HRP20100433T1 - Diazaindol-dikarbonil-piperazinil antivirotici - Google Patents
Diazaindol-dikarbonil-piperazinil antivirotici Download PDFInfo
- Publication number
- HRP20100433T1 HRP20100433T1 HR20100433T HRP20100433T HRP20100433T1 HR P20100433 T1 HRP20100433 T1 HR P20100433T1 HR 20100433 T HR20100433 T HR 20100433T HR P20100433 T HRP20100433 T HR P20100433T HR P20100433 T1 HRP20100433 T1 HR P20100433T1
- Authority
- HR
- Croatia
- Prior art keywords
- group
- phenyl
- heteroaryl
- same
- independently
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title claims 4
- 229910052736 halogen Inorganic materials 0.000 claims abstract 46
- 150000002367 halogens Chemical class 0.000 claims abstract 46
- 150000001875 compounds Chemical class 0.000 claims abstract 28
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 24
- 239000001257 hydrogen Substances 0.000 claims abstract 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 12
- 150000002431 hydrogen Chemical class 0.000 claims abstract 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 9
- 150000003839 salts Chemical class 0.000 claims abstract 7
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 36
- 125000001072 heteroaryl group Chemical group 0.000 claims 35
- 125000004076 pyridyl group Chemical group 0.000 claims 21
- -1 -amino Chemical group 0.000 claims 19
- 125000001424 substituent group Chemical group 0.000 claims 19
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 17
- 125000002541 furyl group Chemical group 0.000 claims 12
- 125000001544 thienyl group Chemical group 0.000 claims 12
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 8
- 125000003226 pyrazolyl group Chemical group 0.000 claims 8
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 8
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 6
- 208000030507 AIDS Diseases 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000005956 isoquinolyl group Chemical group 0.000 claims 6
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 6
- 125000001425 triazolyl group Chemical group 0.000 claims 6
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 claims 5
- 125000000842 isoxazolyl group Chemical group 0.000 claims 5
- 125000003373 pyrazinyl group Chemical group 0.000 claims 5
- 125000002098 pyridazinyl group Chemical group 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 4
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 4
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 4
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical class 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 229960005475 antiinfective agent Drugs 0.000 claims 3
- 239000004599 antimicrobial Substances 0.000 claims 3
- 125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000002835 hiv fusion inhibitor Substances 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 239000002955 immunomodulating agent Substances 0.000 claims 3
- 229940121354 immunomodulator Drugs 0.000 claims 3
- 230000002584 immunomodulator Effects 0.000 claims 3
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 claims 3
- 125000002971 oxazolyl group Chemical group 0.000 claims 3
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 3
- 125000004193 piperazinyl group Chemical group 0.000 claims 3
- 125000005493 quinolyl group Chemical group 0.000 claims 3
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 3
- 125000003831 tetrazolyl group Chemical group 0.000 claims 3
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 3
- 125000000335 thiazolyl group Chemical group 0.000 claims 3
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 229940126154 HIV entry inhibitor Drugs 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52562403P | 2003-11-26 | 2003-11-26 | |
| PCT/US2004/037213 WO2005054247A1 (en) | 2003-11-26 | 2004-11-04 | Diazaindole-dicarbonyl-piperazinyl antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100433T1 true HRP20100433T1 (hr) | 2010-09-30 |
