HRP20110547T1 - Generator stroncij-82/rubidij-82, postupak za dobivanje rubidija-82 koji sadrži dijagnostičko sredstvo, navedeno dijagnostičko sredstvo i njegova uporaba u medicini - Google Patents
Generator stroncij-82/rubidij-82, postupak za dobivanje rubidija-82 koji sadrži dijagnostičko sredstvo, navedeno dijagnostičko sredstvo i njegova uporaba u medicini Download PDFInfo
- Publication number
- HRP20110547T1 HRP20110547T1 HR20110547T HRP20110547T HRP20110547T1 HR P20110547 T1 HRP20110547 T1 HR P20110547T1 HR 20110547 T HR20110547 T HR 20110547T HR P20110547 T HRP20110547 T HR P20110547T HR P20110547 T1 HRP20110547 T1 HR P20110547T1
- Authority
- HR
- Croatia
- Prior art keywords
- rubidium
- buffer
- strontium
- generator
- column
- Prior art date
Links
- IGLNJRXAVVLDKE-OIOBTWANSA-N Rubidium-82 Chemical compound [82Rb] IGLNJRXAVVLDKE-OIOBTWANSA-N 0.000 title claims abstract 10
- CIOAGBVUUVVLOB-VENIDDJXSA-N strontium-82 Chemical compound [82Sr] CIOAGBVUUVVLOB-VENIDDJXSA-N 0.000 title claims abstract 8
- 239000000032 diagnostic agent Substances 0.000 title claims abstract 5
- 229940039227 diagnostic agent Drugs 0.000 title claims abstract 5
- 239000003814 drug Substances 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 claims abstract 6
- 239000000872 buffer Substances 0.000 claims 5
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000001954 sterilising effect Effects 0.000 claims 4
- 239000000463 material Substances 0.000 claims 3
- 238000004659 sterilization and disinfection Methods 0.000 claims 3
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- 239000012149 elution buffer Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000004696 Poly ether ether ketone Substances 0.000 claims 1
- 239000004809 Teflon Substances 0.000 claims 1
- 229920006362 Teflon® Polymers 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 claims 1
- 125000005587 carbonate group Chemical group 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000007769 metal material Substances 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 229910052755 nonmetal Inorganic materials 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920002530 polyetherether ketone Polymers 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0031—Rubidium
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Dispersion Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Inorganic Insulating Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08075710A EP2157583B1 (fr) | 2008-08-18 | 2008-08-18 | Générateur de strontium-82/rubidium-82, procédé de production de rubidium-82 comportant un agent de diagnostic, cet agent de diagnostic et son utilisation médicale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110547T1 true HRP20110547T1 (hr) | 2011-09-30 |
Family
ID=40547891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110547T HRP20110547T1 (hr) | 2008-08-18 | 2011-07-25 | Generator stroncij-82/rubidij-82, postupak za dobivanje rubidija-82 koji sadrži dijagnostičko sredstvo, navedeno dijagnostičko sredstvo i njegova uporaba u medicini |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9023305B2 (fr) |
| EP (1) | EP2157583B1 (fr) |
| AT (1) | ATE515041T1 (fr) |
| AU (1) | AU2009284211B2 (fr) |
| BR (1) | BRPI0916972B8 (fr) |
| CA (1) | CA2733674C (fr) |
| CY (1) | CY1112091T1 (fr) |
| DK (1) | DK2157583T3 (fr) |
| ES (1) | ES2368662T3 (fr) |
| HR (1) | HRP20110547T1 (fr) |
| IL (1) | IL211264A (fr) |
| PL (1) | PL2157583T3 (fr) |
| PT (1) | PT2157583E (fr) |
| RU (1) | RU2507618C2 (fr) |
| SI (1) | SI2157583T1 (fr) |
| WO (1) | WO2010020596A1 (fr) |
| ZA (1) | ZA201100710B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8317674B2 (en) | 2008-06-11 | 2012-11-27 | Bracco Diagnostics Inc. | Shielding assemblies for infusion systems |
| US9597053B2 (en) | 2008-06-11 | 2017-03-21 | Bracco Diagnostics Inc. | Infusion systems including computer-facilitated maintenance and/or operation and methods of use |
| US7862534B2 (en) | 2008-06-11 | 2011-01-04 | Bracco Diagnostics Inc. | Infusion circuit subassemblies |
| CN104784770B (zh) | 2008-06-11 | 2019-06-11 | 布拉科诊断公司 | 包括计算机辅助维护和/或操作的输注系统 |
| US8708352B2 (en) | 2008-06-11 | 2014-04-29 | Bracco Diagnostics Inc. | Cabinet structure configurations for infusion systems |
| US8216181B2 (en) | 2008-11-19 | 2012-07-10 | Bracco Diagnostics, Inc. | Apparatus and methods for support of a membrane filter in a medical infusion system |
| GB201112051D0 (en) * | 2011-07-13 | 2011-08-31 | Mallinckrodt Llc | Process |
| EP2776825B1 (fr) * | 2011-11-10 | 2024-06-19 | F. Hoffmann-La Roche AG | Système de chromatographie colonne préparative |
