HRP20080077T3 - Substituted n-cyclohexylimidazolinones having an mch-modulatory effect - Google Patents
Substituted n-cyclohexylimidazolinones having an mch-modulatory effectInfo
- Publication number
- HRP20080077T3 HRP20080077T3 HR20080077T HRP20080077T HRP20080077T3 HR P20080077 T3 HRP20080077 T3 HR P20080077T3 HR 20080077 T HR20080077 T HR 20080077T HR P20080077 T HRP20080077 T HR P20080077T HR P20080077 T3 HRP20080077 T3 HR P20080077T3
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- group
- independently
- another
- alkoxy
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 13
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 10
- 229910052757 nitrogen Inorganic materials 0.000 abstract 7
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 6
- 229910052760 oxygen Inorganic materials 0.000 abstract 6
- 229910052717 sulfur Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 239000011593 sulfur Chemical group 0.000 abstract 3
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000006553 (C3-C8) cycloalkenyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004003811A DE102004003811A1 (de) | 2004-01-25 | 2004-01-25 | Substituierte N-Cyclohexylimidazolinone, Verfahren ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP2005/000700 WO2005070898A1 (de) | 2004-01-25 | 2005-01-25 | Substituierte n-cyclohexylimidazolinone mit mch-modulatorischer wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20080077T3 true HRP20080077T3 (en) | 2008-03-31 |
Family
ID=34745115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080077T HRP20080077T3 (en) | 2004-01-25 | 2008-02-22 | Substituted n-cyclohexylimidazolinones having an mch-modulatory effect |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1711473B1 (pt) |
| JP (1) | JP2007518771A (pt) |
| KR (1) | KR20060128955A (pt) |
| CN (1) | CN1934090B (pt) |
| AR (1) | AR047453A1 (pt) |
| AT (1) | ATE383342T1 (pt) |
| AU (1) | AU2005206308A1 (pt) |
| BR (1) | BRPI0507104A (pt) |
| CA (1) | CA2554233A1 (pt) |
| CY (1) | CY1107429T1 (pt) |
| DE (2) | DE102004003811A1 (pt) |
| DK (1) | DK1711473T3 (pt) |
| ES (1) | ES2297667T3 (pt) |
| HR (1) | HRP20080077T3 (pt) |
| IL (1) | IL176917A0 (pt) |
| MA (1) | MA28345A1 (pt) |
| MY (1) | MY139107A (pt) |
| NO (1) | NO20063757L (pt) |
| PE (1) | PE20051091A1 (pt) |
| PL (1) | PL1711473T3 (pt) |
| PT (1) | PT1711473E (pt) |
| RS (1) | RS50543B (pt) |
| RU (1) | RU2006130626A (pt) |
| TW (1) | TW200604182A (pt) |
| UY (1) | UY28726A1 (pt) |
| WO (1) | WO2005070898A1 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007071646A1 (en) | 2005-12-21 | 2007-06-28 | Janssen Pharmaceutica N.V. | Novel substituted pyrazinone derivatives for use in mch-1 mediated diseases |
| WO2008017381A1 (de) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| ES2483866T3 (es) | 2006-12-05 | 2014-08-08 | Janssen Pharmaceutica Nv | Derivados de diaza-espiro-piridinona sustituidos novedosos para uso en enfermedades mediadas por MCH-1 |
| KR100893394B1 (ko) * | 2007-05-11 | 2009-04-17 | 한국화학연구원 | 아릴 피페리딘기-함유 이미다졸 유도체, 이의 제조방법 및이를 유효성분으로 포함하는 약학적 조성물 |
| AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
| DE102008060967A1 (de) * | 2008-12-06 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylsulfonyltriazolone und ihre Verwendung |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| CA2771278A1 (en) | 2009-08-26 | 2011-03-03 | Sanofi | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
