HRP20220180T1 - Liposomska otopina kapi za oči i njihova uporaba za liječenje sindroma suhog oka - Google Patents
Liposomska otopina kapi za oči i njihova uporaba za liječenje sindroma suhog oka Download PDFInfo
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- HRP20220180T1 HRP20220180T1 HRP20220180TT HRP20220180T HRP20220180T1 HR P20220180 T1 HRP20220180 T1 HR P20220180T1 HR P20220180T T HRP20220180T T HR P20220180TT HR P20220180 T HRP20220180 T HR P20220180T HR P20220180 T1 HRP20220180 T1 HR P20220180T1
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- vitamin
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- liposomes
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- eye drop
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- 239000000243 solution Substances 0.000 title claims 21
- 239000003889 eye drop Substances 0.000 title claims 14
- 208000003556 Dry Eye Syndromes Diseases 0.000 title claims 7
- 206010013774 Dry eye Diseases 0.000 title claims 7
- 229940012356 eye drops Drugs 0.000 title claims 3
- 239000002502 liposome Substances 0.000 claims 10
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims 8
- 229920002770 condensed tannin Polymers 0.000 claims 6
- 235000018192 pine bark supplement Nutrition 0.000 claims 6
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 6
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims 5
- 229930003779 Vitamin B12 Natural products 0.000 claims 5
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims 5
- 235000019163 vitamin B12 Nutrition 0.000 claims 5
- 239000011715 vitamin B12 Substances 0.000 claims 5
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 238000001914 filtration Methods 0.000 claims 4
- 235000021388 linseed oil Nutrition 0.000 claims 4
- 239000000944 linseed oil Substances 0.000 claims 4
- 150000003904 phospholipids Chemical class 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 229940106796 pycnogenol Drugs 0.000 claims 4
- 235000019172 retinyl palmitate Nutrition 0.000 claims 4
- 229940108325 retinyl palmitate Drugs 0.000 claims 4
- 239000011769 retinyl palmitate Substances 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
- 239000007983 Tris buffer Substances 0.000 claims 3
- 239000000872 buffer Substances 0.000 claims 3
- 239000012153 distilled water Substances 0.000 claims 3
- 239000004615 ingredient Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000001954 sterilising effect Effects 0.000 claims 3
- 238000004659 sterilization and disinfection Methods 0.000 claims 3
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 2
- 239000004327 boric acid Substances 0.000 claims 2
- CDMADVZSLOHIFP-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane;decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 CDMADVZSLOHIFP-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 235000010339 sodium tetraborate Nutrition 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000001125 extrusion Methods 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/55—Linaceae (Flax family), e.g. Linum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines Containing Plant Substances (AREA)
Claims (10)
1. Otopina kapi za oči za uporabu u liječenju sindroma suhog oka, naznačena time, da sadrži liposomsku strukturu s ne-hidrogeniranim fosfolipidima koji sadrže laneno ulje, vitamin A palmitat, vitamin E TPGS, i u vodenoj fazi, vitamin B12 i piknogenole.
2. Otopina kapi za oči prema patentnom zahtjevu 1, naznačena time, da liposomska otopina kapi za oči nadalje sadrži sustav koji čini 2-amino-2(hidroksimetil)-propan-1,3-diol, koji djeluje kao sredstvo za tvorbu soli piknogenola, topive u gaziranoj vodi, i puferski regulator pH.
3. Otopina kapi za oči prema bilo kojem od prethodnih patentnih zahtjeva, naznačena time, da se sterilizira filtracijom kroz 0,2 μm, budući da sterilizacija parom koja se postiže izlaganjem navedene otopine zasićenoj pari pri visokim temperaturama od 121°C tijekom 15 minuta na 1x105 Pa (1 Atm), uništava sve liposomske komponente.