Family
ID=34652366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100433T HRP20100433T1 (hr) | 2003-11-26 | 2010-08-03 | Diazaindol-dikarbonil-piperazinil antivirotici |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20050124623A1 (zh) |
| EP (1) | EP1751161B1 (zh) |
| JP (1) | JP2007512332A (zh) |
| KR (1) | KR20070008526A (zh) |
| CN (1) | CN1906199A (zh) |
| AR (1) | AR046720A1 (zh) |
| AT (1) | ATE473981T1 (zh) |
| AU (1) | AU2004295309A1 (zh) |
| BR (1) | BRPI0417007A (zh) |
| CA (1) | CA2547347C (zh) |
| CY (1) | CY1110831T1 (zh) |
| DE (1) | DE602004028173D1 (zh) |
| DK (1) | DK1751161T3 (zh) |
| ES (1) | ES2347253T3 (zh) |
| HR (1) | HRP20100433T1 (zh) |
| IL (1) | IL175809A (zh) |
| IS (1) | IS2890B (zh) |
| MX (1) | MXPA06005730A (zh) |
| NO (1) | NO336261B1 (zh) |
| NZ (1) | NZ546904A (zh) |
| PE (1) | PE20050587A1 (zh) |
| PL (1) | PL1751161T3 (zh) |
| PT (1) | PT1751161E (zh) |
| RU (1) | RU2362777C2 (zh) |
| SI (1) | SI1751161T1 (zh) |
| TW (1) | TWI336253B (zh) |
| UA (1) | UA85502C2 (zh) |
| WO (1) | WO2005054247A1 (zh) |
| ZA (1) | ZA200604331B (zh) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7449476B2 (en) | 2004-05-26 | 2008-11-11 | Bristol-Myers Squibb Company | Tetrahydrocarboline antiviral agents |
| US20060100432A1 (en) * | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| US20060100209A1 (en) * | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| US7851476B2 (en) * | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
| US7807671B2 (en) * | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
| AR070454A1 (es) * | 2008-02-27 | 2010-04-07 | Nycomed Gmbh | Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprenden |
| AR077898A1 (es) | 2009-08-26 | 2011-09-28 | Nycomed Gmbh | Metilpirrolopirimidincarboxamidas |
| WO2011041713A2 (en) * | 2009-10-02 | 2011-04-07 | Glaxosmithkline Llc | Piperazinyl antiviral agents |
| US9139590B2 (en) | 2011-02-04 | 2015-09-22 | Duquesne University Of The Holy Spirit | Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient |
| EP2978762A1 (en) * | 2013-03-27 | 2016-02-03 | Bristol-Myers Squibb Company | Piperazine and homopiperazine derivatives as hiv attachment inhibitors |
| CN105283455B (zh) * | 2013-03-27 | 2017-06-16 | 百时美施贵宝公司 | 作为hiv吸附抑制剂的2‑酮基酰胺衍生物 |
| DK3177612T3 (da) | 2014-08-04 | 2022-05-16 | Nuevolution As | Eventuelt fusionerede heterocyclylsubstituerede derivater af pyrimidin, der er anvendelige til behandling af inflammatoriske, metaboliske, onkologiske og autoimmune sygdomme |
| WO2016183093A1 (en) * | 2015-05-11 | 2016-11-17 | University Of Kansas | Inhibitors of viruses |
| MX2022007265A (es) | 2019-12-20 | 2022-09-09 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| MX2022012260A (es) | 2020-03-31 | 2022-11-30 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
| MX2022012259A (es) | 2020-03-31 | 2022-12-08 | Nuevolution As | Compuestos activos frente a receptores nucleares. |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023265A (en) * | 1990-06-01 | 1991-06-11 | Schering Corporation | Substituted 1-H-pyrrolopyridine-3-carboxamides |
| IT1265057B1 (it) | 1993-08-05 | 1996-10-28 | Dompe Spa | Tropil 7-azaindolil-3-carbossiamidi |
| US5424329A (en) * | 1993-08-18 | 1995-06-13 | Warner-Lambert Company | Indole-2-carboxamides as inhibitors of cell adhesion |
| GB9420521D0 (en) | 1994-10-12 | 1994-11-30 | Smithkline Beecham Plc | Novel compounds |
| DE19814838C2 (de) | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
| DE69934311D1 (de) | 1998-06-30 | 2007-01-18 | Lilly Co Eli | BICYCLISCHE sPLA 2-INHIBITOREN |
| US6469006B1 (en) * | 1999-06-15 | 2002-10-22 | Bristol-Myers Squibb Company | Antiviral indoleoxoacetyl piperazine derivatives |
