HRP20230310T1 - Mikrobiocidni derivati tiazola - Google Patents
Mikrobiocidni derivati tiazola Download PDFInfo
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- HRP20230310T1 HRP20230310T1 HRP20230310TT HRP20230310T HRP20230310T1 HR P20230310 T1 HRP20230310 T1 HR P20230310T1 HR P20230310T T HRP20230310T T HR P20230310TT HR P20230310 T HRP20230310 T HR P20230310T HR P20230310 T1 HRP20230310 T1 HR P20230310T1
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- Prior art keywords
- alkyl
- compound according
- methyl
- compound
- cyano
- Prior art date
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- 230000003641 microbiacidal effect Effects 0.000 title 1
- 150000007979 thiazole derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 16
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 11
- 229910052757 nitrogen Chemical group 0.000 claims 8
- -1 1-(cyclopropylmethyl)cyclopropylmethyl Chemical group 0.000 claims 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000001301 oxygen Substances 0.000 claims 6
- 239000011593 sulfur Substances 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- HCYYXPPYVVHHAJ-UHFFFAOYSA-N 2-[cyano-(2,6-difluoropyridin-4-yl)amino]-5-methyl-N-spiro[1,3-dihydroindene-2,2'-cyclobutane]-1'-yl-1,3-thiazole-4-carboxamide Chemical compound C(#N)N(C=1SC(=C(N=1)C(=O)NC1CCC11CC2=CC=CC=C2C1)C)C1=CC(=NC(=C1)F)F HCYYXPPYVVHHAJ-UHFFFAOYSA-N 0.000 claims 1
- YZVZFVMXVRJRMH-UHFFFAOYSA-N 2-[cyano-(2,6-difluoropyridin-4-yl)amino]-5-methyl-N-spiro[3.3]heptan-3-yl-1,3-thiazole-4-carboxamide Chemical compound C(#N)N(C=1SC(=C(N=1)C(=O)NC1CCC11CCC1)C)C1=CC(=NC(=C1)F)F YZVZFVMXVRJRMH-UHFFFAOYSA-N 0.000 claims 1
- PERJBSQDGVVKHA-UHFFFAOYSA-N 2-[cyano-(2,6-difluoropyridin-4-yl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-1,3-thiazole-4-carboxamide Chemical compound C(#N)N(C=1SC(=C(N=1)C(=O)NC1CCC11CCCC1)C)C1=CC(=NC(=C1)F)F PERJBSQDGVVKHA-UHFFFAOYSA-N 0.000 claims 1
- MRERKYFRBMOFAH-UHFFFAOYSA-N 2-[cyano-(2,6-difluoropyridin-4-yl)amino]-N-(2,2-dimethylcyclobutyl)-5-formamido-1,3-thiazole-4-carboxamide Chemical compound C(#N)N(C=1SC(=C(N=1)C(=O)NC1C(CC1)(C)C)NC=O)C1=CC(=NC(=C1)F)F MRERKYFRBMOFAH-UHFFFAOYSA-N 0.000 claims 1
- HGXDYWLLAKOYTF-UHFFFAOYSA-N 2-[cyano-(2,6-difluoropyridin-4-yl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-1,3-thiazole-4-carboxamide Chemical compound C(#N)N(C=1SC(=C(N=1)C(=O)NC1C(CC1)(C)C)C)C1=CC(=NC(=C1)F)F HGXDYWLLAKOYTF-UHFFFAOYSA-N 0.000 claims 1
- QJWHRYFNUOMRNQ-UHFFFAOYSA-N 2-[cyano-(2,6-difluoropyridin-4-yl)amino]-N-[[1-(cyclopropylmethyl)cyclopropyl]methyl]-5-methyl-1,3-thiazole-4-carboxamide Chemical compound C(#N)N(C=1SC(=C(N=1)C(=O)NCC1(CC1)CC1CC1)C)C1=CC(=NC(=C1)F)F QJWHRYFNUOMRNQ-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 239000003905 agrochemical Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000000855 fungicidal effect Effects 0.000 claims 1
- 239000000417 fungicide Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 1
