HRP20110813T1 - Idebenon za liječenje respiratornih bolesti u mišićnoj distrofiji - Google Patents
Idebenon za liječenje respiratornih bolesti u mišićnoj distrofiji Download PDFInfo
- Publication number
- HRP20110813T1 HRP20110813T1 HR20110813T HRP20110813T HRP20110813T1 HR P20110813 T1 HRP20110813 T1 HR P20110813T1 HR 20110813 T HR20110813 T HR 20110813T HR P20110813 T HRP20110813 T HR P20110813T HR P20110813 T1 HRP20110813 T1 HR P20110813T1
- Authority
- HR
- Croatia
- Prior art keywords
- ibedenone
- use according
- muscular dystrophy
- administered
- treatment
- Prior art date
Links
- 201000006938 muscular dystrophy Diseases 0.000 title claims abstract 5
- JGPMMRGNQUBGND-UHFFFAOYSA-N idebenone Chemical compound COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O JGPMMRGNQUBGND-UHFFFAOYSA-N 0.000 title claims abstract 4
- 229960004135 idebenone Drugs 0.000 title claims abstract 3
- 230000000241 respiratory effect Effects 0.000 title claims abstract 3
- 238000011282 treatment Methods 0.000 title claims 4
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 5
- 210000000214 mouth Anatomy 0.000 claims 3
- 208000031229 Cardiomyopathies Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 229940030606 diuretics Drugs 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 201000004193 respiratory failure Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Idebenon naznačen time da za upotrebu u profilaksi i/ili u liječenju respiratorne slabosti i/ili respiratorne insuficijencije u mišićnoj distrofiji. Patent sadrži još 10 patentnih zahtjeva.
Claims (11)
1. Idebenon naznačen time da za upotrebu u profilaksi i/ili u liječenju respiratorne slabosti i/ili respiratorne insuficijencije u mišićnoj distrofiji.
2. Ibedenon za upotrebu prema 1. patentnom zahtjevu, naznačen time da je mišićna distrofija Duchenneova mišićna distrofija (DMD).
3. Ibedenon za upotrebu prema 1. patentnom zahtjevu, naznačen time da je mišićna distrofija Beckerova mišićna distrofija.
4. Ibedenon za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 3., naznačen time da se ibedenon primjenjuje u dozi od 5 do 60 mg/kg na dan.
5. Ibedenon za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 4., naznačen time da se ibedenon primjenjuje jedanput ili više puta na dan barem tijekom 3 mjeseca.
6. Ibedenon za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 5., naznačen time da se ibedenon može primjenjivati oralno, i.p., i.v., i.m., i.c., parenteralno, intranazalno, transdermalno ili preko sluznice usne šupljine.
7. Ibedenon za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 5., naznačen time da se ibedenon primjenjuje u obliku tablete.
8. Ibedenon za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 5., naznačen time da se ibedenon primjenjuje u kapsuli od hostije, proizvodu u obliku filma koji se brzo rastapa u ustima i koji sadržava farmaceutske sastojke ili u obliku tablete koja se rastapa u ustima.
9. Ibedenon za upotrebu prema bilo kojem patentnom zahtjevu od 1. do 8., naznačen time da se ibedenon primjenjuje u kombinaciji s drugom terapijskom tvari, po mogućnosti odabranim glukokortikosteroidom i odabranom terapijskom tvari za liječenje kardiomiopatije povezane s DMD-om.
10. Ibedenon za upotrebu prema 9. patentnom zahtjevu, naznačen time da su odabrani glukokortikosteroidi 6ά-metilprednizolon-21 natrij sukcinat i deflazocort.
