HRP20110607T1 - Derivati tioksantena kao samostalna intiinfektivna sredstva namijenjena upotrebi u liječenju zaraznih bolesti - Google Patents
Derivati tioksantena kao samostalna intiinfektivna sredstva namijenjena upotrebi u liječenju zaraznih bolesti Download PDFInfo
- Publication number
- HRP20110607T1 HRP20110607T1 HR20110607T HRP20110607T HRP20110607T1 HR P20110607 T1 HRP20110607 T1 HR P20110607T1 HR 20110607 T HR20110607 T HR 20110607T HR P20110607 T HRP20110607 T HR P20110607T HR P20110607 T1 HRP20110607 T1 HR P20110607T1
- Authority
- HR
- Croatia
- Prior art keywords
- optionally substituted
- agent
- amino
- alkyl
- accordance
- Prior art date
Links
- 229960005475 antiinfective agent Drugs 0.000 title claims abstract 9
- 239000004599 antimicrobial Substances 0.000 title claims abstract 9
- 208000035473 Communicable disease Diseases 0.000 title claims abstract 4
- 238000011282 treatment Methods 0.000 title claims abstract 4
- PQJUJGAVDBINPI-UHFFFAOYSA-N 9H-thioxanthene Chemical compound C1=CC=C2CC3=CC=CC=C3SC2=C1 PQJUJGAVDBINPI-UHFFFAOYSA-N 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- -1 hydroxy, amino Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 230000002924 anti-infective effect Effects 0.000 claims 2
- 244000052616 bacterial pathogen Species 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 244000053095 fungal pathogen Species 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 1
- 101100165225 Arabidopsis thaliana BETA-OHASE 2 gene Proteins 0.000 claims 1
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 1
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005241 heteroarylamino group Chemical group 0.000 claims 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 125000005226 heteroaryloxycarbonyl group Chemical group 0.000 claims 1
- 125000005419 heteroarylsulfonylamino group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229940054058 antipsychotic thioxanthene derivative Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001484 phenothiazinyl group Chemical class C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 abstract 1
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 abstract 1
- 150000005075 thioxanthenes Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Dairy Products (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/DK2007/000006 WO2008080398A1 (en) | 2007-01-05 | 2007-01-05 | Anti - infective agents such as phenothiazine and thioxanthene derivates to treat infectious diseases |
| PCT/DK2008/000005 WO2008080408A1 (en) | 2007-01-05 | 2008-01-07 | Thioxanthene derivates usefulto treat infectious diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110607T1 true HRP20110607T1 (hr) | 2011-09-30 |
Family
ID=37914358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110607T HRP20110607T1 (hr) | 2007-01-05 | 2011-08-17 | Derivati tioksantena kao samostalna intiinfektivna sredstva namijenjena upotrebi u liječenju zaraznih bolesti |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20100113430A1 (ru) |
| EP (2) | EP2301545A1 (ru) |
| JP (2) | JP5399921B2 (ru) |
| CN (1) | CN101594869B (ru) |
| AT (1) | ATE510540T1 (ru) |
| AU (1) | AU2008203743B2 (ru) |
| CA (1) | CA2673809C (ru) |
| CY (1) | CY1111778T1 (ru) |
| DK (1) | DK2114406T3 (ru) |
| EA (1) | EA016886B1 (ru) |
| ES (1) | ES2367151T3 (ru) |
| HK (1) | HK1139309A1 (ru) |
| HR (1) | HRP20110607T1 (ru) |
| MX (1) | MX2009007235A (ru) |
| NZ (1) | NZ577821A (ru) |
| PL (1) | PL2114406T3 (ru) |
| PT (1) | PT2114406E (ru) |
| WO (2) | WO2008080398A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009007235A (es) * | 2007-01-05 | 2009-10-16 | Bkg Pharma Aps | "derivados de tioxanteno utiles para el tratamiento de enfermedades infecciosas.". |
| EP2246349A1 (en) * | 2009-04-20 | 2010-11-03 | BKG Pharma ApS | Treatment of infectious diseases |
| CN103172591B (zh) * | 2013-03-13 | 2014-07-30 | 陕西科技大学 | 含吩噻嗪基的Schiff碱类化合物及其制备方法和应用 |
| CN103709122B (zh) * | 2013-11-29 | 2016-05-25 | 四川大学 | 用于治疗的抗肿瘤和抗真菌化合物 |
| WO2017222466A1 (en) * | 2016-06-23 | 2017-12-28 | Bioimics Ab | Anti-infective heterocyclic compounds and uses thereof |
| CN112353805A (zh) * | 2020-11-17 | 2021-02-12 | 北京化工大学 | 氟哌噻吨在治疗和预防柯萨奇病毒感染中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE578983A (ru) | 1958-05-29 | |||
| DE1210890B (de) | 1960-03-07 | 1966-02-17 | Smith & Kline & French Lab | Verfahren zur Herstellung von Trifluormethyl-xanthen- oder thioxanthenderivaten |
