HRP20080078T3 - Derivati 1-piperazin i 1-homopiperazin karboksilata, postupak za njihovu proizvodnju i njihovu primjenu kao inhibitora enzima faah - Google Patents
Derivati 1-piperazin i 1-homopiperazin karboksilata, postupak za njihovu proizvodnju i njihovu primjenu kao inhibitora enzima faahInfo
- Publication number
- HRP20080078T3 HRP20080078T3 HR20080078T HRP20080078T HRP20080078T3 HR P20080078 T3 HRP20080078 T3 HR P20080078T3 HR 20080078 T HR20080078 T HR 20080078T HR P20080078 T HRP20080078 T HR P20080078T HR P20080078 T3 HRP20080078 T3 HR P20080078T3
- Authority
- HR
- Croatia
- Prior art keywords
- group
- thiadiazolyl
- cycloalkyl
- alkylene
- alkyl
- Prior art date
Links
- QSNVXCLUVMICBZ-UHFFFAOYSA-N 1,4-diazepane-1-carboxylic acid Chemical class OC(=O)N1CCCNCC1 QSNVXCLUVMICBZ-UHFFFAOYSA-N 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 101150042613 FA2H gene Proteins 0.000 title 1
- 101150008770 FAAH gene Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- -1 tetrahydroyl Chemical group 0.000 abstract 18
- 125000001113 thiadiazolyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 2
- 125000004604 benzisothiazolyl group Chemical group S1N=C(C2=C1C=CC=C2)* 0.000 abstract 2
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 abstract 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 2
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 2
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 abstract 2
- 125000004612 furopyridinyl group Chemical group O1C(=CC2=C1C=CC=N2)* 0.000 abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 abstract 2
- 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 abstract 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 abstract 2
- 125000001041 indolyl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 abstract 2
- 125000002971 oxazolyl group Chemical group 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 125000000335 thiazolyl group Chemical group 0.000 abstract 2
- 125000004306 triazinyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004582 dihydrobenzothienyl group Chemical group S1C(CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229960004819 isoxsuprine Drugs 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000005882 oxadiazolinyl group Chemical group 0.000 abstract 1
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Spoj koji odgovara formuli (I) u kojojm predstavlja cijeli broj koji je jednak 1 ili 2; R1 predstavlja skupinu koja je odabrana naročito iz skupine koju sačinjavaju fenil, piridinil, piridazinil, pirimidinil, pirazinil, triazinil, oksazolil, tiazolil, imidazolil, oksadiazolil, tiadiazolil, triazolil, naftil, kinolinil, tetrahidrokinolinil, izokinolinil, tetrahidroizokinolinil, ftalazinil, kinazolinil, kinoksalinil, cinolinil, naftiridinil, benzofuranil, dihidrobenzofuranil, benzotienil, dihidrobenzotienil, indolil, benzoksazolil, benzizoksazolil, benzotiazolil, benzizotiazolil, benzimidazolil, indazolil, pirolopiridinil, furopiridinil, dihidrofuropiridinil, tienopiridinil, dihidrotienopiridinil, imidazopiridinil, imidazopirimidinil, pirazolopiridinil, oksazolopiridinil, izoksazolopiridinil, tiazolopiridinil, izotiazolopiridinil, pri čemuova skupina može biti supstituirana s jednom ili više skupina R3 koje su jednake ili različite jedna od druge, ili sa skupinom R4;R2 predstavlja skupinu opće formule CHR5CONHR6,R3 predstavlja atom halogena ili hidroksi, cijano, nitro, C1-6-alkil, C1-6-alkoksi, C1-6-tioalkil, C1-6-fluoroalkil, C1-6-fluoroalkoksi, -O-(C2-3-alkilen)-, -O-(C1-3-alkilen)-O-, C1-6-fluorotioalkil, C3-7-cikloalkil, C3-7-cikloalkil-C1-3-alkilen, piperidinil, benziloksi, piperazinil, pirolidinil, morfolinil, feniloksi, NR7R8, NHCOR7, NHSO2R7, COR7, CO2R7, CONR7R8, SO2R7ili SO2NR7R8 skupinu, R4 predstavlja skupinu odabranu naročito iz skupine koju sačinjavaju