HRP20120434T1 - Spojevi 4-oksadiazolil-piperidina i njihova uporaba - Google Patents
Spojevi 4-oksadiazolil-piperidina i njihova uporabaInfo
- Publication number
- HRP20120434T1 HRP20120434T1 HRP20120434TT HRP20120434T HRP20120434T1 HR P20120434 T1 HRP20120434 T1 HR P20120434T1 HR P20120434T T HRP20120434T T HR P20120434TT HR P20120434 T HRP20120434 T HR P20120434T HR P20120434 T1 HRP20120434 T1 HR P20120434T1
- Authority
- HR
- Croatia
- Prior art keywords
- oxadiazolyl
- piperidine compounds
- piperidine
- compounds
- diarrhoea
- Prior art date
Links
- TUSLAEPZELMPGR-UHFFFAOYSA-N 4-piperidin-4-yloxadiazole Chemical class C1CNCCC1C1=CON=N1 TUSLAEPZELMPGR-UHFFFAOYSA-N 0.000 title abstract 2
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Spoj formule (I): ili njegova farmaceutski prihvatljiva sol, naznačen time da: Ar1 je fenil nesupstituiran ili supstituiran sa jednom ili više R2 skupina; Ar2 je fenil nesupstituiran ili supstituiran sa jednom, dvije ili tri R2 skupine; Ar4 je fenil nesupstituiran ili supstituiran sa jednom, dvije ili tri R2 skupine; G je -H, -C(O)(CH2)nCO2R4, -C(O)(CH2)nR4, -(C1-C5 alkilen)C(O)OR4, ili -(C1-C5 alkilen)R5;R1 = -H, -C(O)NH2, -C(O)NHOH, -CO2R4, -CHO, -CN, -(C1-C4 alkil), -C(O)NH(C1-C4 alkil), -C(O)N(C1-C4 alkil)2, -CF3, -CHF2, -CH2F, R2 i R3 su svaki nezavisno -halogen, -C1-C3 alkil, -O(C1-C3 alkil), -NH(C1-C3 alkil), -N(C1-C3 alkil)2, -CF3 ili
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73910705P | 2005-11-21 | 2005-11-21 | |
| PCT/EP2006/011150 WO2007057229A1 (en) | 2005-11-21 | 2006-11-21 | 4-oxadiazolyl-piperidine compounds and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20120434T1 true HRP20120434T1 (hr) | 2012-06-30 |
| HRP20120434T2 HRP20120434T2 (hr) | 2012-11-30 |
Family
ID=37898486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120434TT HRP20120434T2 (hr) | 2005-11-21 | 2012-05-23 | Spojevi 4-oksadiazolil-piperidina i njihova uporaba |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20080319020A1 (hr) |
| EP (3) | EP2298765A1 (hr) |
| JP (1) | JP4991746B2 (hr) |
| KR (1) | KR20080080138A (hr) |
| CN (1) | CN101312964A (hr) |
| AT (1) | ATE547414T1 (hr) |
| AU (1) | AU2006314730B2 (hr) |
| BR (1) | BRPI0619679A2 (hr) |
| CA (1) | CA2628750C (hr) |
| CY (1) | CY1112773T1 (hr) |
| DK (1) | DK1951718T3 (hr) |
| EA (1) | EA013510B1 (hr) |
| ES (1) | ES2382712T3 (hr) |
| HR (1) | HRP20120434T2 (hr) |
| NO (1) | NO20082752L (hr) |
| NZ (1) | NZ568430A (hr) |
| PL (1) | PL1951718T3 (hr) |
| PT (1) | PT1951718E (hr) |
| RS (1) | RS52258B (hr) |
| SI (1) | SI1951718T1 (hr) |
| UA (1) | UA91250C2 (hr) |
| WO (1) | WO2007057229A1 (hr) |
| ZA (1) | ZA200803101B (hr) |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) * | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| BE775611A (fr) | 1970-11-24 | 1972-03-16 | Synthelabo | Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US3966748A (en) * | 1975-05-08 | 1976-06-29 | American Cyanamid Company | Para-fluorophenyl-N-heterocyclic substituted butanes |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) * | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) * | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) * | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5591767A (en) * | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| US5717947A (en) * | 1993-03-31 | 1998-02-10 | Motorola, Inc. | Data processing system and method thereof |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| JPH11507670A (ja) | 1995-06-12 | 1999-07-06 | ジー．ディー．サール アンド カンパニー | シクロオキシゲナーゼ−２インヒビターと５−リポキシゲナーゼインヒビターの組合せによる炎症と炎症関連疾患の治療 |
| US5849761A (en) | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
| US6573282B1 (en) | 1995-09-12 | 2003-06-03 | Adolor Corporation | Peripherally active anti-hyperalgesic opiates |
