HRP20110410T1 - Poboljšani postupci proizvodnje daptomicina - Google Patents
Poboljšani postupci proizvodnje daptomicina Download PDFInfo
- Publication number
- HRP20110410T1 HRP20110410T1 HR20110410T HRP20110410T HRP20110410T1 HR P20110410 T1 HRP20110410 T1 HR P20110410T1 HR 20110410 T HR20110410 T HR 20110410T HR P20110410 T HRP20110410 T HR P20110410T HR P20110410 T1 HRP20110410 T1 HR P20110410T1
- Authority
- HR
- Croatia
- Prior art keywords
- oil
- decanal
- daptomycin
- added
- production
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 12
- 108010013198 Daptomycin Proteins 0.000 title claims abstract 3
- DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 title claims abstract 3
- 229960005484 daptomycin Drugs 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- KSMVZQYAVGTKIV-UHFFFAOYSA-N decanal Chemical compound CCCCCCCCCC=O KSMVZQYAVGTKIV-UHFFFAOYSA-N 0.000 claims abstract 10
- 241000219992 Cuphea Species 0.000 claims abstract 6
- -1 n-decanoyl side chain Chemical group 0.000 claims abstract 4
- 239000002904 solvent Substances 0.000 claims abstract 4
- 238000000855 fermentation Methods 0.000 claims abstract 3
- 230000004151 fermentation Effects 0.000 claims abstract 3
- 241000958215 Streptomyces filamentosus Species 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 239000003921 oil Substances 0.000 claims 5
- 235000019198 oils Nutrition 0.000 claims 5
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 claims 4
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 claims 4
- 229940073769 methyl oleate Drugs 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- 235000019482 Palm oil Nutrition 0.000 claims 1
- 235000019486 Sunflower oil Nutrition 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002540 palm oil Substances 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- 239000002600 sunflower oil Substances 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Postupak proizvodnje daptomicina, naznačen time da se provodi fermentacija sa Streptomyces roseosporus u prisutnosti n-dekanala ili ulja Cuphea kao izvora n-dekanoilnog bočnog lanca. Patent sadrži još 9 patentnih zahtjeva.
Claims (10)
1. Postupak proizvodnje daptomicina, naznačen time da se provodi fermentacija sa Streptomyces roseosporus u prisutnosti n-dekanala ili ulja Cuphea kao izvora n-dekanoilnog bočnog lanca.
2. Postupak prema patentnom zahtjevu 1, naznačen time da izvor n-dekanoilnog bočnog lanca jest n-dekanal.
3. Postupak prema patentnom zahtjevu 2, naznačen time da je n-dekanal dodavan u otopinu organskog otapala koje je odabrano od sljedećih: metil-oleat, etanol te etil-acetat.
4. Postupak prema patentnom zahtjevu 3, naznačen time da otapalo jest metil-oleat.
5. Postupak prema patentnom zahtjevu 2, naznačen time da je n-dekanal dodan bez otapala.
6. Postupak prema patentnom zahtjevu 1, naznačen time da izvor n-dekanoilnog bočnog lanca jest ulje Cuphea.
7. Postupak prema patentnom zahtjevu 6, naznačen time da je ulje Cuphea dodano u otopinu organskog otapala koje je odabrano od sljedećih: metil-oleat, etanol ili njegova smjesa sa sojinim uljem, palmino ulje ili suncokretovo ulje.
