HRP20190884T1 - Sastav koji sadrži glikozaminoglikane i proteine - Google Patents
Sastav koji sadrži glikozaminoglikane i proteine Download PDFInfo
- Publication number
- HRP20190884T1 HRP20190884T1 HRP20190884TT HRP20190884T HRP20190884T1 HR P20190884 T1 HRP20190884 T1 HR P20190884T1 HR P20190884T T HRP20190884T T HR P20190884TT HR P20190884 T HRP20190884 T HR P20190884T HR P20190884 T1 HRP20190884 T1 HR P20190884T1
- Authority
- HR
- Croatia
- Prior art keywords
- mixture
- glycosaminoglycans
- composition according
- hydrolyzed
- chemically modified
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims 62
- 229920002683 Glycosaminoglycan Polymers 0.000 title claims 33
- 102000004169 proteins and genes Human genes 0.000 title claims 8
- 108090000623 proteins and genes Proteins 0.000 title claims 8
- 150000005676 cyclic carbonates Chemical class 0.000 claims 32
- 229920000768 polyamine Polymers 0.000 claims 32
- 239000000178 monomer Substances 0.000 claims 23
- 239000004615 ingredient Substances 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 150000002337 glycosamines Chemical class 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 102000007469 Actins Human genes 0.000 claims 9
- 108010085238 Actins Proteins 0.000 claims 9
- 102000008186 Collagen Human genes 0.000 claims 9
- 108010035532 Collagen Proteins 0.000 claims 9
- 102000016942 Elastin Human genes 0.000 claims 9
- 108010014258 Elastin Proteins 0.000 claims 9
- 102000016359 Fibronectins Human genes 0.000 claims 9
- 108010067306 Fibronectins Proteins 0.000 claims 9
- 102000011782 Keratins Human genes 0.000 claims 9
- 108010076876 Keratins Proteins 0.000 claims 9
- 102000003505 Myosin Human genes 0.000 claims 9
- 108060008487 Myosin Proteins 0.000 claims 9
- 229920001436 collagen Polymers 0.000 claims 9
- 229920002549 elastin Polymers 0.000 claims 9
- 238000002360 preparation method Methods 0.000 claims 8
- 102000007547 Laminin Human genes 0.000 claims 7
- 108010085895 Laminin Proteins 0.000 claims 7
- 125000004122 cyclic group Chemical group 0.000 claims 6
- 239000004417 polycarbonate Substances 0.000 claims 6
- 229920000515 polycarbonate Polymers 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 150000001412 amines Chemical group 0.000 claims 4
- 238000006116 polymerization reaction Methods 0.000 claims 4
- -1 1,2-dihydroxyethyl Chemical group 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 230000009435 amidation Effects 0.000 claims 3
- 238000007112 amidation reaction Methods 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 3
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 claims 3
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims 3
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 229920001730 Moisture cure polyurethane Polymers 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 2
- 150000001336 alkenes Chemical class 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- GEHJBWKLJVFKPS-UHFFFAOYSA-N bromochloroacetic acid Chemical compound OC(=O)C(Cl)Br GEHJBWKLJVFKPS-UHFFFAOYSA-N 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 238000007385 chemical modification Methods 0.000 claims 2
- 150000001924 cycloalkanes Chemical class 0.000 claims 2
- 150000001925 cycloalkenes Chemical class 0.000 claims 2
- 230000006196 deacetylation Effects 0.000 claims 2
- 238000003381 deacetylation reaction Methods 0.000 claims 2
- 150000002019 disulfides Chemical class 0.000 claims 2
- 230000032050 esterification Effects 0.000 claims 2
- 238000005886 esterification reaction Methods 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000002576 ketones Chemical class 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 235000021317 phosphate Nutrition 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 2
- 150000003568 thioethers Chemical class 0.000 claims 2
- SERLAGPUMNYUCK-YJOKQAJESA-N 6-O-alpha-D-glucopyranosyl-D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-YJOKQAJESA-N 0.000 claims 1
- 102000016284 Aggrecans Human genes 0.000 claims 1
- 108010067219 Aggrecans Proteins 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 229920000045 Dermatan sulfate Polymers 0.000 claims 1
- 239000004386 Erythritol Substances 0.000 claims 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 229920002971 Heparan sulfate Polymers 0.000 claims 1
- 229920000288 Keratan sulfate Polymers 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000004721 Polyphenylene oxide Substances 0.000 claims 1