| CA2324330A1 (en) | 1999-11-08 | 2001-05-08 | Ssp Co., Ltd. | 4-hydroxy-4-phenylpiperidine derivatives and pharmaceuticals containing the same |
| EP1277737A4 (en) * | 2000-03-24 | 2003-05-07 | Meiji Seika Kaisha | DIPHENYLALKYLAMINE DERIVATIVES AS AGONISTS OF THE OPIOID -g (d) RECEPTOR |
| WO2002038185A2 (en) | 2000-11-13 | 2002-05-16 | Atrix Laboratories, Inc. | Injectable sustained release delivery system with loperamide |
| US7202259B2 (en) * | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| US20090209578A1 (en) * | 2005-12-08 | 2009-08-20 | Pfizer Inc | Chemical compounds |
| CA2634999A1 (en) * | 2005-12-27 | 2007-07-05 | University Of Toledo | Muscarinic agonists and methods of use thereof |
-
2006
- 2006-11-21 US US12/094,556 patent/US20080319020A1/en not_active Abandoned
- 2006-11-21 EP EP10010920A patent/EP2298765A1/en not_active Withdrawn
- 2006-11-21 EP EP06829087A patent/EP1951718B9/en active Active
- 2006-11-21 PT PT06829087T patent/PT1951718E/pt unknown
- 2006-11-21 EA EA200801392A patent/EA013510B1/ru not_active IP Right Cessation
- 2006-11-21 UA UAA200808315A patent/UA91250C2/ru unknown
- 2006-11-21 ES ES06829087T patent/ES2382712T3/es active Active
- 2006-11-21 JP JP2008540535A patent/JP4991746B2/ja not_active Expired - Fee Related
- 2006-11-21 BR BRPI0619679-9A patent/BRPI0619679A2/pt not_active IP Right Cessation
- 2006-11-21 WO PCT/EP2006/011150 patent/WO2007057229A1/en active Application Filing
- 2006-11-21 NZ NZ568430A patent/NZ568430A/en not_active IP Right Cessation
- 2006-11-21 PL PL06829087T patent/PL1951718T3/pl unknown
- 2006-11-21 CN CNA2006800432583A patent/CN101312964A/zh active Pending
- 2006-11-21 AU AU2006314730A patent/AU2006314730B2/en not_active Ceased
- 2006-11-21 SI SI200631317T patent/SI1951718T1/sl unknown
- 2006-11-21 KR KR1020087015177A patent/KR20080080138A/ko not_active Application Discontinuation
- 2006-11-21 AT AT06829087T patent/ATE547414T1/de active
- 2006-11-21 RS RS20120199A patent/RS52258B/en unknown
- 2006-11-21 CA CA2628750A patent/CA2628750C/en not_active Expired - Fee Related
- 2006-11-21 DK DK06829087.3T patent/DK1951718T3/da active
- 2006-11-21 EP EP10010919A patent/EP2298764A1/en not_active Withdrawn
-
2008
- 2008-04-09 ZA ZA200803101A patent/ZA200803101B/xx unknown
- 2008-06-18 NO NO20082752A patent/NO20082752L/no not_active Application Discontinuation
-
2012
- 2012-05-18 CY CY20121100458T patent/CY1112773T1/el unknown
- 2012-05-23 HR HRP20120434TT patent/HRP20120434T2/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080080138A (ko) | 2008-09-02 |
| BRPI0619679A2 (pt) | 2011-10-11 |
| EP1951718A1 (en) | 2008-08-06 |
| AU2006314730B2 (en) | 2011-02-03 |
| HRP20120434T2 (hr) | 2012-11-30 |
| AU2006314730A1 (en) | 2007-05-24 |
| UA91250C2 (en) | 2010-07-12 |
| SI1951718T1 (sl) | 2012-06-29 |
| ES2382712T9 (es) | 2012-10-30 |
| EP2298765A1 (en) | 2011-03-23 |
| CY1112773T1 (el) | 2016-02-10 |
| ATE547414T1 (de) | 2012-03-15 |
| PL1951718T3 (pl) | 2012-08-31 |
| US20080319020A1 (en) | 2008-12-25 |
| PT1951718E (pt) | 2012-05-21 |
| ES2382712T3 (es) | 2012-06-12 |
| CN101312964A (zh) | 2008-11-26 |
| NO20082752L (no) | 2008-08-06 |
| CA2628750A1 (en) | 2007-05-24 |
| CA2628750C (en) | 2013-02-12 |
| WO2007057229A1 (en) | 2007-05-24 |
| JP2009516664A (ja) | 2009-04-23 |
| EA200801392A1 (ru) | 2008-10-30 |
| EP2298764A1 (en) | 2011-03-23 |
| JP4991746B2 (ja) | 2012-08-01 |
| EA013510B1 (ru) | 2010-06-30 |
| EP1951718B1 (en) | 2012-02-29 |
| DK1951718T3 (da) | 2012-05-14 |
| ZA200803101B (en) | 2009-03-25 |
| NZ568430A (en) | 2011-02-25 |
| RS52258B (en) | 2012-10-31 |
| EP1951718B9 (en) | 2012-08-15 |
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