| GB1453828A (en) * | 1972-12-08 | 1976-10-27 | Kefalas As | Fluoro-substituted thiaxanthene derivatives |
| US4407800A (en) * | 1981-11-02 | 1983-10-04 | University Of Virginia Alumni Patents Foundation | Protozoacidal activity of phenothiazines |
| AU625071B2 (en) * | 1988-04-20 | 1992-07-02 | Merrell Dow Pharmaceuticals Inc. | N-alkylamino derivatives of aromatic, tricyclic compounds in the treatment of drug-resistant protozoal infections |
| US20020151543A1 (en) * | 1998-05-28 | 2002-10-17 | Sepracor Inc. | Compositions and methods employing R (-) fluoxetine and other active ingredients |
| FR2813792B1 (fr) * | 2000-09-12 | 2003-03-14 | Inst Necker | Moyens pour la regulation des defenses immunitaires |
| US6569853B1 (en) | 2000-11-06 | 2003-05-27 | Combinatorx, Incorporated | Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders |
| ES2739023T3 (es) | 2001-07-06 | 2020-01-28 | Veloxis Pharmaceuticals As | Aglomeración controlada |
| AU2003222197A1 (en) * | 2002-01-16 | 2003-09-02 | The Regents Of The University Of California | Inhibition of rna function |
| US20060193788A1 (en) * | 2002-11-26 | 2006-08-31 | Hale Ron L | Acute treatment of headache with phenothiazine antipsychotics |
| AU2003205543A1 (en) | 2003-01-14 | 2004-08-10 | Lifecycle Pharma A/S | Dry dispersions |
| DE602004026071D1 (de) * | 2003-08-13 | 2010-04-29 | Kudos Pharm Ltd | Aminopyrone und ihre verwendung als atm inhibitoren |
| CN1976723B (zh) * | 2004-04-30 | 2010-12-29 | Bkg制药有限公司 | 制备治疗或预防感染性疾病的药物的用途 |
| WO2006094207A2 (en) * | 2005-03-03 | 2006-09-08 | St. Jude Children's Research Hospital | Substituted phenoxazines and acridones as inhibitors of akt |
| MX2009007235A (es) * | 2007-01-05 | 2009-10-16 | Bkg Pharma Aps | "derivados de tioxanteno utiles para el tratamiento de enfermedades infecciosas.". |
| EP2246349A1 (en) * | 2009-04-20 | 2010-11-03 | BKG Pharma ApS | Treatment of infectious diseases |
-
2007
- 2007-01-05 MX MX2009007235A patent/MX2009007235A/es active IP Right Grant
- 2007-01-05 WO PCT/DK2007/000006 patent/WO2008080398A1/en active Application Filing
-
2008
- 2008-01-07 PT PT08700129T patent/PT2114406E/pt unknown
- 2008-01-07 NZ NZ577821A patent/NZ577821A/en not_active IP Right Cessation
- 2008-01-07 AT AT08700129T patent/ATE510540T1/de active
- 2008-01-07 EP EP10181816A patent/EP2301545A1/en not_active Withdrawn
- 2008-01-07 EA EA200970663A patent/EA016886B1/ru not_active IP Right Cessation
- 2008-01-07 EP EP08700129A patent/EP2114406B1/en not_active Not-in-force
- 2008-01-07 JP JP2009544361A patent/JP5399921B2/ja not_active Expired - Fee Related
- 2008-01-07 CN CN2008800017965A patent/CN101594869B/zh not_active Expired - Fee Related
- 2008-01-07 US US12/522,163 patent/US20100113430A1/en not_active Abandoned
- 2008-01-07 CA CA2673809A patent/CA2673809C/en not_active Expired - Fee Related
- 2008-01-07 WO PCT/DK2008/000005 patent/WO2008080408A1/en active Search and Examination
- 2008-01-07 ES ES08700129T patent/ES2367151T3/es active Active
- 2008-01-07 DK DK08700129.3T patent/DK2114406T3/da active
- 2008-01-07 AU AU2008203743A patent/AU2008203743B2/en not_active Ceased
- 2008-01-07 PL PL08700129T patent/PL2114406T3/pl unknown
-
2010
- 2010-04-29 HK HK10104252.3A patent/HK1139309A1/xx not_active IP Right Cessation
-
2011
- 2011-08-17 HR HR20110607T patent/HRP20110607T1/hr unknown
- 2011-08-22 CY CY20111100800T patent/CY1111778T1/el unknown
-
2013
- 2013-04-03 JP JP2013077738A patent/JP2013173752A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN101594869A (zh) | 2009-12-02 |
| CY1111778T1 (el) | 2015-10-07 |
| EP2301545A1 (en) | 2011-03-30 |
| AU2008203743A1 (en) | 2008-07-10 |
| JP2010514814A (ja) | 2010-05-06 |
| EA016886B1 (ru) | 2012-08-30 |
| AU2008203743B2 (en) | 2012-07-12 |
| WO2008080398A1 (en) | 2008-07-10 |
| CA2673809A1 (en) | 2008-07-10 |
| PT2114406E (pt) | 2011-08-25 |
| NZ577821A (en) | 2012-07-27 |
| JP5399921B2 (ja) | 2014-01-29 |
| CN101594869B (zh) | 2013-08-07 |
| EP2114406A1 (en) | 2009-11-11 |
| DK2114406T3 (da) | 2011-09-12 |
| PL2114406T3 (pl) | 2011-10-31 |
| CA2673809C (en) | 2013-08-13 |
| EP2114406B1 (en) | 2011-05-25 |
| ATE510540T1 (de) | 2011-06-15 |
| MX2009007235A (es) | 2009-10-16 |
| EA200970663A1 (ru) | 2009-12-30 |
| HK1139309A1 (en) | 2010-09-17 |
| JP2013173752A (ja) | 2013-09-05 |
| WO2008080408A1 (en) | 2008-07-10 |
| US20100113430A1 (en) | 2010-05-06 |
| ES2367151T3 (es) | 2011-10-28 |
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