HRP20110785T8 - Pyrimidinyl-piperazines useful as dopamine d3/d2 receptor ligands - Google Patents
Pyrimidinyl-piperazines useful as dopamine d3/d2 receptor ligandsInfo
- Publication number
- HRP20110785T8 HRP20110785T8 HR20110785T HRP20110785T HRP20110785T8 HR P20110785 T8 HRP20110785 T8 HR P20110785T8 HR 20110785 T HR20110785 T HR 20110785T HR P20110785 T HRP20110785 T HR P20110785T HR P20110785 T8 HRP20110785 T8 HR P20110785T8
- Authority
- HR
- Croatia
- Prior art keywords
- phenyl
- represents hydrogen
- alkyl group
- optionally substituted
- dopamine
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- MRBFGEHILMYPTF-UHFFFAOYSA-N 1-(2-Pyrimidyl)piperazine Chemical class C1CNCCN1C1=NC=CC=N1 MRBFGEHILMYPTF-UHFFFAOYSA-N 0.000 title 1
- 229960003638 dopamine Drugs 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- -1 -NR 3 R 4 Chemical group 0.000 abstract 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0700269A HUP0700269A2 (en) | 2007-04-11 | 2007-04-11 | Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use |
| PCT/HU2008/000032 WO2008125891A2 (en) | 2007-04-11 | 2008-04-10 | Pyrimidinyl-piperazines useful as dopamine d3 /d2 receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20110785T1 HRP20110785T1 (hr) | 2011-11-30 |
| HRP20110785T8 true HRP20110785T8 (en) | 2012-04-30 |
Family
ID=38336883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110785T HRP20110785T8 (en) | 2007-04-11 | 2011-10-26 | Pyrimidinyl-piperazines useful as dopamine d3/d2 receptor ligands |
Country Status (36)
| Country | Link |
|---|---|
| EP (1) | EP2132185B1 (ko) |
| JP (1) | JP4580464B2 (ko) |
| KR (1) | KR101540821B1 (ko) |
| CN (1) | CN101652351B (ko) |
| AP (1) | AP2460A (ko) |
| AT (1) | ATE518843T1 (ko) |
| AU (1) | AU2008237696B2 (ko) |
| BR (1) | BRPI0809641A2 (ko) |
| CA (1) | CA2682817C (ko) |
| CO (1) | CO6241116A2 (ko) |
| CR (1) | CR11071A (ko) |
| CU (1) | CU23853B1 (ko) |
| CY (1) | CY1111962T1 (ko) |
| DK (1) | DK2132185T3 (ko) |
| EA (1) | EA016174B1 (ko) |
| EC (1) | ECSP099702A (ko) |
| ES (1) | ES2370748T3 (ko) |
| GE (1) | GEP20115272B (ko) |
| HK (1) | HK1134491A1 (ko) |
| HR (1) | HRP20110785T8 (ko) |
| HU (1) | HUP0700269A2 (ko) |
| IL (1) | IL200801A0 (ko) |
| MA (1) | MA31359B1 (ko) |
| MX (1) | MX2009010896A (ko) |
| MY (1) | MY148384A (ko) |
| NI (1) | NI200900179A (ko) |
| NZ (1) | NZ579754A (ko) |
| PL (1) | PL2132185T3 (ko) |
| PT (1) | PT2132185E (ko) |
| RS (1) | RS51979B (ko) |
| SI (1) | SI2132185T1 (ko) |
| TN (1) | TN2009000386A1 (ko) |
| TW (1) | TWI445534B (ko) |
| UA (1) | UA103748C2 (ko) |
| WO (1) | WO2008125891A2 (ko) |
| ZA (1) | ZA200906543B (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9091489B2 (en) | 2010-05-14 | 2015-07-28 | Paragon Space Development Corporation | Radiator systems |
| RS55645B1 (sr) * | 2010-06-18 | 2017-06-30 | Altos Therapeutics Llc | Antagonisti d2, postupci za sintezu i postupci upotrebe |
| US9376396B2 (en) * | 2012-10-22 | 2016-06-28 | AbbVie Deutschland GmbH & Co. KG | Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor |
| HU229987B1 (en) * | 2012-11-21 | 2015-04-28 | Richter Gedeon Nyrt | Process for the preparation of pyrimidinyl-piperazines |
| JP7015092B2 (ja) | 2016-07-28 | 2022-02-02 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物 |
| WO2019146739A1 (ja) | 2018-01-26 | 2019-08-01 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する縮環化合物 |
| US11447484B2 (en) | 2018-01-26 | 2022-09-20 | Shionogi & Co., Ltd. | Cyclic compound having dopamine D3 receptor antagonistic effect |
