SG10201908916UA - Stable MIA/CD-RAP formulations - Google Patents
Stable MIA/CD-RAP formulationsInfo
- Publication number
- SG10201908916UA SG10201908916UA SG10201908916UA SG10201908916UA SG 10201908916U A SG10201908916U A SG 10201908916UA SG 10201908916U A SG10201908916U A SG 10201908916UA SG 10201908916U A SG10201908916U A SG 10201908916UA
- Authority
- SG
- Singapore
- Prior art keywords
- rap
- formulations
- stable
- mia
- formulation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Abstract
STABLE MIA/CD-RAP FORMULATIONS The present invention relates to stable aqueous formulations comprising at least 5 mg/mL CD- RAP and a charged amino acid, said amino acid preferably having a net charge at a pH between 5 about 6 and 8. The ingredients of the formulation preferably provide stability over repeated freeze-thaw cycles. In a preferred aspect, the formulation is for use in therapy, preferably for use in the treatment of inflammatory disorders, preferably osteoarthritis. Furthermore, a kit comprising the formulation of the invention is provided. (Fig 1) 10
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10161160 | 2010-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201908916UA true SG10201908916UA (en) | 2019-11-28 |
Family
ID=43806879
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201908916U SG10201908916UA (en) | 2010-04-27 | 2011-04-27 | Stable MIA/CD-RAP formulations |
SG10201502398RA SG10201502398RA (en) | 2010-04-27 | 2011-04-27 | Stable MIA/CD-RAP formulations |
SG2012064804A SG183561A1 (en) | 2010-04-27 | 2011-04-27 | Stable aqueous mia/cd-rap formulations |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201502398RA SG10201502398RA (en) | 2010-04-27 | 2011-04-27 | Stable MIA/CD-RAP formulations |
SG2012064804A SG183561A1 (en) | 2010-04-27 | 2011-04-27 | Stable aqueous mia/cd-rap formulations |
Country Status (20)
Country | Link |
---|---|
US (2) | US9511116B2 (en) |
EP (1) | EP2563809B1 (en) |
JP (2) | JP2013525406A (en) |
KR (1) | KR101880905B1 (en) |
CN (1) | CN102869679B (en) |
AU (1) | AU2011247659B2 (en) |
BR (1) | BR112012027361A2 (en) |
CA (1) | CA2792965A1 (en) |
CL (1) | CL2012002948A1 (en) |
CO (1) | CO6592098A2 (en) |
HK (1) | HK1179273A1 (en) |
IL (1) | IL222712B (en) |
MA (1) | MA34225B1 (en) |
MX (1) | MX344732B (en) |
MY (1) | MY160916A (en) |
NZ (1) | NZ601927A (en) |
RU (2) | RU2588658C2 (en) |
SG (3) | SG10201908916UA (en) |
WO (1) | WO2011134979A2 (en) |
ZA (1) | ZA201206235B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10201908916UA (en) * | 2010-04-27 | 2019-11-28 | Scil Tech Gmbh | Stable MIA/CD-RAP formulations |
WO2014098232A1 (en) * | 2012-12-21 | 2014-06-26 | Yamashita Chikamasa | Pharmaceutical composition comprising pi3 kinase inhibitor, pharmaceutical composition comprising compound which acts on vitamin d receptor, freeze-dried composition, method for producing freeze-dried composition, and pharmaceutical composition for transpulmonary administration |
US10206878B2 (en) * | 2014-05-28 | 2019-02-19 | Nono Inc. | Lyophilized formulation of TAT-NR2B9C with acetylation scavenger |
WO2017046314A2 (en) * | 2015-09-18 | 2017-03-23 | Sanofi | Improvement of expression and folding in the manufacturing process of cd-rap by using a cd-rap precursor protein |
US10279048B2 (en) * | 2016-07-13 | 2019-05-07 | Reform Biologics, Llc | Stabilizing excipients for therapeutic protein formulations |
