EA200801392A1 - Соединения 4-оксадиазолил-пиперидина и их применение - Google Patents

Соединения 4-оксадиазолил-пиперидина и их применение

Info

Publication number
EA200801392A1
EA200801392A1 EA200801392A EA200801392A EA200801392A1 EA 200801392 A1 EA200801392 A1 EA 200801392A1 EA 200801392 A EA200801392 A EA 200801392A EA 200801392 A EA200801392 A EA 200801392A EA 200801392 A1 EA200801392 A1 EA 200801392A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oxadiazolyl
application
piperidine compounds
piperidine
compounds
Prior art date
Application number
EA200801392A
Other languages
English (en)
Other versions
EA013510B1 (ru
Inventor
Лэйкиа Тафессе
Original Assignee
Пэдью Фарма Л.П.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пэдью Фарма Л.П. filed Critical Пэдью Фарма Л.П.
Publication of EA200801392A1 publication Critical patent/EA200801392A1/ru
Publication of EA013510B1 publication Critical patent/EA013510B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

В настоящем изобретении раскрываются соединения 4-оксадиазолил-пиперидина, композиции, содержащие эффективное количество соединения 4-оксадиазолил-пиперидина, способы лечения или профилактики боли или диареи у животных, заключающиеся во введении нуждающемуся животному эффективного количества соединения 4-оксадиазолил-пиперидина, и способы стимуляции функции опиоидных рецепторов клеток, заключающиеся в обеспечении взаимодействия клетки, экспрессирующей опиоидный рецептор, с эффективным количеством соединения 4-оксадиазолил-пиперидина.
EA200801392A 2005-11-21 2006-11-21 Соединения 4-оксадиазолилпиперидина и их применение EA013510B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73910705P 2005-11-21 2005-11-21
PCT/EP2006/011150 WO2007057229A1 (en) 2005-11-21 2006-11-21 4-oxadiazolyl-piperidine compounds and use thereof

Publications (2)

Publication Number Publication Date
EA200801392A1 true EA200801392A1 (ru) 2008-10-30
EA013510B1 EA013510B1 (ru) 2010-06-30

Family

ID=37898486

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801392A EA013510B1 (ru) 2005-11-21 2006-11-21 Соединения 4-оксадиазолилпиперидина и их применение

Country Status (23)

Country Link
US (1) US20080319020A1 (ru)
EP (3) EP2298764A1 (ru)
JP (1) JP4991746B2 (ru)
KR (1) KR20080080138A (ru)
CN (1) CN101312964A (ru)
AT (1) ATE547414T1 (ru)
AU (1) AU2006314730B2 (ru)
BR (1) BRPI0619679A2 (ru)
CA (1) CA2628750C (ru)
CY (1) CY1112773T1 (ru)
DK (1) DK1951718T3 (ru)
EA (1) EA013510B1 (ru)
ES (1) ES2382712T3 (ru)
HR (1) HRP20120434T2 (ru)
NO (1) NO20082752L (ru)
NZ (1) NZ568430A (ru)
PL (1) PL1951718T3 (ru)
PT (1) PT1951718E (ru)
RS (1) RS52258B (ru)
SI (1) SI1951718T1 (ru)
UA (1) UA91250C2 (ru)
WO (1) WO2007057229A1 (ru)
ZA (1) ZA200803101B (ru)

Family Cites Families (27)

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US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
BE775611A (fr) 1970-11-24 1972-03-16 Synthelabo Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) * 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3966748A (en) * 1975-05-08 1976-06-29 American Cyanamid Company Para-fluorophenyl-N-heterocyclic substituted butanes
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5698155A (en) * 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5717947A (en) * 1993-03-31 1998-02-10 Motorola, Inc. Data processing system and method thereof
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
EP0833622B8 (en) * 1995-06-12 2005-10-12 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
CA2324330A1 (en) 1999-11-08 2001-05-08 Ssp Co., Ltd. 4-hydroxy-4-phenylpiperidine derivatives and pharmaceuticals containing the same
WO2001070689A1 (fr) 2000-03-24 2001-09-27 Meiji Seika Kaisha, Ltd. DERIVES DE LA DIPHENYLALKYLAMINE UTILES COMME AGONISTES DU RECEPTEUR DE L'OPIOIDE $g(d)
WO2002038185A2 (en) 2000-11-13 2002-05-16 Atrix Laboratories, Inc. Injectable sustained release delivery system with loperamide
US7202259B2 (en) * 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
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JP2009521531A (ja) * 2005-12-27 2009-06-04 ザ・ユニバーシティ・オブ・トレド ムスカリンアゴニスト及びその使用方法

Also Published As

Publication number Publication date
EP1951718A1 (en) 2008-08-06
CA2628750C (en) 2013-02-12
EP2298764A1 (en) 2011-03-23
NO20082752L (no) 2008-08-06
WO2007057229A1 (en) 2007-05-24
AU2006314730A1 (en) 2007-05-24
AU2006314730B2 (en) 2011-02-03
JP2009516664A (ja) 2009-04-23
PT1951718E (pt) 2012-05-21
CY1112773T1 (el) 2016-02-10
CA2628750A1 (en) 2007-05-24
EP1951718B1 (en) 2012-02-29
BRPI0619679A2 (pt) 2011-10-11
ATE547414T1 (de) 2012-03-15
JP4991746B2 (ja) 2012-08-01
PL1951718T3 (pl) 2012-08-31
ES2382712T3 (es) 2012-06-12
KR20080080138A (ko) 2008-09-02
DK1951718T3 (da) 2012-05-14
NZ568430A (en) 2011-02-25
RS52258B (en) 2012-10-31
ZA200803101B (en) 2009-03-25
EP2298765A1 (en) 2011-03-23
EP1951718B9 (en) 2012-08-15
HRP20120434T1 (en) 2012-06-30
SI1951718T1 (sl) 2012-06-29
HRP20120434T2 (hr) 2012-11-30
ES2382712T9 (es) 2012-10-30
CN101312964A (zh) 2008-11-26
UA91250C2 (en) 2010-07-12
US20080319020A1 (en) 2008-12-25
EA013510B1 (ru) 2010-06-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU