HRP20110397T1 - Antitijela za nik, njihovo dobivanje i upotreba - Google Patents
Antitijela za nik, njihovo dobivanje i upotreba Download PDFInfo
- Publication number
- HRP20110397T1 HRP20110397T1 HR20110397T HRP20110397T HRP20110397T1 HR P20110397 T1 HRP20110397 T1 HR P20110397T1 HR 20110397 T HR20110397 T HR 20110397T HR P20110397 T HRP20110397 T HR P20110397T HR P20110397 T1 HRP20110397 T1 HR P20110397T1
- Authority
- HR
- Croatia
- Prior art keywords
- antibody
- nik
- parts
- preparation
- seq
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 7
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims abstract 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims abstract 3
- 102100028194 Mitogen-activated protein kinase kinase kinase kinase 4 Human genes 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 230000004913 activation Effects 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 2
- USRGIUJOYOXOQJ-GBXIJSLDSA-N phosphothreonine Chemical compound OP(=O)(O)O[C@H](C)[C@H](N)C(O)=O USRGIUJOYOXOQJ-GBXIJSLDSA-N 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 201000003068 rheumatic fever Diseases 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 229920000936 Agarose Polymers 0.000 claims 1
- 229920002684 Sepharose Polymers 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 238000000749 co-immunoprecipitation Methods 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 238000003119 immunoblot Methods 0.000 claims 1
- 238000001114 immunoprecipitation Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000011895 specific detection Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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-
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL15828603A IL158286A0 (en) | 2003-10-07 | 2003-10-07 | Antibodies to nik, their preparation and use |
| IL16325104 | 2004-07-28 | ||
| PCT/IL2004/000920 WO2005033145A1 (en) | 2003-10-07 | 2004-10-05 | Antibodies to nik, their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110397T1 true HRP20110397T1 (hr) | 2011-06-30 |
Family
ID=34424916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110397T HRP20110397T1 (hr) | 2003-10-07 | 2011-05-27 | Antitijela za nik, njihovo dobivanje i upotreba |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20080274102A1 (sl) |
| EP (1) | EP1678209B1 (sl) |
| JP (1) | JP4943848B2 (sl) |
| AT (1) | ATE509034T1 (sl) |
| AU (1) | AU2004278175B2 (sl) |
| CA (1) | CA2541535C (sl) |
| CY (1) | CY1111979T1 (sl) |
| DK (1) | DK1678209T3 (sl) |
| HR (1) | HRP20110397T1 (sl) |
| IL (1) | IL174826A (sl) |
| NO (1) | NO338436B1 (sl) |
| PL (1) | PL1678209T3 (sl) |
| PT (1) | PT1678209E (sl) |
| SI (1) | SI1678209T1 (sl) |
| WO (1) | WO2005033145A1 (sl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US7615211B2 (en) * | 2004-02-09 | 2009-11-10 | Cbr Institute For Biomedical Research, Inc. | CD70 inhibition for the treatment and prevention of inflammatory bowel disease |
| AU2006319358B2 (en) | 2005-11-30 | 2012-01-19 | AbbVie Deutschland GmbH & Co. KG | Anti-Abeta globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
| CN101506236B (zh) | 2005-11-30 | 2012-12-12 | 雅培制药有限公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| WO2012024187A1 (en) | 2010-08-14 | 2012-02-23 | Abbott Laboratories | Amyloid-beta binding proteins |
| US9598460B2 (en) | 2011-01-18 | 2017-03-21 | University Of Notre Dame Du Lac | Antibody purification via affinity chromatography |