| WO2024072930A1 (en) * | 2022-09-30 | 2024-04-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2311776A1 (fr) | 1975-05-23 | 1976-12-17 | Sogeras | Diamino-2,4 bromo-5 chloro-6 pyrimidines et procede pour leur preparation |
| US5047406A (en) * | 1989-12-06 | 1991-09-10 | Warner-Lambert Co. | Substituted cyclohexanols as central nervous system agents |
| US4957921A (en) | 1989-12-06 | 1990-09-18 | Warner-Lambert Company | Substituted cyclohexanols as central nervous system agents |
| SE9802208D0 (sv) | 1998-06-22 | 1998-06-22 | Astra Pharma Inc | Novel compounds |
| US6919342B2 (en) | 2003-06-05 | 2005-07-19 | Abbott Gmbh & Co. Kg | Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
| HU227534B1 (en) * | 2003-08-04 | 2011-08-29 | Richter Gedeon Nyrt | (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them |
| EP1870405A1 (en) * | 2006-06-22 | 2007-12-26 | Bioprojet | Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands |
-
2007
- 2007-04-11 HU HU0700269A patent/HUP0700269A2/hu unknown
-
2008
- 2008-04-10 CA CA2682817A patent/CA2682817C/en not_active Expired - Fee Related
- 2008-04-10 CN CN2008800116439A patent/CN101652351B/zh active Active
- 2008-04-10 EP EP08737283A patent/EP2132185B1/en active Active
- 2008-04-10 GE GEAP200811554A patent/GEP20115272B/en unknown
- 2008-04-10 EA EA200901391A patent/EA016174B1/ru not_active IP Right Cessation
- 2008-04-10 SI SI200830405T patent/SI2132185T1/sl unknown
- 2008-04-10 PT PT08737283T patent/PT2132185E/pt unknown
- 2008-04-10 RS RS20110478A patent/RS51979B/en unknown
- 2008-04-10 WO PCT/HU2008/000032 patent/WO2008125891A2/en active Application Filing
- 2008-04-10 ES ES08737283T patent/ES2370748T3/es active Active
- 2008-04-10 UA UAA200911488A patent/UA103748C2/uk unknown
- 2008-04-10 BR BRPI0809641-4A2A patent/BRPI0809641A2/pt not_active IP Right Cessation
- 2008-04-10 DK DK08737283.5T patent/DK2132185T3/da active
- 2008-04-10 MY MYPI20094131A patent/MY148384A/en unknown
- 2008-04-10 KR KR1020097020486A patent/KR101540821B1/ko not_active IP Right Cessation
- 2008-04-10 AP AP2009004970A patent/AP2460A/xx active
- 2008-04-10 JP JP2010502585A patent/JP4580464B2/ja active Active
- 2008-04-10 PL PL08737283T patent/PL2132185T3/pl unknown
- 2008-04-10 AT AT08737283T patent/ATE518843T1/de active
- 2008-04-10 NZ NZ579754A patent/NZ579754A/en not_active IP Right Cessation
- 2008-04-10 AU AU2008237696A patent/AU2008237696B2/en not_active Ceased
- 2008-04-10 MX MX2009010896A patent/MX2009010896A/es active IP Right Grant
- 2008-07-08 TW TW097125706A patent/TWI445534B/zh not_active IP Right Cessation
-
2009
- 2009-09-08 IL IL200801A patent/IL200801A0/en not_active IP Right Cessation
- 2009-09-18 ZA ZA200906543A patent/ZA200906543B/xx unknown
- 2009-09-18 TN TNP2009000386A patent/TN2009000386A1/fr unknown
- 2009-09-25 CU CU2009000161A patent/CU23853B1/es active IP Right Grant
- 2009-10-07 NI NI200900179A patent/NI200900179A/es unknown
- 2009-10-21 CR CR11071A patent/CR11071A/es unknown
- 2009-10-23 EC EC2009009702A patent/ECSP099702A/es unknown
- 2009-11-02 MA MA32320A patent/MA31359B1/fr unknown
- 2009-11-06 CO CO09126013A patent/CO6241116A2/es active IP Right Grant
-
2010
- 2010-02-10 HK HK10101486.7A patent/HK1134491A1/xx unknown
-
2011
- 2011-10-21 CY CY20111101000T patent/CY1111962T1/el unknown
- 2011-10-26 HR HR20110785T patent/HRP20110785T8/xx unknown
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