HRP20131015T1 - Mikobakterijski antigeni - Google Patents
Mikobakterijski antigeni Download PDFInfo
- Publication number
- HRP20131015T1 HRP20131015T1 HRP20131015AT HRP20131015T HRP20131015T1 HR P20131015 T1 HRP20131015 T1 HR P20131015T1 HR P20131015A T HRP20131015A T HR P20131015AT HR P20131015 T HRP20131015 T HR P20131015T HR P20131015 T1 HRP20131015 T1 HR P20131015T1
- Authority
- HR
- Croatia
- Prior art keywords
- seq
- diagnostic reagent
- kit
- peptide
- diagnostic
- Prior art date
Links
- 241000186359 Mycobacterium Species 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 239000003153 chemical reaction reagent Substances 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 241000589343 Methylobacter luteus Species 0.000 claims 6
- 238000009007 Diagnostic Kit Methods 0.000 claims 4
- 230000024932 T cell mediated immunity Effects 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/5695—Mycobacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (14)
1. Dijagnostički reagens za uporabu kod otkrivanja infekcije sa M. bovis kod životinje, naznačen time da sadrži jedan ili više peptida koji svaki ima jednu od sekvenci SEQ ID br.:9-13, ili funkcionalnu varijantu peptida koji ima barem 90% identičnosti sa sekvencama SEQ ID br.:9, 10, 11, 12 ili 13 i koja je sposobna izazvati sličan imunološki odgovor.
2. Dijagnostički reagens prema zahtjevu 1, naznačen time da sadrži barem dva, tri, četiri ili pet peptida svaki iz skupine peptida koja sadrži SEQ ID br.:9, 10, 11, 12 i 13.
3. Dijagnostički reagens prema zahtjevu 1 ili 2, naznačen time da sadrži sve peptidE iz SEQ ID br.:9-13.
4. Dijagnostički reagens prema bilo kojem prethodnom zahtjevu, naznačen time da dodatno sadrži jedan ili više polipeptida koji svaki ima sekvencu aminokiselinE iz SEQ ID br.: 14-25.
5. Dijagnostički komplet (kit) naznačen time da sadrži dijagnostički reagens kako je definirano u bilo kojem zahtjevu od 1 do 4.
6. Dijagnostički komplet (kit) prema zahtjevu 5, naznačen time da je u njemu dijagnostički reagens koji može otkriti infekciju sa M. bovis kod sisavca i koji je u stanju razlikovati između sisavca inficiranog sa M. bovis i sisavca cijepljenog protiv infekcije sa M. bovis.
7. Dijagnostički komplet (kit) prema zahtjevu 5 ili 6, naznačen time da sadrži peptide iz SEQ ID br.:9-13 i proizvoljno dodatno sadrži peptide iz SEQ ID br.: 16-25.
8. Dijagnostički komplet (kit) prema bilo kojem zahtjevu od 5-7, naznačen time da je za uporabu kod testa stanično posredovanog imuniteta (CMI).
9. Izolirani peptid koji ima M. bovis-specifična antigena i/ili imunogena svojstva, koji sadrži sekvencu aminokiseline iz bilo koje sekvence SEQ 1D br.:9-13, ili izolirani peptid koji je njegova funkcionalna varijanta koja ima barem 90% identičnosti sa sekvencama SEQ ID br.:9, 10, 11, 12 ili 13 i koja je sposobna izazvati sličan imunološki odgovor sa navedenim sekvencama.
10. Nukleinska kiselina koja kodira dijagnostički reagens peptida kako je definirano u zahtjevu 1 ili peptid kako je definirano u zahtjevu 9.
11. Vektor koji je pogodan za ekspresiju peptida kako je definirano u zahtjevu 1 ili 9, naznačen time da sadrži nukleinsku kiselinu kako je definirano u zahtjevu 10.
12. Stanica naznačena time da se transformira sa vektorom kako je definirano u zahtjevu 11.
13. Postupak za dijagnozu kod domaćina infekcije sa ili izloženosti na M. bovis, naznačen time da sadrži korake:
i) kontakt stanične populacije domaćina sa dijagnostičkim reagensom kako je definirano u bilo kojem zahtjevu od 1 do 4 i/ili dijagnostički reagens sadrži peptid iz SEQ ID br.: 1; te
ii) određivanje da li stanice navedene stanične populacijo prepoznaju dijagnostički reagens.