WO2018101358A1 (en) * | 2016-11-29 | 2018-06-07 | Spiber株式会社 | Protein composition, method for producing same and method for improving heat stability |
JP7179717B2 (en) * | 2017-03-31 | 2022-11-29 | Meiji Seikaファルマ株式会社 | Aqueous formulation, aqueous formulation containing syringe, antibody protein disaggregation agent, and antibody protein disaggregation method |
KR20190066941A (en) | 2017-12-06 | 2019-06-14 | 주식회사 에코에너젠 | Reduction apparatus for complex pollutants from semiconductor process |
CN112386575B (en) * | 2019-08-19 | 2023-03-21 | 鲁南制药集团股份有限公司 | Freeze-dried preparation of metabolism regulation fusion protein |
KR102427935B1 (en) | 2022-05-23 | 2022-08-03 | 주식회사 동우이엔티 | Wet electrostatic precipitation system capable of simultaneous treatment of complex gas mixed with particulate and gaseous pollutants including wet scrubber |
Family Cites Families (30)
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JPS54147916A (en) * | 1978-05-12 | 1979-11-19 | Sumitomo Chem Co Ltd | Preparation of urokinase injection |
DE2916711A1 (en) | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blood coagulation factors and process for their manufacture |
US4783441A (en) | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
US4374763A (en) * | 1979-09-17 | 1983-02-22 | Morishita Pharmaceutical Co., Ltd. | Method for producing gamma-globulin for use in intravenous administration and method for producing a pharmaceutical preparation thereof |
EP0158487B1 (en) | 1984-04-09 | 1991-08-28 | Takeda Chemical Industries, Ltd. | Stable composition of interleukin-2 |
US4877608A (en) * | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
GB8903593D0 (en) | 1989-02-16 | 1989-04-05 | Pafra Ltd | Storage of materials |
FR2684878B1 (en) * | 1991-12-12 | 1994-02-11 | Roussel Uclaf | STABILIZED PHARMACEUTICAL COMPOSITION OF RECOMBINANT, NON-GLYCOSYLATED HUMAN IL2 IN REDUCED FORM AND PROCESS FOR PREPARING THE SAME. |
DE4242863A1 (en) * | 1992-12-18 | 1994-06-23 | Boehringer Mannheim Gmbh | Stable lyophilized pharmaceutical preparations of G-CSF |
CA2167693C (en) | 1993-07-20 | 2007-01-30 | Ulrich Bogdahn | Melanoma-inhibiting protein |
US5580856A (en) | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
US6685940B2 (en) * | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
JPH11510170A (en) * | 1995-07-27 | 1999-09-07 | ジェネンテック インコーポレーテッド | Protein Formula |
US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
AU5702099A (en) | 1998-09-01 | 2000-03-21 | Millennium Pharmaceuticals, Inc. | A novel protein related to melanoma-inhibiting protein and uses thereof |
US20020103360A1 (en) * | 1998-09-01 | 2002-08-01 | Yang Pan | Novel protein related to melanoma-inhibiting protein and uses thereof |
EP1025871A1 (en) | 1999-01-28 | 2000-08-09 | F. Hoffmann-La Roche Ag | Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair |
CZ299516B6 (en) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Erythropoietin glycoprotein conjugate, process for its preparation and use and pharmaceutical composition containing thereof |
RU2197238C2 (en) * | 1999-11-22 | 2003-01-27 | Российский научный центр "Восстановительная травматология и ортопедия" им. академика Г.А. Илизарова | Method of prophylaxis and treatment of osteoarthrosis, agent for its realization and method of preparing agent for osteoarthrosis treatment |
US6743446B2 (en) * | 1999-12-15 | 2004-06-01 | The Ohio State University Research Foundation | Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers |
AU2001232967A1 (en) | 2000-01-25 | 2001-08-07 | Hyseq, Inc. | Methods and materials relating to novel growth regulatory-like polypeptides and polynucleotides |
BR0109455A (en) | 2000-03-23 | 2003-06-03 | Akzo Nobel Nv | Use of mia and / or its fragments, method for treating mammals suffering from, or susceptible to, an inflammatory disease, peptide, pharmaceutical composition, and, use of peptides. |
EP1450847B1 (en) * | 2001-11-13 | 2010-09-29 | Genentech, Inc. | APO2 ligand/ TRAIL formulations and uses thereof |
JP4583762B2 (en) * | 2002-02-27 | 2010-11-17 | イミュネックス・コーポレーション | Polypeptide preparation |
AU2003259696A1 (en) * | 2002-08-08 | 2004-02-25 | Nuvelo, Inc. | Methods and materials relating to novel growth regulatory-like polypeptides and polynucleotides |
DE10360483B4 (en) | 2003-12-22 | 2007-11-15 | Scil Proteins Gmbh | Expression vector and its use |
TW200806317A (en) * | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
TWI455731B (en) * | 2006-10-06 | 2014-10-11 | Scil Technology Gmbh | Dried reconstituted vesicle formation for pharmaceutical application |
CL2008000058A1 (en) * | 2007-01-09 | 2008-05-23 | Wyeth Corp | FORMULATION THAT INCLUDES AN ANTI-IL13 ANTIBODY, A CRIPROTECTOR, AND A DAMPING SOLUTION; PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT; METHOD TO TREAT AN IL13-RELATED DISORDER; AND PHARMACEUTICAL FORMS THAT UNDERSTAND IT. |
SG10201908916UA (en) * | 2010-04-27 | 2019-11-28 | Scil Tech Gmbh | Stable MIA/CD-RAP formulations |
-
2011
- 2011-04-27 SG SG10201908916U patent/SG10201908916UA/en unknown
- 2011-04-27 MX MX2012012115A patent/MX344732B/en active IP Right Grant
- 2011-04-27 BR BR112012027361-2A patent/BR112012027361A2/en not_active Application Discontinuation
- 2011-04-27 MA MA35359A patent/MA34225B1/en unknown
- 2011-04-27 JP JP2013506644A patent/JP2013525406A/en active Pending
- 2011-04-27 AU AU2011247659A patent/AU2011247659B2/en not_active Ceased
- 2011-04-27 SG SG10201502398RA patent/SG10201502398RA/en unknown
- 2011-04-27 RU RU2012144771/10A patent/RU2588658C2/en active
- 2011-04-27 SG SG2012064804A patent/SG183561A1/en unknown
- 2011-04-27 EP EP11716269.3A patent/EP2563809B1/en active Active
- 2011-04-27 WO PCT/EP2011/056622 patent/WO2011134979A2/en active Application Filing
- 2011-04-27 CN CN201180021207.1A patent/CN102869679B/en not_active Expired - Fee Related
- 2011-04-27 RU RU2016118646A patent/RU2739078C2/en active
- 2011-04-27 NZ NZ601927A patent/NZ601927A/en not_active IP Right Cessation
- 2011-04-27 MY MYPI2012004713A patent/MY160916A/en unknown
- 2011-04-27 CA CA2792965A patent/CA2792965A1/en not_active Abandoned
- 2011-04-27 KR KR1020127031092A patent/KR101880905B1/en active IP Right Grant
-
2012
- 2012-08-20 ZA ZA2012/06235A patent/ZA201206235B/en unknown
- 2012-09-07 CO CO12153702A patent/CO6592098A2/en not_active Application Discontinuation
- 2012-10-22 CL CL2012002948A patent/CL2012002948A1/en unknown
- 2012-10-25 IL IL222712A patent/IL222712B/en active IP Right Grant
- 2012-10-26 US US13/661,743 patent/US9511116B2/en active Active
-
2013
- 2013-05-28 HK HK13106354.2A patent/HK1179273A1/en not_active IP Right Cessation
-
2015
- 2015-09-10 JP JP2015178485A patent/JP6078129B2/en not_active Expired - Fee Related
-
2016
- 2016-10-27 US US15/336,155 patent/US9907829B2/en not_active Expired - Fee Related
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