HRP20181978T1 - Spoj fenil tetrahidroizokinolina supstituiran s heteroarilom - Google Patents

Spoj fenil tetrahidroizokinolina supstituiran s heteroarilom

Info

Publication number
HRP20181978T1
HRP20181978T1 HRP20181978TT HRP20181978T HRP20181978T1 HR P20181978 T1 HRP20181978 T1 HR P20181978T1 HR P20181978T T HRP20181978T T HR P20181978TT HR P20181978 T HRP20181978 T HR P20181978T HR P20181978 T1 HRP20181978 T1 HR P20181978T1
Authority
HR
Croatia
Prior art keywords
heteroaryl
compound substituted
tetrahydroisoquinoline compound
phenyl tetrahydroisoquinoline
phenyl
Prior art date
Application number
HRP20181978TT
Other languages
English (en)
Inventor
Shoichi Kuroda
Kenichi Kawabe
Yasunobu Ushiki
Hiroshi Ohta
Fumito Uneuchi
Tsuyoshi Shibata
Hideaki Tabuse
Eiji Munetomo
Sumi Chonan
Original Assignee
Taisho Pharmaceutical Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co., Ltd filed Critical Taisho Pharmaceutical Co., Ltd
Publication of HRP20181978T1 publication Critical patent/HRP20181978T1/hr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HRP20181978TT 2014-07-25 2018-11-26 Spoj fenil tetrahidroizokinolina supstituiran s heteroarilom HRP20181978T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2014151726 2014-07-25
JP2015051289 2015-03-13
PCT/JP2015/071111 WO2016013657A1 (ja) 2014-07-25 2015-07-24 ヘテロアリールで置換されたフェニルテトラヒドロイソキノリン化合物
EP15825310.4A EP3173408B1 (en) 2014-07-25 2015-07-24 Phenyl tetrahydroisoquinoline compound substituted with heteroaryl

Publications (1)

Publication Number Publication Date
HRP20181978T1 true HRP20181978T1 (hr) 2019-01-25

Family

ID=55163179

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20181978TT HRP20181978T1 (hr) 2014-07-25 2018-11-26 Spoj fenil tetrahidroizokinolina supstituiran s heteroarilom

Country Status (27)

Country Link
US (1) US9932331B2 (hr)
EP (1) EP3173408B1 (hr)
JP (1) JP6292307B2 (hr)
KR (1) KR102386666B1 (hr)
CN (1) CN106536502B (hr)
AU (1) AU2015293134B2 (hr)
BR (1) BR112017000691B1 (hr)
CA (1) CA2955572C (hr)
CY (1) CY1121401T1 (hr)
DK (1) DK3173408T3 (hr)
ES (1) ES2701498T3 (hr)
HR (1) HRP20181978T1 (hr)
IL (1) IL250117B (hr)
LT (1) LT3173408T (hr)
ME (1) ME03311B (hr)
MX (1) MX2017001117A (hr)
MY (1) MY182318A (hr)
PH (1) PH12017500119A1 (hr)
PL (1) PL3173408T3 (hr)
PT (1) PT3173408T (hr)
RS (1) RS58378B1 (hr)
RU (1) RU2703456C2 (hr)
SG (1) SG11201700398RA (hr)
SI (1) SI3173408T1 (hr)
TW (1) TWI666206B (hr)
WO (1) WO2016013657A1 (hr)
ZA (1) ZA201700563B (hr)

Families Citing this family (4)

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JP6903923B2 (ja) * 2016-01-22 2021-07-14 大正製薬株式会社 ヘテロアリールで置換されたフェニルテトラヒドロイソキノリン化合物を有効成分として含有する医薬
EA201991676A1 (ru) * 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
CN109012748B (zh) * 2018-07-27 2021-03-16 安徽师范大学 吡啶取代吡咯基稀土金属催化剂及其制备方法和应用
EP4149471A1 (en) * 2020-06-30 2023-03-22 Prosetta Biosciences, Inc. Isoquinoline derivatives, methods of synthesis and uses thereof

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DE19945302A1 (de) 1999-09-22 2001-03-29 Merck Patent Gmbh Biphenylderivate als NHE-3-Inhibitoren
DE10015248A1 (de) 2000-03-28 2001-10-04 Merck Patent Gmbh Bisamidino-Verbindungen als NHE-3 Inhibitoren
DE10019062A1 (de) 2000-04-18 2001-10-25 Merck Patent Gmbh 2-Guanidino-4-aryl-chinazoline als NHE-3 Inhibitoren
US6911453B2 (en) 2001-12-05 2005-06-28 Aventis Pharma Deutschland Gmbh Substituted 4-phenyltetrahydroisoquinolinium, process for their preparation, their use as a medicament, and medicament containing them
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US20030187045A1 (en) 2001-12-21 2003-10-02 Uwe Heinelt Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic
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Also Published As

Publication number Publication date
IL250117A0 (en) 2017-03-30
AU2015293134B2 (en) 2019-01-24
KR20170034897A (ko) 2017-03-29
LT3173408T (lt) 2018-12-27
PH12017500119A1 (en) 2017-05-29
US20170210736A1 (en) 2017-07-27
TW201617332A (zh) 2016-05-16
CN106536502A (zh) 2017-03-22
BR112017000691A2 (pt) 2017-11-14
RU2703456C2 (ru) 2019-10-17
CA2955572C (en) 2022-05-31
CA2955572A1 (en) 2016-01-28
ME03311B (me) 2019-10-20
CN106536502B (zh) 2019-03-05
CY1121401T1 (el) 2020-05-29
NZ728313A (en) 2020-09-25
JPWO2016013657A1 (ja) 2017-04-27
BR112017000691B1 (pt) 2023-02-14
EP3173408A4 (en) 2017-12-06
MY182318A (en) 2021-01-19
SG11201700398RA (en) 2017-02-27
EP3173408A1 (en) 2017-05-31
RU2017105836A (ru) 2018-08-27
JP6292307B2 (ja) 2018-03-14
AU2015293134A1 (en) 2017-02-09
DK3173408T3 (en) 2019-03-04
KR102386666B1 (ko) 2022-04-15
RS58378B1 (sr) 2019-04-30
SI3173408T1 (sl) 2019-01-31
PT3173408T (pt) 2019-02-12
PL3173408T3 (pl) 2019-05-31
TWI666206B (zh) 2019-07-21
MX2017001117A (es) 2017-05-08
US9932331B2 (en) 2018-04-03
RU2017105836A3 (hr) 2018-10-31
IL250117B (en) 2019-10-31
ZA201700563B (en) 2018-07-25
EP3173408B1 (en) 2018-11-21
WO2016013657A1 (ja) 2016-01-28
ES2701498T3 (es) 2019-02-22

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