| EP3696824B1 (fr) * | 2012-09-05 | 2023-07-19 | Jubilant Draximage, Inc. | Commande de système d'élution de rubidium |
| FR2995536B1 (fr) * | 2012-09-17 | 2014-09-26 | Lemer Prot Anti X Par Abreviation Soc Lemer Pax | Unite medicale pour l'injection de rubidium 82 a un patient |
| CN106104303B (zh) | 2014-03-13 | 2019-06-14 | 布拉科诊断公司 | 实时核同位素检测 |
| CN117854793A (zh) | 2016-09-20 | 2024-04-09 | 布拉科诊断公司 | 具有检测γ和β发射的多检测器的放射性同位素递送系统 |
| WO2019191386A1 (fr) | 2018-03-28 | 2019-10-03 | Bracco Diagnostics Inc. | Détection précoce de la durée de vie d'un générateur de radio-isotopes |
| US20210265069A1 (en) * | 2020-02-24 | 2021-08-26 | Jubilant Draximage Inc. | Heat resistant generator columns for elution systems |
| US11443866B2 (en) * | 2020-02-24 | 2022-09-13 | Jubilant Draximage Inc. | Generator columns for elution systems loaded with pre-charged matrix |
| RU2765983C1 (ru) * | 2021-03-30 | 2022-02-07 | Федеральное государственное бюджетное учреждение науки Институт ядерных исследований Российской академии наук (ИЯИ РАН) | Способ изготовления и повышения производительности медицинского генератора стронций-82/рубидий-82 |
| RU2767769C1 (ru) * | 2021-09-17 | 2022-03-21 | Общество с ограниченной ответственностью Научно-производственная фирма ПОЗИТОМ-ПРО (ООО НПФ "Позитом-ПРО") | Стронций-82/рубидий-82 генератор и способ его приготовления |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4406877A (en) * | 1980-06-04 | 1983-09-27 | E. R. Squibb & Sons, Inc. | 82 Rb Generating method and eluent |
| EP0650739B1 (fr) * | 1993-10-28 | 2003-02-26 | Medrad, Inc. | Système pour acheminer un moyen de contraste |
| US5966583A (en) * | 1998-05-12 | 1999-10-12 | The Regents Of The University Of California | Recovery of strontium activity from a strontium-82/rubidium-82 generator |
| US7476377B2 (en) * | 2001-08-02 | 2009-01-13 | Lynntech, Inc. | Rubidium-82 generator based on sodium nonatitanate support, and improved separation methods for the recovery of strontium-82 from irradiated targets |
| US7023000B2 (en) * | 2003-05-21 | 2006-04-04 | Triumf | Isotope generator |
| US8071959B2 (en) * | 2005-12-21 | 2011-12-06 | Ottawa Heart Institute Research Corp. | Rubidium generator for cardiac perfusion imaging and method of making and maintaining same |
| RU2467692C1 (ru) * | 2011-06-30 | 2012-11-27 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ И СОЦИАЛЬНОГО РАЗВИТИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ (ФГУ "РНЦРХТ" Минздравсоцразвития России) | Инфузионная система для радиофармпрепаратов на основе рубидия-82 из генератора |
-
2008
- 2008-08-18 SI SI200830360T patent/SI2157583T1/sl unknown
- 2008-08-18 DK DK08075710.7T patent/DK2157583T3/da active
- 2008-08-18 EP EP08075710A patent/EP2157583B1/fr active Active
- 2008-08-18 PT PT08075710T patent/PT2157583E/pt unknown
- 2008-08-18 AT AT08075710T patent/ATE515041T1/de active
- 2008-08-18 ES ES08075710T patent/ES2368662T3/es active Active
- 2008-08-18 PL PL08075710T patent/PL2157583T3/pl unknown
-
2009
- 2009-08-14 BR BRPI0916972A patent/BRPI0916972B8/pt active IP Right Grant
- 2009-08-14 AU AU2009284211A patent/AU2009284211B2/en active Active
- 2009-08-14 RU RU2011110262/07A patent/RU2507618C2/ru active
- 2009-08-14 CA CA2733674A patent/CA2733674C/fr active Active
- 2009-08-14 WO PCT/EP2009/060584 patent/WO2010020596A1/fr active Application Filing
- 2009-08-14 US US13/056,103 patent/US9023305B2/en active Active
-
2011
- 2011-01-27 ZA ZA2011/00710A patent/ZA201100710B/en unknown
- 2011-02-17 IL IL211264A patent/IL211264A/en active IP Right Grant
- 2011-07-25 HR HR20110547T patent/HRP20110547T1/hr unknown
- 2011-08-30 CY CY20111100826T patent/CY1112091T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2507618C2 (ru) | 2014-02-20 |
| CA2733674C (fr) | 2017-03-21 |
| IL211264A (en) | 2016-05-31 |
| US9023305B2 (en) | 2015-05-05 |
| AU2009284211B2 (en) | 2014-09-11 |
| US20110182808A1 (en) | 2011-07-28 |
| CA2733674A1 (fr) | 2010-02-25 |
| PT2157583E (pt) | 2011-08-25 |
| ES2368662T3 (es) | 2011-11-21 |
| SI2157583T1 (sl) | 2011-10-28 |
| WO2010020596A1 (fr) | 2010-02-25 |
| CY1112091T1 (el) | 2015-11-04 |
| IL211264A0 (en) | 2011-04-28 |
| AU2009284211A1 (en) | 2010-02-25 |
| BRPI0916972B1 (pt) | 2020-12-15 |
| ATE515041T1 (de) | 2011-07-15 |
| ZA201100710B (en) | 2012-05-01 |
| BRPI0916972B8 (pt) | 2021-07-27 |
| EP2157583B1 (fr) | 2011-06-29 |
| BRPI0916972A2 (pt) | 2016-07-26 |
| PL2157583T3 (pl) | 2011-11-30 |
| RU2011110262A (ru) | 2012-09-27 |
| EP2157583A1 (fr) | 2010-02-24 |
| DK2157583T3 (da) | 2011-10-24 |
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