| US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683703B1 (de) | 2011-03-08 | 2015-05-27 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8846666B2 (en) | 2011-03-08 | 2014-09-30 | Sanofi | Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| WO2012120051A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| PL223830B1 (pl) | 2012-04-03 | 2016-11-30 | Univ Jagielloński | Pochodne aromatycznych imidazolidynonów i ich zastosowanie |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050044664A (ko) * | 2001-12-04 | 2005-05-12 | 쉐링 코포레이션 | 비만 치료용 ｍｃｈ 길항제로서의ｎ-아릴-ｎ'-아릴사이클로알킬-우레아 유도체 |
| DE10233817A1 (de) * | 2002-07-25 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
-
2004
- 2004-01-25 DE DE102004003811A patent/DE102004003811A1/de not_active Withdrawn
-
2005
- 2005-01-24 AR ARP050100240A patent/AR047453A1/es not_active Application Discontinuation
- 2005-01-25 EP EP05707002A patent/EP1711473B1/de active Active
- 2005-01-25 KR KR1020067015035A patent/KR20060128955A/ko not_active Application Discontinuation
- 2005-01-25 BR BRPI0507104-6A patent/BRPI0507104A/pt not_active IP Right Cessation
- 2005-01-25 TW TW094102156A patent/TW200604182A/zh unknown
- 2005-01-25 DE DE502005002497T patent/DE502005002497D1/de active Active
- 2005-01-25 MY MYPI20050274A patent/MY139107A/en unknown
- 2005-01-25 DK DK05707002T patent/DK1711473T3/da active
- 2005-01-25 RU RU2006130626/04A patent/RU2006130626A/ru not_active Application Discontinuation
- 2005-01-25 PL PL05707002T patent/PL1711473T3/pl unknown
- 2005-01-25 UY UY28726A patent/UY28726A1/es unknown
- 2005-01-25 CN CN2005800091349A patent/CN1934090B/zh not_active Expired - Fee Related
- 2005-01-25 PT PT05707002T patent/PT1711473E/pt unknown
- 2005-01-25 ES ES05707002T patent/ES2297667T3/es active Active
- 2005-01-25 AT AT05707002T patent/ATE383342T1/de not_active IP Right Cessation
- 2005-01-25 AU AU2005206308A patent/AU2005206308A1/en not_active Abandoned
- 2005-01-25 RS RSP-2008/0082A patent/RS50543B/sr unknown
- 2005-01-25 PE PE2005000095A patent/PE20051091A1/es not_active Application Discontinuation
- 2005-01-25 JP JP2006550073A patent/JP2007518771A/ja not_active Abandoned
- 2005-01-25 CA CA002554233A patent/CA2554233A1/en not_active Abandoned
- 2005-01-25 WO PCT/EP2005/000700 patent/WO2005070898A1/de active Application Filing
-
2006
- 2006-07-17 IL IL176917A patent/IL176917A0/en not_active IP Right Cessation
- 2006-08-03 MA MA29233A patent/MA28345A1/fr unknown
- 2006-08-22 NO NO20063757A patent/NO20063757L/no not_active Application Discontinuation
-
2008
- 2008-02-22 HR HR20080077T patent/HRP20080077T3/xx unknown
- 2008-03-21 CY CY20081100322T patent/CY1107429T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20051091A1 (es) | 2006-01-23 |
| DE102004003811A1 (de) | 2005-08-11 |
| DK1711473T3 (da) | 2008-05-26 |
| PL1711473T3 (pl) | 2008-05-30 |
| UY28726A1 (es) | 2005-08-31 |
| TW200604182A (en) | 2006-02-01 |
| ES2297667T3 (es) | 2008-05-01 |
| AR047453A1 (es) | 2006-01-18 |
| CN1934090B (zh) | 2010-04-07 |
| KR20060128955A (ko) | 2006-12-14 |
| CA2554233A1 (en) | 2005-08-04 |
| NO20063757L (no) | 2006-10-11 |
| JP2007518771A (ja) | 2007-07-12 |
| CN1934090A (zh) | 2007-03-21 |
| CY1107429T1 (el) | 2012-12-19 |
| DE502005002497D1 (de) | 2008-02-21 |
| MY139107A (en) | 2009-08-28 |
| AU2005206308A1 (en) | 2005-08-04 |
| ATE383342T1 (de) | 2008-01-15 |
| EP1711473A1 (de) | 2006-10-18 |
| BRPI0507104A (pt) | 2007-06-19 |
| IL176917A0 (en) | 2006-12-10 |
| PT1711473E (pt) | 2008-03-07 |
| EP1711473B1 (de) | 2008-01-09 |
| RS50543B (sr) | 2010-05-07 |
| MA28345A1 (fr) | 2006-12-01 |
| RU2006130626A (ru) | 2008-02-27 |
| WO2005070898A1 (de) | 2005-08-04 |
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