4. Otopina kapi za oči prema bilo kojem od prethodnih patentnih zahtjeva, naznačena time, da liposomske kapi za oči predstavljaju zaštitu protiv UVA UVB zraka (UVA 315-400 nm – UVB 315-280), gdje je ovo svojstvo povezano primarno s liposomima (plus Vitamin E TPGS) i sekundarno s vitaminom B12 i piknogenolima u vodenoj fazi.
5. Otopina kapi za oči prema bilo kojem od patentnih zahtjeva 2-4, naznačena time, da ima slijedeći sastav:
Sastojci % težina/težina
Fosfolipid S80 0,250/0,750
Laneno ulje 0,025/0,075
Vitamin A palmitat 0,005/0,015
Vitamin E TPGS unutar liposoma 0,0125/0,0375
Piknogenol 0,0085/0,0255
Tris (2-amino-2(hidroksimetil)propan-1,3-diol 0,3-0,2/0,4-0,3
Vitamin B12 0,00175/0,00525
Sol hijaluronske kiseline (1,5-1,7 MDa) izvan liposoma 0,0750/0,225
Borna kiselina 0,775
Natrij tetraborat dekahidrat 0,0600
Natrij klorid 0,2-0,15
Destilirana voda 100
Sterilizacija filtracijom kroz 0,2 μm (0,2 mikrona) Da
pH 7,1-7,4
Osmolalnost mMOs/kg 275-290
6. Otopina za oči prema patentnom zahtjevu 5, naznačena time, da ima slijedeći sastav:
Sastojci % težina/težina
Fosfolipid S80 0,500
Laneno ulje 0,050
Vitamin A palmitat 0,010
Piknogenol 0,017
Tris (2-amino-2(hidroksimetil)propan-1,3-diol 0,3-0,2
Vitamin B12 0,0035
Sol hijaluronske kiseline (1,5-1,7 MDa) izvan liposoma 0,150
Vitamin E TPGS unutar liposoma 0,025
Borna kiselina 0,775
Natrij tetraborat dekahidrat 0,060
Natrij klorid 0,2-0,15
Destilirana voda 100
Sterilizacija filtracijom kroz 0,2 μm (0,2 mikrona) Da
pH 7,1-7,4
Osmolalnost mMOs/kg 275-290
7. Postupak za pripravu otopine za oči za uporabu u liječenju sindroma suhog oka, naznačen time, da obuhvaća slijedeće korake:
Prvi korak:
Priprava liposoma koji nose lipofilne supstance:
- otope se svi lipofilni sastojci, ne-hidrogenirani fosfolipidi, laneno ulje, vitamin A palmitata plus vitamin E TPGS u otapalu, često etanolu,
- otapalo se uklanja pod vakuumom kako bi se dobio suhi prah,
- prah se disperzira u boratnom puferu i miješa mehaničkim mikserom, dobije se otopina velikih liposoma, koja se može definirati kao pro liposomi;
- otopina ovakvih velikih liposoma se tada istiskuje pod visokim tlakom, između 600/1000 bar;
- postupak istiskivanja pod visokim tlakom se ponavlja nekoliko puta ,između 4 i 7, kako bi se dobili liposomi veličine manje od 200 nm;
Drugi korak:
Priprava vodene otopine koja sadrži hidrofilne supstance
- u destiliranoj se vodi otope piknogenoli, Tris, vitamin B12, hijaluronska kiselina i boratni pufer; gdje je koncentracija lipofilnih supstanci u prvom koraku i koncentracija hidrofilnih supstanci u drugom koraku takva da dopušta, kad se doda svaka u omjeru 1:1, da se dobije otopina željene koncentracije;
- dobije se bistra i crveno obojena otopina;
Treći korak:
Priprava finalnih sterilnih kapi za oči:
Količina „X“ liposomske otopine, pripravljena u prvom koraku, doda se istoj količini „X“ vodene obojene otopine, pripravljene u drugom koraku, dobivši količinu „2X“ finalne standardne otopine kapi za oči formule prema patentnom zahtjevu 5, i
finalna se standardna otopina kapi za oči sterilizira filtracijom kroz 0,2 μm (0,2 mikron) filter.