14. Postupak prema zahtjevu 13, naznačen time da sadrži test stanično posredovanog imuniteta (CMI).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0722105.4A GB0722105D0 (en) | 2007-11-10 | 2007-11-10 | Antigens |
| PCT/GB2008/003724 WO2009060184A1 (en) | 2007-11-10 | 2008-11-06 | Mycobacterium antigens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20131015T1 true HRP20131015T1 (hr) | 2013-12-20 |
Family
ID=38858506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20131015AT HRP20131015T1 (hr) | 2007-11-10 | 2013-10-24 | Mikobakterijski antigeni |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US8697091B2 (hr) |
| EP (3) | EP2672268B1 (hr) |
| AU (2) | AU2008324031B2 (hr) |
| CA (1) | CA2703395C (hr) |
| DK (3) | DK2827149T3 (hr) |
| ES (3) | ES2431891T3 (hr) |
| GB (1) | GB0722105D0 (hr) |
| HR (1) | HRP20131015T1 (hr) |
| NZ (1) | NZ584481A (hr) |
| PL (1) | PL2210105T3 (hr) |
| PT (1) | PT2210105E (hr) |
| WO (1) | WO2009060184A1 (hr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9915055A (pt) * | 1998-11-04 | 2001-08-07 | Isis Innovation | Teste diagnóstico de tuberculose |
| GB0618127D0 (en) * | 2006-09-14 | 2006-10-25 | Isis Innovation | Biomarker |
| GB0722105D0 (en) | 2007-11-10 | 2007-12-19 | Sec Dep For Environment Food A | Antigens |
| GB0906215D0 (en) * | 2009-04-09 | 2009-05-20 | Lalvani Ajit | Diagnostic test |
| GB201007075D0 (en) | 2010-04-28 | 2010-06-09 | Sec Dep For Environment Food A | Diagnostic reagents |
| GB201012072D0 (en) | 2010-07-19 | 2010-09-01 | Sec Dep For Environment Food A | Diagnostic reagents |
| ITRM20100411A1 (it) * | 2010-07-23 | 2012-01-24 | Massimo Amicosante | Uso di sequenze amminoacidiche da mycobacterium tuberculosis o dei loro corrispondenti acidi nucleici per la diagnosi e la prevenzione di infezione tubercolare, relativo kit diagnostico e vaccino. |
| CN103257236B (zh) * | 2012-02-20 | 2015-04-15 | 南京市疾病预防控制中心 | Hla-a24限制性结核分支杆菌特异性ctl细胞表位肽的应用 |
| TWI638829B (zh) * | 2012-07-10 | 2018-10-21 | 法商傳斯堅公司 | 分枝桿菌抗原疫苗 |
| ES2950436T3 (es) | 2016-12-14 | 2023-10-10 | Becton Dickinson Co | Métodos y composiciones para obtener una valoración de tuberculosis en un sujeto |
| GB201909953D0 (en) | 2019-07-11 | 2019-08-28 | Sec Dep For Environment Food And Rural Affairs Acting Through The Animal And Plant Health Agency | Diagnostic reagents |
| CN116348767A (zh) | 2020-10-06 | 2023-06-27 | 西菲伊德公司 | 诊断结核病以及区分活动性和潜伏性结核病的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10034826A1 (de) | 2000-07-18 | 2002-01-31 | Bosch Gmbh Robert | Baugruppe mit einem strukturierten Tärgerelement und einem mit diesem wirkverbundenen Substrat |
| US7538206B2 (en) * | 2001-02-22 | 2009-05-26 | Institut Pasteur | Comparative mycobacterial geneomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses |
| EP1437367A4 (en) * | 2001-09-26 | 2005-01-26 | Takeda Pharmaceutical | ANTIBODIES AND ITS USE |
| CA2500715A1 (en) * | 2002-10-03 | 2004-04-15 | Epimmune, Inc. | Hla binding peptides and their uses |
| CA2595406C (en) * | 2005-01-20 | 2017-07-11 | Biomarck Pharmaceuticals, Ltd. | Mucin hypersecretion inhibitors based on the structure of mans-related peptides and methods of use |
