HRP20151413T1 - Neimunosupresivni ciklosporin za lijeäśenje pojasne mišiä†ne distrofije ekstremiteta - Google Patents
Neimunosupresivni ciklosporin za lijeäśenje pojasne mišiä†ne distrofije ekstremiteta Download PDFInfo
- Publication number
- HRP20151413T1 HRP20151413T1 HRP20151413TT HRP20151413T HRP20151413T1 HR P20151413 T1 HRP20151413 T1 HR P20151413T1 HR P20151413T T HRP20151413T T HR P20151413TT HR P20151413 T HRP20151413 T HR P20151413T HR P20151413 T1 HRP20151413 T1 HR P20151413T1
- Authority
- HR
- Croatia
- Prior art keywords
- treatment
- muscular dystrophy
- immunosuppressive cyclosporin
- meleu
- cyclosporin
- Prior art date
Links
- 201000006938 muscular dystrophy Diseases 0.000 title claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
- 229930105110 Cyclosporin A Natural products 0.000 title 1
- 108010036949 Cyclosporine Proteins 0.000 title 1
- 229960001265 ciclosporin Drugs 0.000 title 1
- 229930182912 cyclosporin Natural products 0.000 title 1
- XJODGRWDFZVTKW-LURJTMIESA-N (2s)-4-methyl-2-(methylamino)pentanoic acid Chemical group CN[C@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-LURJTMIESA-N 0.000 claims 3
- AHQFCPOIMVMDEZ-UNISNWAASA-N (e,2s,3r,4r)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoic acid Chemical group CN[C@H](C(O)=O)[C@H](O)[C@H](C)C\C=C\C AHQFCPOIMVMDEZ-UNISNWAASA-N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (1)
1. Ciklički undekapeptid sljedeće formule:
[image]
gdje
W je MeBmt;
X je αAbu;
R je (D)-MeAla; Y je N-etilVal (EtVal); Z je Val; Q je MeLeu;
T1 je (D)Ala;
T2 je MeLeu; i
T3 je MeLeu
za uporabu u liječenju pojasne mišićne distrofije ekstremiteta.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2008/000292 WO2009098533A1 (en) | 2008-02-08 | 2008-02-08 | Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy |
| PCT/IB2009/000204 WO2009098577A2 (en) | 2008-02-08 | 2009-02-05 | Non-immunosuppressive cyclosporin for the treatment of muscular dystrophy |
| EP09707226.8A EP2249860B8 (en) | 2008-02-08 | 2009-02-05 | Non-immunosuppressive cyclosporin for the treatment of limb-girdle muscular dystrophy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20151413T1 true HRP20151413T1 (hr) | 2016-02-12 |
Family
ID=39951648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151413TT HRP20151413T1 (hr) | 2008-02-08 | 2015-12-23 | Neimunosupresivni ciklosporin za lijeäśenje pojasne mišiä†ne distrofije ekstremiteta |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20100323972A1 (hr) |
| EP (1) | EP2249860B8 (hr) |
| JP (1) | JP5536673B2 (hr) |
| KR (1) | KR101633772B1 (hr) |
| CN (1) | CN101939021B (hr) |
| AU (1) | AU2009211129B2 (hr) |
| BR (1) | BRPI0908376A8 (hr) |
| CA (1) | CA2713416C (hr) |
| CY (1) | CY1120000T1 (hr) |
| DK (1) | DK2249860T3 (hr) |
| EA (1) | EA021701B1 (hr) |
| ES (1) | ES2558710T3 (hr) |
| HK (1) | HK1148665A1 (hr) |
| HR (1) | HRP20151413T1 (hr) |
| HU (1) | HUE026567T2 (hr) |
| IL (1) | IL207477A (hr) |
| MA (1) | MA32129B1 (hr) |
| MX (1) | MX2010008533A (hr) |
| PL (1) | PL2249860T3 (hr) |
| PT (1) | PT2249860E (hr) |
| RS (1) | RS54494B1 (hr) |
| SI (1) | SI2249860T1 (hr) |
| TN (1) | TN2010000342A1 (hr) |
| UA (1) | UA101177C2 (hr) |
| WO (2) | WO2009098533A1 (hr) |
| ZA (1) | ZA201005483B (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105056207A (zh) * | 2007-01-04 | 2015-11-18 | 德比奥法姆国际股份有限公司 | 用于治疗Ullrich先天性肌营养不良的非免疫抑制性环孢霉素 |
| WO2011141891A1 (en) | 2010-05-12 | 2011-11-17 | Debio Recherche Pharmaceutique S.A. | Use of cycloundecadepsipeptide compounds |
| AU2013259841A1 (en) | 2012-05-07 | 2014-10-30 | Novartis Ag | Pharmacokinetic modulation with alisporivir |
| AR090964A1 (es) | 2012-05-09 | 2014-12-17 | Novartis Ag | Proceso para la elaboracion de undecapeptidos ciclicos |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1091975T3 (da) * | 1998-07-01 | 2006-04-18 | Debiopharm Sa | Ny cyclosporin med forbedret aktivitetsprofil |
| IL158385A0 (en) * | 2001-04-20 | 2004-05-12 | Debiopharm Sa | Modified cyclosporin which can be used as a pro-drug and use thereof |
| JP4892486B2 (ja) * | 2004-10-01 | 2012-03-07 | デビオファーム ソシエテ アノニム | Ｃ型肝炎感染の治療のための［ｄ−ｍｅａｌａ］３−［ｅｔｖａｌ］４−シクロスポリンの使用、及び当該［ｄ−ｍｅａｌａ］３−［ｅｔｖａｌ］４−シクロスポリンを含む医薬組成物 |