fenil, benzofuranil, naftil, piridinil, pirimidinil, piridazinil, pirazinil, triazinil, oksazolil, tiazolil,imidazolil, oksadiazolil, tiadiazolil, triazolil,kinolinil, tetrahidrokinolinil, izokinolinil, tetrahidroizokinolinil, ftalazinil, kinazolinil, kinoksalinil, naftiridinil, cinolinil, imidazol-pirimidinil, benzotienil, indolil, benzoksazolil, benzizoksazolil, benzotiazolil, benzizotiazolil, benzimidazolil, indazolil, pirolopiridinil, furopiridinil, dihidrofuropiridinil, tienopiridinil, dihidrotienopiridinil, imidazopiridinil, imidazopirimidinil,pirazolopiridinil, oksazolopiridinil, izoksazolopiridinil, tiazolopiridinil, izotiazolopiridinil; skupina ili skupine R4 mogu biti supstituirane s jednom ili više skupina R3 koje su identične ili različite jedna od druge; R5 predstavlja atom vodika ili C1-3-alkil skupinu; R6 predstavlja atom vodikaili C1-6-alkil, C3-7-cikloalkil ili C3-7-cikloalkil-C1-3-alkilen skupinu; R7 i R8 predstavljaju, nezavisno jedan od drugog, atom vodika, C1-3-alkil skupinu ili fenil skupinu; u obliku baze, adicijskesoli s kiselinom, hidrata ili solvata. Patent sadrži još 24 patentna zahtjeva.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0315248A FR2864080B1 (fr) | 2003-12-23 | 2003-12-23 | Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique |
PCT/FR2004/003289 WO2005070910A2 (fr) | 2003-12-23 | 2004-12-17 | Derives de 1 -piperazine- et 1-homopiperazine-carboxylates, leur preparation et leur application en tant qu’ inhibiteurs de l’enzyme faah |
Publications (1)
Publication Number | Publication Date |
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HRP20080078T3 true HRP20080078T3 (hr) | 2008-03-31 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HR20080078T HRP20080078T3 (hr) | 2003-12-23 | 2008-02-22 | Derivati 1-piperazin i 1-homopiperazin karboksilata, postupak za njihovu proizvodnju i njihovu primjenu kao inhibitora enzima faah |
Country Status (29)
Country | Link |
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US (2) | US7687503B2 (hr) |
EP (1) | EP1701946B1 (hr) |
JP (1) | JP4833080B2 (hr) |
KR (1) | KR101276427B1 (hr) |
CN (2) | CN101538254B (hr) |
AR (1) | AR046982A1 (hr) |
AT (1) | ATE381552T1 (hr) |
AU (1) | AU2004314287B2 (hr) |
BR (1) | BRPI0418134A (hr) |
CA (1) | CA2550598C (hr) |
CY (1) | CY1107902T1 (hr) |
DE (1) | DE602004010848T2 (hr) |
DK (1) | DK1701946T3 (hr) |
ES (1) | ES2297533T3 (hr) |
FR (1) | FR2864080B1 (hr) |
HK (2) | HK1133009A1 (hr) |
HR (1) | HRP20080078T3 (hr) |
IL (1) | IL176478A (hr) |
MA (1) | MA28234A1 (hr) |
NO (1) | NO20063229L (hr) |
NZ (1) | NZ548194A (hr) |
PL (1) | PL1701946T3 (hr) |
PT (1) | PT1701946E (hr) |
RS (1) | RS50544B (hr) |
RU (1) | RU2356890C2 (hr) |
SI (1) | SI1701946T1 (hr) |
TW (1) | TWI339121B (hr) |
WO (1) | WO2005070910A2 (hr) |
ZA (2) | ZA200505522B (hr) |
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US9474271B2 (en) * | 2013-01-18 | 2016-10-25 | Research Foundation Of The City University Of New York | Method for enhancing amidohydrolase activity of fatty acid amide hydrolase |
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EA201792496A1 (ru) | 2015-05-11 | 2018-04-30 | Абиде Терапеутикс, Инк. | Способы лечения воспаления или нейропатической боли |
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WO2018053447A1 (en) | 2016-09-19 | 2018-03-22 | Abide Therapeutics, Inc. | Piperazine carbamates and methods of making and using same |
JOP20190106A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
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JPH05255089A (ja) * | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
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- 2004-12-17 DE DE602004010848T patent/DE602004010848T2/de active Active
- 2004-12-17 AU AU2004314287A patent/AU2004314287B2/en not_active Ceased
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