8. Postupak prema patentnom zahtjevu 7, naznačen time da organsko otapalo jest metil-oleat.
9. Postupak prema patentnom zahtjevu 6, naznačen time da je ulje Cuphea dodavano bez otapala.
10. Postupak prema bilo kojem od patentnih zahtjeva 6 - 9, naznačen time da se izvodi kao šarža za fermentiranje s čistim uljem Cuphea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08161630A EP2149609B1 (en) | 2008-08-01 | 2008-08-01 | Improved process for the production of daptomycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110410T1 true HRP20110410T1 (hr) | 2011-06-30 |
Family
ID=40162500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110410T HRP20110410T1 (hr) | 2008-08-01 | 2011-06-03 | Poboljšani postupci proizvodnje daptomicina |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8313922B2 (hr) |
| EP (1) | EP2149609B1 (hr) |
| AT (1) | ATE503020T1 (hr) |
| CA (1) | CA2674257C (hr) |
| CY (1) | CY1111777T1 (hr) |
| DE (1) | DE602008005731D1 (hr) |
| DK (1) | DK2149609T3 (hr) |
| ES (1) | ES2359378T3 (hr) |
| HR (1) | HRP20110410T1 (hr) |
| IL (1) | IL200172A (hr) |
| PL (1) | PL2149609T3 (hr) |
| PT (1) | PT2149609E (hr) |
| SI (1) | SI2149609T1 (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102796680B (zh) * | 2012-07-04 | 2018-06-05 | 鲁南新时代生物技术有限公司 | 一种玫瑰孢链霉菌及其利用组合前体生产达托霉素的方法 |
| CN103695511A (zh) * | 2013-12-05 | 2014-04-02 | 成都雅途生物技术有限公司 | 一种发酵生产达托霉素的方法 |
| CN103695509A (zh) * | 2013-12-05 | 2014-04-02 | 成都雅途生物技术有限公司 | 一种流加癸醛发酵生产达托霉素的方法 |
| CN103695510A (zh) * | 2013-12-05 | 2014-04-02 | 成都雅途生物技术有限公司 | 一种流加油酸甲酯发酵生产达托霉素的方法 |
| KR101580370B1 (ko) * | 2013-12-18 | 2015-12-23 | 동국제약 주식회사 | 신규한 스트렙토마이세스 필라멘토서스 변이주 및 이를 이용한 답토마이신의 생산 방법 |
| KR101716879B1 (ko) * | 2014-11-19 | 2017-03-17 | 주식회사 종근당바이오 | 데카노일 글리세라이드를 이용한 답토마이신의 생산방법 |
| IT201600127655A1 (it) | 2016-12-16 | 2018-06-16 | Gnosis Spa | Processo per la purificazione di antibiotici lipopolipeptidici |
| CN108342435A (zh) * | 2017-01-22 | 2018-07-31 | 江苏恒瑞医药股份有限公司 | 一种发酵制备达托霉素的方法 |
| CN109593808B (zh) * | 2017-09-30 | 2022-10-04 | 上海医药工业研究院 | 达托霉素发酵培养基及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331594A (en) | 1978-10-16 | 1982-05-25 | Eli Lilly And Company | A-21978 Antibiotics and process for their production |
| US4885243A (en) | 1984-10-09 | 1989-12-05 | Eli Lilly And Company | Process for producing A-21978C derivatives |
| US4800157A (en) | 1985-09-09 | 1989-01-24 | Eli Lilly And Company | Process for producing the A-21978C antibiotics |
-
2008
- 2008-08-01 SI SI200830253T patent/SI2149609T1/sl unknown
- 2008-08-01 ES ES08161630T patent/ES2359378T3/es active Active
- 2008-08-01 PT PT08161630T patent/PT2149609E/pt unknown
- 2008-08-01 EP EP08161630A patent/EP2149609B1/en active Active
- 2008-08-01 AT AT08161630T patent/ATE503020T1/de active
- 2008-08-01 PL PL08161630T patent/PL2149609T3/pl unknown
- 2008-08-01 DK DK08161630.2T patent/DK2149609T3/da active
- 2008-08-01 DE DE602008005731T patent/DE602008005731D1/de active Active
-
2009
- 2009-07-30 US US12/512,414 patent/US8313922B2/en active Active
- 2009-07-30 CA CA2674257A patent/CA2674257C/en active Active
- 2009-07-30 IL IL200172A patent/IL200172A/en active IP Right Grant
-
2011
- 2011-05-17 CY CY20111100482T patent/CY1111777T1/el unknown
- 2011-06-03 HR HR20110410T patent/HRP20110410T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI2149609T1 (sl) | 2011-06-30 |
| IL200172A0 (en) | 2010-05-31 |
| IL200172A (en) | 2011-12-29 |
| US20100047873A1 (en) | 2010-02-25 |
| EP2149609A1 (en) | 2010-02-03 |
| DE602008005731D1 (de) | 2011-05-05 |
| US8313922B2 (en) | 2012-11-20 |
| EP2149609B1 (en) | 2011-03-23 |
| CA2674257A1 (en) | 2010-02-01 |
| CA2674257C (en) | 2016-04-19 |
| PT2149609E (pt) | 2011-04-14 |
| ES2359378T3 (es) | 2011-05-23 |
| PL2149609T3 (pl) | 2011-08-31 |
| ATE503020T1 (de) | 2011-04-15 |
| CY1111777T1 (el) | 2015-10-07 |
| DK2149609T3 (da) | 2011-05-16 |
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