| PT1853296E (pt) * | 2005-01-10 | 2012-09-26 | Debiopharm Sa | Utilização de um undecapeptídeo cíclico para a preparação de um medicamento para administração em situações de miocardia isquêmica |
| CN105056207A (zh) * | 2007-01-04 | 2015-11-18 | 德比奥法姆国际股份有限公司 | 用于治疗Ullrich先天性肌营养不良的非免疫抑制性环孢霉素 |
-
2008
- 2008-02-08 WO PCT/IB2008/000292 patent/WO2009098533A1/en active Application Filing
-
2009
- 2009-02-05 CN CN2009801043707A patent/CN101939021B/zh not_active Expired - Fee Related
- 2009-02-05 HU HUE09707226A patent/HUE026567T2/hu unknown
- 2009-02-05 US US12/866,844 patent/US20100323972A1/en not_active Abandoned
- 2009-02-05 EA EA201070945A patent/EA021701B1/ru not_active IP Right Cessation
- 2009-02-05 EP EP09707226.8A patent/EP2249860B8/en active Active
- 2009-02-05 RS RS20160008A patent/RS54494B1/en unknown
- 2009-02-05 SI SI200931348T patent/SI2249860T1/sl unknown
- 2009-02-05 JP JP2010545572A patent/JP5536673B2/ja not_active Expired - Fee Related
- 2009-02-05 CA CA2713416A patent/CA2713416C/en not_active Expired - Fee Related
- 2009-02-05 ES ES09707226.8T patent/ES2558710T3/es active Active
- 2009-02-05 PL PL09707226T patent/PL2249860T3/pl unknown
- 2009-02-05 AU AU2009211129A patent/AU2009211129B2/en not_active Ceased
- 2009-02-05 PT PT97072268T patent/PT2249860E/pt unknown
- 2009-02-05 KR KR1020107019296A patent/KR101633772B1/ko active IP Right Grant
- 2009-02-05 MX MX2010008533A patent/MX2010008533A/es active IP Right Grant
- 2009-02-05 UA UAA201010796A patent/UA101177C2/ru unknown
- 2009-02-05 WO PCT/IB2009/000204 patent/WO2009098577A2/en active Application Filing
- 2009-02-05 DK DK09707226.8T patent/DK2249860T3/en active
- 2009-02-05 BR BRPI0908376A patent/BRPI0908376A8/pt not_active Application Discontinuation
-
2010
- 2010-07-21 TN TNP2010000342A patent/TN2010000342A1/fr unknown
- 2010-07-30 ZA ZA2010/05483A patent/ZA201005483B/en unknown
- 2010-08-08 IL IL207477A patent/IL207477A/en not_active IP Right Cessation
- 2010-09-01 MA MA33133A patent/MA32129B1/fr unknown
-
2011
- 2011-03-17 HK HK11102700.4A patent/HK1148665A1/xx not_active IP Right Cessation
-
2015
- 2015-12-23 HR HRP20151413TT patent/HRP20151413T1/hr unknown
-
2016
- 2016-01-11 CY CY20161100018T patent/CY1120000T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20151413T1 (hr) | Neimunosupresivni ciklosporin za lijeäśenje pojasne mišiä†ne distrofije ekstremiteta | |
| JP2016516023A5 (hr) | ||
| EP2528934A4 (en) | AROMATIC-CATIONIC PEPTIDES AND USES THEREOF | |
| Bhattacharjya et al. | Polymyxin B nonapeptide: Conformations in water and in the lipopolysaccharide‐bound state determined by two‐dimensional NMR and molecular dynamics | |
| MA31666B1 (fr) | Cyclic peptide cxcr4 antagonists | |
| MX346193B (es) | Composiciones farmaceuticas. | |
| EP4198041A3 (en) | Cosmetic peptides | |
| NO20061479L (no) | Anvendelse av modifiserte cyklosporiner for behandling av HCV-forstyrrelser | |
| EA201290395A1 (ru) | Иммуномодулирующие полипептиды, полученные из il-2, и их применение для лечения рака и хронических инфекций | |
| EP3064220A3 (en) | Compositions and methods for the treatment of infections and tumors | |
| EP2314274A3 (en) | Compositions comprising a superhydrophilic amphiphilic copolymer and a micellar thickener | |
| DK3692995T3 (da) | Deoxycholat til reduktion af fedt | |
| NZ593204A (en) | Cycloundecadepsipeptide compounds and use of said compounds as a medicament | |
| SG161202A1 (en) | Methods and related compositions for reduction of fat and skin tightening | |
| RS52845B (en) | TREATMENT PROCEDURES USING GLYCOPEGILATED G-CSF | |
| RU2013113184A (ru) | Комбинированное лечение розацеа | |
| EA201001569A1 (ru) | Инкапсуляция биологически активных агентов | |
| TNSN07240A1 (en) | Compounds for flaviviridae treatment | |
| ATE546147T1 (de) | Zusammensetzungen und verfahren zur behandlung und vorbeugung von kardiomyopathie und herzerkrankung | |
| WO2006036729A3 (en) | USE OF TGF-β ANTAGONISTS TO LIMIT NEPHROTOXICITY OF IMMUNOSUPPRESSIVE AGENTS | |
| SG10201908916UA (en) | Stable MIA/CD-RAP formulations | |
| MX2012007896A (es) | Derivados de piridino-piridinonas arilsulfonamidas, su preparacion y su uso en terapeutica. | |
| JP2010514834A5 (hr) | ||
| WO2010093993A3 (en) | Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance | |
| EP3363454A3 (en) | Treatment of diseases related to hyperactivity of the complement system |