- JVWLUVNSQYXYBE-UHFFFAOYSA-N Ribitol Natural products OCC(C)C(O)C(O)CO JVWLUVNSQYXYBE-UHFFFAOYSA-N 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229940107200 chondroitin sulfates Drugs 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims 1
- 235000019414 erythritol Nutrition 0.000 claims 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 1
- 229940009714 erythritol Drugs 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 239000000832 lactitol Substances 0.000 claims 1
- 235000010448 lactitol Nutrition 0.000 claims 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims 1
- 229960003451 lactitol Drugs 0.000 claims 1
- 239000000845 maltitol Substances 0.000 claims 1
- 235000010449 maltitol Nutrition 0.000 claims 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 1
- 229940035436 maltitol Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
- 125000003367 polycyclic group Polymers 0.000 claims 1
- 229920000570 polyether Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920005862 polyol Polymers 0.000 claims 1
- 150000003077 polyols Chemical class 0.000 claims 1
- 230000001012 protector Effects 0.000 claims 1
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/02—Dextran; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/04—Alginic acid; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/10—Heparin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/30—Materials or treatment for tissue regeneration for muscle reconstruction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
Claims (24)
1. Sastav koji sadrži prvi, drugi i treći sastojak, pri čemu
- spomenuti prvi sastojak je glikozaminoglikan, hidrolizirani glikozaminoglikan, glikozamin, kemijski modificirani ili ne ili mješavina različitih glikozaminoglikana, hidroliziranih glikozaminoglikana, glikozamina, kemijski modificiranih ili ne;
- spomenuti drugi sastojak je protein, peptid ili mješavina različitih proteina ili peptida;
- spomenuti treći sastojak je polihidroksiuretan (PHU) koji se dobiva kovalentnim uparivanjem bis ili poli cikličkih karbonata (CC) i di ili poliamin (PA) molekula.
2. Sastav prema zahtjevu 1, pri čemu je spomenuti protein kolagen, elastin, keratin, fibronektin, aktin, miozin, laminin, peptid ili mješavina spomenutih proteina ili peptida, hidroliziranih, kemijski modificiranih, fibriliranih ili ne.
3. Sastav prema zahtjevu 1 ili 2, dobiven polimerizacijom ili kovalentno vezanom formacijom između sastojaka dvaju pripravaka a i b, u kojem
- pripravak a ima barem 1 % glikozaminoglikana, hidroliziranih glikozaminoglikana, glikozamina ili kemijski modificiranih glikozaminoglikana, hidroliziranih glikozaminoglikana, glikozamina s cikličkim polikarbonatima ili s Pre-polimerom polihidroksiuretana terminiranog funkcijama cikličkih karbonata (PRE-CC) ili mješavinu spomenutih različitih sastojaka u mješavini koja sadrži prihvatljiva otapala i izborno CC monomere od PHU ili PRE-CC ili mješavinu PRE-CC i CC kako bi se osiguralo da pripravak a sadrži funkcije cikličkih karbonata, i
- pripravak b ima barem 1 % kolagena, elastina, keratina, fibronektina, aktina, miozina, laminina, peptida, hidroliziranih, fibriliranih ili ne, ili kemijski modificiranih kolagena, elastina, keratina, fibronektina, aktina, miozina, laminina, peptida, hidroliziranih, fibriliranih ili ne s PA ili s Pre-polimerom polihidroksiuretana terminiranog funkcijama amina (PRE-PA) ili mješavinu spomenutih sastojaka u mješavini koja sadrži prihvatljiva otapala i izborno PA monomere od PHU ili PRE-PA ili mješavinu PRE-PA i PA kako bi se osiguralo da pripravak b sadrži funkcije amina od poliamina.
4. Sastav prema zahtjevu 1 ili 2, dobiven polimerizacijom ili kovalentno vezanom formacijom između sastojaka dvaju pripravaka a i b, u kojem,
- pripravak a ima barem 1 % glikozaminoglikana, hidroliziranih glikozaminoglikana, glikozamina ili kemijski modificiranih glikozaminoglikana, hidroliziranih glikozaminoglikana, glikozamina s CC ili s PRE-CC ili mješavinu spomenutih različitih sastojaka i kemijski modificiranih kolagena, elastina, keratina, fibronektina, aktina, miozina, laminina, peptida ili mješavinu spomenutih sastojaka hidroliziranu, fibriliranu ili ne terminiranu CC funkcijama u mješavini koja sadrži prihvatljiva otapala i izborno CC monomere od PHU ili PRE-CC ili mješavinu PRE-CC i CC kako bi se osiguralo da pripravak a sadrži CC funkcije, i
- pripravak b sadrži PA monomere PHU ili PRE-PA ili mješavinu PRE-PA i PA izborno u prihvatljivim otapalima kako bi se osiguralo da pripravak b sadrži funkcije amina od poliamina.