8. Otopina kapi za oči prema bilo kojem od patentnih zahtjeva 4 i 5 za uporabu u liječenju sindroma suhog oka, naznačena time, da se koristi kao zaštita protiv UVA/UVB zraka.
9. Otopina kapi za oči prema bilo kojem od prethodnih patentnih zahtjeva 1-6 za uporabu u liječenju sindroma suhog oka, naznačena time, da je namjera smanjenje negativnog učinka sindroma suhog oka.
10. Otopina kapi za oči dobivene postupkom prema patentnom zahtjevu 7 za uporabu u liječenju sindroma suhog oka, naznačena time, da je se koristi kao zaštita protiv UVA/UVB zraka.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18425109.8A EP3673896B9 (en) | 2018-12-28 | 2018-12-28 | Liposomial eye drops solution and uses thereof for the treatment of dry eye syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220180T1 true HRP20220180T1 (hr) | 2022-04-29 |
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ID=65657191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220180TT HRP20220180T1 (hr) | 2018-12-28 | 2018-12-28 | Liposomska otopina kapi za oči i njihova uporaba za liječenje sindroma suhog oka |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20220304970A1 (hr) |
| EP (1) | EP3673896B9 (hr) |
| JP (1) | JP7280638B2 (hr) |
| KR (1) | KR102493604B1 (hr) |
| CN (1) | CN112804990B (hr) |
| AU (1) | AU2019412448B2 (hr) |
| CA (1) | CA3124727C (hr) |
| DK (1) | DK3673896T3 (hr) |
| ES (1) | ES2910121T3 (hr) |
| HR (1) | HRP20220180T1 (hr) |
| IL (1) | IL284454B2 (hr) |
| PH (1) | PH12021551094A1 (hr) |
| PL (1) | PL3673896T3 (hr) |
| PT (1) | PT3673896T (hr) |
| SG (1) | SG11202105666WA (hr) |
| WO (1) | WO2020135940A1 (hr) |
| ZA (1) | ZA202104891B (hr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111671722A (zh) * | 2020-07-30 | 2020-09-18 | 成都大学 | 一种滴眼液及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5945121A (en) * | 1994-12-19 | 1999-08-31 | Taisho Pharmaceutical Co., Ltd. | Liposome eye drops |
| US20060127505A1 (en) * | 2002-01-16 | 2006-06-15 | David Haines | Anti-inflammatory formulations |
| US20040076695A1 (en) * | 2002-07-08 | 2004-04-22 | Advanced Vision Research | EPA and DHA enriched omega-3 supplement for the treatment of dry eye, meibomianitis and xerostomia |
| ITRM20030153A1 (it) * | 2003-04-03 | 2004-10-04 | Exall S R L | Formulazione idrosolubile contenente ubichinone per uso oftalmico. |
| EP1502594A1 (en) * | 2003-07-31 | 2005-02-02 | Pynogin GmbH | A health care composition for decreasing the risk of thrombosis including a mixture of proanthocyanidins and sesquiterpenes |
| CN100393303C (zh) * | 2006-06-05 | 2008-06-11 | 珠海丽波医药科技有限公司 | 维生素a脂质体人工泪滴眼液 |
| CA2640986C (en) * | 2007-08-16 | 2014-10-21 | Reza Dana | Therapeutic compositions for treatment of inflammation of ocular and adnexal tissues |
| KR20090126785A (ko) * | 2008-06-05 | 2009-12-09 | 홉킨스바이오연구센터(주) | 피크노제놀, 레스베라트롤 및 항산화 비타민을 함유하는항산화 복합 조성물 |
