HRP20180560T1 - Peptidi derivati ezrina i njihove farmaceutske kompozicije - Google Patents
Peptidi derivati ezrina i njihove farmaceutske kompozicije Download PDFInfo
- Publication number
- HRP20180560T1 HRP20180560T1 HRP20180560TT HRP20180560T HRP20180560T1 HR P20180560 T1 HRP20180560 T1 HR P20180560T1 HR P20180560T T HRP20180560T T HR P20180560TT HR P20180560 T HRP20180560 T HR P20180560T HR P20180560 T1 HRP20180560 T1 HR P20180560T1
- Authority
- HR
- Croatia
- Prior art keywords
- peptide
- pharmaceutical composition
- protection according
- seq
- amino acid
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 15
- 239000008194 pharmaceutical composition Substances 0.000 title claims 11
- 102100020903 Ezrin Human genes 0.000 title 1
- 108010055671 ezrin Proteins 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 150000001413 amino acids Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 2
- 208000025865 Ulcer Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 230000036269 ulceration Effects 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 206010022714 Intestinal ulcer Diseases 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 206010023799 Large intestinal ulcer Diseases 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 210000004347 intestinal mucosa Anatomy 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4735—Villin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Rehabilitation Therapy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (14)
1. Peptid koji sadrži aminokiselinsku sekvencu opće formule (I)
X1EKKRRETVEREX2X3 (SEQ ID No:5)
naznačeno time da svaki od X1, X2 i X3 predstavlja nepolarni aminokiselinski ostatak i naznačeno time da je aminokiselinska sekvenca dužine 14 do 25 ostataka.
2. Peptid kao što je tražena zaštita prema patentnom zahtjevu 1, naznačeno time da je nepolarna aminokiselina nezavisno izabrana iz grupe koja se sastoji od glicina, alanina, valina, leucina, metionina, izoleucina, prolina, fenilalanina, triptofana, i/ili njihovih kombinacija.
3. Peptid kao što je tražena zaštita prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, naznačeno time da X1, X2 i X3 je glicin.
4. Peptid kao što je tražena zaštita prema patentnom zahtjevu 3, naznačeno time da je aminokiselinska sekvenca GEKKRRETVEREGG (SEQ ID No: 1).
5. Farmaceutska kompozicija, koja sadrži efikasnu količinu peptida kao što je tražena zaštita prema bilo kojem od patentnih zahtjeva 1 do 4, i farmaceutski prihvatljiv nosač ili punjač.
6. Farmaceutska kompozicija kao što je tražena zaštita prema patentnom zahtjevu 5, koja dodatno sadrži efikasnu količinu peptida prema SEQ ID No. 2 (TEKKRRETVEREKE).
7. Farmaceutska kompozicija kao što je tražena zaštita prema patentnom zahtjevu 5, koja dodatno sadrži efikasnu količinu peptida prema SEQ ID No.3 (TEKKR).
8. Farmaceutska kompozicija kao što je tražena zaštita prema patentnom zahtjevu 5, koja dodatno sadrži efikasnu količinu peptida prema SEQ ID No. 4 (RETVEREKE).
9. Peptid kao što je tražena zaštita prema bilo kojem od patentnih zahtjeva 1 do 4, ili farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 5 do 8, za uporabu u stimuliranju imunološkog odgovora kod subjekta.
10. Peptid kao što je tražena zaštita prema bilo kojem od patentnih zahteva 1 do 4, ili farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 5 do 8, za uporabu u tretmanu ili prevenciji virusne, bakterijske ili gljivične infekcije.
11. Peptid kao što je tražena zaštita prema bilo kojem od patentnih zahtjeva 1 do 4, ili farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 5 do 8, za uporabu u tretmanu ili prevenciji ulceracije mukoznih membrana crijeva.
12. Peptid ili farmaceutska kompozicija za uporabu kao što je tražena zaštita prema patentnom zahtjevu 11, naznačeno time da je ulceracija mukozne membrane crijeva čir želuca, čir debelog crijeva, čir dvanaesnika, ili čir tankog crijeva.
13. Peptid kao što je tražena zaštita prema bilo kojem od patentnih zahteva 1 do 4, ili farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 5 do 8, za uporabu u tretmanu ili prevenciji upalne bolesti crijeva ili bolesti ili poremećaja povezanog s upalnom bolesti crijeva.