- 230000003032 phytopathogenic effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 244000045561 useful plants Species 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (15)
1. Spoj s formulom (I):
[image]
naznačen time što,
Y je C-F, C-H ili N;
R1 je vodik, halogen, cijano, C1-C4alkil, C1-C4alkoksi, C1-C4haloalkil, ili HC(O)NH-;
R2 je C1-C8 alkil, C1-C8haloalkil C1-C8alkoksi, C3-C8cikloalkil, C3-C8cikloalkilC1-C2alkil (pri čemu su cikloalkilne skupine izborno supstituirane s 1 do 3 skupine predstavljene s R3), fenilom, fenilC1-C2alkil (pri čemu su fenilni prstenovi izborno supstituirani s 1 do 3 skupine predstavljene s R3), heteroarilom, heteroarilC1-C2alkilom, pri čemu je heteroaril 5- ili 6-člani aromatski monociklički prsten koji sadrži 1, 2, 3 ili 4 heteroatoma pojedinačno odabrana od dušika, kisika i sumpora, heterocikilom, heterocikilC1-C2alkilom, pri čemu je heterociklil 4-, 5- ili 6-člani ne-aromatski monociklički prsten koji sadrži 1, 2 ili 3 heteroatoma pojedinačno odabrana od dušika, kisika i sumpora, ili 5- do 12-člani ne-aromatski prstenasti ili spirociklički karbobi- ili karbotri-cikililni prstenasti sustav koji izborno sadrži 1, 2, 3, 4 ili 5 heteroatoma pojedinačno odabrana od dušika, kisika i sumpora, te pri čemu je svaki od spirocikličkih karbobi- ili karbotri-cikililnih prstenastih sustava izborno vezan na ostatak molekule preko C1-C2alkilenske poveznice;
R3 je halogen, C1-C4alkil, C1-C4alkoksi, C1-C4haloalkil, C3-C8cikloalkil ili C3-C8cikloalkilC1-C2alkil;
X je N ili C-H;
ili njihova sol ili N-oksid.
2. Spoj prema zahtjevu 1, naznačen time što R1 je klor, brom, metil, metoksi, ili HC(O)NH-.
3. Spoj prema zahtjevu 1 ili zahtjevu 2, naznačen time što R1 je metil ili HC(O)NH-.
4. Spoj prema bilo kojem od zahtjeva 1 do 3, naznačen time što R1 je metil.
5. Spoj prema bilo kojem od zahtjeva 1 do 4, naznačen time što R2 je C1-C6alkil, C1-C3alkoksi, C3-C6cikloalkil, C3-C6cikloalkilC1-C2alkil (pri čemu su cikloalkilne skupine izborno supstituirane s 1 do 3 skupine predstavljene s R3), fenilom, fenilC1-C2alkilom (pri čemu su fenilni prstenovi izborno supstituirani s 1 do 3 skupine predstavljene s R3), heteroarilom pri čemu je heteroaril 5- ili 6-člani aromatski monociklički prsten koji sadrži 1, 2 ili 3 heteroatoma pojedinačno odabrana od dušika, kisika i sumpora, heterocikil pri čemu je heterociklil 4-, 5- ili 6-člani ne-aromatski monociklički prsten koji sadrži 1, 2 ili 3 heteroatoma pojedinačno odabrana od dušika, kisika i sumpora, ili 5- do 12-člani ne-aromatski spirociklički karbobi- ili karbotri-cikililni prstenasti sustav koji izborno sadrži jedan heteroatom odabran od dušika, kisika i sumpora.
6. Spoj prema bilo kojem od zahtjeva 1 do 5, naznačen time što R2 je C1-C6alkil, C3-C6cikloalkil, C3-C6cikloalkilC1-C2alkil (pri čemu su cikloalkilne skupine izborno supstituirane s 1 ili 2 skupine predstavljene s R3), fenilC1-C2alkilom (pri čemu su fenilni prstenovi izborno supstituirani s 1 ili 2 skupine predstavljene s R3), ili 5- do 12-članim ne-aromatskim spirocikličkim karbobi- ili karbotri-cikililnim prstenastim sustavom.