11. Ibedenon za upotrebu prema 9. patentnom zahtjevu, naznačen time da su odabrane terapijske tvari za liječenje kardiomiopatije povezane s DMD-om ACE inhibitori, beta blokatori i diuretici.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08007069A EP2108366B1 (en) | 2008-04-09 | 2008-04-09 | Idebenone for the treatment of respiratory illness in muscular dystrophy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110813T1 true HRP20110813T1 (hr) | 2011-11-30 |
Family
ID=39691216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110813T HRP20110813T1 (hr) | 2008-04-09 | 2011-11-02 | Idebenon za liječenje respiratornih bolesti u mišićnoj distrofiji |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20110092469A1 (hr) |
| EP (1) | EP2108366B1 (hr) |
| JP (1) | JP2011516513A (hr) |
| AT (1) | ATE529104T1 (hr) |
| AU (1) | AU2009235681B2 (hr) |
| CA (1) | CA2719440C (hr) |
| CY (1) | CY1112313T1 (hr) |
| DK (1) | DK2108366T3 (hr) |
| ES (1) | ES2370607T3 (hr) |
| HR (1) | HRP20110813T1 (hr) |
| MX (1) | MX2010011099A (hr) |
| NZ (1) | NZ588181A (hr) |
| PL (1) | PL2108366T3 (hr) |
| PT (1) | PT2108366E (hr) |
| SI (1) | SI2108366T1 (hr) |
| WO (1) | WO2009124693A1 (hr) |
| ZA (1) | ZA201006905B (hr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10806703B2 (en) | 2012-01-20 | 2020-10-20 | Lts Lohmann Therapie-System Ag | Transmucosal administration system for a pharmaceutical drug |
| EP2620141A1 (en) * | 2012-01-25 | 2013-07-31 | Santhera Pharmaceuticals (Schweiz) AG | Thin film drug delivery system for the transmucosal administration of a 1,4-benzoquinone derivative |
| WO2014035356A1 (en) * | 2012-08-31 | 2014-03-06 | Mahmut Bilgic | Tablet formulations comprising a quinone derivative active agent |
| CN103040779B (zh) * | 2013-01-01 | 2015-04-15 | 刘炜 | 用于神经系统疾病的口服固体药物组合物 |
| KR20200139271A (ko) * | 2013-03-15 | 2020-12-11 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | 근육 이영양증의 치료를 위한 개선된 조성물 |
| CN109364050B (zh) * | 2018-10-19 | 2021-02-02 | 大连医科大学 | 艾地苯醌在制备治疗肺动脉高压药物中的应用 |
| WO2022258629A1 (en) | 2021-06-07 | 2022-12-15 | Katholieke Universiteit Leuven | Idebenone in the treatment of drug resistant epilepsy |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51128932A (en) | 1975-04-30 | 1976-11-10 | Takeda Chem Ind Ltd | Organic compounds |
| JPH11116470A (ja) | 1997-08-12 | 1999-04-27 | Takeda Chem Ind Ltd | イデベノン含有経皮投与製剤 |
| AU8562998A (en) | 1997-08-12 | 1999-03-01 | Takeda Chemical Industries Ltd. | Idebenone-containing preparation for percutaneous administration |
| CA2272971C (en) | 1998-10-29 | 2008-01-15 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Quinone derivatives for treating or preventing diseases associated with iron overload |
| US7977388B2 (en) * | 2005-03-21 | 2011-07-12 | Santhera Pharmaceuticals (Schweiz) Ag | Quinone derivative 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone for the treatment of muscular dystrophies |
| EP1891946A1 (en) | 2006-08-14 | 2008-02-27 | Santhera Pharmaceuticals (Schweiz) AG | Transmucosal administration of 2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone |
-
2008
- 2008-04-09 PT PT08007069T patent/PT2108366E/pt unknown
- 2008-04-09 DK DK08007069.1T patent/DK2108366T3/da active
- 2008-04-09 ES ES08007069T patent/ES2370607T3/es active Active
- 2008-04-09 AT AT08007069T patent/ATE529104T1/de active
- 2008-04-09 EP EP08007069A patent/EP2108366B1/en active Active
- 2008-04-09 SI SI200830477T patent/SI2108366T1/sl unknown
- 2008-04-09 PL PL08007069T patent/PL2108366T3/pl unknown
-
2009
- 2009-04-03 AU AU2009235681A patent/AU2009235681B2/en not_active Ceased
- 2009-04-03 CA CA2719440A patent/CA2719440C/en not_active Expired - Fee Related
- 2009-04-03 JP JP2011503366A patent/JP2011516513A/ja active Pending
- 2009-04-03 NZ NZ588181A patent/NZ588181A/en not_active IP Right Cessation
- 2009-04-03 WO PCT/EP2009/002478 patent/WO2009124693A1/en active Application Filing
- 2009-04-03 MX MX2010011099A patent/MX2010011099A/es active IP Right Grant
- 2009-04-03 US US12/934,089 patent/US20110092469A1/en not_active Abandoned
-
2010
- 2010-09-28 ZA ZA2010/06905A patent/ZA201006905B/en unknown
-
2011
- 2011-11-02 HR HR20110813T patent/HRP20110813T1/hr unknown
-
2012
- 2012-01-18 CY CY20121100068T patent/CY1112313T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009235681A1 (en) | 2009-10-15 |
| NZ588181A (en) | 2011-11-25 |
| AU2009235681B2 (en) | 2012-04-05 |
| DK2108366T3 (da) | 2012-01-30 |
| ES2370607T3 (es) | 2011-12-20 |
| CA2719440C (en) | 2013-07-16 |
| CY1112313T1 (el) | 2015-12-09 |
| CA2719440A1 (en) | 2009-10-15 |
| WO2009124693A1 (en) | 2009-10-15 |
| SI2108366T1 (sl) | 2012-01-31 |
| PL2108366T3 (pl) | 2012-03-30 |
| US20110092469A1 (en) | 2011-04-21 |
| MX2010011099A (es) | 2010-11-01 |
| EP2108366A1 (en) | 2009-10-14 |
| ZA201006905B (en) | 2011-06-29 |
| EP2108366B1 (en) | 2011-10-19 |
| ATE529104T1 (de) | 2011-11-15 |
| PT2108366E (pt) | 2011-11-10 |
| JP2011516513A (ja) | 2011-05-26 |
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