14. Peptid ili farmaceutska kompozicija za uporabu kao što je tražena zaštita prema patentnom zahtjevu 13, gdje je bolest ili poremećaj povezan s upalnom bolesti crijeva izabran iz grupe koja se sastoji od sindroma iritabilnog crijeva (IBS), ulceroznog kolitisa i Crohn-ove bolesti.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2015120667 | 2015-06-01 | ||
| PCT/EP2016/062336 WO2016193285A1 (en) | 2015-06-01 | 2016-06-01 | Ezrin-derived peptides and pharmaceutical compositions thereof |
| EP16728271.4A EP3191504B1 (en) | 2015-06-01 | 2016-06-01 | Ezrin-derived peptides and pharmaceutical compositions thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20180560T1 true HRP20180560T1 (hr) | 2018-05-04 |
Family
ID=56117690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20180560TT HRP20180560T1 (hr) | 2015-06-01 | 2018-04-06 | Peptidi derivati ezrina i njihove farmaceutske kompozicije |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9682140B2 (hr) |
| EP (1) | EP3191504B1 (hr) |
| JP (1) | JP6721419B2 (hr) |
| KR (1) | KR101842978B1 (hr) |
| CN (1) | CN106188267B (hr) |
| AU (1) | AU2016203656B2 (hr) |
| BR (1) | BR102016012501A2 (hr) |
| CA (1) | CA2931875C (hr) |
| CY (1) | CY1120501T1 (hr) |
| DK (1) | DK3191504T3 (hr) |
| ES (1) | ES2660894T3 (hr) |
| GB (1) | GB2546439B (hr) |
| HR (1) | HRP20180560T1 (hr) |
| HU (1) | HUE038737T2 (hr) |
| LT (1) | LT3191504T (hr) |
| MA (1) | MA39421A (hr) |
| MD (1) | MD3191504T2 (hr) |
| ME (1) | ME03033B (hr) |
| MX (1) | MX2016007122A (hr) |
| PL (1) | PL3191504T3 (hr) |
| PT (1) | PT3191504T (hr) |
| RS (1) | RS57067B1 (hr) |
| SG (1) | SG10201604401UA (hr) |
| SI (1) | SI3191504T1 (hr) |
| WO (1) | WO2016193285A1 (hr) |
| ZA (1) | ZA201603723B (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11174288B2 (en) | 2016-12-06 | 2021-11-16 | Northeastern University | Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria |
| CN106596977B (zh) * | 2017-02-08 | 2018-06-08 | 南京医科大学第一附属医院 | ezrin在制备哮喘诊断试剂中的应用 |
| WO2021198346A2 (en) | 2020-04-01 | 2021-10-07 | Dr. Nesselhut Besitzgesellschaft Mbh | Ezrin peptide 1 for use in a method of treating covid-19 |
| JP2024511660A (ja) | 2021-03-31 | 2024-03-14 | パンタファルム・アー・ゲー | ポストｃｏｖｉｄ－１９を治療する方法における使用のためのエズリンペプチド１ |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2290293A (en) * | 1994-06-08 | 1995-12-20 | Rupert Donald Holms | Preparation which inhibits the autoimmune response in HIV, or SLE, patients |
| GB2354241A (en) * | 1999-09-17 | 2001-03-21 | Rupert Donald Holms | Regulatory/unfolding peptides of ezrin |
| GB0301879D0 (en) | 2003-01-27 | 2003-02-26 | Regent Res Llp | HCV combination therapy |
| WO2007060440A2 (en) | 2005-11-23 | 2007-05-31 | Regent Research L.L.P. | The use of peptides in anti-ulcer therapy |
-
2016
- 2016-06-01 BR BR102016012501A patent/BR102016012501A2/pt active IP Right Grant
- 2016-06-01 MA MA039421A patent/MA39421A/fr unknown
- 2016-06-01 LT LTEP16728271.4T patent/LT3191504T/lt unknown
- 2016-06-01 PT PT167282714T patent/PT3191504T/pt unknown
- 2016-06-01 CA CA2931875A patent/CA2931875C/en active Active
- 2016-06-01 WO PCT/EP2016/062336 patent/WO2016193285A1/en active Application Filing
- 2016-06-01 DK DK16728271.4T patent/DK3191504T3/en active
- 2016-06-01 GB GB1705990.8A patent/GB2546439B/en active Active
- 2016-06-01 SG SG10201604401UA patent/SG10201604401UA/en unknown
- 2016-06-01 MX MX2016007122A patent/MX2016007122A/es active IP Right Grant
- 2016-06-01 SI SI201630027T patent/SI3191504T1/en unknown
- 2016-06-01 KR KR1020160068187A patent/KR101842978B1/ko active IP Right Grant
- 2016-06-01 PL PL16728271T patent/PL3191504T3/pl unknown
- 2016-06-01 US US15/170,362 patent/US9682140B2/en active Active
- 2016-06-01 HU HUE16728271A patent/HUE038737T2/hu unknown
- 2016-06-01 JP JP2016110444A patent/JP6721419B2/ja active Active
- 2016-06-01 ES ES16728271.4T patent/ES2660894T3/es active Active
- 2016-06-01 RS RS20180392A patent/RS57067B1/sr unknown
- 2016-06-01 AU AU2016203656A patent/AU2016203656B2/en active Active
- 2016-06-01 ME MEP-2018-96A patent/ME03033B/me unknown
- 2016-06-01 MD MDE20170043T patent/MD3191504T2/ro unknown
- 2016-06-01 CN CN201610384013.2A patent/CN106188267B/zh active Active
- 2016-06-01 EP EP16728271.4A patent/EP3191504B1/en active Active
- 2016-06-01 ZA ZA2016/03723A patent/ZA201603723B/en unknown
-
2018
- 2018-03-26 CY CY20181100335T patent/CY1120501T1/el unknown
- 2018-04-06 HR HRP20180560TT patent/HRP20180560T1/hr unknown
Also Published As
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