7. Spoj prema bilo kojem od zahtjeva 1 do 6, naznačen time što R2 je n-butil, izobutil, n-pentil, izopentil, 2,2-dimetilpropil, n-heksil, 1-(ciklopropilmetil)ciklopropilmetil, ciklobutil, 2,2-dimetilciklobutil, 1-metilciklopentil, benzil, 1-feniletil, 3,5-bis(trifluormetil)fenilmetil, spiro[3.3]heptanil, spiro[3.4]oktanil ili spiro[ciklobutan-1,2'-indanil].
8. Spoj prema bilo kojem od patentnih zahtjeva 1 do 7, naznačen time što R3 je C1-C3alkil, C1-C3haloalkil, ili C3-C6cikloalkilC1-C2alkil.
9. Spoj prema bilo kojem od patentnih zahtjeva 1 do 8, naznačen time što X je N.
10. Spoj prema bilo kojem od patentnih zahtjeva 1 do 9, naznačen time što Y je C-F.
11. Spoj prema bilo kojem od zahtjeva 1 do 9, naznačen time što je spoj formule (I) 2-[cijano-(2,6-difluor-4-piridil)amino]-N-(2,2-dimetilciklobutil)- 5-formamido-tiazol-4-karboksamid (1.b.25), 2-[cijano-(2,6-difluor-4-piridil)amino]-N-[[1-(ciklopropilmetil)ciklopropil]metil]- 5-metiltiazol-4-karboksamid (1.f.23), 2-[cijano-(2,6-difluor-4-piridil)amino]-5-metil-N-spiro[3.3]heptan-3-il- tiazol-4-karboksamid (1.e.23), 2-[cijano-(2,6-difluor-4-piridil)amino]-5-metil-N-spiro[3.4]oktan-3-il-tiazol- 4-karboksamid (1.c.23), 2-[cijano-(2,6-difluor-4-piridil)amino]-5-metil-N-spiro[ciklobutan-2,2'-indan]-1- il-tiazol-4-karboksamid (1.d.23) ili 2-[cijano-(2,6-difluor-4-piridil)amino]-N-(2,2-dimetilciklobutil)-5-metil-tiazol- 4-karboksamid (1.b.23).
12. Agrokemijski pripravak naznačen time što sadrži fungicidno učinkovitu količinu spoja s formulom (I) prema bilo kojem od patentnih zahtjeva 1 do 11.
13. Pripravak prema patentnom zahtjevu 12, naznačen time što nadalje sadrži barem jedan dodatni aktivni sastojak i/ili agrokemijski prihvatljiv razrjeđivač ili nosač.
14. Postupak suzbijanja ili sprečavanja zaraze korisnih biljaka s fitopatogenim mikroorganizmima, naznačen time što se fungicidno učinkovita količina spoja formule (I) u skladu s bilo kojim od patentnih zahtjeva 1 do 11, ili pripravka koji sadrži ovaj spoj kao aktivni sastojak, primjenjuje na biljke, na njihove dijelove ili na njihov lokus.