5. Sastav prema zahtjevu 1 ili 2, dobiven polimerizacijom ili kovalentno vezanom formacijom između sastojaka dvaju pripravaka a i b, u kojem,
- pripravak a sadrži CC monomere od PHU ili PRE-CC od PHU ili mješavinu PRE-CC i CC izborno u prihvatljivim otapalima kako bi se osiguralo da pripravak a sadrži CC funkcije i,
- pripravak b sadrži kemijski modificirane, glikozaminoglikan, hidrolizirane glikozaminoglikane, glikozamine ili mješavinu spomenutih sastojaka, terminiranih funkcijama amina i barem 1% kolagena, elastina, keratina, fibronektina, aktina, miozina, laminina, peptida, hidroliziranih, fibriliranih ili ne, ili kemijski modificiranih kolagena, elastina, keratina, fibronektina, aktina, miozina, laminina, peptida, hidroliziranih, fibriliranih ili ne s PA ili s PRE-PA ili mješavinu spomenutih sastojaka u mješavini koja sadrži prihvatljiva otapala i izborno PA monomere PHU ili PRE-PA ili mješavinu PRE-PA i PA kako bi se osiguralo da pripravak b sadrži funkcije amina od PA.
6. Sastav prema bilo kojem od zahtjeva 1 do 5, u kojem su CC monomeri ciklički polikarbonati s prstenima od 5 do 8 atoma dobiveni iz polihidroksiliranih molekula koje sadrže barem tri, primarne ili sekundarne, nearomatske, hidroksilne funkcije, te su PA monomeri primarni ili sekundarni PA.
7. Sastav prema zahtjevu 5, u kojem PRE-CC je PHU od 1 do 200'000, poželjno 1 do 20'000, CC i PA monomeri, terminirani CC monomerima i PRE-PA je PHU od 1 do 200'000, poželjno 1 do 20'000, CC i PA monomeri, terminirani PA monomerima.
8. Sastav prema zahtjevu 1, 3 ili 4, u kojem kemijska modifikacija glikozaminoglikana, hidroliziranih glikozaminoglikana, glikozamina iz glikozaminoglikana ili mješavine različitih glikozaminoglikana, hidroliziranih glikozaminoglikana, glikozamina iz glikozaminoglikana je esterifikacija ili deacetilacija nakon koje slijedi esterifikacija i karbamatacija ili deacetilacija nakon koje slijedi karbamatacija s CC ili PRE-CC.
9. Sastav prema zahtjevu 1 ili 5, u kojem je prvi sastojak kemijski modificiran kroz amidaciju s monomerom PA ili PRE-PA ili kombinacijom oba.
10. Sastav prema bilo kojem od zahtjeva 1, 3-4 ili 8, u kojem je prvi sastojak kemijski modificiran i karbamatiran s monomerom PA ili PRE-PA.
11. Sastav prema bilo kojem od zahtjeva 1, 3-5 ili 8-10, koji je nadalje karbamatiran sukcesivno s CC i PA kako bi se dobili CC ili PA terminirani PHU kemijski cijepljeni glikozaminoglikani, hidrolizirani glikozaminoglikan, glikozamini iz glikozaminoglikana ili mješavina različitih glikozaminoglikana, hidroliziranih glikozaminoglikana, glikozamina iz glikozaminoglikana.
12. Sastav prema bilo kojem od zahtjeva 1, 3 do 8 ili 10-11, u kojem su CC monomeri ciklički polikarbonati eritritola, ksilitola, arabitola, ribitola, sorbitola, dulcitola, manitola, maltitola, izomaltitola, laktitola ili polieter polioli ili njihove smjese.
13. Sastav prema bilo kojem od zahtjeva 1, 3 do 8 ili 10-11, u kojem su CC monomeri ciklički polikarbonati (1,2-dihidroksietil) ili (2,3-dihidroksipropil) etera, estera, ketona, amida, fosfata, sulfata, sulfida, disulfida, alkana, cikloalkana, alkena, cikloalkena, arila ili heterocikala koji sadrže jedan ili više atoma kisika ili aromatskih heterocikala koji sadrže jedan ili više atom dušika ili sumpora.
14. Sastav prema bilo kojem od zahtjeva 1, 3 do 8 ili 10 do 11, u kojem su monomeri cikličkih polikarbonata (CC) smjesa cikličkih polikarbonata prema zahtjevu 12 i 13.
15. Sastav prema bilo kojem od prethodnih zahtjeva, u kojem sastojak (A)
je glikozaminoglikan, hidrolizirani glikozaminoglikan, glikozamin iz glikozaminoglikana, kemijski modificiran ili ne ili smjesa različitih glikozaminoglikana, hidroliziranih glikozaminoglikana, glikozamina iz glikozaminoglikana kemijski modificiranih ili ne uzet iz popisa sljedećih tvari:
- Kondroitin sulfati;
- Hijaluronska kiselina;
- Heparan sulfati;
- Dermatan sulfati;
- Keratan sulfati;
- Agrekani;
16. Sastav prema bilo kojem od zahtjeva 2 ili 3 do 5, u kojem kemijske modifikacije kolagena, elastina, keratina, fibronektina, aktina, miozina, laminina, peptida ili smjese navedenih proteina ili peptida, hidroliziranih, fibriliranih ili ne su amidacija s PA ili PRE-PA ili mješavinom PA i PRE-PA ili sukcesivna amidacija s PA i PRE-PA.
17. Sastav prema bilo kojem od zahtjeva 2, 3-5 ili 16, u kojem kemijski modificirani kolageni, elastini, keratini, fibronektini, aktini, miozini, laminini, peptidi ili mješavina navedenih proteina ili peptida, hidroliziranih, fibriliranih ili ne su karbamatirani s CC monomerom ili Pre-polimerom PRE-CC.
18. Sastav prema bilo kojem od zahtjeva 2, 3-5, 16 ili 17, koji je nadalje karbamatiran sukcesivno s PA i CC kako bi se dobili PA ili CC terminirani PHU kemijski cijepljeni kolageni, elastini, keratini, fibronektini, aktini, miozini, laminini, peptidi ili mješavina navedenih proteina ili peptida, hidroliziranih, fibriliranih ili ne.
19. Sastav prema bilo kojem od zahtjeva 1 do 11 ili 16 do 18, u kojem su primarni i sekundarni PA monomeri primarni ili sekundarni poliamini etera, estera, ketona, amida, fosfata, sulfata, sulfida, disulfida, alkana, cikloalkana, alkena, cikloalkena, arila, supstituiranih ili ne s hidroksil funkcijama; ili primarni ili sekundarni poliamini i primarni ili sekundarni polialkilamini iz heterocikala koji sadrže jedan ili više atoma kisika, dušika ili sumpora, supstituiranih ili ne s hidroksil funkcijama; ili polieteramini jednostavni ili miješani s etilen glikolom i propilen glikolom; ili smjesom navedenih spojeva.
20. Sastav prema bilo kojem od zahtjeva 1 i 3 do 5, u kojem je omjer broja nepolimeriziranih, ili kovalentno vezanih funkcija cikličkog karbonata iz CC monomera, PRE-CC i kemijski modificiranih prvih i drugih sastojaka, i broj nepolimeriziranih, ili kovalentno vezanih primarnih i sekundarnih funkcija amina iz PA monomera, PRE-PA i kemijski modificiranih prvih i drugih sastojaka između 50 i 0,02.
21. Sastav prema bilo kojem od zahtjeva 1 do 20, u kojem se koristi katalizator ili smjesa katalizatora uzeta iz ionskog ili kovalentnog oblika Li, Na, K, Mg, Zn, B i Al ili infracrvenog fotonskog izvora za kontrolu polimerizacije ili formiranje kovalentnih veza između cikličkih karbonata i primarnih ili sekundarnih funkcija amina.
22. Sastav prema bilo kojem od zahtjeva 1 ili 3 do 14 ili 16 do 21, za supstituciju ili rekonstrukciju vezivne, epitelne, živčane, mišićne, koštane, žilne ili kožne, životinjske ili ljudske izvanstanične matrice, za koju je omjer broja nepolimeriziranih ili kovalentno vezanih funkcija cikličkog karbonata iz CC monomera, PRE-CC i kemijski modificiranih prvih i drugih sastojaka, i broj nepolimeriziranih, ili kovalentno vezanih primarnih i sekundarnih funkcija amina iz PA monomera, PRE-PA i kemijski modificiranih prvih i drugih sastojaka između 2 i 0,5.
23. Sastav prema bilo kojem od zahtjeva 1 do 21, za premazivanje površina stranih materijala koji se umeću u žive organizme na trajni ili privremeni rok.
24. Sastav prema bilo kojem od zahtjeva 1 do 21, kao nosač, modifikator ili zaštitnik živih stanica, bioloških i farmakoloških materijala i tvari.