| TWI269654B (en) | 1999-09-28 | 2007-01-01 | Baxter Healthcare Sa | N-substituted indole-3-glyoxylamide compounds having anti-tumor action |
| US6476034B2 (en) * | 2000-02-22 | 2002-11-05 | Bristol-Myers Squibb Company | Antiviral azaindole derivatives |
| US6573262B2 (en) * | 2000-07-10 | 2003-06-03 | Bristol-Myers Sqibb Company | Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives |
| DE10037310A1 (de) | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
| US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| EP1363705B9 (en) * | 2001-02-02 | 2012-11-07 | Bristol-Myers Squibb Company | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US20030207910A1 (en) * | 2001-02-02 | 2003-11-06 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US6825201B2 (en) | 2001-04-25 | 2004-11-30 | Bristol-Myers Squibb Company | Indole, azaindole and related heterocyclic amidopiperazine derivatives |
| US20030236277A1 (en) | 2002-02-14 | 2003-12-25 | Kadow John F. | Indole, azaindole and related heterocyclic pyrrolidine derivatives |
| US7037913B2 (en) | 2002-05-01 | 2006-05-02 | Bristol-Myers Squibb Company | Bicyclo 4.4.0 antiviral derivatives |
| US20040063744A1 (en) | 2002-05-28 | 2004-04-01 | Tao Wang | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides |
| US6900206B2 (en) | 2002-06-20 | 2005-05-31 | Bristol-Myers Squibb Company | Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives |
| US20040063746A1 (en) | 2002-07-25 | 2004-04-01 | Alicia Regueiro-Ren | Indole, azaindole and related heterocyclic ureido and thioureido piperazine derivatives |
| US20050075364A1 (en) * | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
-
2004
- 2004-11-02 US US10/979,558 patent/US20050124623A1/en not_active Abandoned
- 2004-11-04 RU RU2006122661/04A patent/RU2362777C2/ru not_active IP Right Cessation
- 2004-11-04 PL PL04810538T patent/PL1751161T3/pl unknown
- 2004-11-04 DE DE602004028173T patent/DE602004028173D1/de active Active
- 2004-11-04 AT AT04810538T patent/ATE473981T1/de active
- 2004-11-04 CN CNA2004800410157A patent/CN1906199A/zh active Pending
- 2004-11-04 AU AU2004295309A patent/AU2004295309A1/en not_active Abandoned
- 2004-11-04 NZ NZ546904A patent/NZ546904A/en not_active IP Right Cessation
- 2004-11-04 PT PT04810538T patent/PT1751161E/pt unknown
- 2004-11-04 MX MXPA06005730A patent/MXPA06005730A/es active IP Right Grant
- 2004-11-04 ES ES04810538T patent/ES2347253T3/es active Active
- 2004-11-04 CA CA2547347A patent/CA2547347C/en not_active Expired - Fee Related
- 2004-11-04 EP EP04810538A patent/EP1751161B1/en active Active
- 2004-11-04 UA UAA200607023A patent/UA85502C2/ru unknown
- 2004-11-04 KR KR1020067010260A patent/KR20070008526A/ko not_active Application Discontinuation
- 2004-11-04 DK DK04810538.1T patent/DK1751161T3/da active
- 2004-11-04 BR BRPI0417007-5A patent/BRPI0417007A/pt not_active IP Right Cessation
- 2004-11-04 WO PCT/US2004/037213 patent/WO2005054247A1/en active Application Filing
- 2004-11-04 SI SI200431509T patent/SI1751161T1/sl unknown
- 2004-11-04 JP JP2006541240A patent/JP2007512332A/ja active Pending
- 2004-11-22 TW TW093135865A patent/TWI336253B/zh not_active IP Right Cessation
- 2004-11-26 AR ARP040104394A patent/AR046720A1/es not_active Application Discontinuation
- 2004-11-26 PE PE2004001165A patent/PE20050587A1/es not_active Application Discontinuation
-
2006
- 2006-05-21 IL IL175809A patent/IL175809A/en not_active IP Right Cessation
- 2006-05-23 IS IS8479A patent/IS2890B/is unknown
- 2006-05-25 ZA ZA200604331A patent/ZA200604331B/xx unknown
- 2006-05-30 NO NO20062474A patent/NO336261B1/no not_active IP Right Cessation
-
2008
- 2008-02-06 US US12/026,633 patent/US7902204B2/en not_active Expired - Fee Related
-
2010
- 2010-08-03 HR HR20100433T patent/HRP20100433T1/hr unknown
- 2010-10-14 CY CY20101100918T patent/CY1110831T1/el unknown
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