| AU2009302167B9 (en) * | 2008-10-09 | 2014-05-29 | Ramscor, Inc. | Composition and method for treating dry eye syndrome |
| IT1404931B1 (it) * | 2010-06-11 | 2013-12-09 | Medivis S R L | Composizioni oftalmiche per la somministrazione di principi attivi liposolubili . |
| CN102100665B (zh) * | 2011-01-14 | 2012-05-30 | 华南理工大学 | 一种含维生素e衍生物的滴眼液及其制备方法 |
| WO2017115316A1 (en) * | 2015-12-29 | 2017-07-06 | Noivita S.R.L.S. | Lipophilic formulations |
| EP3412276A3 (de) * | 2017-06-09 | 2019-07-17 | Omnivision GmbH | Zusammensetzung zur behandlung des trockenen auges |
| KR101882736B1 (ko) * | 2017-07-10 | 2018-07-27 | 김삼 | 멜라토닌, 비타민 c 및 피크노제놀을 유효 성분으로 함유한 피부보호용 조성물 |
-
2018
- 2018-12-28 DK DK18425109.8T patent/DK3673896T3/da active
- 2018-12-28 PL PL18425109T patent/PL3673896T3/pl unknown
- 2018-12-28 PT PT184251098T patent/PT3673896T/pt unknown
- 2018-12-28 ES ES18425109T patent/ES2910121T3/es active Active
- 2018-12-28 HR HRP20220180TT patent/HRP20220180T1/hr unknown
- 2018-12-28 EP EP18425109.8A patent/EP3673896B9/en active Active
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2019
- 2019-10-24 CA CA3124727A patent/CA3124727C/en active Active
- 2019-10-24 IL IL284454A patent/IL284454B2/en unknown
- 2019-10-24 WO PCT/EP2019/079029 patent/WO2020135940A1/en active Application Filing
- 2019-10-24 KR KR1020217023928A patent/KR102493604B1/ko active IP Right Grant
- 2019-10-24 US US17/418,908 patent/US20220304970A1/en not_active Abandoned
- 2019-10-24 CN CN201980065758.4A patent/CN112804990B/zh active Active
- 2019-10-24 AU AU2019412448A patent/AU2019412448B2/en active Active
- 2019-10-24 SG SG11202105666WA patent/SG11202105666WA/en unknown
- 2019-10-24 JP JP2021514622A patent/JP7280638B2/ja active Active
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2021
- 2021-05-11 PH PH12021551094A patent/PH12021551094A1/en unknown
- 2021-07-12 ZA ZA2021/04891A patent/ZA202104891B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT3673896T (pt) | 2022-02-03 |
| CN112804990B (zh) | 2024-05-24 |
| SG11202105666WA (en) | 2021-07-29 |
| KR102493604B1 (ko) | 2023-01-31 |
| CA3124727A1 (en) | 2020-07-02 |
| EP3673896B9 (en) | 2022-05-18 |
| EP3673896B1 (en) | 2022-01-12 |
| AU2019412448B2 (en) | 2023-04-20 |
| US20220304970A1 (en) | 2022-09-29 |
| AU2019412448A1 (en) | 2021-08-12 |
| CN112804990A (zh) | 2021-05-14 |
| CA3124727C (en) | 2023-10-31 |
| EP3673896A1 (en) | 2020-07-01 |
| JP7280638B2 (ja) | 2023-05-24 |
| PH12021551094A1 (en) | 2021-11-22 |
| IL284454A (en) | 2021-08-31 |
| PL3673896T3 (pl) | 2022-06-27 |
| KR20210110653A (ko) | 2021-09-08 |
| DK3673896T3 (da) | 2022-02-07 |
| WO2020135940A1 (en) | 2020-07-02 |
| JP2022514809A (ja) | 2022-02-16 |
| IL284454B1 (en) | 2024-04-01 |
| ZA202104891B (en) | 2022-07-27 |
| ES2910121T3 (es) | 2022-05-11 |
| IL284454B2 (en) | 2024-08-01 |
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