HRP20110436T1 - Supstituirani karboksamidi kao antagonisti metabotropnih receptora iz skupine i - Google Patents
Supstituirani karboksamidi kao antagonisti metabotropnih receptora iz skupine i Download PDFInfo
- Publication number
- HRP20110436T1 HRP20110436T1 HR20110436T HRP20110436T HRP20110436T1 HR P20110436 T1 HRP20110436 T1 HR P20110436T1 HR 20110436 T HR20110436 T HR 20110436T HR P20110436 T HRP20110436 T HR P20110436T HR P20110436 T1 HRP20110436 T1 HR P20110436T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- acceptable salt
- hydrogen
- Prior art date
Links
- 150000003857 carboxamides Chemical class 0.000 title 1
- 239000003512 metabotropic receptor antagonist Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract 7
- -1 carboxamide compound Chemical class 0.000 claims abstract 5
- 150000001875 compounds Chemical class 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- LXZFJIRPRVGCDF-PRHODGIISA-N (1r,2r)-n-[3-(4-chlorophenyl)-4-methyl-1,2-thiazol-5-yl]-2-methylcyclopropane-1-carboxamide Chemical group C[C@@H]1C[C@H]1C(=O)NC1=C(C)C(C=2C=CC(Cl)=CC=2)=NS1 LXZFJIRPRVGCDF-PRHODGIISA-N 0.000 claims 1
- 125000006002 1,1-difluoroethyl group Chemical group 0.000 claims 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81183906P | 2006-06-08 | 2006-06-08 | |
| PCT/US2007/070572 WO2008103185A2 (fr) | 2006-06-08 | 2007-06-07 | Carboxamides substitués |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110436T1 true HRP20110436T1 (hr) | 2011-08-31 |
Family
ID=39673278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110436T HRP20110436T1 (hr) | 2006-06-08 | 2011-06-09 | Supstituirani karboksamidi kao antagonisti metabotropnih receptora iz skupine i |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7960419B2 (fr) |
| EP (1) | EP2076502B1 (fr) |
| JP (1) | JP5108878B2 (fr) |
| KR (1) | KR101051559B1 (fr) |
| CN (1) | CN101466691B (fr) |
| AT (1) | ATE509921T1 (fr) |
| AU (1) | AU2007347428B2 (fr) |
| BR (1) | BRPI0712862A2 (fr) |
| CA (1) | CA2652074C (fr) |
| CR (1) | CR10410A (fr) |
| CY (1) | CY1111588T1 (fr) |
| DK (1) | DK2076502T3 (fr) |
| EA (1) | EA014233B1 (fr) |
| EC (1) | ECSP088939A (fr) |
| ES (1) | ES2362949T3 (fr) |
| HK (1) | HK1131984A1 (fr) |
| HR (1) | HRP20110436T1 (fr) |
| IL (1) | IL195632A (fr) |
| MA (1) | MA30620B1 (fr) |
| MX (1) | MX2008015485A (fr) |
| MY (1) | MY148084A (fr) |
| NO (1) | NO341474B1 (fr) |
| NZ (1) | NZ573352A (fr) |
| PL (1) | PL2076502T3 (fr) |
| PT (1) | PT2076502E (fr) |
| RS (1) | RS51818B (fr) |
| SI (1) | SI2076502T1 (fr) |
| TN (1) | TNSN08506A1 (fr) |
| UA (1) | UA95480C2 (fr) |
| WO (1) | WO2008103185A2 (fr) |
| ZA (1) | ZA200809111B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0804685D0 (en) | 2008-03-13 | 2008-04-16 | Univ Edinburgh | Therapeutic compounds and their use |
| PL2276759T3 (pl) | 2008-04-04 | 2012-03-30 | Lilly Co Eli | 3-indazolilo-4-pirydyloizotiazole |
| WO2010146338A1 (fr) * | 2009-06-15 | 2010-12-23 | The University Of Edinburgh | Composés amido-isothiazole et leur utilisation comme inhibiteurs de la 11 β-hsd1 dans le traitement du syndrome métabolique et des troubles apparentés |
| ES2540547T3 (es) | 2009-09-16 | 2015-07-10 | The University Of Edinburgh | Compuestos de (4-fenil-piperidin-1-il)-[5-(1H-pirazol-4-il)-tiofen-3-il]-metanona y su uso |
| DK2563780T3 (en) | 2010-04-29 | 2015-07-27 | Univ Edinburgh | 3,3-DISUBSTITUEREDE- (8-aza-bicyclo [3.2.1] oct-8-yl) - [5- (1H-pyrazol-4-yl) -thiophene-3-yl] -METHANONER as inhibitors of 11 ( BETA) -HSD1 |