| DE602007013620D1 (de) | 2006-09-05 | 2011-05-12 | Hvidovre Hospital | Auf IP-10 basierende immunologische Überwachung |
| GB0716070D0 (en) | 2007-08-17 | 2007-09-26 | Fusion Antibodies Ltd | Diagnostic method and kit |
| GB0722105D0 (en) * | 2007-11-10 | 2007-12-19 | Sec Dep For Environment Food A | Antigens |
| GB0906215D0 (en) | 2009-04-09 | 2009-05-20 | Lalvani Ajit | Diagnostic test |
-
2007
- 2007-11-10 GB GBGB0722105.4A patent/GB0722105D0/en not_active Ceased
-
2008
- 2008-11-06 PT PT88482989T patent/PT2210105E/pt unknown
- 2008-11-06 CA CA2703395A patent/CA2703395C/en active Active
- 2008-11-06 AU AU2008324031A patent/AU2008324031B2/en active Active
- 2008-11-06 US US12/742,223 patent/US8697091B2/en active Active
- 2008-11-06 PL PL08848298T patent/PL2210105T3/pl unknown
- 2008-11-06 ES ES08848298T patent/ES2431891T3/es active Active
- 2008-11-06 NZ NZ584481A patent/NZ584481A/en unknown
- 2008-11-06 EP EP13182794.1A patent/EP2672268B1/en active Active
- 2008-11-06 DK DK14188545.9T patent/DK2827149T3/en active
- 2008-11-06 ES ES14188545.9T patent/ES2618336T3/es active Active
- 2008-11-06 DK DK08848298.9T patent/DK2210105T3/da active
- 2008-11-06 EP EP08848298.9A patent/EP2210105B1/en active Active
- 2008-11-06 ES ES13182794.1T patent/ES2564026T3/es active Active
- 2008-11-06 WO PCT/GB2008/003724 patent/WO2009060184A1/en active Application Filing
- 2008-11-06 EP EP14188545.9A patent/EP2827149B1/en active Active
- 2008-11-06 DK DK13182794.1T patent/DK2672268T3/en active
-
2010
- 2010-04-30 AU AU2010100407A patent/AU2010100407A4/en not_active Expired
-
2013
- 2013-10-24 HR HRP20131015AT patent/HRP20131015T1/hr unknown
-
2014
- 2014-02-21 US US14/186,291 patent/US9285364B2/en active Active
-
2016
- 2016-02-05 US US15/016,859 patent/US9618509B2/en active Active
-
2017
- 2017-03-31 US US15/475,472 patent/US20170269079A1/en not_active Abandoned
-
2018
- 2018-07-03 US US16/026,590 patent/US10578617B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20160153987A1 (en) | 2016-06-02 |
| NZ584481A (en) | 2011-12-22 |
| ES2618336T3 (es) | 2017-06-21 |
| ES2431891T3 (es) | 2013-11-28 |
| US8697091B2 (en) | 2014-04-15 |
| US10578617B2 (en) | 2020-03-03 |
| DK2210105T3 (da) | 2013-11-04 |
| EP2672268B1 (en) | 2016-02-10 |
| GB0722105D0 (en) | 2007-12-19 |
| EP2827149A1 (en) | 2015-01-21 |
| US20170269079A1 (en) | 2017-09-21 |
| US20100317036A1 (en) | 2010-12-16 |
| AU2008324031B2 (en) | 2013-06-27 |
| AU2008324031A1 (en) | 2009-05-14 |
| DK2827149T3 (en) | 2017-02-06 |
| ES2564026T3 (es) | 2016-03-17 |
| EP2210105A1 (en) | 2010-07-28 |
| WO2009060184A1 (en) | 2009-05-14 |
| EP2827149B1 (en) | 2017-01-04 |
| EP2672268A1 (en) | 2013-12-11 |
| EP2210105B1 (en) | 2013-09-04 |
| CA2703395C (en) | 2018-09-25 |
| US9618509B2 (en) | 2017-04-11 |
| US20140296091A1 (en) | 2014-10-02 |
| PL2210105T3 (pl) | 2014-01-31 |
| US20190170746A1 (en) | 2019-06-06 |
| CA2703395A1 (en) | 2009-05-14 |
| US9285364B2 (en) | 2016-03-15 |
| PT2210105E (pt) | 2013-10-30 |
| AU2010100407A4 (en) | 2010-05-27 |
| DK2672268T3 (en) | 2016-03-29 |
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