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| IB2015054225 | 2015-06-04 | ||
| PCT/IB2015/056740 WO2016042434A1 (en) | 2014-09-18 | 2015-09-04 | Composition containing glycosaminoglycans and proteins |
| EP15778723.5A EP3193952B1 (en) | 2014-09-18 | 2015-09-04 | Composition containing glycosaminoglycans and proteins |
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| CN115850121A (zh) * | 2022-11-17 | 2023-03-28 | 中国科学院天津工业生物技术研究所 | 一种基于赤藓糖醇的聚氨酯预聚物及其合成和应用 |
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| US3072613A (en) | 1957-08-20 | 1963-01-08 | Union Carbide Corp | Multiple cyclic carbonate polymers |
| US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| US5475052A (en) * | 1988-11-21 | 1995-12-12 | Collagen Corporation | Collagen-synthetic polymer matrices prepared using a multiple step reaction |
| US6562781B1 (en) * | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
| ITPD980037A1 (it) * | 1998-02-25 | 1999-08-25 | Fidia Advanced Biopolymers Srl | Acido ialuronico solfatato e i suoi derivati legati covalentemente a polimeri sintetici pe la preparazione di biomateriali e per il rivesti |
| CN1454097A (zh) * | 2000-09-08 | 2003-11-05 | 格莱风治疗公司 | 聚合物修饰的合成的蛋白质类 |
| EP1384774A1 (en) * | 2001-04-02 | 2004-01-28 | Netech Inc. | Glycosaminoglycan/collagen complexes and use thereof |
| JP4464395B2 (ja) * | 2003-03-05 | 2010-05-19 | ヘイローザイム インコーポレイテッド | 可溶性ヒアルロニダーゼ糖タンパク質（ｓＨＡＳＥＧＰ）、その調製プロセス、使用およびそれを含む薬学的組成物 |
| EP1541568A1 (de) * | 2003-12-09 | 2005-06-15 | Deutsches Wollforschungsinstitut an der Rheinisch-Westfälischen Technischen Hochschule Aachen e.V. | Reaktive cyclische Carbonate und Harnstoffe zur Modifizierung von Biomolekülen, Polymeren und Oberflächen |
| US20070184087A1 (en) * | 2006-02-06 | 2007-08-09 | Bioform Medical, Inc. | Polysaccharide compositions for use in tissue augmentation |
| AU2008251338B2 (en) * | 2007-05-14 | 2013-11-14 | Covidien Lp | Biodegradable peptide releasing polymers |
| US20090068250A1 (en) * | 2007-09-07 | 2009-03-12 | Philippe Gravagna | Bioresorbable and biocompatible compounds for surgical use |
| JP5277233B2 (ja) * | 2010-11-19 | 2013-08-28 | 大日精化工業株式会社 | 熱可塑性ポリヒドロキシウレタンの製造方法 |
| US20130116411A1 (en) * | 2011-09-06 | 2013-05-09 | Allergan, Inc. | Methods of making hyaluronic acid/collagen compositions |
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| WO2016042434A1 (en) | 2016-03-24 |
| EA035414B1 (ru) | 2020-06-10 |
| PL3193952T3 (pl) | 2019-09-30 |
| JP6648142B2 (ja) | 2020-02-14 |
| EP3193952B1 (en) | 2019-05-08 |
| US20170296698A1 (en) | 2017-10-19 |
| IL251236A0 (en) | 2017-05-29 |
| US10478523B2 (en) | 2019-11-19 |
| CN106714856B (zh) | 2020-03-03 |
| CA2960832A1 (en) | 2016-03-24 |
| DK3193952T3 (da) | 2019-06-11 |
| ZA201701816B (en) | 2018-05-30 |
| ES2729301T3 (es) | 2019-10-31 |
| CN106714856A (zh) | 2017-05-24 |
| SG11201702160TA (en) | 2017-04-27 |
| AU2015316497B2 (en) | 2019-08-22 |
| JP2017528296A (ja) | 2017-09-28 |
| BR112017005338A2 (pt) | 2017-12-19 |
| IL251236B (en) | 2019-09-26 |
| EA201790574A1 (ru) | 2017-09-29 |
| EP3193952A1 (en) | 2017-07-26 |
| KR20170075723A (ko) | 2017-07-03 |
| HUE044268T2 (hu) | 2019-10-28 |
| BR112017005338B1 (pt) | 2021-04-06 |
| AU2015316497A1 (en) | 2017-04-06 |
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