| JP5828079B2 (ja) | 2011-08-30 | 2015-12-02 | パナソニックＩｐマネジメント株式会社 | 照明装置及び照明システム |
| AU2015320341B2 (en) * | 2014-09-26 | 2021-05-27 | Rajendra Sahai Bhatnagar | Inhibitors of NF kappa-B activity for treatment of diseases and disorders |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4699880A (en) | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US6132764A (en) | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| UA71889C2 (uk) * | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
| US6037137A (en) | 1997-02-20 | 2000-03-14 | Oncoimmunin, Inc. | Fluorogenic peptides for the detection of protease activity |
| US5843721A (en) * | 1997-07-03 | 1998-12-01 | Tularik Inc. | Nucleic acids encoding human NIK protein |
| AU2877899A (en) * | 1998-02-27 | 1999-09-15 | Regents Of The University Of California, The | A novel inhibitor of the inflammatory response induced by tnfalpha and il-1 |
| US20010053769A1 (en) * | 2000-01-21 | 2001-12-20 | Christiane Ferran | Use of pro-apoptotic factors in treatment of atherosclerosis |
| EP1201765A3 (en) * | 2000-10-16 | 2003-08-27 | Axxima Pharmaceuticals Aktiengesellschaft | Cellular kinases involved in cytomegalovirus infection and their inhibition |
| US6822138B1 (en) * | 2000-11-02 | 2004-11-23 | Washington University In St. Louis | NIK-knockout mice |
| WO2002098782A1 (fr) * | 2001-06-04 | 2002-12-12 | Mitsubishi Denki Kabushiki Kaisha | Dispositif ascenseur |
-
2004
- 2004-10-05 PL PL04770591T patent/PL1678209T3/pl unknown
- 2004-10-05 PT PT04770591T patent/PT1678209E/pt unknown
- 2004-10-05 US US10/573,136 patent/US20080274102A1/en not_active Abandoned
- 2004-10-05 AT AT04770591T patent/ATE509034T1/de active
- 2004-10-05 WO PCT/IL2004/000920 patent/WO2005033145A1/en active Application Filing
- 2004-10-05 DK DK04770591.8T patent/DK1678209T3/da active
- 2004-10-05 JP JP2006531016A patent/JP4943848B2/ja not_active Expired - Fee Related
- 2004-10-05 SI SI200431697T patent/SI1678209T1/sl unknown
- 2004-10-05 CA CA2541535A patent/CA2541535C/en not_active Expired - Lifetime
- 2004-10-05 AU AU2004278175A patent/AU2004278175B2/en not_active Ceased
- 2004-10-05 EP EP04770591A patent/EP1678209B1/en not_active Expired - Lifetime
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2006
- 2006-04-06 IL IL174826A patent/IL174826A/en not_active IP Right Cessation
- 2006-05-05 NO NO20062018A patent/NO338436B1/no not_active IP Right Cessation
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2011
- 2011-05-27 HR HR20110397T patent/HRP20110397T1/hr unknown
- 2011-06-16 CY CY20111100574T patent/CY1111979T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2541535C (en) | 2013-12-10 |
| PT1678209E (pt) | 2011-06-30 |
| DK1678209T3 (da) | 2011-06-27 |
| EP1678209B1 (en) | 2011-05-11 |
| ATE509034T1 (de) | 2011-05-15 |
| NO20062018L (no) | 2006-05-05 |
| IL174826A (en) | 2011-04-28 |
| WO2005033145A8 (en) | 2005-12-15 |
| CY1111979T1 (el) | 2015-11-04 |
| SI1678209T1 (sl) | 2011-07-29 |
| JP4943848B2 (ja) | 2012-05-30 |
| US20080274102A1 (en) | 2008-11-06 |
| WO2005033145A1 (en) | 2005-04-14 |
| CA2541535A1 (en) | 2005-04-14 |
| JP2007537708A (ja) | 2007-12-27 |
| EP1678209A1 (en) | 2006-07-12 |
| NO338436B1 (no) | 2016-08-15 |
| PL1678209T3 (pl) | 2011-09-30 |
| IL174826A0 (en) | 2006-08-20 |
| AU2004278175B2 (en) | 2010-11-04 |
| AU2004278175A1 (en) | 2005-04-14 |
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