15. Uporaba spoja formule (I) prema bilo kojem od patentnih zahtjeva 1 do 11 kao fungicida, pri čemu navedena uporaba ne uključuje postupke za liječenje ljudskog ili životinjskog tijela kirurškim zahvatom ili terapijom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18209591 | 2018-11-30 | ||
| PCT/EP2019/082975 WO2020109509A1 (en) | 2018-11-30 | 2019-11-28 | Microbiocidal thiazole derivatives |
| EP19809480.7A EP3887360B1 (en) | 2018-11-30 | 2019-11-28 | Microbiocidal thiazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20230310T1 true HRP20230310T1 (hr) | 2023-05-12 |
Family
ID=64564711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20230310TT HRP20230310T1 (hr) | 2018-11-30 | 2019-11-28 | Mikrobiocidni derivati tiazola |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20220017501A1 (hr) |
| EP (1) | EP3887360B1 (hr) |
| JP (1) | JP2022509694A (hr) |
| KR (1) | KR20210098979A (hr) |
| CN (1) | CN113166082A (hr) |
| AR (1) | AR117200A1 (hr) |
| AU (1) | AU2019389778B2 (hr) |
| BR (1) | BR112021010367A2 (hr) |
| CA (1) | CA3120029A1 (hr) |
| CL (1) | CL2021001349A1 (hr) |
| CO (1) | CO2021007062A2 (hr) |
| CR (1) | CR20210282A (hr) |
| DK (1) | DK3887360T3 (hr) |
| EA (1) | EA202191456A1 (hr) |
| ES (1) | ES2941648T3 (hr) |
| FI (1) | FI3887360T3 (hr) |
| GE (1) | GEP20227439B (hr) |
| HR (1) | HRP20230310T1 (hr) |
| HU (1) | HUE061398T2 (hr) |
| IL (1) | IL283486B1 (hr) |
| MX (1) | MX2021006099A (hr) |
| PL (1) | PL3887360T3 (hr) |
| PT (1) | PT3887360T (hr) |
| TW (1) | TWI810412B (hr) |
| UA (1) | UA127364C2 (hr) |
| UY (1) | UY38492A (hr) |
| WO (1) | WO2020109509A1 (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| CN109475531B (zh) | 2016-05-31 | 2021-08-17 | 得克萨斯州立大学董事会 | Ptpn11的杂环抑制剂 |
| BR112020022224A2 (pt) | 2018-05-02 | 2021-06-08 | Navire Pharma, Inc. | inibidores heterocíclicos substituídos de ptpn11 |
| CN112601750B (zh) | 2018-08-10 | 2023-10-31 | 纳维尔制药有限公司 | Ptpn11（shp2）抑制剂 |
| CR20220615A (es) * | 2020-06-03 | 2023-01-17 | Syngenta Crop Protection Ag | Composiciones fungicidas |
| WO2023099460A1 (en) | 2021-12-02 | 2023-06-08 | Syngenta Crop Protection Ag | Fungicidal compositions |
| WO2024068655A1 (en) | 2022-09-28 | 2024-04-04 | Syngenta Crop Protection Ag | Fungicidal compositions |
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| DK3887360T3 (da) | 2023-04-03 |
| PT3887360T (pt) | 2023-04-03 |
| IL283486B1 (en) | 2024-05-01 |
| AR117200A1 (es) | 2021-07-21 |
| US20220017501A1 (en) | 2022-01-20 |
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| EP3887360B1 (en) | 2023-01-18 |
| EP3887360A1 (en) | 2021-10-06 |
| CA3120029A1 (en) | 2020-06-04 |
| TWI810412B (zh) | 2023-08-01 |
| TW202031130A (zh) | 2020-09-01 |
| CR20210282A (es) | 2021-06-30 |
| UA127364C2 (uk) | 2023-07-26 |
| KR20210098979A (ko) | 2021-08-11 |
| GEP20227439B (en) | 2022-11-25 |
| CN113166082A (zh) | 2021-07-23 |
| AU2019389778A1 (en) | 2021-06-03 |
| JP2022509694A (ja) | 2022-01-21 |
| CO2021007062A2 (es) | 2021-06-10 |
| ES2941648T3 (es) | 2023-05-24 |
| HUE061398T2 (hu) | 2023-06-28 |
| EA202191456A1 (ru) | 2021-10-14 |
| FI3887360T3 (fi) | 2023-04-04 |
| PL3887360T3 (pl) | 2023-05-08 |
| WO2020109509A1 (en) | 2020-06-04 |
| IL283486A (en) | 2021-07-29 |
| AU2019389778B2 (en) | 2024-03-14 |
| MX2021006099A (es) | 2021-07-07 |
| CL2021001349A1 (es) | 2021-11-12 |
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