| NO2921489T3 (fr) | 2012-11-13 | 2018-02-03 | ||
| JP2019529452A (ja) | 2016-09-23 | 2019-10-17 | バイエル・アクチエンゲゼルシヤフト | Ｎ３−環状置換チエノウラシルおよびその使用 |
| CN117567266B (zh) * | 2023-11-07 | 2024-06-14 | 康龙化成手性医药技术(宁波)有限公司 | 一种制备2-甲基环丙羧酸的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL72091A0 (en) * | 1983-06-20 | 1984-10-31 | Lilly Co Eli | N'-substituted(3-aryl 5-isothiazolyl)urea derivatives |
| DE4328425A1 (de) | 1993-08-24 | 1995-03-02 | Basf Ag | Acylamino-substituierte Isoxazol- bzw. Isothiazolderivate, Verfahren zu deren Herstellung und ihre Verwendung |
| DK124393D0 (da) * | 1993-11-03 | 1993-11-03 | Lundbeck & Co As H | Compounds |
| DE19542372A1 (de) * | 1995-11-14 | 1997-05-15 | Bayer Ag | Acylierte 5-Aminoisothiazole |
| UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| JP3411262B2 (ja) * | 1999-08-20 | 2003-05-26 | 萬有製薬株式会社 | 新規スピロ化合物 |
| EP1435948A1 (fr) * | 2001-08-06 | 2004-07-14 | Pharmacia Italia S.p.A. | D riv s d'aminoisoxazole agissant comme inhibiteurs de la kinase |
| EP1667983A4 (fr) * | 2003-09-23 | 2010-07-21 | Merck Sharp & Dohme | Modulateurs pyrazole de recepteurs de glutamate metabotropiques |
| CN1984899B (zh) * | 2004-05-12 | 2011-07-27 | 先灵公司 | Cxcr1和cxcr2趋化因子拮抗剂 |
| BRPI0515571A (pt) * | 2004-09-23 | 2008-07-29 | Pfizer Prod Inc | agonistas de receptor de trombopoetina |
-
2007
- 2007-06-07 WO PCT/US2007/070572 patent/WO2008103185A2/fr active Application Filing
- 2007-06-07 UA UAA200813907A patent/UA95480C2/uk unknown
- 2007-06-07 ES ES07873705T patent/ES2362949T3/es active Active
- 2007-06-07 US US12/300,415 patent/US7960419B2/en active Active
- 2007-06-07 SI SI200730695T patent/SI2076502T1/sl unknown
- 2007-06-07 CA CA2652074A patent/CA2652074C/fr not_active Expired - Fee Related
- 2007-06-07 PT PT07873705T patent/PT2076502E/pt unknown
- 2007-06-07 AT AT07873705T patent/ATE509921T1/de active
- 2007-06-07 AU AU2007347428A patent/AU2007347428B2/en not_active Ceased
- 2007-06-07 EP EP07873705A patent/EP2076502B1/fr active Active
- 2007-06-07 KR KR1020087029772A patent/KR101051559B1/ko not_active IP Right Cessation
- 2007-06-07 MY MYPI20084973A patent/MY148084A/en unknown
- 2007-06-07 JP JP2009514523A patent/JP5108878B2/ja not_active Expired - Fee Related
- 2007-06-07 PL PL07873705T patent/PL2076502T3/pl unknown
- 2007-06-07 CN CN2007800211890A patent/CN101466691B/zh not_active Expired - Fee Related
- 2007-06-07 DK DK07873705.3T patent/DK2076502T3/da active
- 2007-06-07 BR BRPI0712862-2A patent/BRPI0712862A2/pt not_active IP Right Cessation
- 2007-06-07 NZ NZ573352A patent/NZ573352A/en not_active IP Right Cessation
- 2007-06-07 MX MX2008015485A patent/MX2008015485A/es active IP Right Grant
- 2007-06-07 RS RS20110336A patent/RS51818B/en unknown
- 2007-06-07 EA EA200870516A patent/EA014233B1/ru not_active IP Right Cessation
- 2007-10-29 CR CR10410A patent/CR10410A/es unknown
-
2008
- 2008-10-23 ZA ZA200809111A patent/ZA200809111B/xx unknown
- 2008-12-01 IL IL195632A patent/IL195632A/en not_active IP Right Cessation
- 2008-12-02 NO NO20085028A patent/NO341474B1/no not_active IP Right Cessation
- 2008-12-03 EC EC2008008939A patent/ECSP088939A/es unknown
- 2008-12-05 TN TNP2008000506A patent/TNSN08506A1/en unknown
-
2009
- 2009-01-06 MA MA31553A patent/MA30620B1/fr unknown
- 2009-12-02 HK HK09111272.7A patent/HK1131984A1/xx not_active IP Right Cessation
-
2011
- 2011-06-09 HR HR20110436T patent/HRP20110436T1/hr unknown
- 2011-06-24 CY CY20111100600T patent/CY1111588T1/el unknown
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