Hospital Research Institute | Pharmaceutical compositions comprising vanadium salts |
| CN114427010A (zh) * | 2021-12-28 | 2022-05-03 | 云舟生物科技(广州)股份有限公司 | 一种检测水疱性口炎病毒滴度的引物、试剂盒及方法 |
| WO2023225268A1 (en) * | 2022-05-19 | 2023-11-23 | The University Of Chicago | Vanadyl sulfate compositions and methods of use therefor for the treatment and prevention of aging-related diseases and cancer |
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| US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
| US7063835B2 (en) | 2000-01-21 | 2006-06-20 | Biovex Limited | Virus strains |
| DE60110593T2 (de) | 2000-06-26 | 2006-01-19 | Wellstat Biologics Corp. | Entfernung von zellen mit viren |
| DE60142485D1 (de) | 2000-11-09 | 2010-08-12 | Oncolytics Biotech Inc | Verfahren zur Beurteilung von zellulären proliferativen Erkrankungen |
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| US20040115170A1 (en) | 2001-11-30 | 2004-06-17 | Brown Earl Garnet | Oncolytic virus |
| CN101161248B (zh) * | 2007-11-06 | 2011-05-04 | 辽宁大学 | 一种抗乙型肝炎病毒药物的制备方法 |
| CU20080028A6 (es) * | 2008-02-29 | 2011-02-24 | Ct Ingenieria Genetica Biotech | Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus |
| EP2172211B1 (en) * | 2008-10-01 | 2014-12-03 | Immatics Biotechnologies GmbH | Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers |
| KR101942237B1 (ko) * | 2011-01-04 | 2019-01-25 | 신라젠(주) | 종양 항원에 대한 항체의 생산 및 종양용해 우두 바이러스의 투여에 의한 종양 특이적 보체 의존적 세포독성의 생산 |
| SG11202003842UA (en) * | 2017-11-24 | 2020-06-29 | Ottawa Hospital Res Inst | Compositions and methods for enhancing production, growth, spread, or oncolytic and immunotherapeutic efficacy of interferon-sensitive viruses |
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| ES2950435T3 (es) | 2023-10-10 |
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| US11517598B2 (en) | 2022-12-06 |
| US20190231832A1 (en) | 2019-08-01 |
| DK3518948T5 (da) | 2024-09-02 |
| CN110022889B (zh) | 2024-05-10 |
| EP3518948B1 (en) | 2023-04-12 |
| SI3518948T1 (sl) | 2023-09-29 |
| WO2018064762A1 (en) | 2018-04-12 |
| CA3034983A1 (en) | 2018-04-12 |
| CN110022889A (zh) | 2019-07-16 |
| EP3518948A1 (en) | 2019-08-07 |
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